Scores & Fixtures 2021-2022 Eredivisie
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-08-13 | 20:00 | Go Ahead Eag | 0.8 | 0–1 | 1.2 | Heerenveen | 1,173 | De Adelaarshorst | Kevin Blom | Match Report | |
| 1 | Sat | 2021-08-14 | 16:30 | RKC Waalwijk | 0.8 | 1–0 | 1.6 | AZ Alkmaar | 3,860 | Mandemakers Stadion | Joey Kooij | Match Report | |
| 1 | Sat | 2021-08-14 | 18:45 | Heracles Almelo | 0.3 | 0–2 | 1.9 | PSV Eindhoven | 8,053 | Erve Asito | Danny Makkelie | Match Report | |
| 1 | Sat | 2021-08-14 | 20:00 | Fortuna Sittard | 1.7 | 2–1 | 1.3 | Twente | 6,300 | Fortuna Sittard Stadion | Jochem Kamphuis | Match Report | |
| 1 | Sat | 2021-08-14 | 21:00 | Ajax | 3.4 | 5–0 | 0.5 | NEC Nijmegen | 32,275 | Johan Cruyff ArenA | Bas Nijhuis | Match Report | |
| 1 | Sun | 2021-08-15 | 12:15 | Cambuur | 0.5 | 1–2 | 1.6 | Groningen | 7,000 | Cambuurstadion | Allard Lindhout | Match Report | |
| 1 | Sun | 2021-08-15 | 14:30 | Zwolle | 1.5 | 0–1 | 1.0 | Vitesse | 9,000 | MAC³PARK Stadion | Richard Martens | Match Report | |
| 1 | Sun | 2021-08-15 | 14:30 | Utrecht | 3.3 | 4–0 | 0.7 | Sparta R'dam | 16,000 | Stadion Galgenwaard | Martin van den Kerkhof | Match Report | |
| 1 | Sun | 2021-08-15 | 16:45 | Willem II | 0.8 | 0–4 | 2.5 | Feyenoord | 9,700 | Koning Willem II Stadion | Serdar Gözübüyük | Match Report | |
| 2 | Fri | 2021-08-20 | 20:00 | NEC Nijmegen | 0.7 | 2–0 | 1.0 | Zwolle | 8,500 | Goffertstadion | Sander Van der Eijk | Match Report | |
| 2 | Sat | 2021-08-21 | 18:45 | Heerenveen | 2.1 | 3–2 | 1.0 | RKC Waalwijk | 13,600 | Abe Lenstra Stadion | Marc Nagtegaal | Match Report | |
| 2 | Sat | 2021-08-21 | 20:00 | Sparta R'dam | 0.8 | 1–1 | 0.5 | Heracles Almelo | 7,000 | Sparta-Stadion Het Kasteel | Bas Nijhuis | Match Report | |
| 2 | Sat | 2021-08-21 | 20:00 | PSV Eindhoven | 2.2 | 4–1 | 0.6 | Cambuur | 23,500 | Philips Stadion | Martin van den Kerkhof | Match Report | |
| 2 | Sat | 2021-08-21 | 21:00 | Groningen | 1.2 | 0–0 | 0.4 | Utrecht | 14,800 | Hitachi Capital Mobility Stadion | Danny Makkelie | Match Report | |
| 2 | Sun | 2021-08-22 | 12:15 | Twente | 0.9 | 1–1 | 1.6 | Ajax | 20,000 | De Grolsch Veste | Dennis Higler | Match Report | |
| 2 | Sun | 2021-08-22 | 14:30 | Feyenoord | 2.6 | 2–0 | 0.7 | Go Ahead Eag | 34,384 | Stadion Feijenoord | Rob Dieperink | Match Report | |
| 2 | Sun | 2021-08-22 | 16:45 | Vitesse | 1.1 | 0–3 | 1.3 | Willem II | 10,157 | GelreDome | Allard Lindhout | Match Report | |
| 3 | Fri | 2021-08-27 | 20:00 | Fortuna Sittard | 0.9 | 2–2 | 2.2 | RKC Waalwijk | 6,470 | Fortuna Sittard Stadion | Jeroen Manschot | Match Report | |
