Scores & Fixtures 2022 Major League Soccer
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2022-02-26 | 12:30 | Los Angeles FC | 2.4 | 3–0 | 0.4 | Colorado Rapids | 22,010 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-02-26 | 13:00 | Philadelphia | 1.1 | 1–1 | 1.1 | Minnesota Utd | 17,487 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sat | 2022-02-26 | 15:00 | San Jose | 1.1 | 1–3 | 3.0 | NY Red Bulls | 16,146 | PayPal Park | Drew Fischer | Match Report | |
| Sat | 2022-02-26 | 15:30 | Columbus Crew | 3.4 | 4–0 | 0.5 | Vancouver | 18,939 | Lower.com Field | Nima Saghafi | Match Report | |
| Sat | 2022-02-26 | 16:30 | FC Dallas | 1.9 | 1–1 | 1.5 | Toronto FC | 12,233 | Toyota Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-02-26 | 17:00 | Austin | 2.3 | 5–0 | 1.7 | FC Cincinnati | 20,738 | Q2 Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-02-26 | 18:00 | D.C. United | 1.6 | 3–0 | 1.2 | Charlotte | 16,412 | Audi Field | Victor Rivas | Match Report | |
| Sat | 2022-02-26 | 18:00 | Inter Miami | 1.6 | 0–0 | 1.1 | Chicago Fire | 15,973 | DRV PNK Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-02-27 | 13:00 | Orlando City | 1.4 | 2–0 | 0.6 | CF Montréal | 21,283 | Exploria Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-02-27 | 14:00 | LA Galaxy | 1.6 | 1–0 | 1.0 | NYCFC | 25,174 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sun | 2022-02-27 | 15:00 | Atlanta Utd | 1.5 | 3–1 | 1.2 | Sporting KC | 67,523 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Sat | 2022-02-26 | 16:30 | Portland Timbers | 2.7 | 2–2 | 1.2 | New England | 23,411 | Providence Park | Chris Penso | Match Report | |
| Sun | 2022-02-27 | 17:00 | Seattle | 0.5 | 0–1 | 1.0 | Nashville | 30,013 | Lumen Field | Alex Chilowicz | Match Report | |
| Sun | 2022-02-27 | 18:00 | Dynamo FC | 0.5 | 0–0 | 0.4 | Real Salt Lake | 18,561 | PNC Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-03-05 | 13:30 | New England | 1.7 | 1–0 | 1.0 | FC Dallas | 14,554 | Gillette Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-05 | 14:00 | Toronto FC | 0.7 | 1–4 | 2.3 | NY Red Bulls | 23,121 | BMO Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-03-05 | 14:30 | Sporting KC | 1.5 | 1–0 | 0.2 | Dynamo FC | 18,872 | Children's Mercy Park | Victor Rivas | Match Report | |
| Sat | 2022-03-05 | 14:30 | San Jose | 1.3 | 3–3 | 1.9 | Columbus Crew | 12,888 | PayPal Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-05 | 15:00 | Vancouver | 0.5 | 0–0 | 1.9 | NYCFC | 18,643 | BC Place Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2022-03-05 | 16:00 | CF Montréal | 0.7 | 1–2 | 1.1 | Philadelphia | 13,067 | Stade Olympique | Drew Fischer | Match Report | |
| Sat | 2022-03-05 | 16:00 | Colorado Rapids | 1.6 | 3–0 | 1.1 | Atlanta Utd | 12,538 | Dick's Sporting Goods Park | Joe Dickerson | Match Report | |
| Sat | 2022-03-05 | 16:00 | Real Salt Lake | 2.3 | 1–0 | 0.8 | Seattle | 20,017 | Rio Tinto Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-03-05 | 17:00 | Minnesota Utd | 1.9 | 1–1 | 1.7 | Nashville | 18,107 | Allianz Field | Armando Villarreal | Match Report | |
| Sat | 2022-03-05 | 17:00 | Chicago Fire | 0.5 | 0–0 | 0.2 | Orlando City | 25,477 | Soldier Field | Ismir Pekmic | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-03-05 | 18:00 | FC Cincinnati | 2.4 | 0–1 | 1.7 | D.C. United | 22,183 | TQL Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-03-06 | 15:00 | Austin | 1.9 | 5–1 | 0.7 | Inter Miami | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-05 | 19:30 | Charlotte | 0.5 | 0–1 | 2.1 | LA Galaxy | 74,479 | Bank of America Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-03-06 | 19:00 | Los Angeles FC | 2.2 | 1–1 | 0.6 | Portland Timbers | 22,102 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-03-12 | 12:30 | Seattle | 2.1 | 3–2 | 2.2 | LA Galaxy | 33,200 | Lumen Field | Allen Chapman | Match Report | |
| Sat | 2022-03-12 | 13:00 | NYCFC | 1.9 | 4–1 | 2.4 | CF Montréal | 21,113 | Yankee Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-03-12 | 13:30 | Columbus Crew | 1.5 | 2–1 | 0.9 | Toronto FC | 16,116 | Lower.com Field | Ismail Elfath | Match Report | |
| Sat | 2022-03-12 | 13:30 | Inter Miami | 0.4 | 0–2 | 0.5 | Los Angeles FC | 11,465 | DRV PNK Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-12 | 17:30 | Dynamo FC | 2.2 | 2–1 | 1.5 | Vancouver | 13,028 | PNC Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-03-13 | 16:30 | Atlanta Utd | 2.0 | 2–1 | 1.0 | Charlotte | 43,055 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-12 | 19:00 | Portland Timbers | 1.3 | 1–0 | 1.1 | Austin | 22,795 | Providence Park | Joe Dickerson | Match Report | |
| Sun | 2022-03-13 | 19:00 | NY Red Bulls | 2.3 | 0–1 | 0.7 | Minnesota Utd | 14,848 | Red Bull Arena | Lukasz Szpala | Match Report | |
| Sat | 2022-03-12 | 19:00 | Colorado Rapids | 2.4 | 2–0 | 0.8 | Sporting KC | 12,387 | Dick's Sporting Goods Park | Alex Chilowicz | Match Report | |
| Sat | 2022-03-12 | 19:30 | Orlando City | 1.4 | 1–2 | 1.2 | FC Cincinnati | 16,512 | Exploria Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-12 | 19:30 | New England | 1.2 | 2–3 | 2.2 | Real Salt Lake | 10,633 | Gillette Stadium | Drew Fischer | Match Report | |
| Sat | 2022-03-12 | 19:30 | FC Dallas | 1.7 | 2–0 | 0.2 | Nashville | 13,448 | Toyota Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-03-12 | 19:30 | Philadelphia | 2.7 | 2–0 | 0.3 | San Jose | 14,533 | Subaru Park | Victor Rivas | Match Report | |
| Sat | 2022-03-12 | 19:30 | D.C. United | 1.3 | 0–2 | 1.7 | Chicago Fire | 13,795 | Audi Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-03-19 | 12:30 | LA Galaxy | 2.3 | 0–1 | 0.5 | Orlando City | 25,174 | Dignity Health Sports Park | Alex Chilowicz | Match Report | |
| Sat | 2022-03-19 | 13:00 | NYCFC | 1.4 | 0–2 | 2.1 | Philadelphia | 15,968 | Yankee Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-19 | 13:00 | FC Cincinnati | 2.5 | 3–1 | 1.4 | Inter Miami | 19,365 | TQL Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-03-19 | 15:00 | Toronto FC | 1.4 | 2–1 | 1.1 | D.C. United | 21,501 | BMO Field | Ramy Touchan | Match Report | |
| Sat | 2022-03-19 | 16:00 | Atlanta Utd | 0.7 | 3–3 | 2.9 | CF Montréal | 42,578 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-19 | 17:00 | Chicago Fire | 1.7 | 3–1 | 0.5 | Sporting KC | 9,352 | Soldier Field | Tim Ford | Match Report | |
| Sat | 2022-03-19 | 19:00 | Charlotte | 1.3 | 3–1 | 1.8 | New England | 29,318 | Bank of America Stadium | Marcos de Oliveira | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-03-20 | 14:00 | NY Red Bulls | 1.4 | 1–1 | 2.7 | Columbus Crew | 15,323 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sun | 2022-03-20 | 15:30 | Austin | 2.0 | 1–1 | 1.7 | Seattle | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-03-19 | 19:00 | Minnesota Utd | 1.8 | 1–0 | 0.3 | San Jose | 18,685 | Allianz Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-03-19 | 19:30 | Dynamo FC | 1.1 | 1–1 | 1.2 | Colorado Rapids | 17,007 | PNC Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-03-19 | 19:30 | FC Dallas | 1.6 | 4–1 | 0.8 | Portland Timbers | 19,096 | Toyota Stadium | Allen Chapman | Match Report | |
| Sat | 2022-03-19 | 19:30 | Real Salt Lake | 0.9 | 2–1 | 2.3 | Nashville | 20,036 | Rio Tinto Stadium | Tori Penso | Match Report | |
| Sun | 2022-03-20 | 19:00 | Los Angeles FC | 1.7 | 3–1 | 1.1 | Vancouver | 22,065 | Banc of California Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-26 | 17:00 | Charlotte | 1.0 | 2–0 | 1.6 | FC Cincinnati | 30,242 | Bank of America Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-03-26 | 18:00 | Sporting KC | 1.0 | 1–0 | 1.0 | Real Salt Lake | 19,107 | Children's Mercy Park | Joe Dickerson | Match Report | |
| Sun | 2022-03-27 | 13:00 | Portland Timbers | 1.9 | 1–1 | 0.8 | Orlando City | 22,948 | Providence Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-04-02 | 14:30 | Chicago Fire | 0.7 | 0–0 | 0.3 | FC Dallas | 11,411 | Soldier Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-04-02 | 16:00 | Toronto FC | 0.9 | 2–1 | 1.1 | NYCFC | 21,802 | BMO Field | Drew Fischer | Match Report | |
| Sat | 2022-04-02 | 16:00 | FC Cincinnati | 2.6 | 3–4 | 1.7 | CF Montréal | 20,386 | TQL Stadium | Tori Penso | Match Report | |
| Sat | 2022-04-02 | 16:30 | San Jose | 2.9 | 2–2 | 2.3 | Austin | 13,062 | PayPal Park | Alex Chilowicz | Match Report | |
