Scores & Fixtures 2021 Major League Soccer
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2021-04-17 | 14:00 | CF Montréal | 1.3 | 4–2 | 2.0 | Toronto FC | DRV PNK Stadium | Ismail Elfath | Match Report | ||
| Sat | 2021-04-17 | 15:00 | Los Angeles FC | 3.2 | 2–0 | 0.8 | Austin | 4,900 | Banc of California Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-04-17 | 15:00 | Orlando City | 1.4 | 0–0 | 1.2 | Atlanta Utd | 11,503 | Exploria Stadium | Jair Marrufo | Match Report | |
| Fri | 2021-04-16 | 18:30 | Seattle | 3.2 | 4–0 | 1.3 | Minnesota Utd | 7,042 | Lumen Field | Joe Dickerson | Match Report | |
| Fri | 2021-04-16 | 19:00 | Dynamo FC | 1.7 | 2–1 | 1.2 | San Jose | BBVA Stadium | Armando Villarreal | Match Report | ||
| Sun | 2021-04-18 | 15:00 | Inter Miami | 2.9 | 2–3 | 1.7 | LA Galaxy | DRV PNK Stadium | Chris Penso | Match Report | ||
| Sun | 2021-04-18 | 17:30 | Columbus Crew | 1.1 | 0–0 | 1.3 | Philadelphia | 5,180 | MAPFRE Stadium | Ramy Touchan | Match Report | |
| Sat | 2021-04-17 | 19:00 | FC Dallas | 0.9 | 0–0 | 1.0 | Colorado Rapids | 8,621 | Toyota Stadium | Nima Saghafi | Match Report | |
| Sat | 2021-04-17 | 19:30 | Nashville | 3.7 | 2–2 | 2.1 | FC Cincinnati | Nissan Stadium | Rubiel Vazquez | Match Report | ||
| Sat | 2021-04-17 | 19:30 | Chicago Fire | 2.2 | 2–2 | 2.0 | New England | Soldier Field | Fotis Bazakos | Match Report | ||
| Sat | 2021-04-17 | 20:00 | NY Red Bulls | 0.9 | 1–2 | 2.0 | Sporting KC | Red Bull Arena | Robert Sibiga | Match Report | ||
| Sat | 2021-04-17 | 20:00 | D.C. United | 0.6 | 2–1 | 1.0 | NYCFC | 4,500 | Audi Field | Ted Unkel | Match Report | |
| Sun | 2021-04-18 | 20:00 | Vancouver | 0.5 | 1–0 | 1.2 | Portland Timbers | Rio Tinto Stadium | Allen Chapman | Match Report | ||
| Fri | 2021-04-23 | 18:30 | Sporting KC | 0.6 | 1–1 | 1.1 | Orlando City | Children's Mercy Park | Joe Dickerson | Match Report | ||
| Sat | 2021-04-24 | 12:30 | San Jose | 3.3 | 3–1 | 1.5 | FC Dallas | Earthquakes Stadium | Tim Ford | Match Report | ||
| Sat | 2021-04-24 | 13:00 | NYCFC | 2.5 | 5–0 | 1.4 | FC Cincinnati | Yankee Stadium | Dave Gantar | Match Report | ||
| Sat | 2021-04-24 | 13:00 | Nashville | 2.7 | 2–2 | 0.8 | CF Montréal | Nissan Stadium | Fotis Bazakos | Match Report | ||
| Sat | 2021-04-24 | 15:00 | Toronto FC | 1.7 | 2–2 | 1.6 | Vancouver | Exploria Stadium | Jair Marrufo | Match Report | ||
| Sat | 2021-04-24 | 15:00 | Los Angeles FC | 0.6 | 1–1 | 0.8 | Seattle | Banc of California Stadium | Armando Villarreal | Match Report | ||
| Sun | 2021-04-25 | 14:30 | LA Galaxy | 2.0 | 3–2 | 1.2 | NY Red Bulls | Dignity Health Sports Park | Victor Rivas | Match Report | ||
| Sat | 2021-04-24 | 19:00 | Minnesota Utd | 1.7 | 1–2 | 1.4 | Real Salt Lake | 4,100 | Allianz Field | Drew Fischer | Match Report | |
| Sat | 2021-04-24 | 19:00 | Colorado Rapids | 1.3 | 1–3 | 2.1 | Austin | Dick's Sporting Goods Park | Marcos de Oliveira | Match Report | ||
| Sat | 2021-04-24 | 19:30 | Portland Timbers | 2.6 | 2–1 | 1.2 | Dynamo FC | Providence Park | Ismail Elfath | Match Report | ||
| Sat | 2021-04-24 | 20:00 | New England | 0.2 | 1–0 | 0.3 | D.C. United | Gillette Stadium | Guido Gonzalez Jr. | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-04-24 | 20:00 | Atlanta Utd | 1.7 | 3–1 | 1.0 | Chicago Fire | 20,335 | Mercedes-Benz Stadium | Allen Chapman | Match Report | |
| Sat | 2021-04-24 | 20:00 | Philadelphia | 0.9 | 1–2 | 1.0 | Inter Miami | 5,000 | Subaru Park | Alex Chilowicz | Match Report | |
| Sat | 2021-05-01 | 12:00 | Real Salt Lake | 1.2 | 3–1 | 0.3 | Sporting KC | Rio Tinto Stadium | Dave Gantar | Match Report | ||
| Sat | 2021-05-01 | 13:00 | NY Red Bulls | 1.6 | 2–0 | 0.3 | Chicago Fire | Red Bull Arena | Ted Unkel | Match Report | ||
| Sat | 2021-05-01 | 14:30 | Dynamo FC | 1.4 | 1–1 | 1.3 | Los Angeles FC | 7,850 | BBVA Stadium | Robert Sibiga | Match Report | |
| Sat | 2021-05-01 | 15:00 | CF Montréal | 1.6 | 0–0 | 0.2 | Columbus Crew | DRV PNK Stadium | Tim Ford | Match Report | ||
| Sat | 2021-05-01 | 19:00 | New England | 2.4 | 2–1 | 1.5 | Atlanta Utd | Gillette Stadium | Chris Penso | Match Report | ||
| Sat | 2021-05-01 | 19:30 | Philadelphia | 0.3 | 0–2 | 3.0 | NYCFC | Subaru Park | Ismail Elfath | Match Report | ||
| Sat | 2021-05-01 | 19:30 | Orlando City | 2.8 | 3–0 | 1.0 | FC Cincinnati | Exploria Stadium | Drew Fischer | Match Report | ||
| Sun | 2021-05-02 | 12:00 | Nashville | 0.9 | 0–0 | 0.4 | Inter Miami | 13,855 | Nissan Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-05-01 | 19:00 | Minnesota Utd | 0.9 | 0–1 | 1.8 | Austin | 4,100 | Allianz Field | Ramy Touchan | Match Report | |
| Sat | 2021-05-01 | 19:00 | FC Dallas | 1.8 | 4–1 | 0.8 | Portland Timbers | 8,621 | Toyota Stadium | Alan Kelly | Match Report | |
| Sat | 2021-05-01 | 20:00 | San Jose | 2.0 | 4–1 | 2.0 | D.C. United | Earthquakes Stadium | Kevin Stott | Match Report | ||
| Sun | 2021-05-02 | 18:00 | Seattle | 2.1 | 3–0 | 0.9 | LA Galaxy | 7,148 | Lumen Field | Jair Marrufo | Match Report | |
| Sun | 2021-05-02 | 20:00 | Vancouver | 0.7 | 0–1 | 2.0 | Colorado Rapids | Rio Tinto Stadium | Baldomero Toledo | Match Report | ||
| Sat | 2021-05-08 | 12:00 | Chicago Fire | 1.0 | 0–2 | 1.4 | Philadelphia | 6,457 | Soldier Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-05-08 | 12:00 | Vancouver | 1.5 | 2–0 | 1.5 | CF Montréal | Rio Tinto Stadium | Rosendo Mendoza | Match Report | ||
| Sat | 2021-05-08 | 12:30 | Nashville | 1.4 | 2–0 | 0.9 | New England | 12,510 | Nissan Stadium | Victor Rivas | Match Report | |
| Sat | 2021-05-08 | 13:00 | NY Red Bulls | 1.7 | 2–0 | 0.4 | Toronto FC | Red Bull Arena | Guido Gonzalez Jr. | Match Report | ||
| Sat | 2021-05-08 | 13:30 | Columbus Crew | 0.4 | 3–1 | 1.0 | D.C. United | 5,180 | MAPFRE Stadium | Silviu Petrescu | Match Report | |
| Sat | 2021-05-08 | 14:30 | FC Dallas | 1.6 | 1–1 | 1.7 | Dynamo FC | 8,749 | Toyota Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-05-08 | 18:00 | Orlando City | 0.7 | 1–1 | 1.9 | NYCFC | 11,503 | Exploria Stadium | Robert Sibiga | Match Report | |
| Fri | 2021-05-07 | 19:30 | Real Salt Lake | 1.1 | 1–2 | 2.0 | San Jose | 10,448 | Rio Tinto Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-05-09 | 12:00 | Portland Timbers | 1.7 | 1–2 | 2.4 | Seattle | Providence Park | Chris Penso | Match Report | ||
| Sun | 2021-05-09 | 13:00 | Inter Miami | 2.2 | 1–1 | 1.3 | Atlanta Utd | 8,074 | DRV PNK Stadium | Joe Dickerson | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-05-08 | 17:00 | LA Galaxy | 1.0 | 2–1 | 1.2 | Los Angeles FC | 7,193 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Sun | 2021-05-09 | 18:30 | Sporting KC | 3.6 | 2–1 | 0.9 | Austin | Children's Mercy Park | Ted Unkel | Match Report | ||
| Sat | 2021-05-08 | 20:00 | Colorado Rapids | 1.2 | 3–2 | 1.3 | Minnesota Utd | Dick's Sporting Goods Park | Tim Ford | Match Report | ||
| Wed | 2021-05-12 | 19:00 | Toronto FC | 2.2 | 2–0 | 0.7 | Columbus Crew | Exploria Stadium | Fotis Bazakos | Match Report | ||
| Wed | 2021-05-12 | 19:30 | Inter Miami | 0.5 | 0–2 | 1.6 | CF Montréal | 8,220 | DRV PNK Stadium | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-05-12 | 19:30 | Philadelphia | 2.3 | 1–1 | 1.5 | New England | 5,000 | Subaru Park | Tori Penso | Match Report | |
| Wed | 2021-05-12 | 19:30 | Dynamo FC | 1.5 | 1–0 | 2.1 | Sporting KC | 7,054 | BBVA Stadium | Chris Penso | Match Report | |
| Wed | 2021-05-12 | 19:30 | San Jose | 1.8 | 0–1 | 1.3 | Seattle | 5,000 | Earthquakes Stadium | Baldomero Toledo | Match Report | |
| Wed | 2021-05-12 | 20:00 | Minnesota Utd | 1.6 | 1–0 | 0.8 | Vancouver | 4,100 | Allianz Field | Jon Freemon | Match Report | |
| Thu | 2021-05-13 | 20:00 | D.C. United | 1.4 | 1–0 | 1.8 | Chicago Fire | 3,935 | Audi Field | Ramy Touchan | Match Report | |
| Sat | 2021-05-15 | 12:30 | LA Galaxy | 2.5 | 2–0 | 1.2 | Austin | 7,193 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Sat | 2021-05-15 | 13:00 | NYCFC | 1.6 | 1–1 | 0.6 | Toronto FC | Yankee Stadium | Dave Gantar | Match Report | ||