| 3 | Sat | 2021-08-28 | 18:45 | Cambuur | 2.7 | 2–0 | 1.1 | Twente | 6,672 | Cambuurstadion | Kevin Blom | Match Report | |
| 3 | Sat | 2021-08-28 | 20:00 | PSV Eindhoven | 1.4 | 5–2 | 1.7 | Groningen | 23,447 | Philips Stadion | Serdar Gözübüyük | Match Report | |
| 3 | Sat | 2021-08-28 | 20:00 | Go Ahead Eag | 2.5 | 2–0 | 1.0 | Sparta R'dam | 6,650 | De Adelaarshorst | Jannick van der Laan | Match Report | |
| 3 | Sat | 2021-08-28 | 21:00 | Willem II | 1.2 | 1–0 | 0.7 | Zwolle | 9,352 | Koning Willem II Stadion | Gerard van Oostrom | Match Report | |
| 3 | Sun | 2021-08-29 | 12:15 | Utrecht | 3.7 | 3–1 | 1.0 | Feyenoord | 16,000 | Stadion Galgenwaard | Dennis Higler | Match Report | |
| 3 | Sun | 2021-08-29 | 14:30 | Heracles Almelo | 0.6 | 0–1 | 1.6 | NEC Nijmegen | 8,053 | Erve Asito | Jochem Kamphuis | Match Report | |
| 3 | Sun | 2021-08-29 | 14:30 | Ajax | 3.4 | 5–0 | 0.6 | Vitesse | 8,053 | Johan Cruyff ArenA | Danny Makkelie | Match Report | |
| 3 | Sun | 2021-08-29 | 16:45 | Heerenveen | 1.2 | 1–3 | 2.8 | AZ Alkmaar | 16,000 | Abe Lenstra Stadion | Bas Nijhuis | Match Report | |
| 4 | Sat | 2021-09-11 | 16:30 | Twente | 1.3 | 1–0 | 0.9 | Utrecht | 20,000 | De Grolsch Veste | Serdar Gözübüyük | Match Report | |
| 4 | Sat | 2021-09-11 | 18:45 | Cambuur | 3.1 | 5–2 | 0.9 | Go Ahead Eag | 6,682 | Cambuurstadion | Danny Makkelie | Match Report | |
| 4 | Sat | 2021-09-11 | 18:45 | Zwolle | 0.5 | 0–2 | 1.3 | Ajax | 9,000 | MAC³PARK Stadion | Jeroen Manschot | Match Report | |
| 4 | Sat | 2021-09-11 | 21:00 | AZ Alkmaar | 1.1 | 0–3 | 1.4 | PSV Eindhoven | 13,000 | AFAS Stadion | Allard Lindhout | Match Report | |
| 4 | Sun | 2021-09-12 | 12:15 | NEC Nijmegen | 1.5 | 0–0 | 0.3 | Willem II | 8,333 | Goffertstadion | Pol van Boekel | Match Report | |
| 4 | Sun | 2021-09-12 | 14:30 | Groningen | 1.1 | 1–1 | 0.6 | Heerenveen | 15,000 | Hitachi Capital Mobility Stadion | Rob Dieperink | Match Report | |
| 4 | Sun | 2021-09-12 | 14:30 | Sparta R'dam | 1.6 | 3–1 | 0.2 | Fortuna Sittard | 6,623 | Sparta-Stadion Het Kasteel | Erwin Blank | Match Report | |
| 4 | Sun | 2021-09-12 | 16:45 | RKC Waalwijk | 1.0 | 1–2 | 0.7 | Vitesse | 4,989 | Mandemakers Stadion | Jochem Kamphuis | Match Report | |
| 5 | Fri | 2021-09-17 | 20:00 | Sparta R'dam | 1.4 | 1–1 | 0.8 | NEC Nijmegen | 7,041 | Sparta-Stadion Het Kasteel | Edwin van de Graaf | Match Report | |
| 5 | Sat | 2021-09-18 | 16:30 | Heerenveen | 1.8 | 1–0 | 0.7 | Fortuna Sittard | 16,400 | Abe Lenstra Stadion | Laurens Gerrets | Match Report | |
| 5 | Sat | 2021-09-18 | 18:45 | Willem II | 0.7 | 2–1 | 1.6 | Groningen | 9,463 | Koning Willem II Stadion | Jeroen Manschot | Match Report | |