| Sat | 2022-04-02 | 18:00 | Columbus Crew | 1.7 | 0–1 | 0.9 | Nashville | 20,371 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-02 | 19:30 | New England | 1.1 | 0–1 | 0.8 | NY Red Bulls | 16,265 | Gillette Stadium | Victor Rivas | Match Report | |
| Sat | 2022-04-02 | 19:30 | Philadelphia | 1.0 | 2–0 | 0.6 | Charlotte | 18,136 | Subaru Park | Tim Ford | Match Report | |
| Sat | 2022-04-02 | 19:30 | Orlando City | 1.4 | 2–4 | 2.7 | Los Angeles FC | 16,753 | Exploria Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-04-02 | 19:30 | D.C. United | 0.5 | 0–1 | 1.0 | Atlanta Utd | 17,289 | Audi Field | Armando Villarreal | Match Report | |
| Sun | 2022-04-03 | 13:30 | Portland Timbers | 1.1 | 1–3 | 1.5 | LA Galaxy | 24,534 | Providence Park | Nima Saghafi | Match Report | |
| Sat | 2022-04-02 | 17:00 | Vancouver | 1.0 | 1–0 | 0.6 | Sporting KC | 16,772 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-04-02 | 19:00 | Minnesota Utd | 2.1 | 1–2 | 1.5 | Seattle | 19,615 | Allianz Field | Ismail Elfath | Match Report | |
| Sat | 2022-04-02 | 19:00 | Colorado Rapids | 1.7 | 1–1 | 1.1 | Real Salt Lake | 13,380 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2022-04-02 | 20:00 | Inter Miami | 1.8 | 1–3 | 2.5 | Dynamo FC | 13,083 | DRV PNK Stadium | Allen Chapman | Match Report | |
| Sat | 2022-04-09 | 13:00 | Orlando City | 3.4 | 1–0 | 0.5 | Chicago Fire | 16,051 | Exploria Stadium | Victor Rivas | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-09 | 15:00 | Inter Miami | 1.3 | 3–2 | 1.2 | New England | 11,472 | DRV PNK Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-04-09 | 16:00 | NY Red Bulls | 1.4 | 1–2 | 1.7 | CF Montréal | 15,734 | Red Bull Arena | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-04-09 | 16:30 | LA Galaxy | 1.0 | 2–1 | 2.0 | Los Angeles FC | 25,174 | Dignity Health Sports Park | Chris Penso | Match Report | |
| Sat | 2022-04-09 | 18:00 | Philadelphia | 1.8 | 1–0 | 1.4 | Columbus Crew | 18,321 | Subaru Park | Armando Villarreal | Match Report | |
| Sun | 2022-04-10 | 13:30 | Charlotte | 0.9 | 1–0 | 1.3 | Atlanta Utd | 32,496 | Bank of America Stadium | Allen Chapman | Match Report | |
| Sat | 2022-04-09 | 18:00 | Real Salt Lake | 1.3 | 2–2 | 0.9 | Toronto FC | 20,136 | Rio Tinto Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-04-10 | 18:30 | Austin | 1.2 | 1–0 | 0.5 | Minnesota Utd | 20,738 | Q2 Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-09 | 19:00 | Vancouver | 2.5 | 2–3 | 1.3 | Portland Timbers | 16,772 | BC Place Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-04-09 | 19:30 | Dynamo FC | 1.4 | 4–3 | 1.4 | San Jose | 15,414 | PNC Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-04-09 | 19:30 | Sporting KC | 1.2 | 1–2 | 2.8 | Nashville | 18,852 | Children's Mercy Park | Ismail Elfath | Match Report | |
| Sat | 2022-04-09 | 19:30 | FC Dallas | 1.4 | 3–1 | 2.1 | Colorado Rapids | 15,893 | Toyota Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-04-16 | 12:30 | San Jose | 1.3 | 2–2 | 1.8 | Nashville | 10,394 | PayPal Park | Tim Ford | Match Report | |
| Sat | 2022-04-16 | 15:00 | CF Montréal | 1.5 | 2–1 | 0.3 | Vancouver | 12,042 | Stade Saputo | Nima Saghafi | Match Report | |
| Sat | 2022-04-16 | 17:00 | Dynamo FC | 1.5 | 0–0 | 1.5 | Portland Timbers | 13,650 | PNC Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-16 | 18:00 | Atlanta Utd | 2.8 | 0–0 | 1.3 | FC Cincinnati | 42,948 | Mercedes-Benz Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-16 | 19:00 | NY Red Bulls | 1.6 | 0–0 | 0.5 | FC Dallas | 14,456 | Red Bull Arena | Fotis Bazakos | Match Report | |
| Sat | 2022-04-16 | 19:30 | D.C. United | 1.5 | 2–3 | 2.8 | Austin | 16,840 | Audi Field | Tori Penso | Match Report | |
| Sat | 2022-04-16 | 19:30 | Toronto FC | 0.4 | 2–1 | 1.7 | Philadelphia | 20,809 | BMO Field | Alex Chilowicz | Match Report | |
| Sat | 2022-04-16 | 19:30 | Columbus Crew | 1.3 | 0–2 | 1.3 | Orlando City | 18,030 | Lower.com Field | Drew Fischer | Match Report | |
| Sat | 2022-04-16 | 19:30 | New England | 1.3 | 2–1 | 0.5 | Charlotte | 15,344 | Gillette Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-04-17 | 13:00 | Los Angeles FC | 2.0 | 3–1 | 1.0 | Sporting KC | 22,097 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-04-17 | 13:00 | NYCFC | 3.3 | 6–0 | 1.2 | Real Salt Lake | 14,513 | Yankee Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-04-16 | 19:00 | Seattle | 1.1 | 0–1 | 0.7 | Inter Miami | 32,126 | Lumen Field | Joe Dickerson | Match Report | |
| Sat | 2022-04-16 | 19:00 | Minnesota Utd | 1.9 | 3–1 | 2.0 | Colorado Rapids | 19,629 | Allianz Field | Chris Penso | Match Report | |
| Sat | 2022-04-16 | 19:00 | Chicago Fire | 0.4 | 0–0 | 0.4 | LA Galaxy | 30,282 | Soldier Field | Ted Unkel | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-23 | 14:00 | FC Dallas | 2.2 | 2–1 | 1.0 | Dynamo FC | 15,792 | Toyota Stadium | Victor Rivas | Match Report | |
| Sat | 2022-04-23 | 15:00 | Philadelphia | 1.2 | 1–1 | 0.5 | CF Montréal | 18,476 | Subaru Park | Lukasz Szpala | Match Report | |
| Sat | 2022-04-23 | 16:00 | Minnesota Utd | 0.9 | 3–0 | 1.0 | Chicago Fire | 19,658 | Allianz Field | Silviu Petrescu | Match Report | |
| Sat | 2022-04-23 | 19:30 | D.C. United | 1.5 | 3–2 | 2.0 | New England | 17,131 | Audi Field | Marcos de Oliveira | Match Report | |
| Sun | 2022-04-24 | 13:00 | Inter Miami | 1.9 | 2–1 | 2.1 | Atlanta Utd | 13,433 | DRV PNK Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-04-24 | 15:30 | Orlando City | 0.1 | 0–3 | 2.3 | NY Red Bulls | 17,503 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sun | 2022-04-24 | 17:00 | FC Cincinnati | 1.5 | 1–2 | 1.8 | Los Angeles FC | 20,883 | TQL Stadium | Ismail Elfath | Match Report | |
| Sun | 2022-04-24 | 17:00 | NYCFC | 4.2 | 5–4 | 1.2 | Toronto FC | 17,626 | Citi Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-23 | 19:00 | Colorado Rapids | 0.6 | 0–0 | 1.2 | Charlotte | 13,160 | Dick's Sporting Goods Park | Ismir Pekmic | Match Report | |
| Sat | 2022-04-23 | 19:00 | San Jose | 2.7 | 4–3 | 2.5 | Seattle | 12,467 | PayPal Park | Ted Unkel | Match Report | |
| Sat | 2022-04-23 | 19:00 | Portland Timbers | 0.5 | 0–0 | 0.9 | Real Salt Lake | 24,206 | Providence Park | Chris Penso | Match Report | |
| Sat | 2022-04-23 | 19:30 | Austin | 0.9 | 3–0 | 0.7 | Vancouver | 20,738 | Q2 Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-04-23 | 19:30 | LA Galaxy | 0.9 | 1–0 | 0.4 | Nashville | 26,674 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Sat | 2022-04-23 | 19:30 | Sporting KC | 0.3 | 0–0 | 0.7 | Columbus Crew | 18,483 | Children's Mercy Park | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-30 | 12:30 | Dynamo FC | 1.8 | 1–2 | 0.7 | Austin | 16,296 | PNC Stadium | Ted Unkel | Match Report | |
| Sat | 2022-04-30 | 13:30 | Real Salt Lake | 0.6 | 1–0 | 1.0 | LA Galaxy | 20,775 | Rio Tinto Stadium | Drew Fischer | Match Report | |
| Sat | 2022-04-30 | 15:00 | Toronto FC | 1.0 | 1–2 | 0.8 | FC Cincinnati | 23,591 | BMO Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-04-30 | 16:00 | CF Montréal | 1.9 | 2–1 | 0.8 | Atlanta Utd | 15,060 | Stade Saputo | Alex Chilowicz | Match Report | |
| Sat | 2022-04-30 | 19:30 | New England | 1.8 | 2–0 | 0.5 | Inter Miami | 25,509 | Gillette Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-04-30 | 19:30 | Columbus Crew | 1.5 | 3–0 | 1.4 | D.C. United | 19,402 | Lower.com Field | Tim Ford | Match Report | |
| Sat | 2022-04-30 | 19:30 | Orlando City | 1.5 | 2–1 | 1.2 | Charlotte | 17,012 | Exploria Stadium | Fotis Bazakos | Match Report | |
| Sun | 2022-05-01 | 13:00 | NYCFC | 3.3 | 3–0 | 0.4 | San Jose | 17,174 | Yankee Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-05-01 | 15:00 | Nashville | 2.0 | 1–1 | 1.1 | Philadelphia | 30,109 | Geodis Park | Chris Penso | Match Report | |
| Sat | 2022-04-30 | 19:00 | Chicago Fire | 1.3 | 1–2 | 2.0 | NY Red Bulls | 11,108 | Soldier Field | Jon Freemon | Match Report | |
| Sat | 2022-04-30 | 19:00 | Colorado Rapids | 1.6 | 2–0 | 1.0 | Portland Timbers | 14,038 | Dick's Sporting Goods Park | Armando Villarreal | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-30 | 19:30 | Sporting KC | 1.8 | 2–2 | 1.0 | FC Dallas | 17,334 | Children's Mercy Park | Nima Saghafi | Match Report | |