| Sat | 2021-05-15 | 19:00 | Atlanta Utd | 0.8 | 1–0 | 0.8 | CF Montréal | 40,116 | Mercedes-Benz Stadium | Silviu Petrescu | Match Report | |
| Sat | 2021-05-15 | 19:30 | Philadelphia | 1.0 | 1–0 | 1.1 | NY Red Bulls | 5,000 | Subaru Park | Allen Chapman | Match Report | |
| Sun | 2021-05-16 | 13:00 | Sporting KC | 3.2 | 3–0 | 1.1 | Vancouver | Children's Mercy Park | Alan Kelly | Match Report | ||
| Sun | 2021-05-16 | 16:00 | FC Cincinnati | 1.2 | 2–3 | 1.9 | Inter Miami | 6,000 | TQL Stadium | Ramy Touchan | Match Report | |
| Sun | 2021-05-16 | 18:00 | New England | 1.4 | 1–0 | 0.3 | Columbus Crew | Gillette Stadium | Robert Sibiga | Match Report | ||
| Sat | 2021-05-15 | 19:00 | Minnesota Utd | 2.1 | 1–0 | 1.0 | FC Dallas | 4,100 | Allianz Field | Ted Unkel | Match Report | |
| Sat | 2021-05-15 | 19:00 | San Jose | 2.7 | 0–2 | 2.1 | Portland Timbers | Earthquakes Stadium | Tim Ford | Match Report | ||
| Sat | 2021-05-15 | 19:00 | Colorado Rapids | 2.2 | 3–1 | 0.4 | Dynamo FC | Dick's Sporting Goods Park | Victor Rivas | Match Report | ||
| Sat | 2021-05-15 | 19:30 | Real Salt Lake | 0.8 | 0–0 | 1.0 | Nashville | 10,555 | Rio Tinto Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2021-05-16 | 18:30 | Seattle | 1.3 | 2–0 | 0.6 | Los Angeles FC | 7,173 | Lumen Field | Joe Dickerson | Match Report | |
| Sun | 2021-05-16 | 20:00 | D.C. United | 0.9 | 0–1 | 0.6 | Orlando City | 5,280 | Audi Field | Alex Chilowicz | Match Report | |
| Sat | 2021-05-22 | 12:30 | Portland Timbers | 3.3 | 3–0 | 1.2 | LA Galaxy | Providence Park | Alan Kelly | Match Report | ||
| Sat | 2021-05-22 | 13:00 | CF Montréal | 2.6 | 1–2 | 1.5 | FC Cincinnati | DRV PNK Stadium | Fotis Bazakos | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-05-22 | 17:00 | Chicago Fire | 1.9 | 1–0 | 0.3 | Inter Miami | 10,844 | Soldier Field | Silviu Petrescu | Match Report | |
| Sat | 2021-05-22 | 19:00 | Orlando City | 1.9 | 1–0 | 1.5 | Toronto FC | 11,525 | Exploria Stadium | Victor Rivas | Match Report | |
| Sat | 2021-05-22 | 19:30 | NYCFC | 1.4 | 1–2 | 0.6 | Columbus Crew | 3,154 | Red Bull Arena | Drew Fischer | Match Report | |
| Sun | 2021-05-23 | 13:30 | Seattle | 0.5 | 1–1 | 1.1 | Atlanta Utd | 11,011 | Lumen Field | Kevin Stott | Match Report | |
| Sat | 2021-05-22 | 19:00 | San Jose | 1.8 | 1–3 | 1.7 | Sporting KC | Earthquakes Stadium | Allen Chapman | Match Report | ||
| Sat | 2021-05-22 | 19:00 | FC Dallas | 2.9 | 2–2 | 1.1 | Real Salt Lake | 8,621 | Toyota Stadium | Joe Dickerson | Match Report | |
| Sun | 2021-05-23 | 19:15 | D.C. United | 1.2 | 0–1 | 1.2 | Philadelphia | 6,200 | Audi Field | Tim Ford | Match Report | |
| Sat | 2021-05-22 | 19:30 | Los Angeles FC | 1.5 | 2–1 | 1.1 | Colorado Rapids | 10,483 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-05-22 | 20:00 | Dynamo FC | 1.4 | 2–1 | 1.3 | Vancouver | 9,255 | BBVA Stadium | Dave Gantar | Match Report | |
| Sat | 2021-05-22 | 20:00 | New England | 3.7 | 3–1 | 1.2 | NY Red Bulls | Gillette Stadium | Jair Marrufo | Match Report | ||
| Sun | 2021-05-23 | 20:00 | Nashville | 2.3 | 1–0 | 0.7 | Austin | 22,421 | Nissan Stadium | Chris Penso | Match Report | |
| Sat | 2021-05-29 | 12:00 | Chicago Fire | 2.0 | 0–1 | 0.6 | CF Montréal | 6,680 | Soldier Field | Victor Rivas | Match Report | |
| Sat | 2021-05-29 | 13:00 | NY Red Bulls | 1.7 | 2–1 | 1.2 | Orlando City | Red Bull Arena | Ismail Elfath | Match Report | ||
| Sat | 2021-05-29 | 14:00 | Los Angeles FC | 2.3 | 1–2 | 1.0 | NYCFC | 10,703 | Banc of California Stadium | Kevin Stott | Match Report | |
| Sat | 2021-05-29 | 15:00 | FC Cincinnati | 0.8 | 0–1 | 1.9 | New England | 11,000 | TQL Stadium | Dave Gantar | Match Report | |
| Sat | 2021-05-29 | 15:00 | Columbus Crew | 1.1 | 2–1 | 1.0 | Toronto FC | 5,700 | MAPFRE Stadium | Allen Chapman | Match Report | |
| Sat | 2021-05-29 | 15:30 | Atlanta Utd | 1.5 | 2–2 | 1.8 | Nashville | 40,748 | Mercedes-Benz Stadium | Alan Kelly | Match Report | |
| Sat | 2021-05-29 | 16:00 | LA Galaxy | 1.6 | 1–0 | 1.9 | San Jose | Dignity Health Sports Park | Joe Dickerson | Match Report | ||
| Sat | 2021-05-29 | 19:00 | Colorado Rapids | 1.9 | 3–0 | 1.9 | FC Dallas | Dick's Sporting Goods Park | Guido Gonzalez Jr. | Match Report | ||
| Sun | 2021-05-30 | 19:00 | Philadelphia | 2.8 | 3–0 | 1.2 | Portland Timbers | 6,635 | Subaru Park | Robert Sibiga | Match Report | |
| Sat | 2021-05-29 | 19:30 | Real Salt Lake | 1.1 | 1–1 | 0.9 | Minnesota Utd | 10,853 | Rio Tinto Stadium | Jair Marrufo | Match Report | |
| Sat | 2021-05-29 | 19:30 | Sporting KC | 2.3 | 3–2 | 2.1 | Dynamo FC | 20,086 | Children's Mercy Park | Drew Fischer | Match Report | |
| Sat | 2021-05-29 | 20:00 | Inter Miami | 0.7 | 0–3 | 2.2 | D.C. United | DRV PNK Stadium | Armando Villarreal | Match Report | ||
| Sun | 2021-05-30 | 18:30 | Seattle | 1.0 | 0–0 | 0.9 | Austin | 12,895 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2021-06-12 | 14:00 | Sporting KC | 2.9 | 1–1 | 1.9 | Austin | 18,519 | Children's Mercy Park | Robert Sibiga | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-06-19 | 19:30 | Columbus Crew | 2.2 | 2–0 | 1.0 | Chicago Fire | 20,064 | MAPFRE Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-06-19 | 19:30 | NYCFC | 3.2 | 2–3 | 1.1 | New England | 4,929 | Red Bull Arena | Allen Chapman | Match Report | |
| Sat | 2021-06-19 | 19:30 | Toronto FC | 2.4 | 2–3 | 1.3 | Orlando City | Exploria Stadium | Armando Villarreal | Match Report | ||
| Sat | 2021-06-19 | 19:30 | FC Cincinnati | 2.2 | 0–2 | 0.8 | Colorado Rapids | 25,054 | TQL Stadium | Baldomero Toledo | Match Report | |
| Fri | 2021-06-18 | 20:00 | Real Salt Lake | 1.5 | 3–1 | 1.4 | Vancouver | 15,109 | Rio Tinto Stadium | Rubiel Vazquez | Match Report | |
| Fri | 2021-06-18 | 20:00 | NY Red Bulls | 1.1 | 2–0 | 0.8 | Nashville | 10,173 | Red Bull Arena | Nima Saghafi | Match Report | |
| Sun | 2021-06-20 | 14:00 | Atlanta Utd | 1.4 | 2–2 | 1.6 | Philadelphia | 42,523 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Sat | 2021-06-19 | 18:00 | LA Galaxy | 1.4 | 1–2 | 1.6 | Seattle | 23,165 | Dignity Health Sports Park | Drew Fischer | Match Report | |
| Sat | 2021-06-19 | 19:30 | FC Dallas | 1.0 | 1–1 | 2.1 | Minnesota Utd | 16,455 | Toyota Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-06-19 | 19:30 | Portland Timbers | 1.3 | 2–1 | 1.9 | Sporting KC | Providence Park | Alan Kelly | Match Report | ||
| Sat | 2021-06-19 | 20:00 | Austin | 1.7 | 0–0 | 0.8 | San Jose | Q2 Stadium | Ismail Elfath | Match Report | ||
| Sat | 2021-06-19 | 20:00 | D.C. United | 2.8 | 1–0 | 1.0 | Inter Miami | 16 | Audi Field | Fotis Bazakos | Match Report | |
| Sat | 2021-06-19 | 20:00 | Los Angeles FC | 1.9 | 1–1 | 0.5 | Dynamo FC | 22,043 | Banc of California Stadium | Joe Dickerson | Match Report | |
| Tue | 2021-06-22 | 19:30 | Orlando City | 3.0 | 5–0 | 0.7 | San Jose | 15,476 | Exploria Stadium | Chris Penso | Match Report | |
| Wed | 2021-06-23 | 19:00 | New England | 1.6 | 3–2 | 1.5 | NY Red Bulls | Gillette Stadium | Robert Sibiga | Match Report | ||
| Wed | 2021-06-23 | 19:30 | NYCFC | 2.2 | 1–0 | 0.3 | Atlanta Utd | 3,564 | Red Bull Arena | Ismail Elfath | Match Report | |
| Wed | 2021-06-23 | 19:30 | Philadelphia | 0.5 | 1–0 | 0.5 | Columbus Crew | 16,234 | Subaru Park | Joe Dickerson | Match Report | |
| Wed | 2021-06-23 | 19:00 | Chicago Fire | 2.1 | 0–1 | 1.9 | FC Cincinnati | 5,926 | Soldier Field | Ismir Pekmic | Match Report | |
| Wed | 2021-06-23 | 19:00 | Seattle | 2.4 | 2–1 | 1.2 | Real Salt Lake | 24,652 | Lumen Field | Ted Unkel | Match Report | |
| Wed | 2021-06-23 | 19:00 | Minnesota Utd | 1.4 | 2–0 | 1.0 | Austin | 19,209 | Allianz Field | Silviu Petrescu | Match Report | |
| Wed | 2021-06-23 | 19:30 | Sporting KC | 2.5 | 3–1 | 1.5 | Colorado Rapids | 18,690 | Children's Mercy Park | Dave Gantar | Match Report | |
| Wed | 2021-06-23 | 19:30 | Los Angeles FC | 3.1 | 2–0 | 0.8 | FC Dallas | 22,510 | Banc of California Stadium | Rosendo Mendoza | Match Report | |
| Wed | 2021-06-23 | 19:30 | Nashville | 2.4 | 3–2 | 1.7 | Toronto FC | 17,008 | Nissan Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-06-23 | 19:30 | Dynamo FC | 1.9 | 2–2 | 1.6 | Portland Timbers | 10,791 | BBVA Stadium | Armando Villarreal | Match Report | |