| 5 | Sat | 2021-09-18 | 20:00 | Ajax | 4.1 | 9–0 | 0.9 | Cambuur | 36,711 | Johan Cruyff ArenA | Sander Van der Eijk | Match Report | |
| 5 | Sat | 2021-09-18 | 21:00 | Utrecht | 3.3 | 2–2 | 1.7 | RKC Waalwijk | 16,000 | Stadion Galgenwaard | Richard Martens | Match Report | |
| 5 | Sun | 2021-09-19 | 12:15 | Go Ahead Eag | 1.8 | 1–0 | 0.6 | Zwolle | 6,600 | De Adelaarshorst | Kevin Blom | Match Report | |
| 5 | Sun | 2021-09-19 | 14:30 | PSV Eindhoven | 1.2 | 0–4 | 1.2 | Feyenoord | 24,356 | Philips Stadion | Danny Makkelie | Match Report | |
| 5 | Sun | 2021-09-19 | 16:45 | Heracles Almelo | 1.3 | 3–2 | 0.5 | AZ Alkmaar | 8,053 | Erve Asito | Serdar Gözübüyük | Match Report | |
| 5 | Sun | 2021-09-19 | 16:45 | Vitesse | 1.5 | 1–4 | 2.3 | Twente | 13,808 | GelreDome | Pol van Boekel | Match Report | |
| 6 | Tue | 2021-09-21 | 18:45 | Fortuna Sittard | 0.6 | 0–5 | 3.7 | Ajax | 8,333 | Fortuna Sittard Stadion | Jochem Kamphuis | Match Report | |
| 6 | Tue | 2021-09-21 | 21:00 | RKC Waalwijk | 0.6 | 1–2 | 1.5 | Willem II | 2,000 | Mandemakers Stadion | Dennis Higler | Match Report | |
| 6 | Wed | 2021-09-22 | 18:45 | Go Ahead Eag | 1.2 | 1–2 | 2.1 | PSV Eindhoven | 6,650 | De Adelaarshorst | Bas Nijhuis | Match Report | |
| 6 | Wed | 2021-09-22 | 18:45 | NEC Nijmegen | 0.7 | 0–3 | 1.6 | Utrecht | 8,333 | Goffertstadion | Marc Nagtegaal | Match Report | |
| 6 | Wed | 2021-09-22 | 20:00 | Groningen | 0.7 | 0–1 | 1.1 | Vitesse | 14,963 | Hitachi Capital Mobility Stadion | Allard Lindhout | Match Report | |
| 6 | Wed | 2021-09-22 | 21:00 | Feyenoord | 1.7 | 3–1 | 0.5 | Heerenveen | 32,775 | Stadion Feijenoord | Martin van den Kerkhof | Match Report | |
| 6 | Wed | 2021-09-22 | 21:00 | Zwolle | 1.4 | 1–1 | 0.7 | Sparta R'dam | 9,000 | MAC³PARK Stadion | Martin Perez | Match Report | |
| 6 | Thu | 2021-09-23 | 18:45 | Cambuur | 0.5 | 2–1 | 1.9 | Heracles Almelo | 6,676 | Cambuurstadion | Alex Bos | Match Report | |
| 6 | Thu | 2021-09-23 | 21:00 | Twente | 1.3 | 3–1 | 0.9 | AZ Alkmaar | 18,000 | De Grolsch Veste | Danny Makkelie | Match Report | |
| 7 | Sat | 2021-09-25 | 16:30 | Willem II | 0.3 | 2–1 | 3.1 | PSV Eindhoven | 14,503 | Koning Willem II Stadion | Kevin Blom | Match Report | |
| 7 | Sat | 2021-09-25 | 18:45 | Vitesse | 1.7 | 1–1 | 0.0 | Fortuna Sittard | 11,631 | GelreDome | Ingmar Oostrom | Match Report | |
| 7 | Sat | 2021-09-25 | 18:45 | Ajax | 3.8 | 3–0 | 0.3 | Groningen | 53,148 | Johan Cruyff ArenA | Pol van Boekel | Match Report | |
| 7 | Sat | 2021-09-25 | 21:00 | Feyenoord | 2.9 | 5–3 | 1.1 | NEC Nijmegen | 45,495 | Stadion Feijenoord | Joey Kooij | Match Report | |