| Sun | 2022-05-01 | 19:00 | Los Angeles FC | 2.3 | 2–0 | 0.7 | Minnesota Utd | 22,010 | Banc of California Stadium | Allen Chapman | Match Report | |
| Wed | 2022-05-04 | 19:30 | FC Cincinnati | 4.4 | 2–0 | 0.5 | Toronto FC | 19,563 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-05-07 | 15:30 | Charlotte | 1.7 | 1–0 | 1.2 | Inter Miami | 32,018 | Bank of America Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2022-05-07 | 16:00 | CF Montréal | 3.3 | 4–1 | 0.2 | Orlando City | 14,068 | Stade Saputo | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-05-07 | 18:00 | Atlanta Utd | 2.5 | 4–1 | 1.8 | Chicago Fire | 42,547 | Mercedes-Benz Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-05-07 | 19:00 | NYCFC | 1.4 | 0–0 | 0.3 | Sporting KC | 15,031 | Citi Field | Tim Ford | Match Report | |
| Sat | 2022-05-07 | 19:00 | NY Red Bulls | 1.2 | 1–1 | 0.5 | Portland Timbers | 17,107 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sat | 2022-05-07 | 19:30 | D.C. United | 0.9 | 2–0 | 0.7 | Dynamo FC | 15,194 | Audi Field | Jon Freemon | Match Report | |
| Sat | 2022-05-07 | 19:30 | New England | 1.0 | 2–2 | 1.1 | Columbus Crew | 26,421 | Gillette Stadium | Nima Saghafi | Match Report | |
| Sun | 2022-05-08 | 13:00 | Vancouver | 2.3 | 1–0 | 1.8 | Toronto FC | 17,709 | BC Place Stadium | Victor Rivas | Match Report | |
| Sun | 2022-05-08 | 16:00 | Nashville | 2.4 | 2–0 | 0.3 | Real Salt Lake | 28,226 | Geodis Park | Fotis Bazakos | Match Report | |
| Sun | 2022-05-08 | 18:00 | Austin | 1.2 | 0–1 | 1.3 | LA Galaxy | 20,738 | Q2 Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-05-07 | 19:00 | Minnesota Utd | 1.0 | 0–1 | 2.0 | FC Cincinnati | 19,662 | Allianz Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-05-07 | 19:00 | San Jose | 1.1 | 1–0 | 0.8 | Colorado Rapids | 14,077 | PayPal Park | Tori Penso | Match Report | |
| Sat | 2022-05-07 | 19:30 | FC Dallas | 2.6 | 2–0 | 0.7 | Seattle | 19,096 | Toyota Stadium | Allen Chapman | Match Report | |
| Sat | 2022-05-07 | 20:00 | Los Angeles FC | 1.4 | 2–2 | 1.1 | Philadelphia | 22,022 | Banc of California Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-05-14 | 15:00 | Toronto FC | 0.7 | 0–1 | 1.5 | Orlando City | 26,146 | BMO Field | Nima Saghafi | Match Report | |
| Sat | 2022-05-14 | 15:30 | Colorado Rapids | 3.1 | 2–0 | 1.3 | Los Angeles FC | 15,022 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2022-05-14 | 16:00 | Vancouver | 1.3 | 3–3 | 1.7 | San Jose | 15,087 | BC Place Stadium | Tim Ford | Match Report | |
| Sat | 2022-05-14 | 19:00 | NYCFC | 2.6 | 2–0 | 0.5 | Columbus Crew | 18,813 | Yankee Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2022-05-14 | 19:00 | Charlotte | 1.3 | 0–2 | 1.8 | CF Montréal | 33,323 | Bank of America Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-05-14 | 19:30 | Philadelphia | 2.5 | 1–1 | 1.1 | NY Red Bulls | 18,579 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sun | 2022-05-15 | 13:00 | Seattle | 2.8 | 3–1 | 1.5 | Minnesota Utd | 32,613 | Lumen Field | Joe Dickerson | Match Report | |
| Sun | 2022-05-15 | 13:30 | Atlanta Utd | 2.2 | 2–2 | 1.3 | New England | 42,516 | Mercedes-Benz Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-05-14 | 19:00 | Chicago Fire | 1.5 | 1–2 | 0.9 | FC Cincinnati | 14,049 | Soldier Field | Tori Penso | Match Report | |
| Sat | 2022-05-14 | 19:00 | Portland Timbers | 3.1 | 7–2 | 1.7 | Sporting KC | 23,503 | Providence Park | Victor Rivas | Match Report | |
| Sat | 2022-05-14 | 19:30 | LA Galaxy | 1.6 | 1–3 | 3.1 | FC Dallas | 25,174 | Dignity Health Sports Park | Chris Penso | Match Report | |
| Sat | 2022-05-14 | 19:30 | Real Salt Lake | 1.8 | 2–1 | 0.9 | Austin | 20,122 | Rio Tinto Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-05-14 | 19:30 | Dynamo FC | 1.7 | 2–0 | 1.4 | Nashville | 16,035 | PNC Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-05-14 | 20:00 | Inter Miami | 0.8 | 2–2 | 1.1 | D.C. United | 13,317 | DRV PNK Stadium | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-05-18 | 19:30 | Philadelphia | 1.6 | 0–0 | 0.9 | Inter Miami | 15,747 | Subaru Park | Fotis Bazakos | Match Report | |
| Wed | 2022-05-18 | 19:30 | NY Red Bulls | 2.2 | 3–3 | 1.7 | Chicago Fire | 13,257 | Red Bull Arena | Ted Unkel | Match Report | |
| Wed | 2022-05-18 | 19:30 | D.C. United | 0.6 | 0–2 | 1.5 | NYCFC | 16,072 | Audi Field | Chris Penso | Match Report | |
| Wed | 2022-05-18 | 19:00 | Minnesota Utd | 2.7 | 1–1 | 2.4 | LA Galaxy | 19,645 | Allianz Field | Jair Marrufo | Match Report | |
| Wed | 2022-05-18 | 19:00 | Vancouver | 1.2 | 2–1 | 1.0 | FC Dallas | 12,716 | BC Place Stadium | Ismir Pekmic | Match Report | |
| Wed | 2022-05-18 | 19:30 | San Jose | 2.0 | 3–2 | 1.1 | Portland Timbers | 11,788 | PayPal Park | Lukasz Szpala | Match Report | |
| Wed | 2022-05-18 | 19:30 | Nashville | 0.6 | 2–1 | 0.8 | CF Montréal | 26,003 | Geodis Park | Jon Freemon | Match Report | |
| Wed | 2022-05-18 | 19:30 | Dynamo FC | 1.2 | 0–1 | 1.3 | Seattle | 11,093 | PNC Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2022-05-18 | 19:30 | Sporting KC | 0.5 | 2–1 | 1.3 | Colorado Rapids | 17,233 | Children's Mercy Park | Drew Fischer | Match Report | |
| Wed | 2022-05-18 | 19:30 | Los Angeles FC | 1.9 | 1–2 | 0.7 | Austin | 22,034 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-05-21 | 15:30 | Columbus Crew | 0.9 | 0–2 | 1.8 | Los Angeles FC | 19,649 | Lower.com Field | Victor Rivas | Match Report | |
| Sat | 2022-05-21 | 18:00 | FC Cincinnati | 0.9 | 2–3 | 0.8 | New England | 22,844 | TQL Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-05-21 | 18:30 | Nashville | 1.5 | 2–2 | 1.9 | Atlanta Utd | 30,109 | Geodis Park | Ted Unkel | Match Report | |
| Sat | 2022-05-21 | 18:30 | D.C. United | 3.0 | 2–2 | 2.0 | Toronto FC | 18,320 | Audi Field | Ismir Pekmic | Match Report | |
| Sun | 2022-05-22 | 16:00 | CF Montréal | 0.6 | 1–2 | 2.0 | Real Salt Lake | 14,205 | Stade Saputo | Ramy Touchan | Match Report | |
| Sun | 2022-05-22 | 16:30 | San Jose | 1.0 | 1–1 | 1.3 | Sporting KC | 14,233 | PayPal Park | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-05-22 | 17:00 | Charlotte | 1.9 | 2–1 | 1.0 | Vancouver | 32,034 | Bank of America Stadium | Nima Saghafi | Match Report | |
| Sun | 2022-05-22 | 17:00 | NYCFC | 2.0 | 1–0 | 1.3 | Chicago Fire | 18,823 | Yankee Stadium | Fotis Bazakos | Match Report | |
| Sun | 2022-05-22 | 18:00 | Inter Miami | 1.9 | 2–0 | 1.3 | NY Red Bulls | 11,007 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-05-22 | 18:00 | FC Dallas | 1.3 | 1–2 | 0.8 | Minnesota Utd | 15,280 | Toyota Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-05-22 | 17:00 | LA Galaxy | 1.3 | 0–3 | 1.5 | Dynamo FC | 22,471 | Dignity Health Sports Park | Marcos de Oliveira | Match Report | |
| Sun | 2022-05-22 | 18:00 | Colorado Rapids | 1.7 | 1–0 | 0.7 | Seattle | 14,923 | Dick's Sporting Goods Park | Tim Ford | Match Report | |
| Sun | 2022-05-22 | 19:00 | Portland Timbers | 0.8 | 0–2 | 1.1 | Philadelphia | 22,288 | Providence Park | Allen Chapman | Match Report | |
| Sun | 2022-05-22 | 19:00 | Austin | 3.1 | 2–2 | 1.8 | Orlando City | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-05-28 | 15:00 | Los Angeles FC | 2.1 | 3–2 | 1.9 | San Jose | 22,007 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-05-28 | 19:00 | NY Red Bulls | 1.0 | 4–1 | 0.7 | D.C. United | 13,678 | Red Bull Arena | Allen Chapman | Match Report | |
| Sat | 2022-05-28 | 19:00 | Atlanta Utd | 2.0 | 1–2 | 0.8 | Columbus Crew | 42,504 | Mercedes-Benz Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-05-28 | 19:00 | Toronto FC | 1.1 | 3–2 | 3.2 | Chicago Fire | 25,906 | BMO Field | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-05-28 | 19:30 | CF Montréal | 2.8 | 4–3 | 0.9 | FC Cincinnati | 14,225 | Stade Saputo | Fotis Bazakos | Match Report | |
| Sat | 2022-05-28 | 19:30 | New England | 2.9 | 1–1 | 0.7 | Philadelphia | 20,398 | Gillette Stadium | Jon Freemon | Match Report | |
| Sat | 2022-05-28 | 19:30 | Orlando City | 1.2 | 1–3 | 1.5 | FC Dallas | 17,380 | Exploria Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-05-29 | 15:00 | LA Galaxy | 3.6 | 4–1 | 0.9 | Austin | 20,433 | Dignity Health Sports Park | Rubiel Vazquez | Match Report | |
| Sat | 2022-05-28 | 19:00 | Minnesota Utd | 1.1 | 0–1 | 0.6 | NYCFC | 19,695 | Allianz Field | Michael Radchuk | Match Report | |