| Wed | 2021-06-23 | 20:00 | CF Montréal | 0.2 | 0–0 | 2.8 | D.C. United | DRV PNK Stadium | Drew Fischer | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-06-23 | 20:30 | Vancouver | 1.2 | 1–2 | 1.0 | LA Galaxy | Rio Tinto Stadium | Tori Penso | Match Report | ||
| Sat | 2021-06-26 | 16:30 | Sporting KC | 1.4 | 2–1 | 0.8 | Los Angeles FC | 20,213 | Children's Mercy Park | Chris Penso | Match Report | |
| Sat | 2021-06-26 | 19:00 | Toronto FC | 0.5 | 0–2 | 1.4 | FC Cincinnati | Exploria Stadium | Rubiel Vazquez | Match Report | ||
| Fri | 2021-06-25 | 20:00 | Inter Miami | 0.9 | 1–2 | 0.7 | Orlando City | 17,926 | DRV PNK Stadium | Allen Chapman | Match Report | |
| Sun | 2021-06-27 | 15:30 | Atlanta Utd | 1.6 | 0–0 | 0.7 | NY Red Bulls | 42,575 | Mercedes-Benz Stadium | Alan Kelly | Match Report | |
| Sat | 2021-06-26 | 18:00 | Seattle | 2.5 | 2–2 | 1.6 | Vancouver | 25,603 | Lumen Field | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-06-27 | 18:00 | NYCFC | 1.5 | 2–1 | 0.9 | D.C. United | 4,533 | Red Bull Arena | Robert Sibiga | Match Report | |
| Sat | 2021-06-26 | 18:00 | Real Salt Lake | 2.8 | 1–1 | 1.0 | Dynamo FC | 13,588 | Rio Tinto Stadium | Nima Saghafi | Match Report | |
| Sat | 2021-06-26 | 19:00 | San Jose | 0.9 | 1–3 | 2.1 | LA Galaxy | 18,000 | Stanford Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-06-26 | 19:00 | Chicago Fire | 1.3 | 3–3 | 1.5 | Philadelphia | 7,308 | Soldier Field | Fotis Bazakos | Match Report | |
| Sat | 2021-06-26 | 19:30 | Nashville | 2.1 | 1–1 | 0.6 | CF Montréal | 22,523 | Nissan Stadium | Jon Freemon | Match Report | |
| Sat | 2021-06-26 | 20:30 | Portland Timbers | 1.8 | 0–1 | 2.6 | Minnesota Utd | Providence Park | Rosendo Mendoza | Match Report | ||
| Sun | 2021-06-27 | 19:00 | Austin | 1.4 | 0–0 | 1.1 | Columbus Crew | 20,738 | Q2 Stadium | Ted Unkel | Match Report | |
| Sun | 2021-06-27 | 20:00 | FC Dallas | 0.9 | 2–1 | 1.3 | New England | 14,889 | Toyota Stadium | Kevin Stott | Match Report | |
| Thu | 2021-07-01 | 20:30 | Austin | 1.7 | 4–1 | 0.6 | Portland Timbers | 20,738 | Q2 Stadium | Ted Unkel | Match Report | |
| Sat | 2021-07-03 | 17:00 | Columbus Crew | 1.3 | 2–2 | 1.4 | New England | 20,407 | Lower.com Field | Alan Kelly | Match Report | |
| Sat | 2021-07-03 | 17:30 | D.C. United | 3.1 | 7–1 | 1.2 | Toronto FC | 14,000 | Audi Field | Lukasz Szpala | Match Report | |
| Sat | 2021-07-03 | 19:30 | CF Montréal | 1.9 | 1–0 | 0.3 | Inter Miami | Red Bull Arena | Rosendo Mendoza | Match Report | ||
| Sat | 2021-07-03 | 19:30 | Orlando City | 1.7 | 1–2 | 1.9 | NY Red Bulls | 19,009 | Exploria Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-07-03 | 19:00 | Minnesota Utd | 2.8 | 2–2 | 0.8 | San Jose | 19,687 | Allianz Field | Michael Radchuk | Match Report | |
| Sat | 2021-07-03 | 19:00 | Chicago Fire | 1.5 | 3–0 | 1.0 | Atlanta Utd | 14,898 | Soldier Field | Baldomero Toledo | Match Report | |
| Sat | 2021-07-03 | 19:00 | Nashville | 1.3 | 1–0 | 0.9 | Philadelphia | 21,822 | Nissan Stadium | Robert Sibiga | Match Report | |
| Sat | 2021-07-03 | 19:30 | Dynamo FC | 1.8 | 1–1 | 1.5 | FC Cincinnati | 20,021 | BBVA Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-03 | 20:00 | Real Salt Lake | 1.3 | 0–1 | 0.6 | Los Angeles FC | 18,253 | Rio Tinto Stadium | Silviu Petrescu | Match Report | |
| Sun | 2021-07-04 | 19:00 | Colorado Rapids | 1.1 | 1–1 | 0.9 | Seattle | 17,104 | Dick's Sporting Goods Park | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-07-04 | 19:30 | LA Galaxy | 1.6 | 0–2 | 2.2 | Sporting KC | 23,556 | Dignity Health Sports Park | Alex Chilowicz | Match Report | |
| Sun | 2021-07-04 | 19:30 | FC Dallas | 1.6 | 2–2 | 1.0 | Vancouver | 19,096 | Toyota Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-07-07 | 19:00 | New England | 2.8 | 2–3 | 1.9 | Toronto FC | Gillette Stadium | Rosendo Mendoza | Match Report | ||
| Wed | 2021-07-07 | 19:30 | CF Montréal | 2.3 | 2–1 | 0.6 | NYCFC | Exploria Stadium | Marcos de Oliveira | Match Report | ||
| Wed | 2021-07-07 | 18:00 | Seattle | 2.2 | 2–0 | 0.8 | Dynamo FC | 27,421 | Lumen Field | Robert Sibiga | Match Report | |
| Wed | 2021-07-07 | 19:00 | Colorado Rapids | 1.6 | 2–0 | 0.7 | Minnesota Utd | Dick's Sporting Goods Park | Ted Unkel | Match Report | ||
| Wed | 2021-07-07 | 19:00 | Chicago Fire | 1.6 | 3–1 | 2.6 | Orlando City | 8,002 | Soldier Field | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-07-07 | 19:30 | LA Galaxy | 1.4 | 3–1 | 1.8 | FC Dallas | 16,453 | Dignity Health Sports Park | Alan Kelly | Match Report | |
| Wed | 2021-07-07 | 20:00 | Austin | 0.7 | 0–2 | 2.0 | Los Angeles FC | 20,738 | Q2 Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-07-07 | 20:00 | Vancouver | 1.1 | 0–4 | 3.1 | Real Salt Lake | 12,009 | Rio Tinto Stadium | Alex Chilowicz | Match Report | |
| Thu | 2021-07-08 | 19:30 | Nashville | 2.1 | 2–2 | 0.6 | Atlanta Utd | 22,913 | Nissan Stadium | Joe Dickerson | Match Report | |
| Fri | 2021-07-09 | 19:30 | FC Cincinnati | 0.9 | 2–2 | 1.0 | Columbus Crew | 25,701 | TQL Stadium | Kevin Stott | Match Report | |
| Thu | 2021-07-08 | 20:00 | NY Red Bulls | 2.1 | 1–1 | 0.9 | Philadelphia | 10,013 | Red Bull Arena | Victor Rivas | Match Report | |
| Sat | 2021-07-17 | 17:00 | Atlanta Utd | 0.7 | 0–1 | 1.3 | New England | 42,517 | Mercedes-Benz Stadium | Victor Rivas | Match Report | |
| Sat | 2021-07-17 | 19:30 | CF Montréal | 2.9 | 5–4 | 1.3 | FC Cincinnati | Stade Saputo | Silviu Petrescu | Match Report | ||
| Sat | 2021-07-17 | 19:30 | Philadelphia | 1.2 | 2–1 | 1.4 | D.C. United | 16,821 | Subaru Park | Alex Chilowicz | Match Report | |
| Sat | 2021-07-17 | 19:30 | Toronto FC | 0.7 | 1–1 | 1.3 | Orlando City | 7,000 | BMO Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-17 | 19:30 | Columbus Crew | 0.8 | 2–1 | 1.8 | NYCFC | 19,113 | Lower.com Field | Ramy Touchan | Match Report | |
| Sun | 2021-07-18 | 13:00 | Minnesota Utd | 1.7 | 1–0 | 0.7 | Seattle | 19,679 | Allianz Field | Alan Kelly | Match Report | |
| Sat | 2021-07-17 | 19:00 | Colorado Rapids | 0.8 | 1–1 | 0.4 | San Jose | 14,664 | Dick's Sporting Goods Park | Rosendo Mendoza | Match Report | |
| Sat | 2021-07-17 | 19:30 | Los Angeles FC | 4.8 | 2–1 | 0.9 | Real Salt Lake | 22,490 | Banc of California Stadium | Robert Sibiga | Match Report | |
| Sat | 2021-07-17 | 19:30 | Portland Timbers | 1.0 | 1–0 | 0.8 | FC Dallas | 23,255 | Providence Park | Joe Dickerson | Match Report | |
| Sat | 2021-07-17 | 19:30 | Nashville | 3.4 | 5–1 | 1.9 | Chicago Fire | 23,113 | Nissan Stadium | Lukasz Szpala | Match Report | |
| Sat | 2021-07-17 | 20:00 | Vancouver | 1.5 | 2–1 | 0.8 | LA Galaxy | Rio Tinto Stadium | Ismir Pekmic | Match Report | ||
| Wed | 2021-07-21 | 19:30 | NYCFC | 1.9 | 1–0 | 0.5 | CF Montréal | 2,873 | Red Bull Arena | Ted Unkel | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-07-21 | 19:30 | Columbus Crew | 1.6 | 0–0 | 0.6 | Nashville | 18,395 | Lower.com Field | Rosendo Mendoza | Match Report | |
| Wed | 2021-07-21 | 19:30 | Toronto FC | 0.3 | 1–1 | 2.0 | NY Red Bulls | BMO Field | Silviu Petrescu | Match Report | ||
| Wed | 2021-07-21 | 19:30 | Inter Miami | 1.2 | 0–5 | 3.3 | New England | 13,963 | DRV PNK Stadium | Robert Sibiga | Match Report | |
| Tue | 2021-07-20 | 20:00 | Vancouver | 0.7 | 0–0 | 0.3 | Dynamo FC | Rio Tinto Stadium | Guido Gonzalez Jr. | Match Report | ||
| Wed | 2021-07-21 | 19:00 | Chicago Fire | 0.6 | 2–2 | 2.2 | D.C. United | 8,306 | Soldier Field | Marcos de Oliveira | Match Report | |
| Wed | 2021-07-21 | 19:00 | Colorado Rapids | 0.7 | 2–0 | 0.7 | FC Dallas | 8,321 | Dick's Sporting Goods Park | Jon Freemon | Match Report | |
| Wed | 2021-07-21 | 19:30 | Sporting KC | 2.2 | 1–1 | 1.6 | San Jose | 17,872 | Children's Mercy Park | Joe Dickerson | Match Report | |
| Wed | 2021-07-21 | 19:30 | Portland Timbers | 0.6 | 2–1 | 2.2 | Los Angeles FC | 23,500 | Providence Park | Victor Rivas | Match Report | |
| Thu | 2021-07-22 | 19:30 | Orlando City | 0.9 | 2–1 | 1.3 | Philadelphia | 15,432 | Exploria Stadium | Alan Kelly | Match Report | |