| 7 | Sat | 2021-09-25 | 21:00 | Utrecht | 4.5 | 5–1 | 0.5 | Zwolle | 19,451 | Stadion Galgenwaard | Allard Lindhout | Match Report | |
| 7 | Sun | 2021-09-26 | 12:15 | Sparta R'dam | 1.1 | 0–4 | 1.6 | Cambuur | 8,645 | Sparta-Stadion Het Kasteel | Martin van den Kerkhof | Match Report | |
| 7 | Sun | 2021-09-26 | 14:30 | Heerenveen | 1.3 | 2–3 | 1.1 | Twente | 18,500 | Abe Lenstra Stadion | Jeroen Manschot | Match Report | |
| 7 | Sun | 2021-09-26 | 14:30 | AZ Alkmaar | 3.1 | 5–0 | 0.4 | Go Ahead Eag | 13,612 | AFAS Stadion | Dennis Higler | Match Report | |
| 7 | Sun | 2021-09-26 | 16:45 | Heracles Almelo | 1.5 | 1–0 | 0.3 | RKC Waalwijk | 10,035 | Erve Asito | Bas Nijhuis | Match Report | |
| 8 | Fri | 2021-10-01 | 20:00 | Groningen | 0.5 | 1–1 | 1.0 | Twente | 16,250 | Hitachi Capital Mobility Stadion | Martin van den Kerkhof | Match Report | |
| 8 | Sat | 2021-10-02 | 18:45 | RKC Waalwijk | 1.9 | 1–1 | 1.3 | Go Ahead Eag | 6,018 | Mandemakers Stadion | Erwin Blank | Match Report | |
| 8 | Sat | 2021-10-02 | 20:00 | Heracles Almelo | 3.8 | 3–2 | 0.9 | Willem II | 9,251 | Erve Asito | Rob Dieperink | Match Report | |
| 8 | Sat | 2021-10-02 | 20:00 | Zwolle | 1.0 | 0–1 | 0.6 | Heerenveen | 13,655 | MAC³PARK Stadion | Dennis Higler | Match Report | |
| 8 | Sat | 2021-10-02 | 21:00 | Fortuna Sittard | 1.9 | 1–3 | 2.3 | NEC Nijmegen | 7,011 | Fortuna Sittard Stadion | Jeroen Manschot | Match Report | |
| 8 | Sun | 2021-10-03 | 14:30 | Ajax | 2.0 | 0–1 | 0.6 | Utrecht | 52,621 | Johan Cruyff ArenA | Bas Nijhuis | Match Report | |
| 8 | Sun | 2021-10-03 | 14:30 | Cambuur | 0.9 | 1–3 | 1.9 | AZ Alkmaar | 10,000 | Cambuurstadion | Jochem Kamphuis | Match Report | |
| 8 | Sun | 2021-10-03 | 16:45 | Vitesse | 1.4 | 2–1 | 1.8 | Feyenoord | 14,238 | GelreDome | Serdar Gözübüyük | Match Report | |
| 8 | Sun | 2021-10-03 | 20:00 | PSV Eindhoven | 3.1 | 2–1 | 1.0 | Sparta R'dam | 30,500 | Philips Stadion | Sander Van der Eijk | Match Report | |
| 9 | Sat | 2021-10-16 | 16:30 | Feyenoord | 3.9 | 2–2 | 1.0 | RKC Waalwijk | 47,183 | Stadion Feijenoord | Pol van Boekel | Match Report | |
| 9 | Sat | 2021-10-16 | 18:45 | Heerenveen | 1.4 | 0–2 | 2.0 | Ajax | 25,133 | Abe Lenstra Stadion | Danny Makkelie | Match Report | |
| 9 | Sat | 2021-10-16 | 18:45 | Go Ahead Eag | 1.2 | 4–2 | 1.9 | Heracles Almelo | 9,701 | De Adelaarshorst | Richard Martens | Match Report | |
| 9 | Sat | 2021-10-16 | 21:00 | Fortuna Sittard | 1.0 | 1–0 | 0.8 | Cambuur | 6,873 | Fortuna Sittard Stadion | Dennis Higler | Match Report | |
| 9 | Sat | 2021-10-16 | 21:00 | PSV Eindhoven | 2.6 | 3–1 | 0.5 | Zwolle | 30,500 | Philips Stadion | Joey Kooij | Match Report | |