| Sat | 2022-05-28 | 19:00 | Colorado Rapids | 0.9 | 1–3 | 1.7 | Nashville | 15,465 | Dick's Sporting Goods Park | Nima Saghafi | Match Report | |
| Sat | 2022-05-28 | 19:30 | Real Salt Lake | 2.7 | 3–0 | 1.1 | Dynamo FC | 20,489 | Rio Tinto Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-05-28 | 20:00 | Sporting KC | 1.1 | 0–1 | 1.3 | Vancouver | 19,206 | Children's Mercy Park | Ted Unkel | Match Report | |
| Sat | 2022-05-28 | 20:00 | Inter Miami | 1.8 | 2–1 | 1.3 | Portland Timbers | 11,161 | DRV PNK Stadium | Chris Penso | Match Report | |
| Sun | 2022-05-29 | 18:30 | Seattle | 1.4 | 2–1 | 1.0 | Charlotte | 32,763 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2022-06-04 | 16:00 | Vancouver | 1.4 | 2–1 | 0.8 | Real Salt Lake | 17,134 | BC Place Stadium | Jon Freemon | Match Report | |
| Sat | 2022-06-11 | 15:00 | Charlotte | 2.1 | 2–0 | 0.6 | NY Red Bulls | 32,064 | Bank of America Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-06-12 | 14:00 | Sporting KC | 1.0 | 1–2 | 1.3 | New England | 18,703 | Children's Mercy Park | Chris Penso | Match Report | |
| Sat | 2022-06-11 | 19:00 | Nashville | 1.3 | 0–0 | 0.6 | San Jose | 28,672 | Geodis Park | Allen Chapman | Match Report | |
| Tue | 2022-06-14 | 19:30 | Seattle | 2.5 | 4–0 | 0.9 | Vancouver | 31,165 | Lumen Field | Lukasz Szpala | Match Report | |
| Wed | 2022-06-15 | 19:30 | New England | 1.1 | 1–1 | 0.8 | Orlando City | 15,308 | Gillette Stadium | Ramy Touchan | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-18 | 12:00 | Seattle | 1.2 | 1–1 | 1.3 | Los Angeles FC | 34,642 | Lumen Field | Allen Chapman | Match Report | |
| Sat | 2022-06-18 | 14:00 | LA Galaxy | 1.5 | 1–1 | 0.9 | Portland Timbers | 21,414 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sat | 2022-06-18 | 19:00 | NY Red Bulls | 1.7 | 2–0 | 1.4 | Toronto FC | 19,142 | Red Bull Arena | Ramy Touchan | Match Report | |
| Sat | 2022-06-18 | 19:30 | Columbus Crew | 1.1 | 1–1 | 0.7 | Charlotte | 20,446 | Lower.com Field | Silviu Petrescu | Match Report | |
| Sat | 2022-06-18 | 19:30 | Philadelphia | 1.3 | 1–1 | 1.0 | FC Cincinnati | 18,717 | Subaru Park | Tim Ford | Match Report | |
| Sat | 2022-06-18 | 19:30 | CF Montréal | 1.4 | 0–1 | 1.5 | Austin | 15,045 | Stade Saputo | Ted Unkel | Match Report | |
| Sat | 2022-06-18 | 19:30 | Orlando City | 3.0 | 2–1 | 0.7 | Dynamo FC | 16,333 | Exploria Stadium | Rosendo Mendoza | Match Report | |
| Sun | 2022-06-19 | 15:00 | Atlanta Utd | 2.1 | 2–0 | 0.9 | Inter Miami | 42,539 | Mercedes-Benz Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-06-19 | 17:00 | NYCFC | 1.3 | 1–1 | 0.3 | Colorado Rapids | 19,812 | Yankee Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-06-19 | 17:00 | Nashville | 0.9 | 1–2 | 0.4 | Sporting KC | 29,269 | Geodis Park | Victor Rivas | Match Report | |
| Sun | 2022-06-19 | 17:00 | New England | 0.5 | 2–1 | 1.3 | Minnesota Utd | 21,289 | Gillette Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-06-18 | 19:00 | Chicago Fire | 1.3 | 1–0 | 0.9 | D.C. United | 17,650 | Soldier Field | Nima Saghafi | Match Report | |
| Sat | 2022-06-18 | 19:30 | Real Salt Lake | 2.6 | 2–0 | 0.6 | San Jose | 20,517 | Rio Tinto Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-06-18 | 20:00 | FC Dallas | 1.0 | 0–2 | 0.5 | Vancouver | 19,096 | Toyota Stadium | Tori Penso | Match Report | |
| Fri | 2022-06-24 | 19:30 | FC Cincinnati | 1.2 | 1–0 | 0.3 | Orlando City | 24,263 | TQL Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-06-25 | 12:00 | Seattle | 2.6 | 3–0 | 0.6 | Sporting KC | 33,380 | Lumen Field | Alex Chilowicz | Match Report | |
| Sat | 2022-06-25 | 17:00 | D.C. United | 0.8 | 1–3 | 1.1 | Nashville | 19,325 | Audi Field | Lukasz Szpala | Match Report | |
| Sat | 2022-06-25 | 19:30 | CF Montréal | 0.8 | 2–1 | 1.2 | Charlotte | 13,520 | Stade Saputo | Nima Saghafi | Match Report | |
| Sat | 2022-06-25 | 19:30 | Toronto FC | 2.0 | 2–1 | 1.4 | Atlanta Utd | 25,527 | BMO Field | Jon Freemon | Match Report | |
| Sun | 2022-06-26 | 12:00 | Los Angeles FC | 1.7 | 2–0 | 0.6 | NY Red Bulls | Banc of California Stadium | Joe Dickerson | Match Report | ||
| Sun | 2022-06-26 | 18:00 | Philadelphia | 1.8 | 2–1 | 1.4 | NYCFC | 18,589 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2022-06-25 | 19:00 | Dynamo FC | 1.6 | 2–0 | 2.0 | Chicago Fire | 13,081 | PNC Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-06-25 | 19:30 | Portland Timbers | 3.1 | 3–0 | 1.5 | Colorado Rapids | 23,448 | Providence Park | Rosendo Mendoza | Match Report | |
| Sat | 2022-06-25 | 20:00 | Inter Miami | 1.6 | 2–1 | 0.8 | Minnesota Utd | 12,147 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sat | 2022-06-25 | 20:00 | Austin | 1.6 | 2–2 | 2.0 | FC Dallas | 20,738 | Q2 Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-25 | 20:00 | Real Salt Lake | 0.7 | 0–0 | 0.5 | Columbus Crew | 20,311 | Rio Tinto Stadium | Mark Allatin | Match Report | |
| Sun | 2022-06-26 | 17:00 | Vancouver | 1.2 | 0–0 | 1.2 | New England | 15,084 | BC Place Stadium | Filip Dujic | Match Report | |
| Wed | 2022-06-29 | 19:30 | Toronto FC | 1.7 | 1–2 | 0.8 | Columbus Crew | 21,289 | BMO Field | Armando Villarreal | Match Report | |
| Wed | 2022-06-29 | 19:30 | FC Cincinnati | 2.2 | 4–4 | 2.7 | NYCFC | 21,258 | TQL Stadium | Ismir Pekmic | Match Report | |
| Thu | 2022-06-30 | 19:00 | Charlotte | 0.5 | 0–1 | 0.4 | Austin | 31,661 | Bank of America Stadium | Tim Ford | Match Report | |
| Wed | 2022-06-29 | 19:00 | Chicago Fire | 0.7 | 1–0 | 0.5 | Philadelphia | 10,384 | Soldier Field | Michael Radchuk | Match Report | |
| Wed | 2022-06-29 | 19:00 | Seattle | 0.9 | 1–2 | 1.4 | CF Montréal | 32,375 | Lumen Field | Joe Dickerson | Match Report | |
| Wed | 2022-06-29 | 19:30 | Los Angeles FC | 1.9 | 3–1 | 0.6 | FC Dallas | 22,014 | Banc of California Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-06-29 | 19:30 | Portland Timbers | 1.4 | 2–1 | 2.2 | Dynamo FC | 22,932 | Providence Park | Lukasz Szpala | Match Report | |
| Wed | 2022-06-29 | 19:30 | LA Galaxy | 2.4 | 2–3 | 1.2 | Minnesota Utd | 18,337 | Dignity Health Sports Park | Ted Unkel | Match Report | |
| Thu | 2022-06-30 | 20:00 | NY Red Bulls | 1.8 | 2–1 | 1.3 | Atlanta Utd | 14,122 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Sat | 2022-07-02 | 19:30 | Toronto FC | 1.2 | 0–2 | 1.9 | Seattle | 23,594 | BMO Field | Silviu Petrescu | Match Report | |
| Sun | 2022-07-03 | 17:00 | NYCFC | 2.2 | 2–2 | 1.5 | Atlanta Utd | 17,704 | Yankee Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-07-02 | 19:00 | Vancouver | 0.9 | 1–0 | 0.4 | Los Angeles FC | 18,292 | BC Place Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-07-03 | 19:30 | New England | 1.5 | 2–2 | 1.5 | FC Cincinnati | 20,193 | Gillette Stadium | Jon Freemon | Match Report | |
| Sun | 2022-07-03 | 19:30 | Columbus Crew | 1.3 | 0–0 | 0.3 | Philadelphia | 20,469 | Lower.com Field | Nima Saghafi | Match Report | |
| Sun | 2022-07-03 | 18:00 | San Jose | 2.5 | 2–1 | 1.6 | Chicago Fire | 13,224 | PayPal Park | Victor Rivas | Match Report | |
| Sun | 2022-07-03 | 19:00 | Minnesota Utd | 2.7 | 3–2 | 1.5 | Real Salt Lake | Allianz Field | Ramy Touchan | Match Report | ||
| Sun | 2022-07-03 | 19:00 | Sporting KC | 0.6 | 0–1 | 0.6 | NY Red Bulls | 19,065 | Children's Mercy Park | Marcos de Oliveira | Match Report | |
| Mon | 2022-07-04 | 19:00 | Orlando City | 2.4 | 3–5 | 1.4 | D.C. United | 16 | Exploria Stadium | Allen Chapman | Match Report | |
| Sun | 2022-07-03 | 19:30 | Dynamo FC | 1.1 | 1–2 | 1.7 | Charlotte | 19,242 | PNC Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-07-03 | 19:30 | Nashville | 1.2 | 2–2 | 1.9 | Portland Timbers | 28,387 | Geodis Park | Armando Villarreal | Match Report | |
| Mon | 2022-07-04 | 19:00 | Colorado Rapids | 1.8 | 2–3 | 1.8 | Austin | 18,084 | Dick's Sporting Goods Park | Joe Dickerson | Match Report | |
| Mon | 2022-07-04 | 19:30 | LA Galaxy | 3.2 | 4–0 | 0.9 | CF Montréal | 23,855 | Dignity Health Sports Park | Tim Ford | Match Report | |
| Mon | 2022-07-04 | 20:00 | FC Dallas | 1.1 | 1–1 | 2.6 | Inter Miami | 19,096 | Toyota Stadium | Alex Chilowicz | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Fri | 2022-07-08 | 19:30 | Philadelphia | 5.6 | 7–0 | 0.7 | D.C. United | 19,007 | Subaru Park | Ted Unkel | Match Report | |
| Sat | 2022-07-09 | 13:00 | NYCFC | 5.3 | 4–2 | 1.6 | New England | 17,991 | Yankee Stadium | Tim Ford | Match Report | |