| Wed | 2021-07-21 | 20:00 | FC Cincinnati | 1.0 | 1–1 | 1.9 | Atlanta Utd | 23,162 | TQL Stadium | Tori Penso | Match Report | |
| Wed | 2021-07-21 | 20:00 | Real Salt Lake | 1.4 | 2–2 | 1.4 | LA Galaxy | 16,169 | Rio Tinto Stadium | Kevin Stott | Match Report | |
| Thu | 2021-07-22 | 20:30 | Austin | 0.9 | 0–1 | 0.6 | Seattle | 20,738 | Q2 Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-07-24 | 15:30 | Atlanta Utd | 1.8 | 0–1 | 1.7 | Columbus Crew | 67,507 | Mercedes-Benz Stadium | Robert Sibiga | Match Report | |
| Sun | 2021-07-25 | 18:00 | New England | 1.4 | 2–1 | 1.8 | CF Montréal | 18,217 | Gillette Stadium | Alex Chilowicz | Match Report | |
| Sun | 2021-07-25 | 18:00 | NYCFC | 3.9 | 5–0 | 0.6 | Orlando City | 13,503 | Yankee Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-07-24 | 19:00 | San Jose | 1.1 | 1–1 | 0.7 | Dynamo FC | 12,793 | Earthquakes Stadium | Ted Unkel | Match Report | |
| Sat | 2021-07-24 | 19:00 | Minnesota Utd | 2.2 | 2–1 | 0.4 | Portland Timbers | 19,691 | Allianz Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-24 | 19:00 | Chicago Fire | 3.9 | 1–2 | 0.8 | Toronto FC | 12,288 | Soldier Field | Victor Rivas | Match Report | |
| Sun | 2021-07-25 | 19:30 | Inter Miami | 1.1 | 1–1 | 1.6 | Philadelphia | 14,057 | DRV PNK Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-07-24 | 19:30 | Los Angeles FC | 1.0 | 2–2 | 1.2 | Vancouver | 22,049 | Banc of California Stadium | Kevin Stott | Match Report | |
| Sat | 2021-07-24 | 19:30 | FC Dallas | 1.7 | 4–0 | 1.4 | LA Galaxy | 14,812 | Toyota Stadium | Silviu Petrescu | Match Report | |
| Sat | 2021-07-24 | 19:30 | Nashville | 0.9 | 3–0 | 0.5 | FC Cincinnati | 23,832 | Nissan Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-07-24 | 20:00 | Real Salt Lake | 1.0 | 3–0 | 0.5 | Colorado Rapids | 17,325 | Rio Tinto Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-07-25 | 18:00 | Seattle | 0.9 | 1–3 | 1.1 | Sporting KC | 32,790 | Lumen Field | Ramy Touchan | Match Report | |
| Sun | 2021-07-25 | 20:00 | D.C. United | 1.1 | 1–0 | 0.2 | NY Red Bulls | 15,912 | Audi Field | Alan Kelly | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-07-28 | 19:30 | Los Angeles FC | 2.2 | 2–2 | 1.1 | Minnesota Utd | 22,003 | Banc of California Stadium | Baldomero Toledo | Match Report | |
| Fri | 2021-07-30 | 19:30 | NYCFC | 3.3 | 4–1 | 1.5 | Columbus Crew | Yankee Stadium | Alan Kelly | Match Report | ||
| Sat | 2021-07-31 | 14:00 | Seattle | 1.0 | 0–1 | 0.6 | San Jose | 32,704 | Lumen Field | Joe Dickerson | Match Report | |
| Sat | 2021-07-31 | 18:00 | NY Red Bulls | 1.3 | 2–3 | 2.5 | New England | 13,444 | Red Bull Arena | Ramy Touchan | Match Report | |
| Fri | 2021-07-30 | 19:00 | LA Galaxy | 3.0 | 4–1 | 1.0 | Portland Timbers | 15,644 | Dignity Health Sports Park | Robert Sibiga | Match Report | |
| Sat | 2021-07-31 | 19:30 | FC Cincinnati | 1.7 | 0–0 | 0.5 | D.C. United | 25,060 | TQL Stadium | Rosendo Mendoza | Match Report | |
| Fri | 2021-07-30 | 20:00 | Orlando City | 2.6 | 3–2 | 0.5 | Atlanta Utd | 18,910 | Exploria Stadium | Rubiel Vazquez | Match Report | |
| Sun | 2021-08-01 | 18:00 | Philadelphia | 2.6 | 1–1 | 0.3 | Chicago Fire | 16,677 | Subaru Park | Michael Radchuk | Match Report | |
| Sat | 2021-07-31 | 19:30 | Sporting KC | 1.7 | 1–2 | 1.1 | FC Dallas | 19,975 | Children's Mercy Park | Alex Chilowicz | Match Report | |
| Sat | 2021-07-31 | 19:30 | Dynamo FC | 1.4 | 0–0 | 1.4 | Real Salt Lake | 13,462 | BBVA Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-08-01 | 19:30 | Toronto FC | 0.6 | 1–1 | 1.1 | Nashville | BMO Field | Fotis Bazakos | Match Report | ||
| Sat | 2021-07-31 | 20:00 | Austin | 0.9 | 0–1 | 2.3 | Colorado Rapids | 20,738 | Q2 Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-07-31 | 20:00 | Inter Miami | 2.0 | 2–1 | 1.6 | CF Montréal | 14,303 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sat | 2021-07-31 | 20:00 | Vancouver | 1.7 | 2–2 | 1.2 | Minnesota Utd | Rio Tinto Stadium | Lukasz Szpala | Match Report | ||
| Wed | 2021-08-04 | 19:00 | New England | 0.6 | 0–0 | 0.5 | Nashville | 10,279 | Gillette Stadium | Silviu Petrescu | Match Report | |
| Wed | 2021-08-04 | 19:30 | Columbus Crew | 1.5 | 2–4 | 1.7 | D.C. United | 18,398 | Lower.com Field | Victor Rivas | Match Report | |
| Wed | 2021-08-04 | 19:30 | Philadelphia | 2.6 | 3–0 | 1.4 | Toronto FC | 14,303 | Subaru Park | Ted Unkel | Match Report | |
| Wed | 2021-08-04 | 19:30 | CF Montréal | 1.6 | 2–2 | 1.8 | Atlanta Utd | 11,000 | Stade Saputo | Dave Gantar | Match Report | |
| Wed | 2021-08-04 | 19:00 | Seattle | 2.0 | 1–1 | 1.2 | FC Dallas | 31,628 | Lumen Field | Fotis Bazakos | Match Report | |
| Wed | 2021-08-04 | 19:00 | Chicago Fire | 0.3 | 0–0 | 1.4 | NYCFC | 8,371 | Soldier Field | Baldomero Toledo | Match Report | |
| Wed | 2021-08-04 | 19:30 | Los Angeles FC | 2.3 | 1–4 | 2.0 | Sporting KC | 22,114 | Banc of California Stadium | Alan Kelly | Match Report | |
| Wed | 2021-08-04 | 19:30 | LA Galaxy | 1.6 | 1–0 | 1.3 | Real Salt Lake | 15,544 | Dignity Health Sports Park | Nima Saghafi | Match Report | |
| Wed | 2021-08-04 | 19:30 | Portland Timbers | 2.1 | 1–1 | 2.4 | San Jose | 22,233 | Providence Park | Allen Chapman | Match Report | |
| Wed | 2021-08-04 | 20:00 | Orlando City | 1.0 | 1–1 | 0.2 | Inter Miami | 17,966 | Exploria Stadium | Armando Villarreal | Match Report | |
| Wed | 2021-08-04 | 20:00 | NY Red Bulls | 2.2 | 0–0 | 0.5 | FC Cincinnati | 9,203 | Red Bull Arena | Jon Freemon | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-08-04 | 20:00 | Austin | 1.4 | 3–2 | 0.8 | Dynamo FC | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-08-07 | 19:30 | Columbus Crew | 1.7 | 2–3 | 2.7 | Atlanta Utd | 20,094 | Lower.com Field | Allen Chapman | Match Report | |
| Sat | 2021-08-07 | 19:30 | FC Cincinnati | 1.2 | 1–1 | 1.2 | Orlando City | 24,113 | TQL Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-08-08 | 16:00 | San Jose | 1.8 | 2–1 | 1.6 | Los Angeles FC | 18,000 | Earthquakes Stadium | Rubiel Vazquez | Match Report | |
| Sun | 2021-08-08 | 17:00 | Chicago Fire | 1.1 | 2–1 | 1.3 | NY Red Bulls | 11,894 | Soldier Field | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-08-08 | 18:00 | Inter Miami | 1.5 | 2–1 | 0.6 | Nashville | 14,062 | DRV PNK Stadium | Nima Saghafi | Match Report | |
| Sun | 2021-08-08 | 18:00 | New England | 2.3 | 2–1 | 2.1 | Philadelphia | 17,054 | Gillette Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-08-07 | 19:00 | Minnesota Utd | 1.2 | 2–0 | 0.6 | Dynamo FC | 19,625 | Allianz Field | Silviu Petrescu | Match Report | |
| Sat | 2021-08-07 | 19:00 | Colorado Rapids | 2.3 | 0–0 | 0.7 | Sporting KC | 11,753 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2021-08-07 | 19:30 | Portland Timbers | 1.8 | 3–2 | 2.6 | Real Salt Lake | 23,577 | Providence Park | Rosendo Mendoza | Match Report | |
| Sat | 2021-08-07 | 19:30 | FC Dallas | 1.1 | 2–0 | 1.2 | Austin | 16,625 | Toyota Stadium | Alan Kelly | Match Report | |
| Sat | 2021-08-07 | 20:00 | Toronto FC | 2.5 | 2–2 | 1.3 | NYCFC | 9,331 | BMO Field | Robert Sibiga | Match Report | |
| Sun | 2021-08-08 | 17:00 | LA Galaxy | 1.6 | 1–1 | 1.0 | Vancouver | 16,234 | Dignity Health Sports Park | Baldomero Toledo | Match Report | |
| Sun | 2021-08-08 | 20:00 | D.C. United | 1.6 | 2–1 | 1.0 | CF Montréal | 14,169 | Audi Field | Marcos de Oliveira | Match Report | |
| Sat | 2021-08-14 | 17:00 | Minnesota Utd | 2.0 | 0–1 | 1.6 | LA Galaxy | 19,787 | Allianz Field | Joe Dickerson | Match Report | |
| Fri | 2021-08-13 | 19:30 | San Jose | 1.0 | 0–0 | 1.0 | Vancouver | 11,967 | Earthquakes Stadium | Tim Ford | Match Report | |
| Sun | 2021-08-15 | 16:00 | Atlanta Utd | 1.1 | 1–0 | 1.2 | Los Angeles FC | 67,503 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sun | 2021-08-15 | 17:00 | Chicago Fire | 1.5 | 1–0 | 0.8 | Columbus Crew | 13,005 | Soldier Field | Nima Saghafi | Match Report | |
| Sun | 2021-08-15 | 18:00 | Nashville | 2.1 | 5–2 | 0.9 | D.C. United | 20,022 | Nissan Stadium | Drew Fischer | Match Report | |