| 9 | Sun | 2021-10-17 | 12:15 | AZ Alkmaar | 2.8 | 5–1 | 0.4 | Utrecht | 17,037 | AFAS Stadion | Kevin Blom | Match Report | |
| 9 | Sun | 2021-10-17 | 14:30 | NEC Nijmegen | 0.5 | 0–1 | 1.0 | Vitesse | 12,500 | Goffertstadion | Allard Lindhout | Match Report | |
| 9 | Sun | 2021-10-17 | 14:30 | Sparta R'dam | 1.9 | 1–1 | 0.4 | Groningen | 9,038 | Sparta-Stadion Het Kasteel | Serdar Gözübüyük | Match Report | |
| 9 | Sun | 2021-10-17 | 16:45 | Twente | 0.6 | 1–1 | 0.8 | Willem II | 27,000 | De Grolsch Veste | Jochem Kamphuis | Match Report | |
| 10 | Fri | 2021-10-22 | 20:00 | Willem II | 1.7 | 1–1 | 1.3 | Fortuna Sittard | 14,057 | Koning Willem II Stadion | Jannick van der Laan | Match Report | |
| 10 | Sat | 2021-10-23 | 18:45 | Utrecht | 2.7 | 2–1 | 1.1 | Heerenveen | 21,875 | Stadion Galgenwaard | Jochem Kamphuis | Match Report | |
| 10 | Sat | 2021-10-23 | 20:00 | Zwolle | 1.6 | 1–0 | 1.4 | Heracles Almelo | 13,026 | MAC³PARK Stadion | Marc Nagtegaal | Match Report | |
| 10 | Sat | 2021-10-23 | 21:00 | RKC Waalwijk | 1.4 | 1–0 | 0.8 | Sparta R'dam | 5,304 | Mandemakers Stadion | Jeroen Manschot | Match Report | |
| 10 | Sun | 2021-10-24 | 12:15 | Twente | 1.3 | 1–2 | 1.2 | NEC Nijmegen | 26,000 | De Grolsch Veste | Kevin Blom | Match Report | |
| 10 | Sun | 2021-10-24 | 14:30 | Vitesse | 1.5 | 1–2 | 1.9 | Go Ahead Eag | 12,783 | GelreDome | Dennis Higler | Match Report | |
| 10 | Sun | 2021-10-24 | 14:30 | Cambuur | 1.0 | 2–3 | 1.8 | Feyenoord | 10,000 | Cambuurstadion | Bas Nijhuis | Match Report | |
| 10 | Sun | 2021-10-24 | 16:45 | Ajax | 2.3 | 5–0 | 0.9 | PSV Eindhoven | 53,585 | Johan Cruyff ArenA | Serdar Gözübüyük | Match Report | |
| 10 | Sun | 2021-10-24 | 20:00 | Groningen | 0.6 | 2–0 | 1.7 | AZ Alkmaar | 11,300 | Hitachi Capital Mobility Stadion | Danny Makkelie | Match Report | |
| 11 | Sat | 2021-10-30 | 16:30 | PSV Eindhoven | 3.6 | 5–2 | 0.9 | Twente | 32,500 | Philips Stadion | Danny Makkelie | Match Report | |
| 11 | Sat | 2021-10-30 | 18:45 | Heracles Almelo | 0.7 | 0–0 | 1.8 | Ajax | 12,080 | Erve Asito | Jeroen Manschot | Match Report | |
| 11 | Sat | 2021-10-30 | 20:00 | Heerenveen | 0.6 | 1–2 | 2.3 | Vitesse | 17,187 | Abe Lenstra Stadion | Martin van den Kerkhof | Match Report | |
| 11 | Sat | 2021-10-30 | 21:00 | AZ Alkmaar | 1.2 | 3–2 | 0.8 | Zwolle | 15,328 | AFAS Stadion | Serdar Gözübüyük | Match Report | |
| 11 | Sun | 2021-10-31 | 12:15 | Sparta R'dam | 0.3 | 0–1 | 1.3 | Feyenoord | 10,599 | Sparta-Stadion Het Kasteel | Kevin Blom | Match Report | |