| Sat | 2022-07-09 | 13:30 | Seattle | 1.4 | 0–3 | 2.8 | Portland Timbers | 47,722 | Lumen Field | Chris Penso | Match Report | |
| Sat | 2022-07-09 | 19:00 | Atlanta Utd | 1.2 | 0–3 | 2.4 | Austin | 67,516 | Mercedes-Benz Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-07-09 | 19:00 | Charlotte | 2.1 | 4–1 | 2.4 | Nashville | 36,244 | Bank of America Stadium | Joe Dickerson | Match Report | |
| Fri | 2022-07-08 | 19:00 | Los Angeles FC | 1.5 | 3–2 | 1.7 | LA Galaxy | 22,231 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-07-09 | 19:30 | FC Cincinnati | 1.5 | 1–1 | 1.2 | NY Red Bulls | 24,476 | TQL Stadium | Rosendo Mendoza | Match Report | |
| Fri | 2022-07-08 | 19:30 | Vancouver | 0.7 | 1–3 | 0.9 | Minnesota Utd | 14,201 | BC Place Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-07-09 | 19:30 | CF Montréal | 1.9 | 1–2 | 0.5 | Sporting KC | 14,127 | Stade Saputo | Ismir Pekmic | Match Report | |
| Sat | 2022-07-09 | 19:30 | Toronto FC | 1.8 | 2–2 | 1.3 | San Jose | 27,149 | BMO Field | Fotis Bazakos | Match Report | |
| Sat | 2022-07-09 | 19:00 | Chicago Fire | 2.1 | 2–3 | 1.7 | Columbus Crew | 15,157 | Soldier Field | Ramy Touchan | Match Report | |
| Sat | 2022-07-09 | 19:30 | Dynamo FC | 2.5 | 2–2 | 1.4 | FC Dallas | 21,284 | PNC Stadium | Jon Freemon | Match Report | |
| Sat | 2022-07-09 | 20:00 | Real Salt Lake | 1.3 | 2–2 | 2.9 | Colorado Rapids | 20,242 | Rio Tinto Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-07-09 | 22:00 | Orlando City | 0.9 | 1–0 | 0.8 | Inter Miami | 20,052 | Exploria Stadium | Nima Saghafi | Match Report | |
| Wed | 2022-07-13 | 19:30 | Atlanta Utd | 1.3 | 2–1 | 0.8 | Real Salt Lake | 42,509 | Mercedes-Benz Stadium | Drew Fischer | Match Report | |
| Tue | 2022-07-12 | 20:00 | Austin | 2.1 | 3–1 | 0.7 | Dynamo FC | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Wed | 2022-07-13 | 19:00 | Minnesota Utd | 1.1 | 1–1 | 0.9 | Sporting KC | 19,657 | Allianz Field | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-07-13 | 19:00 | LA Galaxy | 2.2 | 2–3 | 1.7 | San Jose | 18,453 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Wed | 2022-07-13 | 19:00 | Chicago Fire | 1.3 | 2–0 | 0.4 | Toronto FC | 10,450 | Soldier Field | Lukasz Szpala | Match Report | |
| Wed | 2022-07-13 | 19:00 | Colorado Rapids | 2.4 | 1–1 | 0.7 | Orlando City | 12,538 | Dick's Sporting Goods Park | Fotis Bazakos | Match Report | |
| Wed | 2022-07-13 | 19:30 | Nashville | 1.3 | 1–0 | 0.8 | Seattle | 26,927 | Geodis Park | Rubiel Vazquez | Match Report | |
| Wed | 2022-07-13 | 20:00 | FC Cincinnati | 1.7 | 2–2 | 1.6 | Vancouver | 21,078 | TQL Stadium | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-07-13 | 20:00 | FC Dallas | 1.3 | 0–1 | 0.9 | NYCFC | 13,656 | Toyota Stadium | Victor Rivas | Match Report | |
| Wed | 2022-07-13 | 20:00 | Inter Miami | 0.8 | 1–2 | 1.4 | Philadelphia | 10,027 | DRV PNK Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-07-13 | 20:00 | D.C. United | 3.0 | 2–2 | 0.3 | Columbus Crew | 10,128 | Audi Field | Rosendo Mendoza | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-16 | 19:30 | CF Montréal | 2.2 | 1–0 | 0.3 | Toronto FC | 19,619 | Stade Saputo | Ted Unkel | Match Report | |
| Sat | 2022-07-16 | 19:30 | Philadelphia | 1.4 | 2–1 | 1.3 | New England | 18,257 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sun | 2022-07-17 | 15:00 | Atlanta Utd | 2.2 | 1–1 | 0.2 | Orlando City | 42,526 | Mercedes-Benz Stadium | Victor Rivas | Match Report | |
| Sun | 2022-07-17 | 17:00 | NY Red Bulls | 0.9 | 0–1 | 1.4 | NYCFC | 25,219 | Red Bull Arena | Chris Penso | Match Report | |
| Sat | 2022-07-16 | 19:00 | Colorado Rapids | 1.6 | 2–0 | 1.0 | LA Galaxy | 17,975 | Dick's Sporting Goods Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-07-16 | 19:00 | Chicago Fire | 1.0 | 1–0 | 0.9 | Seattle | 13,601 | Soldier Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-07-16 | 19:00 | Minnesota Utd | 1.9 | 2–0 | 0.3 | D.C. United | 19,718 | Allianz Field | Jair Marrufo | Match Report | |
| Sun | 2022-07-17 | 19:30 | Columbus Crew | 2.2 | 2–0 | 1.0 | FC Cincinnati | 20,741 | Lower.com Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-07-16 | 20:00 | FC Dallas | 2.1 | 1–1 | 0.7 | Austin | 16,833 | Toyota Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-07-16 | 20:30 | Inter Miami | 1.4 | 3–2 | 0.5 | Charlotte | 12,274 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Sun | 2022-07-17 | 18:30 | San Jose | 2.2 | 1–2 | 1.3 | Dynamo FC | 13,445 | PayPal Park | Tim Ford | Match Report | |
| Sun | 2022-07-17 | 19:30 | Nashville | 2.0 | 1–2 | 1.6 | Los Angeles FC | 30,109 | Geodis Park | Drew Fischer | Match Report | |
| Sun | 2022-07-17 | 19:30 | Real Salt Lake | 2.0 | 3–0 | 0.3 | Sporting KC | 20,132 | Rio Tinto Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-07-17 | 19:30 | Portland Timbers | 2.3 | 1–1 | 1.7 | Vancouver | 24,337 | Providence Park | Ramy Touchan | Match Report | |
| Sat | 2022-07-23 | 19:00 | NYCFC | 1.8 | 2–0 | 0.7 | Inter Miami | 23,277 | Yankee Stadium | Allen Chapman | Match Report | |
| Sat | 2022-07-23 | 19:30 | Columbus Crew | 1.0 | 0–0 | 0.2 | New England | 20,383 | Lower.com Field | Silviu Petrescu | Match Report | |
| Sat | 2022-07-23 | 19:30 | Orlando City | 0.7 | 0–1 | 0.8 | Philadelphia | 16,031 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-07-23 | 19:30 | Toronto FC | 1.2 | 4–0 | 0.7 | Charlotte | 29,067 | BMO Field | Filip Dujic | Match Report | |
| Sat | 2022-07-23 | 19:30 | FC Cincinnati | 1.4 | 1–1 | 1.6 | Nashville | 23,420 | TQL Stadium | Chris Penso | Match Report | |
| Sat | 2022-07-23 | 19:00 | Vancouver | 1.3 | 1–3 | 1.1 | Chicago Fire | 14,984 | BC Place Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-07-23 | 19:00 | Seattle | 2.8 | 2–1 | 1.3 | Colorado Rapids | 32,476 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2022-07-23 | 19:30 | Portland Timbers | 1.7 | 2–1 | 1.3 | San Jose | 23,795 | Providence Park | Jon Freemon | Match Report | |
| Sat | 2022-07-23 | 19:30 | Sporting KC | 0.5 | 0–2 | 1.0 | Los Angeles FC | 20,142 | Children's Mercy Park | Lukasz Szpala | Match Report | |
| Sat | 2022-07-23 | 19:30 | Dynamo FC | 1.5 | 1–2 | 1.3 | Minnesota Utd | 15,223 | PNC Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-07-23 | 20:00 | D.C. United | 1.5 | 1–2 | 1.5 | CF Montréal | 15,734 | Audi Field | Rubiel Vazquez | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-23 | 20:00 | Real Salt Lake | 2.1 | 0–1 | 0.7 | FC Dallas | 20,437 | Rio Tinto Stadium | Matt Conger | Match Report | |
| Sun | 2022-07-24 | 18:30 | LA Galaxy | 1.9 | 2–0 | 1.2 | Atlanta Utd | 24,122 | Dignity Health Sports Park | Marcos de Oliveira | Match Report | |
| Sun | 2022-07-24 | 19:00 | Austin | 1.6 | 3–4 | 0.9 | NY Red Bulls | 20,738 | Q2 Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-07-30 | 14:00 | Minnesota Utd | 2.3 | 4–4 | 1.3 | Portland Timbers | 19,792 | Allianz Field | Victor Rivas | Match Report | |
| Sat | 2022-07-30 | 16:00 | Chicago Fire | 1.0 | 0–0 | 1.3 | Atlanta Utd | 23,951 | Soldier Field | Tim Ford | Match Report | |
| Sat | 2022-07-30 | 19:30 | Philadelphia | 2.6 | 6–0 | 0.6 | Dynamo FC | 19,089 | Subaru Park | Kevin Stott | Match Report | |
| Sat | 2022-07-30 | 19:30 | CF Montréal | 0.8 | 0–0 | 0.1 | NYCFC | 19,619 | Stade Saputo | Ramy Touchan | Match Report | |
| Fri | 2022-07-29 | 20:00 | Los Angeles FC | 1.6 | 2–1 | 0.9 | Seattle | 22,111 | Banc of California Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-07-31 | 17:00 | D.C. United | 1.0 | 2–1 | 1.6 | Orlando City | 15,805 | Audi Field | Armando Villarreal | Match Report | |
| Sat | 2022-07-30 | 19:00 | San Jose | 1.5 | 2–2 | 1.6 | Real Salt Lake | 12,411 | PayPal Park | Nima Saghafi | Match Report | |
| Sat | 2022-07-30 | 19:00 | Nashville | 1.8 | 1–1 | 1.3 | Vancouver | 26,578 | Geodis Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-07-30 | 19:30 | Sporting KC | 1.5 | 0–2 | 0.8 | Austin | 17,287 | Children's Mercy Park | Fotis Bazakos | Match Report | |
| Sat | 2022-07-30 | 20:00 | Inter Miami | 2.5 | 4–4 | 2.6 | FC Cincinnati | DRV PNK Stadium | Tori Penso | Match Report | ||
| Sat | 2022-07-30 | 20:00 | FC Dallas | 1.1 | 1–0 | 1.4 | LA Galaxy | 19,096 | Toyota Stadium | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-07-30 | 20:00 | New England | 0.6 | 0–0 | 1.7 | Toronto FC | 29,097 | Gillette Stadium | Ismir Pekmic | Match Report | |