| Sat | 2021-08-14 | 19:30 | FC Dallas | 1.7 | 0–2 | 0.9 | Sporting KC | 14,133 | Toyota Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-08-14 | 19:30 | Dynamo FC | 2.7 | 1–3 | 1.8 | Colorado Rapids | 13,908 | BBVA Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-08-14 | 20:00 | Toronto FC | 1.1 | 1–2 | 1.3 | New England | BMO Field | Rubiel Vazquez | Match Report | ||
| Sat | 2021-08-14 | 20:00 | CF Montréal | 2.9 | 2–1 | 1.7 | NY Red Bulls | Stade Saputo | Allen Chapman | Match Report | ||
| Sat | 2021-08-14 | 20:00 | Real Salt Lake | 1.5 | 1–0 | 1.1 | Austin | 17,506 | Rio Tinto Stadium | Dave Gantar | Match Report | |
| Sat | 2021-08-14 | 20:00 | NYCFC | 2.2 | 2–0 | 0.3 | Inter Miami | Red Bull Arena | Alex Chilowicz | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-08-15 | 19:00 | Portland Timbers | 1.8 | 2–6 | 2.4 | Seattle | 25,218 | Providence Park | Jair Marrufo | Match Report | |
| Wed | 2021-08-18 | 19:00 | Atlanta Utd | 1.8 | 1–0 | 1.3 | Toronto FC | 42,502 | Mercedes-Benz Stadium | Alan Kelly | Match Report | |
| Wed | 2021-08-18 | 19:00 | New England | 1.9 | 3–2 | 2.2 | D.C. United | 11,419 | Gillette Stadium | Ted Unkel | Match Report | |
| Tue | 2021-08-17 | 19:30 | LA Galaxy | 1.4 | 1–2 | 2.1 | Colorado Rapids | 15,101 | Dignity Health Sports Park | Silviu Petrescu | Match Report | |
| Wed | 2021-08-18 | 19:30 | FC Cincinnati | 0.9 | 0–0 | 0.4 | CF Montréal | 21,115 | TQL Stadium | Ramy Touchan | Match Report | |
| Tue | 2021-08-17 | 19:30 | San Jose | 0.2 | 1–1 | 1.5 | Minnesota Utd | 10,353 | Earthquakes Stadium | Victor Rivas | Match Report | |
| Wed | 2021-08-18 | 19:30 | Inter Miami | 1.9 | 3–2 | 1.3 | Chicago Fire | 13,196 | DRV PNK Stadium | Baldomero Toledo | Match Report | |
| Wed | 2021-08-18 | 19:30 | Philadelphia | 0.7 | 1–0 | 1.3 | NYCFC | 15,263 | Subaru Park | Drew Fischer | Match Report | |
| Wed | 2021-08-18 | 19:30 | Nashville | 1.1 | 1–1 | 0.8 | Orlando City | 13,154 | Nissan Stadium | Fotis Bazakos | Match Report | |
| Wed | 2021-08-18 | 19:30 | Sporting KC | 2.1 | 1–1 | 1.3 | Portland Timbers | 17,081 | Children's Mercy Park | Ismail Elfath | Match Report | |
| Wed | 2021-08-18 | 19:30 | FC Dallas | 1.4 | 0–1 | 0.7 | Seattle | 11,535 | Toyota Stadium | Robert Sibiga | Match Report | |
| Wed | 2021-08-18 | 20:00 | Real Salt Lake | 1.0 | 2–1 | 1.4 | Dynamo FC | 13,570 | Rio Tinto Stadium | Jair Marrufo | Match Report | |
| Wed | 2021-08-18 | 20:00 | Austin | 0.9 | 1–2 | 2.3 | Vancouver | 20,738 | Q2 Stadium | Rosendo Mendoza | Match Report | |
| Wed | 2021-08-18 | 20:00 | NY Red Bulls | 1.0 | 1–0 | 1.4 | Columbus Crew | 10,002 | Red Bull Arena | Chris Penso | Match Report | |
| Sat | 2021-08-21 | 14:30 | Minnesota Utd | 3.0 | 0–0 | 0.9 | Sporting KC | Allianz Field | Marcos de Oliveira | Match Report | ||
| Sat | 2021-08-21 | 17:30 | Columbus Crew | 0.9 | 1–2 | 1.6 | Seattle | 19,401 | Lower.com Field | Joe Dickerson | Match Report | |
| Fri | 2021-08-20 | 19:30 | LA Galaxy | 1.3 | 1–2 | 1.7 | San Jose | 17,568 | Dignity Health Sports Park | Armando Villarreal | Match Report | |
| Sat | 2021-08-21 | 19:00 | Colorado Rapids | 1.7 | 2–1 | 1.9 | Real Salt Lake | 13,134 | Dick's Sporting Goods Park | Drew Fischer | Match Report | |
| Sat | 2021-08-21 | 19:00 | Vancouver | 1.5 | 2–1 | 3.9 | Los Angeles FC | BC Place Stadium | Alex Chilowicz | Match Report | ||
| Sat | 2021-08-21 | 19:30 | Dynamo FC | 2.3 | 2–2 | 0.9 | FC Dallas | 13,548 | BBVA Stadium | Allen Chapman | Match Report | |
| Sat | 2021-08-21 | 20:00 | Austin | 3.0 | 3–1 | 1.0 | Portland Timbers | 20,738 | Q2 Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-08-21 | 20:00 | New England | 1.8 | 4–1 | 0.9 | FC Cincinnati | 18,268 | Gillette Stadium | Fotis Bazakos | Match Report | |
| Sat | 2021-08-21 | 20:00 | D.C. United | 2.3 | 1–2 | 1.4 | Atlanta Utd | 17,180 | Audi Field | Nima Saghafi | Match Report | |
| Sat | 2021-08-21 | 20:00 | Philadelphia | 1.2 | 1–1 | 1.3 | CF Montréal | 14,794 | Subaru Park | Chris Penso | Match Report | |
| Sat | 2021-08-21 | 20:00 | Orlando City | 0.9 | 1–0 | 1.4 | Chicago Fire | 15,538 | Exploria Stadium | Tim Ford | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-08-21 | 20:00 | Inter Miami | 2.8 | 3–1 | 0.8 | Toronto FC | 14,897 | DRV PNK Stadium | Jair Marrufo | Match Report | |
| Fri | 2021-08-27 | 18:30 | Columbus Crew | 2.6 | 3–2 | 1.6 | FC Cincinnati | 19,949 | Lower.com Field | Robert Sibiga | Match Report | |
| Fri | 2021-08-27 | 19:30 | CF Montréal | 2.7 | 3–1 | 0.5 | Toronto FC | Stade Saputo | Drew Fischer | Match Report | ||
| Sat | 2021-08-28 | 15:30 | Atlanta Utd | 0.6 | 0–2 | 1.9 | Nashville | 42,506 | Mercedes-Benz Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-08-28 | 16:00 | Los Angeles FC | 2.9 | 3–3 | 1.3 | LA Galaxy | 22,032 | Banc of California Stadium | Allen Chapman | Match Report | |
| Sat | 2021-08-28 | 18:00 | NY Red Bulls | 1.4 | 0–1 | 1.0 | Chicago Fire | 12,018 | Red Bull Arena | Victor Rivas | Match Report | |
| Sat | 2021-08-28 | 19:30 | NYCFC | 1.9 | 2–0 | 1.3 | New England | Yankee Stadium | Kevin Stott | Match Report | ||
| Fri | 2021-08-27 | 20:30 | Orlando City | 2.1 | 0–0 | 0.8 | Inter Miami | 17,817 | Exploria Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-08-28 | 20:00 | D.C. United | 2.8 | 3–1 | 0.4 | Philadelphia | 16,593 | Audi Field | Rubiel Vazquez | Match Report | |
| Sat | 2021-08-28 | 20:00 | Dynamo FC | 0.9 | 1–2 | 1.7 | Minnesota Utd | 14,521 | BBVA Stadium | Ted Unkel | Match Report | |
| Sat | 2021-08-28 | 20:00 | Sporting KC | 2.1 | 1–1 | 2.2 | Colorado Rapids | 19,883 | Children's Mercy Park | Fotis Bazakos | Match Report | |
| Sun | 2021-08-29 | 19:00 | Austin | 1.6 | 3–5 | 3.6 | FC Dallas | 20,738 | Q2 Stadium | Jair Marrufo | Match Report | |
| Sun | 2021-08-29 | 19:00 | Vancouver | 2.0 | 4–1 | 1.0 | Real Salt Lake | 7,503 | BC Place Stadium | Ramy Touchan | Match Report | |
| Sun | 2021-08-29 | 19:30 | Seattle | 1.5 | 0–2 | 1.4 | Portland Timbers | 45,737 | Lumen Field | Alan Kelly | Match Report | |
| Fri | 2021-09-03 | 18:30 | Nashville | 1.0 | 3–1 | 1.7 | NYCFC | 20,126 | Nissan Stadium | Tim Ford | Match Report | |
| Fri | 2021-09-03 | 19:30 | Philadelphia | 1.2 | 0–1 | 1.4 | New England | 15,152 | Subaru Park | Jair Marrufo | Match Report | |
| Sat | 2021-09-04 | 16:00 | Vancouver | 2.0 | 2–1 | 1.4 | Austin | 9,223 | BC Place Stadium | Pierre-Luc Lauziere | Match Report | |
| Fri | 2021-09-03 | 19:00 | Dynamo FC | 1.2 | 0–2 | 2.1 | Portland Timbers | 9,872 | BBVA Stadium | Rubiel Vazquez | Match Report | |
| Fri | 2021-09-03 | 19:00 | Los Angeles FC | 3.5 | 4–0 | 0.4 | Sporting KC | 22,018 | Banc of California Stadium | Drew Fischer | Match Report | |
| Sat | 2021-09-04 | 19:30 | Orlando City | 1.6 | 3–2 | 0.8 | Columbus Crew | 15,366 | Exploria Stadium | Armando Villarreal | Match Report | |
| Sat | 2021-09-04 | 18:00 | Real Salt Lake | 2.5 | 3–2 | 1.3 | FC Dallas | 15,882 | Rio Tinto Stadium | Baldomero Toledo | Match Report | |
| Sat | 2021-09-04 | 19:00 | San Jose | 1.3 | 0–1 | 1.5 | Colorado Rapids | 14,142 | Earthquakes Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-09-04 | 20:00 | FC Cincinnati | 0.7 | 0–1 | 1.1 | Inter Miami | 22,234 | TQL Stadium | Lukasz Szpala | Match Report | |
| Fri | 2021-09-10 | 19:00 | Atlanta Utd | 1.3 | 3–0 | 0.4 | Orlando City | 42,507 | Mercedes-Benz Stadium | Victor Rivas | Match Report | |
| Sat | 2021-09-11 | 14:00 | Seattle | 1.2 | 1–0 | 1.2 | Minnesota Utd | 33,130 | Lumen Field | Alex Chilowicz | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-09-11 | 15:30 | Colorado Rapids | 1.2 | 1–1 | 1.2 | LA Galaxy | 11,736 | Dick's Sporting Goods Park | Rosendo Mendoza | Match Report | |
| Fri | 2021-09-10 | 19:00 | Vancouver | 1.2 | 0–1 | 0.9 | Portland Timbers | BC Place Stadium | Marcos de Oliveira | Match Report | ||
| Sat | 2021-09-11 | 19:00 | New England | 1.9 | 2–1 | 0.8 | NYCFC | 19,481 | Gillette Stadium | Chris Penso | Match Report | |
| Sat | 2021-09-11 | 19:00 | NY Red Bulls | 0.7 | 1–1 | 2.0 | D.C. United | 12,574 | Red Bull Arena | Robert Sibiga | Match Report | |