| Tue | 2022-08-02 | 19:30 | NY Red Bulls | 2.4 | 4–5 | 1.5 | Colorado Rapids | 13,812 | Red Bull Arena | Drew Fischer | Match Report | |
| Wed | 2022-08-03 | 19:00 | Charlotte | 2.2 | 3–0 | 0.5 | D.C. United | 31,520 | Bank of America Stadium | Guido Gonzalez Jr. | Match Report | |
| Tue | 2022-08-02 | 19:00 | Seattle | 1.3 | 1–0 | 0.5 | FC Dallas | 32,207 | Lumen Field | Allen Chapman | Match Report | |
| Wed | 2022-08-03 | 19:30 | Columbus Crew | 1.3 | 1–2 | 1.2 | CF Montréal | 19,010 | Lower.com Field | Lukasz Szpala | Match Report | |
| Wed | 2022-08-03 | 19:30 | San Jose | 1.3 | 0–1 | 1.4 | Inter Miami | 11,806 | PayPal Park | Mark Allatin | Match Report | |
| Wed | 2022-08-03 | 19:30 | Portland Timbers | 1.5 | 1–1 | 1.3 | Nashville | 23,101 | Providence Park | Silviu Petrescu | Match Report | |
| Sat | 2022-08-06 | 15:00 | Atlanta Utd | 1.0 | 2–1 | 1.2 | Seattle | 68,586 | Mercedes-Benz Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-08-06 | 19:00 | Charlotte | 1.3 | 2–3 | 2.2 | Chicago Fire | 32,538 | Bank of America Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-06 | 19:30 | Columbus Crew | 0.6 | 3–2 | 1.5 | NYCFC | 18,609 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-08-06 | 19:30 | CF Montréal | 1.7 | 2–2 | 0.6 | Inter Miami | 18,007 | Stade Saputo | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-06 | 19:30 | D.C. United | 0.3 | 0–0 | 0.7 | NY Red Bulls | 16,258 | Audi Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-08-06 | 19:30 | FC Cincinnati | 1.7 | 3–1 | 1.3 | Philadelphia | 23,443 | TQL Stadium | Drew Fischer | Match Report | |
| Fri | 2022-08-05 | 19:30 | Vancouver | 1.0 | 2–1 | 0.9 | Dynamo FC | 14,668 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-08-06 | 19:30 | Orlando City | 1.2 | 0–3 | 1.0 | New England | Exploria Stadium | Ramy Touchan | Match Report | ||
| Sat | 2022-08-06 | 19:00 | Colorado Rapids | 3.2 | 4–3 | 1.4 | Minnesota Utd | 14,738 | Dick's Sporting Goods Park | Ismir Pekmic | Match Report | |
| Sat | 2022-08-06 | 19:00 | Nashville | 2.4 | 3–4 | 1.8 | Toronto FC | 26,326 | Geodis Park | Allen Chapman | Match Report | |
| Sat | 2022-08-06 | 19:30 | Portland Timbers | 1.2 | 1–1 | 0.8 | FC Dallas | 24,114 | Providence Park | Ted Unkel | Match Report | |
| Sat | 2022-08-06 | 19:30 | Sporting KC | 3.3 | 4–2 | 1.5 | LA Galaxy | 18,101 | Children's Mercy Park | Michael Radchuk | Match Report | |
| Sat | 2022-08-06 | 20:00 | Real Salt Lake | 0.7 | 1–4 | 1.4 | Los Angeles FC | 21,810 | Rio Tinto Stadium | Victor Rivas | Match Report | |
| Sat | 2022-08-06 | 20:00 | Austin | 2.6 | 3–3 | 0.8 | San Jose | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-08-13 | 18:00 | NY Red Bulls | 0.5 | 0–1 | 0.2 | Orlando City | 18,218 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| Sat | 2022-08-13 | 19:30 | FC Cincinnati | 1.4 | 2–2 | 1.3 | Atlanta Utd | 25,037 | TQL Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-08-13 | 19:30 | New England | 2.4 | 1–0 | 0.7 | D.C. United | 24,240 | Gillette Stadium | Malik Badawi | Match Report | |
| Sat | 2022-08-13 | 19:30 | Philadelphia | 2.6 | 4–1 | 1.3 | Chicago Fire | 18,682 | Subaru Park | Ismail Elfath | Match Report | |
| Sat | 2022-08-13 | 19:30 | Toronto FC | 2.5 | 3–1 | 0.5 | Portland Timbers | 28,598 | BMO Field | Nima Saghafi | Match Report | |
| Sat | 2022-08-13 | 19:00 | Colorado Rapids | 1.2 | 1–1 | 1.3 | Columbus Crew | 13,254 | Dick's Sporting Goods Park | Jon Freemon | Match Report | |
| Sat | 2022-08-13 | 19:00 | LA Galaxy | 2.9 | 5–2 | 1.0 | Vancouver | 21,465 | Dignity Health Sports Park | Silviu Petrescu | Match Report | |
| Sat | 2022-08-13 | 19:30 | Los Angeles FC | 2.6 | 5–0 | 0.2 | Charlotte | 22,140 | Banc of California Stadium | Chris Penso | Match Report | |
| Sat | 2022-08-13 | 20:00 | Inter Miami | 1.9 | 3–2 | 2.2 | NYCFC | 11,419 | DRV PNK Stadium | Drew Fischer | Match Report | |
| Sat | 2022-08-13 | 20:00 | Dynamo FC | 0.7 | 2–3 | 2.1 | CF Montréal | 21,284 | PNC Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-08-13 | 20:00 | FC Dallas | 1.6 | 4–1 | 0.6 | San Jose | 15,106 | Toyota Stadium | Victor Rivas | Match Report | |
| Sat | 2022-08-13 | 20:00 | Austin | 1.3 | 4–3 | 2.6 | Sporting KC | 20,738 | Q2 Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-08-14 | 19:00 | Seattle | 1.9 | 1–2 | 1.2 | Real Salt Lake | 33,093 | Lumen Field | Tim Ford | Match Report | |
| Sun | 2022-08-14 | 20:00 | Nashville | 1.5 | 1–2 | 1.0 | Minnesota Utd | 25,240 | Geodis Park | Alex Chilowicz | Match Report | |
| Wed | 2022-08-17 | 19:30 | Toronto FC | 1.7 | 2–2 | 1.1 | New England | 28,464 | BMO Field | Fotis Bazakos | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Tue | 2022-08-16 | 19:30 | Los Angeles FC | 2.0 | 1–0 | 0.6 | D.C. United | 22,063 | Banc of California Stadium | Ramy Touchan | Match Report | |
| Wed | 2022-08-17 | 19:30 | Atlanta Utd | 0.9 | 1–2 | 0.9 | NY Red Bulls | 42,555 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Wed | 2022-08-17 | 19:00 | Vancouver | 1.0 | 2–1 | 2.4 | Colorado Rapids | 14,682 | BC Place Stadium | Filip Dujic | Match Report | |
| Wed | 2022-08-17 | 20:00 | NYCFC | 1.2 | 1–3 | 1.7 | Charlotte | 8,531 | Red Bull Arena | Jon Freemon | Match Report | |
| Wed | 2022-08-17 | 20:00 | FC Dallas | 0.9 | 1–0 | 0.5 | Philadelphia | 12,479 | Toyota Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-20 | 18:00 | NY Red Bulls | 1.6 | 1–1 | 0.4 | FC Cincinnati | 16,525 | Red Bull Arena | Ismail Elfath | Match Report | |
| Fri | 2022-08-19 | 19:00 | LA Galaxy | 1.5 | 3–3 | 2.5 | Seattle | 23,278 | Dignity Health Sports Park | Victor Rivas | Match Report | |
| Sat | 2022-08-20 | 19:30 | CF Montréal | 3.1 | 4–0 | 1.0 | New England | 19,619 | Stade Saputo | Chris Penso | Match Report | |
| Sat | 2022-08-20 | 19:30 | D.C. United | 1.5 | 0–6 | 3.6 | Philadelphia | 17,941 | Audi Field | Ted Unkel | Match Report | |
| Sun | 2022-08-21 | 17:00 | Chicago Fire | 1.7 | 0–2 | 1.0 | NYCFC | 11,720 | Soldier Field | Rosendo Mendoza | Match Report | |
| Sun | 2022-08-21 | 17:30 | Columbus Crew | 0.7 | 2–2 | 2.0 | Atlanta Utd | 17,461 | Lower.com Field | Joe Dickerson | Match Report | |
| Sun | 2022-08-21 | 18:30 | Sporting KC | 1.3 | 4–1 | 1.3 | Portland Timbers | 17,348 | Children's Mercy Park | Armando Villarreal | Match Report | |
| Sat | 2022-08-20 | 19:00 | Minnesota Utd | 2.1 | 2–1 | 1.4 | Austin | 19,829 | Allianz Field | Allen Chapman | Match Report | |
| Sun | 2022-08-21 | 19:00 | Charlotte | 0.7 | 1–2 | 1.4 | Orlando City | 30,855 | Bank of America Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-08-20 | 19:00 | Colorado Rapids | 0.7 | 1–1 | 0.4 | Dynamo FC | 15,380 | Dick's Sporting Goods Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-08-20 | 19:00 | San Jose | 0.9 | 2–1 | 1.3 | Los Angeles FC | 18,000 | PayPal Park | Michael Radchuk | Match Report | |
| Sat | 2022-08-20 | 20:00 | Real Salt Lake | 1.0 | 1–1 | 0.7 | Vancouver | 20,567 | Rio Tinto Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-08-20 | 20:00 | Inter Miami | 0.8 | 2–1 | 0.8 | Toronto FC | 14,388 | DRV PNK Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-08-21 | 19:30 | Nashville | 1.8 | 4–0 | 0.2 | FC Dallas | 25,571 | Geodis Park | Kevin Stott | Match Report | |
| Sat | 2022-08-27 | 14:30 | Minnesota Utd | 0.9 | 2–1 | 0.7 | Dynamo FC | 19,624 | Allianz Field | Rosendo Mendoza | Match Report | |
| Fri | 2022-08-26 | 19:00 | Austin | 0.6 | 4–1 | 1.5 | Los Angeles FC | 20,738 | Q2 Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-08-27 | 19:00 | Charlotte | 1.1 | 0–2 | 0.7 | Toronto FC | 32,495 | Bank of America Stadium | Tim Ford | Match Report | |
| Sat | 2022-08-27 | 19:00 | NY Red Bulls | 1.2 | 3–1 | 1.9 | Inter Miami | 21,374 | Red Bull Arena | Fotis Bazakos | Match Report | |
| Fri | 2022-08-26 | 19:00 | Portland Timbers | 2.6 | 2–1 | 0.7 | Seattle | 25,218 | Providence Park | Ismail Elfath | Match Report | |
| Sat | 2022-08-27 | 19:30 | FC Cincinnati | 1.4 | 2–2 | 0.4 | Columbus Crew | 25,037 | TQL Stadium | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-27 | 19:30 | Philadelphia | 5.7 | 6–0 | 0.8 | Colorado Rapids | 18,005 | Subaru Park | Allen Chapman | Match Report | |