| Sat | 2021-09-11 | 19:30 | Sporting KC | 2.2 | 2–0 | 1.1 | Chicago Fire | 18,467 | Children's Mercy Park | Jon Freemon | Match Report | |
| Sat | 2021-09-11 | 19:30 | FC Dallas | 1.4 | 1–1 | 1.6 | San Jose | 15,237 | Toyota Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-09-11 | 19:30 | Dynamo FC | 1.6 | 3–0 | 1.1 | Austin | 14,070 | BBVA Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-09-11 | 20:00 | FC Cincinnati | 1.4 | 2–0 | 0.7 | Toronto FC | 22,636 | TQL Stadium | Dave Gantar | Match Report | |
| Sat | 2021-09-11 | 20:00 | Inter Miami | 0.7 | 1–0 | 0.6 | Columbus Crew | 15,014 | DRV PNK Stadium | Alan Kelly | Match Report | |
| Sat | 2021-09-11 | 20:00 | CF Montréal | 0.9 | 0–1 | 1.1 | Nashville | Stade Saputo | Silviu Petrescu | Match Report | ||
| Sun | 2021-09-12 | 19:30 | Los Angeles FC | 1.0 | 3–2 | 1.0 | Real Salt Lake | 22,130 | Banc of California Stadium | Ted Unkel | Match Report | |
| Tue | 2021-09-14 | 19:30 | Toronto FC | 1.0 | 0–1 | 1.7 | Inter Miami | 7,970 | BMO Field | Ramy Touchan | Match Report | |
| Tue | 2021-09-14 | 19:30 | NYCFC | 2.2 | 3–3 | 1.5 | FC Dallas | Yankee Stadium | Joe Dickerson | Match Report | ||
| Tue | 2021-09-14 | 19:30 | Columbus Crew | 1.5 | 2–1 | 1.0 | NY Red Bulls | 17,358 | Lower.com Field | Jair Marrufo | Match Report | |
| Wed | 2021-09-15 | 19:00 | Atlanta Utd | 2.1 | 4–0 | 1.1 | FC Cincinnati | 42,501 | Mercedes-Benz Stadium | Drew Fischer | Match Report | |
| Wed | 2021-09-15 | 19:30 | Orlando City | 0.7 | 2–4 | 1.7 | CF Montréal | 14,133 | Exploria Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2021-09-15 | 19:30 | D.C. United | 2.0 | 3–0 | 1.6 | Chicago Fire | 13,524 | Audi Field | Dave Gantar | Match Report | |
| Wed | 2021-09-15 | 19:00 | Portland Timbers | 1.8 | 2–2 | 2.1 | Colorado Rapids | 16,808 | Providence Park | Armando Villarreal | Match Report | |
| Wed | 2021-09-15 | 19:30 | LA Galaxy | 1.1 | 1–1 | 1.3 | Dynamo FC | 15,341 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Wed | 2021-09-15 | 19:30 | Sporting KC | 2.2 | 4–0 | 1.1 | Minnesota Utd | 16,888 | Children's Mercy Park | Robert Sibiga | Match Report | |
| Wed | 2021-09-15 | 19:30 | San Jose | 1.2 | 3–4 | 2.6 | Real Salt Lake | 9,636 | Earthquakes Stadium | Nima Saghafi | Match Report | |
| Wed | 2021-09-15 | 20:00 | Austin | 1.3 | 1–2 | 2.5 | Los Angeles FC | 20,738 | Q2 Stadium | Tim Ford | Match Report | |
| Fri | 2021-09-17 | 19:00 | Inter Miami | 0.1 | 0–4 | 3.3 | NY Red Bulls | 18,535 | DRV PNK Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-09-18 | 15:30 | Atlanta Utd | 3.2 | 3–2 | 1.3 | D.C. United | 42,608 | Mercedes-Benz Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-09-18 | 19:00 | New England | 3.0 | 1–1 | 0.9 | Columbus Crew | 19,004 | Gillette Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-09-18 | 19:30 | Toronto FC | 1.2 | 2–1 | 1.8 | Nashville | 9,892 | BMO Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2021-09-18 | 19:30 | FC Cincinnati | 0.9 | 1–2 | 1.4 | NYCFC | 21,978 | TQL Stadium | Ted Unkel | Match Report | |
| Sun | 2021-09-19 | 13:00 | CF Montréal | 1.1 | 2–0 | 0.7 | Chicago Fire | Stade Saputo | Marcos de Oliveira | Match Report | ||
| Sun | 2021-09-19 | 16:00 | Philadelphia | 2.1 | 3–1 | 0.7 | Orlando City | 15,032 | Subaru Park | Alan Kelly | Match Report | |
| Sun | 2021-09-19 | 16:30 | Portland Timbers | 1.9 | 2–1 | 2.6 | Los Angeles FC | 21,311 | Providence Park | Chris Penso | Match Report | |
| Sat | 2021-09-18 | 19:00 | Minnesota Utd | 1.0 | 3–0 | 0.6 | LA Galaxy | 19,400 | Allianz Field | Jair Marrufo | Match Report | |
| Sat | 2021-09-18 | 19:00 | Austin | 2.5 | 3–4 | 2.8 | San Jose | 20,738 | Q2 Stadium | Baldomero Toledo | Match Report | |
| Sat | 2021-09-18 | 19:30 | Real Salt Lake | 1.9 | 1–0 | 0.5 | Seattle | 19,850 | Rio Tinto Stadium | Ismail Elfath | Match Report | |
| Sat | 2021-09-18 | 20:30 | Dynamo FC | 2.2 | 3–2 | 1.6 | FC Dallas | 12,353 | BBVA Stadium | Victor Rivas | Match Report | |
| Sun | 2021-09-19 | 19:00 | Colorado Rapids | 2.1 | 1–1 | 0.9 | Vancouver | 8,454 | Dick's Sporting Goods Park | Rubiel Vazquez | Match Report | |
| Wed | 2021-09-22 | 19:30 | Inter Miami | 0.9 | 1–5 | 3.3 | Nashville | 13,033 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Wed | 2021-09-22 | 19:00 | Chicago Fire | 2.8 | 2–3 | 1.9 | New England | 7,052 | Soldier Field | Lukasz Szpala | Match Report | |
| Wed | 2021-09-22 | 20:00 | NY Red Bulls | 1.4 | 1–1 | 1.0 | NYCFC | 16,072 | Red Bull Arena | Ismail Elfath | Match Report | |
| Sat | 2021-09-25 | 15:30 | Philadelphia | 1.5 | 1–0 | 0.3 | Atlanta Utd | Subaru Park | Robert Sibiga | Match Report | ||
| Sat | 2021-09-25 | 19:00 | New England | 1.1 | 2–1 | 1.8 | Orlando City | 23,506 | Gillette Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-09-25 | 19:30 | NYCFC | 1.3 | 0–1 | 1.4 | NY Red Bulls | Yankee Stadium | Armando Villarreal | Match Report | ||
| Sat | 2021-09-25 | 19:30 | D.C. United | 2.4 | 4–2 | 1.2 | FC Cincinnati | 16,069 | Audi Field | Chris Penso | Match Report | |
| Sat | 2021-09-25 | 19:30 | Columbus Crew | 0.8 | 2–1 | 1.4 | CF Montréal | 19,423 | Lower.com Field | Nima Saghafi | Match Report | |
| Sun | 2021-09-26 | 12:00 | Chicago Fire | 0.2 | 0–0 | 0.5 | Nashville | 15,915 | Soldier Field | Ismir Pekmic | Match Report | |
| Sun | 2021-09-26 | 18:00 | Sporting KC | 0.5 | 1–2 | 1.1 | Seattle | 19,248 | Children's Mercy Park | Joe Dickerson | Match Report | |
| Sat | 2021-09-25 | 18:00 | Colorado Rapids | 0.7 | 0–0 | 0.5 | Toronto FC | 12,613 | Dick's Sporting Goods Park | Michael Radchuk | Match Report | |
| Sat | 2021-09-25 | 19:00 | Vancouver | 1.7 | 1–0 | 1.9 | FC Dallas | 16,927 | BC Place Stadium | Kevin Stott | Match Report | |
| Sat | 2021-09-25 | 19:00 | Minnesota Utd | 1.3 | 2–0 | 1.6 | Dynamo FC | 19,471 | Allianz Field | Allen Chapman | Match Report | |
| Sat | 2021-09-25 | 19:00 | San Jose | 1.7 | 2–0 | 1.3 | Los Angeles FC | 16,927 | Earthquakes Stadium | Jair Marrufo | Match Report | |
| Sat | 2021-09-25 | 19:30 | Portland Timbers | 1.7 | 6–1 | 1.7 | Real Salt Lake | 21,579 | Providence Park | Fotis Bazakos | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-09-26 | 20:30 | Austin | 1.0 | 2–0 | 1.2 | LA Galaxy | Q2 Stadium | Guido Gonzalez Jr. | Match Report | ||
| Wed | 2021-09-29 | 19:00 | Toronto FC | 3.4 | 3–2 | 0.8 | FC Cincinnati | 5,110 | BMO Field | Silviu Petrescu | Match Report | |
| Wed | 2021-09-29 | 19:00 | Atlanta Utd | 2.4 | 1–0 | 0.6 | Inter Miami | 42,519 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Wed | 2021-09-29 | 19:30 | D.C. United | 3.4 | 3–1 | 0.3 | Minnesota Utd | 12,262 | Audi Field | Ramy Touchan | Match Report | |
| Wed | 2021-09-29 | 19:30 | NY Red Bulls | 0.7 | 1–1 | 1.0 | Philadelphia | 9,193 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Wed | 2021-09-29 | 19:30 | CF Montréal | 1.8 | 1–4 | 1.9 | New England | Stade Saputo | Ismail Elfath | Match Report | ||
| Wed | 2021-09-29 | 19:00 | FC Dallas | 1.2 | 1–3 | 1.9 | Sporting KC | 12,387 | Toyota Stadium | Jair Marrufo | Match Report | |
| Wed | 2021-09-29 | 19:00 | Chicago Fire | 1.3 | 2–0 | 0.6 | NYCFC | 5,593 | Soldier Field | Baldomero Toledo | Match Report | |
| Wed | 2021-09-29 | 19:00 | Colorado Rapids | 1.2 | 3–0 | 0.5 | Austin | 8,582 | Dick's Sporting Goods Park | Michael Radchuk | Match Report | |
| Wed | 2021-09-29 | 19:30 | San Jose | 0.8 | 1–3 | 2.2 | Seattle | 11,361 | Earthquakes Stadium | Allen Chapman | Match Report | |
| Wed | 2021-09-29 | 19:30 | Los Angeles FC | 1.2 | 1–2 | 1.1 | Portland Timbers | 22,056 | Banc of California Stadium | Joe Dickerson | Match Report | |
| Wed | 2021-09-29 | 19:30 | Nashville | 1.7 | 2–2 | 1.2 | Orlando City | 18,648 | Nissan Stadium | Drew Fischer | Match Report | |
| Wed | 2021-09-29 | 19:30 | Real Salt Lake | 1.0 | 2–1 | 1.9 | LA Galaxy | 18,121 | Rio Tinto Stadium | Tori Penso | Match Report | |
| Wed | 2021-09-29 | 20:00 | Dynamo FC | 1.9 | 0–0 | 0.2 | Vancouver | 12,114 | BBVA Stadium | Alan Kelly | Match Report | |
| Sat | 2021-10-02 | 14:30 | Austin | 3.1 | 2–1 | 1.3 | Real Salt Lake | Q2 Stadium | Rosendo Mendoza | Match Report | ||