| Sun | 2022-08-28 | 16:00 | Atlanta Utd | 2.1 | 3–2 | 1.1 | D.C. United | 42,561 | Mercedes-Benz Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-27 | 19:00 | Chicago Fire | 0.9 | 0–2 | 1.1 | CF Montréal | 13,907 | Soldier Field | Michael Radchuk | Match Report | |
| Sat | 2022-08-27 | 19:00 | Vancouver | 0.5 | 0–3 | 1.5 | Nashville | 16,351 | BC Place Stadium | Jon Freemon | Match Report | |
| Sun | 2022-08-28 | 19:30 | Orlando City | 1.2 | 2–1 | 0.5 | NYCFC | Exploria Stadium | Chris Penso | Match Report | ||
| Sat | 2022-08-27 | 19:30 | Sporting KC | 1.5 | 1–0 | 1.0 | San Jose | 18,241 | Children's Mercy Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-08-27 | 20:00 | FC Dallas | 0.8 | 1–1 | 1.3 | Real Salt Lake | 15,573 | Toyota Stadium | Ramy Touchan | Match Report | |
| Sun | 2022-08-28 | 20:00 | New England | 1.9 | 1–2 | 0.9 | LA Galaxy | 21,517 | Gillette Stadium | Lukasz Szpala | Match Report | |
| Wed | 2022-08-31 | 19:00 | Philadelphia | 2.9 | 4–1 | 1.5 | Atlanta Utd | 18,214 | Subaru Park | Lukasz Szpala | Match Report | |
| Wed | 2022-08-31 | 19:30 | CF Montréal | 0.9 | 0–1 | 0.7 | NY Red Bulls | 15,075 | Stade Saputo | Victor Rivas | Match Report | |
| Wed | 2022-08-31 | 19:30 | Columbus Crew | 0.8 | 1–0 | 0.3 | Inter Miami | 18,034 | Lower.com Field | Armando Villarreal | Match Report | |
| Wed | 2022-08-31 | 19:30 | Toronto FC | 1.9 | 2–2 | 0.5 | LA Galaxy | 29,130 | BMO Field | Ted Unkel | Match Report | |
| Wed | 2022-08-31 | 19:30 | New England | 1.3 | 0–0 | 1.5 | Chicago Fire | 13,325 | Gillette Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-08-31 | 19:30 | Nashville | 2.7 | 4–1 | 0.8 | Colorado Rapids | 24,127 | Geodis Park | Mark Allatin | Match Report | |
| Wed | 2022-08-31 | 19:30 | Dynamo FC | 1.4 | 2–1 | 2.7 | Los Angeles FC | 21,284 | PNC Stadium | Matt Conger | Match Report | |
| Wed | 2022-08-31 | 19:30 | Real Salt Lake | 1.7 | 3–0 | 0.3 | Minnesota Utd | 20,358 | Rio Tinto Stadium | Drew Fischer | Match Report | |
| Wed | 2022-08-31 | 20:00 | NYCFC | 0.4 | 1–2 | 1.2 | D.C. United | 8,113 | Yankee Stadium | Ismir Pekmic | Match Report | |
| Wed | 2022-08-31 | 20:00 | Austin | 2.2 | 1–2 | 2.0 | Portland Timbers | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Wed | 2022-08-31 | 22:00 | Orlando City | 3.4 | 3–2 | 0.5 | Seattle | 14,483 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-09-03 | 14:30 | Minnesota Utd | 1.2 | 0–3 | 0.9 | FC Dallas | 19,761 | Allianz Field | Ismail Elfath | Match Report | |
| Sat | 2022-09-03 | 17:30 | Columbus Crew | 1.1 | 0–0 | 0.2 | Chicago Fire | 18,189 | Lower.com Field | Ismir Pekmic | Match Report | |
| Sat | 2022-09-03 | 19:00 | NY Red Bulls | 1.2 | 0–2 | 0.8 | Philadelphia | 16,247 | Red Bull Arena | Tim Ford | Match Report | |
| Sat | 2022-09-03 | 19:30 | FC Cincinnati | 1.1 | 2–0 | 0.9 | Charlotte | 21,165 | TQL Stadium | Michael Radchuk | Match Report | |
| Sun | 2022-09-04 | 14:30 | Portland Timbers | 2.6 | 2–1 | 1.2 | Atlanta Utd | 24,438 | Providence Park | Jon Freemon | Match Report | |
| Sat | 2022-09-03 | 19:30 | Nashville | 1.8 | 3–0 | 0.9 | Austin | 25,293 | Geodis Park | Nima Saghafi | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-09-04 | 19:30 | Toronto FC | 1.7 | 3–4 | 2.1 | CF Montréal | 28,793 | BMO Field | Allen Chapman | Match Report | |
| Sun | 2022-09-04 | 19:30 | D.C. United | 1.7 | 0–0 | 1.0 | Colorado Rapids | 16,502 | Audi Field | Tori Penso | Match Report | |
| Sun | 2022-09-04 | 17:00 | LA Galaxy | 2.5 | 2–2 | 1.5 | Sporting KC | 20,104 | Dignity Health Sports Park | Ramy Touchan | Match Report | |
| Sun | 2022-09-04 | 18:00 | Seattle | 2.3 | 2–1 | 0.4 | Dynamo FC | 33,621 | Lumen Field | Silviu Petrescu | Match Report | |
| Sun | 2022-09-04 | 18:30 | San Jose | 0.7 | 2–0 | 1.4 | Vancouver | 13,211 | PayPal Park | Rosendo Mendoza | Match Report | |
| Sun | 2022-09-04 | 19:30 | Los Angeles FC | 3.1 | 2–0 | 0.3 | Real Salt Lake | 22,199 | Banc of California Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-09-04 | 20:00 | New England | 0.4 | 3–0 | 2.1 | NYCFC | 17,793 | Gillette Stadium | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-09-07 | 20:00 | NYCFC | 1.5 | 1–1 | 0.2 | FC Cincinnati | 14,248 | Citi Field | Ted Unkel | Match Report | |
| Fri | 2022-09-09 | 19:30 | CF Montréal | 2.3 | 2–2 | 0.7 | Columbus Crew | 19,619 | Stade Saputo | Lukasz Szpala | Match Report | |
| Sat | 2022-09-10 | 13:00 | Charlotte | 0.7 | 1–0 | 0.8 | NYCFC | 30,159 | Bank of America Stadium | Victor Rivas | Match Report | |
| Sat | 2022-09-10 | 14:30 | Nashville | 1.4 | 1–1 | 2.6 | LA Galaxy | 28,753 | Geodis Park | Chris Penso | Match Report | |
| Sat | 2022-09-10 | 18:00 | NY Red Bulls | 1.6 | 2–1 | 0.5 | New England | 16,301 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Sat | 2022-09-10 | 19:30 | Philadelphia | 2.8 | 5–1 | 0.4 | Orlando City | 19,079 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2022-09-10 | 19:30 | Atlanta Utd | 4.1 | 4–2 | 2.4 | Toronto FC | 42,670 | Mercedes-Benz Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-09-10 | 19:30 | FC Cincinnati | 3.8 | 6–0 | 0.9 | San Jose | 22,557 | TQL Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-09-10 | 17:00 | Seattle | 1.1 | 3–0 | 1.1 | Austin | 34,721 | Lumen Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-09-10 | 19:00 | Chicago Fire | 1.7 | 3–1 | 1.1 | Inter Miami | 15,104 | SeatGeek Stadium | Matt Conger | Match Report | |
| Sat | 2022-09-10 | 19:00 | Portland Timbers | 1.1 | 1–0 | 2.4 | Minnesota Utd | 25,019 | Providence Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-09-10 | 19:30 | Real Salt Lake | 0.5 | 0–0 | 0.6 | D.C. United | 20,487 | Rio Tinto Stadium | Kevin Broadley | Match Report | |
| Sat | 2022-09-10 | 19:30 | Colorado Rapids | 2.2 | 3–1 | 0.9 | Vancouver | 14,036 | Dick's Sporting Goods Park | Kevin Stott | Match Report | |
| Sat | 2022-09-10 | 19:30 | Dynamo FC | 1.3 | 0–0 | 1.3 | Sporting KC | 15,169 | PNC Stadium | Tori Penso | Match Report | |
| Sat | 2022-09-10 | 19:30 | FC Dallas | 0.9 | 2–1 | 1.1 | Los Angeles FC | 19,096 | Toyota Stadium | Jon Freemon | Match Report | |
| Tue | 2022-09-13 | 19:30 | CF Montréal | 0.9 | 3–2 | 1.7 | Chicago Fire | 11,535 | Stade Saputo | Ted Unkel | Match Report | |
| Wed | 2022-09-14 | 18:00 | Orlando City | 1.3 | 0–1 | 2.0 | Atlanta Utd | 15,340 | Exploria Stadium | Rubiel Vazquez | Match Report | |
| Tue | 2022-09-13 | 19:00 | Minnesota Utd | 1.6 | 1–1 | 1.1 | Los Angeles FC | 19,861 | Allianz Field | Tim Ford | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Tue | 2022-09-13 | 19:30 | Dynamo FC | 4.4 | 3–1 | 2.1 | New England | 10,305 | PNC Stadium | Ismail Elfath | Match Report | |
| Tue | 2022-09-13 | 19:30 | Sporting KC | 1.9 | 3–0 | 0.4 | D.C. United | 15,106 | Children's Mercy Park | Rosendo Mendoza | Match Report | |
| Tue | 2022-09-13 | 20:00 | Inter Miami | 0.9 | 2–1 | 1.0 | Columbus Crew | 9,778 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Wed | 2022-09-14 | 19:00 | Vancouver | 1.6 | 3–0 | 0.7 | LA Galaxy | 16,681 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Wed | 2022-09-14 | 20:00 | Colorado Rapids | 0.7 | 2–1 | 1.2 | San Jose | 11,938 | Dick's Sporting Goods Park | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-09-14 | 20:15 | Austin | 1.9 | 3–0 | 1.2 | Real Salt Lake | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-09-17 | 13:00 | NYCFC | 1.0 | 2–0 | 0.7 | NY Red Bulls | 30,151 | Yankee Stadium | Allen Chapman | Match Report | |
| Sat | 2022-09-17 | 15:30 | Atlanta Utd | 1.3 | 0–0 | 0.2 | Philadelphia | 42,521 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-09-17 | 19:30 | Orlando City | 1.0 | 4–0 | 0.7 | Toronto FC | 17,189 | Exploria Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-09-17 | 19:30 | New England | 0.8 | 0–1 | 1.3 | CF Montréal | 35,455 | Gillette Stadium | Rosendo Mendoza | Match Report | |
| Sun | 2022-09-18 | 13:00 | Columbus Crew | 1.1 | 1–1 | 0.8 | Portland Timbers | 20,421 | Lower.com Field | Victor Rivas | Match Report | |
| Sun | 2022-09-18 | 17:00 | D.C. United | 0.8 | 2–3 | 1.2 | Inter Miami | 14,284 | Audi Field | Ismail Elfath | Match Report | |
| Sat | 2022-09-17 | 19:00 | Vancouver | 1.2 | 2–1 | 0.6 | Seattle | 19,722 | BC Place Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-09-17 | 19:00 | Chicago Fire | 1.6 | 2–3 | 2.1 | Charlotte | 21,450 | Soldier Field | Tori Penso | Match Report | |
| Sat | 2022-09-17 | 19:30 | Sporting KC | 1.6 | 4–1 | 0.4 | Minnesota Utd | 19,680 | Children's Mercy Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-09-17 | 19:30 | Real Salt Lake | 1.6 | 1–2 | 0.6 | FC Cincinnati | 20,222 | Rio Tinto Stadium | Chris Penso | Match Report | |
| Sat | 2022-09-17 | 19:30 | San Jose | 1.8 | 1–1 | 1.1 | FC Dallas | 12,355 | PayPal Park | Drew Fischer | Match Report | |
| Sat | 2022-09-17 | 19:30 | LA Galaxy | 1.9 | 4–1 | 1.1 | Colorado Rapids | 20,325 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sat | 2022-09-17 | 20:00 | Austin | 0.8 | 1–1 | 1.4 | Nashville | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-09-18 | 19:30 | Los Angeles FC | 3.0 | 3–1 | 0.9 | Dynamo FC | 22,131 | Banc of California Stadium | Kevin Stott | Match Report | |
| Sat | 2022-09-24 | 19:00 | San Jose | 1.8 | 2–3 | 1.5 | LA Galaxy | 44,200 | Stanford Stadium | Alex Chilowicz | Match Report | |
| Tue | 2022-09-27 | 19:00 | Seattle | 0.4 | 1–1 | 2.0 | FC Cincinnati | 31,291 | Lumen Field | Rubiel Vazquez | Match Report | |
| Fri | 2022-09-30 | 19:30 | Toronto FC | 0.9 | 0–1 | 1.1 | Inter Miami | 27,703 | BMO Field | Silviu Petrescu | Match Report | |
| Sat | 2022-10-01 | 13:30 | New England | 2.4 | 2–1 | 1.3 | Atlanta Utd | 33,421 | Gillette Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-10-01 | 15:30 | Colorado Rapids | 0.6 | 1–0 | 0.8 | FC Dallas | 17,193 | Dick's Sporting Goods Park | Chris Penso | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-10-01 | 17:30 | Charlotte | 2.9 | 4–0 | 0.8 | Philadelphia | 43,860 | Bank of America Stadium | Jon Freemon | Match Report | |
| Sat | 2022-10-01 | 19:30 | Columbus Crew | 1.1 | 2–1 | 0.5 | NY Red Bulls | 20,757 | Lower.com Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-10-01 | 19:30 | FC Cincinnati | 2.5 | 2–3 | 1.6 | Chicago Fire | 25,316 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-10-01 | 19:30 | CF Montréal | 2.0 | 1–0 | 0.6 | D.C. United | 19,619 | Stade Saputo | Ramy Touchan | Match Report | |
| Sun | 2022-10-02 | 12:00 | Portland Timbers | 1.2 | 1–2 | 1.0 | Los Angeles FC | 25,218 | Providence Park | Ismail Elfath | Match Report | |
| Sun | 2022-10-02 | 13:00 | NYCFC | 1.9 | 2–1 | 1.0 | Orlando City | 13,169 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sun | 2022-10-02 | 16:00 | Sporting KC | 1.7 | 1–0 | 1.1 | Seattle | 19,439 | Children's Mercy Park | Ted Unkel | Match Report | |
| Sat | 2022-10-01 | 19:00 | Vancouver | 1.5 | 2–0 | 1.4 | Austin | 19,292 | BC Place Stadium | Tim Ford | Match Report | |
| Sat | 2022-10-01 | 19:00 | San Jose | 1.6 | 2–0 | 1.2 | Minnesota Utd | 15,709 | PayPal Park | Nima Saghafi | Match Report | |
| Sat | 2022-10-01 | 19:30 | LA Galaxy | 2.4 | 1–1 | 1.6 | Real Salt Lake | 26,674 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Sun | 2022-10-02 | 19:30 | Nashville | 1.3 | 1–2 | 1.9 | Dynamo FC | 28,720 | Geodis Park | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-10-05 | 19:00 | Charlotte | 2.4 | 2–2 | 1.2 | Columbus Crew | 34,122 | Bank of America Stadium | Matt Conger | Match Report | |
| Wed | 2022-10-05 | 20:00 | Inter Miami | 2.0 | 4–1 | 0.8 | Orlando City | 15,228 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sun | 2022-10-09 | 13:30 | Chicago Fire | 2.1 | 1–1 | 1.5 | New England | 14,357 | SeatGeek Stadium | Michael Radchuk | Match Report | |
| Sun | 2022-10-09 | 14:00 | Los Angeles FC | 4.5 | 0–1 | 1.2 | Nashville | 22,205 | Banc of California Stadium | Ted Unkel | Match Report | |
| Sun | 2022-10-09 | 14:00 | Seattle | 1.3 | 2–2 | 1.5 | San Jose | 33,910 | Lumen Field | Marcos de Oliveira | Match Report | |
| Sun | 2022-10-09 | 14:30 | Philadelphia | 2.0 | 4–0 | 0.4 | Toronto FC | 19,228 | Subaru Park | Lukasz Szpala | Match Report | |
| Sun | 2022-10-09 | 14:30 | Inter Miami | 0.8 | 1–3 | 2.4 | CF Montréal | 15,635 | DRV PNK Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-10-09 | 14:30 | Atlanta Utd | 1.5 | 1–2 | 1.4 | NYCFC | 43,312 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sun | 2022-10-09 | 14:30 | NY Red Bulls | 0.9 | 2–0 | 1.0 | Charlotte | 23,672 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| Sun | 2022-10-09 | 14:30 | D.C. United | 0.4 | 2–5 | 2.1 | FC Cincinnati | 19,325 | Audi Field | Tim Ford | Match Report | |
| Sun | 2022-10-09 | 14:30 | Orlando City | 1.1 | 2–1 | 0.9 | Columbus Crew | 21,693 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sun | 2022-10-09 | 15:00 | Real Salt Lake | 1.7 | 3–1 | 0.8 | Portland Timbers | 21,333 | Rio Tinto Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-10-09 | 16:00 | FC Dallas | 1.3 | 2–1 | 0.9 | Sporting KC | 19,096 | Toyota Stadium | Victor Rivas | Match Report | |
| Sun | 2022-10-09 | 16:00 | Dynamo FC | 0.6 | 1–3 | 2.3 | LA Galaxy | 21,284 | PNC Stadium | Drew Fischer | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-10-09 | 16:00 | Austin | 1.6 | 1–1 | 1.2 | Colorado Rapids | 20,738 | Q2 Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-10-09 | 16:00 | Minnesota Utd | 0.9 | 2–0 | 0.6 | Vancouver | 19,941 | Allianz Field | Allen Chapman | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First Round | Sat | 2022-10-15 | 12:00 | NY Red Bulls | 1.1 | 1–2 | 2.1 | FC Cincinnati | 17,113 | Red Bull Arena | Alex Chilowicz | Match Report | |
| First Round | Sat | 2022-10-15 | 12:00 | LA Galaxy | 1.2 | 1–0 | 0.8 | Nashville | 22,280 | Dignity Health Sports Park | Armando Villarreal | Match Report | |
| First Round | Sun | 2022-10-16 | 14:00 | Austin | 4.2 | (3) 2–2 (1) | 1.5 | Real Salt Lake | 20,738 | Q2 Stadium | Victor Rivas | Match Report | Austin won on penalty kicks following extra time |
| First Round | Mon | 2022-10-17 | 19:00 | NYCFC | 2.9 | 3–0 | 0.6 | Inter Miami | 18,066 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| First Round | Sun | 2022-10-16 | 20:00 | CF Montréal | 1.6 | 2–0 | 0.7 | Orlando City | 19,619 | Stade Saputo | Ismail Elfath | Match Report | |
| First Round | Mon | 2022-10-17 | 20:30 | FC Dallas | 1.5 | (5) 1–1 (4) | 0.4 | Minnesota Utd | 19,096 | Toyota Stadium | Ted Unkel | Match Report | FC Dallas won on penalty kicks following extra time |
| Conference Semifinals | Thu | 2022-10-20 | 19:00 | Los Angeles FC | 2.5 | 3–2 | 0.4 | LA Galaxy | 22,305 | Banc of California Stadium | Allen Chapman | Match Report | |
| Conference Semifinals | Thu | 2022-10-20 | 20:00 | Philadelphia | 1.8 | 1–0 | 0.8 | FC Cincinnati | 19,289 | Subaru Park | Tim Ford | Match Report | |
| Conference Semifinals | Sun | 2022-10-23 | 13:00 | CF Montréal | 2.6 | 1–3 | 1.8 | NYCFC | 19,619 | Stade Saputo | Drew Fischer | Match Report | |
| Conference Semifinals | Sun | 2022-10-23 | 19:00 | Austin | 1.4 | 2–1 | 0.6 | FC Dallas | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Conference Finals | Sun | 2022-10-30 | 12:00 | Los Angeles FC | 2.1 | 3–0 | 0.3 | Austin | 22,175 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Conference Finals | Sun | 2022-10-30 | 20:00 | Philadelphia | 1.7 | 3–1 | 0.6 | NYCFC | 19,770 | Subaru Park | Allen Chapman | Match Report | |
| MLS Cup | Sat | 2022-11-05 | 13:00 | Los Angeles FC | 1.0 | (3) 3–3 (0) | 1.6 | Philadelphia | 22,384 | Banc of California Stadium | Ismail Elfath | Match Report | Los Angeles FC won on penalty kicks following extra time |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
FBref is the most complete sources for women's football data on the internet. This includes the entire history of the FIFA Women's World Cup as well as recent domestic league seasons from nine countries, including advanced stats like xG for most of those nine.
In collaboration with Opta, we are including advanced analytical data such as xG, xA, progressive passing, duels and more for over twenty competitions. For more information on the expected goals model and which competitions have advanced data, see our xG explainer.
Note that player records are likely not complete for their careers. Players may come from or move to leagues we don't currently cover. This issue will go down over time, as we add new leagues and seasons. We will never in the future have less data than we do today.
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For more information, see our Launch Blog Post, the overall leagues/competition page with details on leagues and seasons we include, or our About Page. Let us know if you find an issue or have a suggestion.
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