| Sat | 2021-10-02 | 19:00 | CF Montréal | 1.9 | 2–1 | 1.1 | Atlanta Utd | Stade Saputo | Fotis Bazakos | Match Report | ||
| Sat | 2021-10-02 | 19:30 | Orlando City | 1.4 | 2–1 | 0.6 | D.C. United | 16,848 | Exploria Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2021-10-02 | 19:30 | FC Cincinnati | 0.5 | 0–1 | 1.3 | NY Red Bulls | 22,141 | TQL Stadium | Tim Ford | Match Report | |
| Sun | 2021-10-03 | 12:00 | NYCFC | 2.0 | 0–0 | 0.9 | Nashville | Red Bull Arena | Marcos de Oliveira | Match Report | ||
| Sun | 2021-10-03 | 14:30 | Portland Timbers | 2.1 | 1–0 | 0.8 | Inter Miami | 22,006 | Providence Park | Robert Sibiga | Match Report | |
| Sun | 2021-10-03 | 15:00 | Sporting KC | 3.5 | 4–2 | 1.9 | Dynamo FC | 17,867 | Children's Mercy Park | Alex Chilowicz | Match Report | |
| Sun | 2021-10-03 | 16:00 | Philadelphia | 1.2 | 3–0 | 1.4 | Columbus Crew | 15,578 | Subaru Park | Victor Rivas | Match Report | |
| Sun | 2021-10-03 | 16:00 | Toronto FC | 2.7 | 3–1 | 0.8 | Chicago Fire | BMO Field | Nima Saghafi | Match Report | ||
| Sat | 2021-10-02 | 19:00 | FC Dallas | 1.1 | 0–0 | 1.4 | Minnesota Utd | 17,231 | Toyota Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2021-10-02 | 19:00 | Vancouver | 2.5 | 3–0 | 0.6 | San Jose | BC Place Stadium | Pierre-Luc Lauziere | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-10-03 | 17:00 | LA Galaxy | 1.6 | 1–1 | 1.3 | Los Angeles FC | 25,174 | Dignity Health Sports Park | Armando Villarreal | Match Report | |
| Sun | 2021-10-03 | 19:00 | Seattle | 1.4 | 3–0 | 0.9 | Colorado Rapids | 31,425 | Lumen Field | Chris Penso | Match Report | |
| Sat | 2021-10-09 | 18:00 | NY Red Bulls | 2.3 | 1–0 | 0.3 | Inter Miami | 17,516 | Red Bull Arena | Tori Penso | Match Report | |
| Sun | 2021-10-10 | 15:00 | Minnesota Utd | 1.4 | 1–3 | 2.6 | Colorado Rapids | Allianz Field | Jon Freemon | Match Report | ||
| Sat | 2021-10-09 | 18:00 | Seattle | 1.9 | 4–1 | 2.1 | Vancouver | 31,842 | Lumen Field | Ted Unkel | Match Report | |
| Sat | 2021-10-09 | 20:00 | FC Cincinnati | 1.7 | 1–2 | 1.3 | Philadelphia | 21,674 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2021-10-16 | 12:30 | Los Angeles FC | 2.8 | 3–1 | 2.4 | San Jose | 22,003 | Banc of California Stadium | Alan Kelly | Match Report | |
| Sat | 2021-10-16 | 13:00 | CF Montréal | 0.8 | 2–2 | 0.2 | Philadelphia | Stade Saputo | Pierre-Luc Lauziere | Match Report | ||
| Sat | 2021-10-16 | 18:00 | Columbus Crew | 2.5 | 4–0 | 0.7 | Inter Miami | 19,338 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2021-10-16 | 19:00 | New England | 1.4 | 2–2 | 1.1 | Chicago Fire | 28,414 | Gillette Stadium | Joe Dickerson | Match Report | |
| Sat | 2021-10-16 | 19:30 | Toronto FC | 1.4 | 0–2 | 1.8 | Atlanta Utd | 7,490 | BMO Field | Tim Ford | Match Report | |
| Sat | 2021-10-16 | 19:30 | D.C. United | 1.1 | 0–0 | 0.3 | Nashville | 18,034 | Audi Field | Ismail Elfath | Match Report | |
| Sat | 2021-10-16 | 19:30 | FC Cincinnati | 0.6 | 0–1 | 1.1 | Orlando City | 22,488 | TQL Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2021-10-17 | 13:00 | NY Red Bulls | 1.9 | 1–0 | 0.6 | NYCFC | 18,613 | Red Bull Arena | Jair Marrufo | Match Report | |
| Sat | 2021-10-16 | 19:30 | Dynamo FC | 1.1 | 2–1 | 1.2 | Seattle | 14,265 | BBVA Stadium | Nima Saghafi | Match Report | |
| Sat | 2021-10-16 | 19:30 | Real Salt Lake | 1.2 | 3–1 | 0.7 | Colorado Rapids | Rio Tinto Stadium | Kevin Stott | Match Report | ||
| Sat | 2021-10-16 | 19:30 | LA Galaxy | 3.1 | 2–1 | 0.4 | Portland Timbers | 15,322 | Dignity Health Sports Park | Victor Rivas | Match Report | |
| Sat | 2021-10-16 | 20:00 | Austin | 1.5 | 0–1 | 1.8 | Minnesota Utd | 20,738 | Q2 Stadium | Michael Radchuk | Match Report | |
| Sun | 2021-10-17 | 19:00 | Vancouver | 0.6 | 2–1 | 0.4 | Sporting KC | 10,990 | BC Place Stadium | Silviu Petrescu | Match Report | |
| Wed | 2021-10-20 | 19:30 | Orlando City | 1.4 | 1–1 | 0.8 | CF Montréal | 15,775 | Exploria Stadium | Robert Sibiga | Match Report | |
| Wed | 2021-10-20 | 19:30 | D.C. United | 2.1 | 2–3 | 1.9 | New England | 13,387 | Audi Field | Nima Saghafi | Match Report | |
| Wed | 2021-10-20 | 19:30 | Atlanta Utd | 1.0 | 1–1 | 0.9 | NYCFC | 42,511 | Mercedes-Benz Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2021-10-20 | 19:30 | FC Cincinnati | 2.6 | 3–4 | 2.3 | Chicago Fire | 21,369 | TQL Stadium | Jon Freemon | Match Report | |
| Wed | 2021-10-20 | 19:30 | Inter Miami | 1.5 | 3–0 | 0.7 | Toronto FC | DRV PNK Stadium | Armando Villarreal | Match Report | ||
| Wed | 2021-10-20 | 19:00 | Minnesota Utd | 1.5 | 3–2 | 2.2 | Philadelphia | Allianz Field | Allen Chapman | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-10-20 | 19:00 | FC Dallas | 2.0 | 2–3 | 1.8 | Los Angeles FC | 12,532 | Toyota Stadium | Chris Penso | Match Report | |
| Wed | 2021-10-20 | 19:00 | Colorado Rapids | 1.2 | 1–1 | 1.4 | Seattle | 9,316 | Dick's Sporting Goods Park | Drew Fischer | Match Report | |
| Wed | 2021-10-20 | 19:00 | Portland Timbers | 1.2 | 2–3 | 1.8 | Vancouver | 16,722 | Providence Park | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-10-20 | 19:30 | San Jose | 2.6 | 4–0 | 1.0 | Austin | 12,035 | Earthquakes Stadium | Ismir Pekmic | Match Report | |
| Wed | 2021-10-20 | 19:30 | Nashville | 1.1 | 1–1 | 0.6 | Columbus Crew | 18,381 | Nissan Stadium | Alex Chilowicz | Match Report | |
| Wed | 2021-10-20 | 19:30 | Dynamo FC | 2.1 | 0–3 | 1.8 | LA Galaxy | 13,798 | BBVA Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-10-23 | 12:30 | Seattle | 1.7 | 1–2 | 1.2 | Sporting KC | 32,139 | Lumen Field | Ismail Elfath | Match Report | |
| Sat | 2021-10-23 | 18:00 | Columbus Crew | 0.6 | 1–2 | 2.5 | NY Red Bulls | 17,891 | Lower.com Field | Alan Kelly | Match Report | |
| Sat | 2021-10-23 | 19:30 | Philadelphia | 1.8 | 1–0 | 0.3 | Nashville | 18,575 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2021-10-23 | 19:30 | NYCFC | 3.1 | 6–0 | 0.7 | D.C. United | Yankee Stadium | Joe Dickerson | Match Report | ||
| Sat | 2021-10-23 | 19:30 | Toronto FC | 2.2 | 1–1 | 2.1 | CF Montréal | 8,095 | BMO Field | Allen Chapman | Match Report | |
| Sun | 2021-10-24 | 16:00 | Austin | 1.9 | 2–1 | 0.8 | Dynamo FC | Q2 Stadium | Tim Ford | Match Report | ||
| Sat | 2021-10-23 | 19:00 | LA Galaxy | 2.0 | 2–2 | 1.5 | FC Dallas | 15,136 | Dignity Health Sports Park | Baldomero Toledo | Match Report | |
| Sat | 2021-10-23 | 19:00 | Colorado Rapids | 1.4 | 2–0 | 0.4 | Portland Timbers | 12,200 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2021-10-23 | 19:00 | San Jose | 1.4 | 1–1 | 0.7 | Vancouver | 15,025 | Earthquakes Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2021-10-23 | 19:00 | Minnesota Utd | 2.2 | 1–1 | 0.6 | Los Angeles FC | 19,406 | Allianz Field | Robert Sibiga | Match Report | |
| Sat | 2021-10-23 | 19:00 | Chicago Fire | 2.0 | 1–0 | 1.2 | Real Salt Lake | 31,308 | Soldier Field | Rosendo Mendoza | Match Report | |
| Sun | 2021-10-24 | 19:30 | Orlando City | 2.0 | 2–2 | 1.3 | New England | 17,539 | Exploria Stadium | Chris Penso | Match Report | |
| Sat | 2021-10-23 | 20:00 | Inter Miami | 2.1 | 5–1 | 1.8 | FC Cincinnati | 14,927 | DRV PNK Stadium | Drew Fischer | Match Report | |
| Wed | 2021-10-27 | 19:00 | New England | 1.5 | 1–0 | 0.7 | Colorado Rapids | 10,199 | Gillette Stadium | Victor Rivas | Match Report | |
| Wed | 2021-10-27 | 19:30 | D.C. United | 0.9 | 1–0 | 2.2 | NY Red Bulls | 14,109 | Audi Field | Rubiel Vazquez | Match Report | |
| Wed | 2021-10-27 | 19:30 | FC Cincinnati | 2.4 | 3–6 | 1.8 | Nashville | 20,581 | TQL Stadium | Ramy Touchan | Match Report | |
| Wed | 2021-10-27 | 19:30 | NYCFC | 2.1 | 1–0 | 0.5 | Chicago Fire | Red Bull Arena | Fotis Bazakos | Match Report | ||
| Tue | 2021-10-26 | 19:30 | Los Angeles FC | 1.1 | 3–0 | 1.7 | Seattle | 22,030 | Banc of California Stadium | Kevin Stott | Match Report | |
| Wed | 2021-10-27 | 19:30 | Toronto FC | 1.3 | 2–2 | 2.0 | Philadelphia | 5,026 | BMO Field | Silviu Petrescu | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-10-27 | 19:30 | Atlanta Utd | 1.5 | 2–1 | 2.1 | Inter Miami | 42,536 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Wed | 2021-10-27 | 19:30 | Columbus Crew | 1.7 | 3–2 | 1.7 | Orlando City | 16,676 | Lower.com Field | Joe Dickerson | Match Report | |
| Wed | 2021-10-27 | 19:00 | Portland Timbers | 3.2 | 2–0 | 1.2 | San Jose | 16,086 | Providence Park | Alex Chilowicz | Match Report | |
| Wed | 2021-10-27 | 19:00 | Vancouver | 1.0 | 2–1 | 2.3 | Minnesota Utd | 10,833 | BC Place Stadium | Nima Saghafi | Match Report | |
| Wed | 2021-10-27 | 19:00 | FC Dallas | 1.7 | 1–2 | 1.3 | Real Salt Lake | 12,486 | Toyota Stadium | Ismail Elfath | Match Report | |
| Wed | 2021-10-27 | 19:30 | Sporting KC | 0.7 | 2–0 | 0.7 | LA Galaxy | 18,711 | Children's Mercy Park | Alan Kelly | Match Report | |
| Sat | 2021-10-30 | 13:30 | Real Salt Lake | 2.3 | 3–4 | 2.7 | San Jose | 15,553 | Rio Tinto Stadium | Jon Freemon | Match Report | |
| Sat | 2021-10-30 | 13:30 | Inter Miami | 1.1 | 1–3 | 1.4 | NYCFC | 17,595 | DRV PNK Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2021-10-30 | 16:00 | NY Red Bulls | 1.4 | 1–0 | 0.9 | CF Montréal | 16,344 | Red Bull Arena | Chris Penso | Match Report | |
| Sat | 2021-10-30 | 18:00 | Atlanta Utd | 2.4 | 1–1 | 0.9 | Toronto FC | 43,372 | Mercedes-Benz Stadium | Alex Chilowicz | Match Report | |
| Sat | 2021-10-30 | 19:30 | D.C. United | 0.9 | 1–3 | 2.7 | Columbus Crew | 16,787 | Audi Field | Drew Fischer | Match Report | |
| Sun | 2021-10-31 | 12:00 | Minnesota Utd | 1.8 | 2–1 | 0.6 | Sporting KC | Allianz Field | Victor Rivas | Match Report | ||
| Sun | 2021-10-31 | 14:00 | Dynamo FC | 0.6 | 0–1 | 0.4 | Colorado Rapids | 14,474 | BBVA Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2021-10-31 | 16:00 | Orlando City | 1.0 | 1–1 | 0.8 | Nashville | 15,959 | Exploria Stadium | Allen Chapman | Match Report | |
| Sun | 2021-10-31 | 19:30 | Philadelphia | 2.8 | 2–0 | 0.5 | FC Cincinnati | 13,488 | Subaru Park | Fotis Bazakos | Match Report | |
| Sat | 2021-10-30 | 20:00 | FC Dallas | 1.6 | 2–1 | 0.5 | Austin | 16,080 | Toyota Stadium | Silviu Petrescu | Match Report | |
| Mon | 2021-11-01 | 19:00 | Seattle | 1.4 | 1–1 | 1.1 | LA Galaxy | 32,781 | Lumen Field | Joe Dickerson | Match Report | |
| Wed | 2021-11-03 | 19:30 | NY Red Bulls | 1.3 | 0–0 | 0.2 | Atlanta Utd | 15,934 | Red Bull Arena | Alan Kelly | Match Report | |
| Tue | 2021-11-02 | 19:30 | Los Angeles FC | 3.1 | 1–1 | 0.8 | Vancouver | 22,221 | Banc of California Stadium | Alex Chilowicz | Match Report | |
| Wed | 2021-11-03 | 19:30 | CF Montréal | 1.3 | 2–0 | 0.7 | Dynamo FC | Stade Saputo | Ted Unkel | Match Report | ||
| Wed | 2021-11-03 | 20:00 | Austin | 2.0 | 3–1 | 0.7 | Sporting KC | 20,738 | Q2 Stadium | Nima Saghafi | Match Report | |
| Wed | 2021-11-03 | 20:30 | Real Salt Lake | 2.2 | 1–3 | 1.8 | Portland Timbers | 18,405 | Rio Tinto Stadium | Chris Penso | Match Report | |
| Sun | 2021-11-07 | 14:30 | Nashville | 1.0 | 1–1 | 1.6 | NY Red Bulls | 26,913 | Nissan Stadium | Drew Fischer | Match Report | |
| Sun | 2021-11-07 | 15:00 | LA Galaxy | 2.1 | 3–3 | 2.6 | Minnesota Utd | 23,803 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Sun | 2021-11-07 | 15:00 | San Jose | 2.6 | 1–1 | 1.6 | FC Dallas | Earthquakes Stadium | Victor Rivas | Match Report | ||
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-11-07 | 15:00 | Portland Timbers | 4.2 | 3–0 | 0.4 | Austin | 23,127 | Providence Park | Rosendo Mendoza | Match Report | |
| Sun | 2021-11-07 | 15:00 | Vancouver | 1.0 | 1–1 | 1.6 | Seattle | 25,117 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sun | 2021-11-07 | 15:30 | New England | 2.0 | 0–1 | 0.5 | Inter Miami | 31,635 | Gillette Stadium | Alan Kelly | Match Report | |
| Sun | 2021-11-07 | 15:30 | FC Cincinnati | 0.6 | 1–2 | 2.3 | Atlanta Utd | 23,663 | TQL Stadium | Nima Saghafi | Match Report | |
| Sun | 2021-11-07 | 15:30 | Columbus Crew | 4.0 | 2–0 | 0.7 | Chicago Fire | 19,351 | Lower.com Field | Tim Ford | Match Report | |
| Sun | 2021-11-07 | 15:30 | CF Montréal | 1.4 | 0–2 | 0.7 | Orlando City | Stade Saputo | Armando Villarreal | Match Report | ||
| Sun | 2021-11-07 | 15:30 | NYCFC | 0.6 | 1–1 | 1.6 | Philadelphia | Yankee Stadium | Guido Gonzalez Jr. | Match Report | ||
| Sun | 2021-11-07 | 15:30 | Toronto FC | 1.4 | 1–3 | 2.6 | D.C. United | 11,166 | BMO Field | Marcos de Oliveira | Match Report | |
| Sun | 2021-11-07 | 16:00 | Colorado Rapids | 3.1 | 5–2 | 1.8 | Los Angeles FC | 16,292 | Dick's Sporting Goods Park | Allen Chapman | Match Report | |
| Sun | 2021-11-07 | 17:00 | Sporting KC | 1.3 | 0–1 | 1.5 | Real Salt Lake | 19,022 | Children's Mercy Park | Ted Unkel | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First Round | Sat | 2021-11-20 | 14:30 | Philadelphia | 2.0 | 1–0 | 0.9 | NY Red Bulls | 18,623 | Subaru Park | Fotis Bazakos | Match Report | Required Extra Time |
| First Round | Sat | 2021-11-20 | 16:00 | Sporting KC | 1.4 | 3–1 | 1.1 | Vancouver | 19,817 | Children's Mercy Park | Alan Kelly | Match Report | |
| First Round | Sun | 2021-11-21 | 14:30 | Portland Timbers | 2.3 | 3–1 | 1.7 | Minnesota Utd | 22,533 | Providence Park | Armando Villarreal | Match Report | |
| First Round | Sun | 2021-11-21 | 15:00 | NYCFC | 1.1 | 2–0 | 0.4 | Atlanta Utd | 25,267 | Yankee Stadium | Chris Penso | Match Report | |
| First Round | Tue | 2021-11-23 | 19:00 | Nashville | 0.5 | 3–1 | 0.5 | Orlando City | 26,043 | Nissan Stadium | Ismail Elfath | Match Report | |
| First Round | Tue | 2021-11-23 | 19:30 | Seattle | 1.1 | (5) 0–0 (6) | 0.0 | Real Salt Lake | 34,012 | Lumen Field | Joe Dickerson | Match Report | Real Salt Lake won on penalty kicks following extra time |
| Conference Semifinals | Thu | 2021-11-25 | 14:30 | Colorado Rapids | 1.2 | 0–1 | 2.0 | Portland Timbers | 17,438 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Conference Semifinals | Sun | 2021-11-28 | 14:00 | Sporting KC | 1.0 | 1–2 | 1.1 | Real Salt Lake | 21,650 | Children's Mercy Park | Kevin Stott | Match Report | |
| Conference Semifinals | Sun | 2021-11-28 | 17:30 | Philadelphia | 2.0 | (2) 1–1 (0) | 0.9 | Nashville | 19,076 | Subaru Park | Allen Chapman | Match Report | Philadelphia won on penalty kicks following extra time |
| Conference Semifinals | Tue | 2021-11-30 | 19:30 | New England | 1.1 | (3) 2–2 (5) | 0.9 | NYCFC | 25,509 | Gillette Stadium | Drew Fischer | Match Report | NYCFC won on penalty kicks following extra time |
| Conference Finals | Sat | 2021-12-04 | 15:30 | Portland Timbers | 1.3 | 2–0 | 0.4 | Real Salt Lake | Providence Park | Alan Kelly | Match Report | ||
| Conference Finals | Sun | 2021-12-05 | 15:00 | Philadelphia | 0.7 | 1–2 | 1.6 | NYCFC | 19,487 | Subaru Park | Ted Unkel | Match Report | |
| MLS Cup | Sat | 2021-12-11 | 12:00 | Portland Timbers | 1.3 | (2) 1–1 (4) | 0.9 | NYCFC | 25,218 | Providence Park | Armando Villarreal | Match Report | NYCFC won on penalty kicks following extra time |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
FBref is the most complete sources for women's football data on the internet. This includes the entire history of the FIFA Women's World Cup as well as recent domestic league seasons from nine countries, including advanced stats like xG for most of those nine.
In collaboration with Opta, we are including advanced analytical data such as xG, xA, progressive passing, duels and more for over twenty competitions. For more information on the expected goals model and which competitions have advanced data, see our xG explainer.
Note that player records are likely not complete for their careers. Players may come from or move to leagues we don't currently cover. This issue will go down over time, as we add new leagues and seasons. We will never in the future have less data than we do today.
You can sign up to receive an e-mail when new countries and features launch.
For more information, see our Launch Blog Post, the overall leagues/competition page with details on leagues and seasons we include, or our About Page. Let us know if you find an issue or have a suggestion.
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