| 11 | Sun | 2021-10-31 | 14:30 | NEC Nijmegen | 2.9 | 3–0 | 0.8 | Groningen | Goffertstadion | Ingmar Oostrom | Match Report | ||
| 11 | Sun | 2021-10-31 | 16:45 | RKC Waalwijk | 1.7 | 0–1 | 2.0 | Cambuur | 4,754 | Mandemakers Stadion | Edwin van de Graaf | Match Report | |
| 11 | Sun | 2021-10-31 | 16:45 | Utrecht | 1.7 | 5–1 | 1.2 | Willem II | 20,469 | Stadion Galgenwaard | Pol van Boekel | Match Report | |
| 11 | Sun | 2021-10-31 | 20:00 | Go Ahead Eag | 2.2 | 4–3 | 0.7 | Fortuna Sittard | 8,807 | De Adelaarshorst | Alex Bos | Match Report | |
| 12 | Fri | 2021-11-05 | 20:00 | Twente | 1.8 | 1–0 | 0.5 | Heracles Almelo | 30,000 | De Grolsch Veste | Dennis Higler | Match Report | |
| 12 | Sat | 2021-11-06 | 18:45 | NEC Nijmegen | 2.1 | 1–1 | 1.7 | Heerenveen | Goffertstadion | Bas Nijhuis | Match Report | ||
| 12 | Sat | 2021-11-06 | 20:00 | Willem II | 0.6 | 0–3 | 0.9 | Sparta R'dam | 13,028 | Koning Willem II Stadion | Joey Kooij | Match Report | |
| 12 | Sat | 2021-11-06 | 21:00 | Zwolle | 1.3 | 1–2 | 0.7 | Cambuur | 13,098 | MAC³PARK Stadion | Sander Van der Eijk | Match Report | |
| 12 | Sun | 2021-11-07 | 12:15 | Groningen | 1.2 | 1–1 | 0.5 | RKC Waalwijk | 20,313 | Hitachi Capital Mobility Stadion | Kevin Blom | Match Report | |
| 12 | Sun | 2021-11-07 | 14:30 | Fortuna Sittard | 0.5 | 1–4 | 2.6 | PSV Eindhoven | 9,527 | Fortuna Sittard Stadion | Pol van Boekel | Match Report | |
| 12 | Sun | 2021-11-07 | 16:45 | Vitesse | 2.2 | 2–1 | 0.5 | Utrecht | 15,867 | GelreDome | Danny Makkelie | Match Report | |
| 12 | Sun | 2021-11-07 | 16:45 | Feyenoord | 1.6 | 1–0 | 1.0 | AZ Alkmaar | 47,500 | Stadion Feijenoord | Allard Lindhout | Match Report | |
| 12 | Sun | 2021-11-07 | 20:00 | Ajax | 2.8 | 0–0 | 0.1 | Go Ahead Eag | 53,497 | Johan Cruyff ArenA | Rob Dieperink | Match Report | |
| 13 | Sat | 2021-11-20 | 16:30 | PSV Eindhoven | 0.8 | 2–0 | 0.8 | Vitesse | Philips Stadion | Bas Nijhuis | Match Report | ||
| 13 | Sat | 2021-11-20 | 18:45 | Sparta R'dam | 0.7 | 0–1 | 1.3 | Twente | Sparta-Stadion Het Kasteel | Edwin van de Graaf | Match Report | ||
| 13 | Sat | 2021-11-20 | 20:00 | AZ Alkmaar | 1.9 | 1–1 | 0.7 | NEC Nijmegen | AFAS Stadion | Jeroen Manschot | Match Report | ||
| 13 | Sat | 2021-11-20 | 21:00 | Heracles Almelo | 1.9 | 3–1 | 1.4 | Fortuna Sittard | Erve Asito | Danny Makkelie | Match Report | ||
| 13 | Sun | 2021-11-21 | 12:15 | Go Ahead Eag | 0.8 | 0–1 | 1.8 | Groningen | De Adelaarshorst | Sander Van der Eijk | Match Report | ||
| 13 | Sun | 2021-11-21 | 14:30 | Heerenveen | 1.8 | 2–1 | 2.3 | Willem II | Abe Lenstra Stadion | Serdar Gözübüyük | Match Report | ||
| 13 | Sun | 2021-11-21 | 14:30 | Feyenoord | 3.0 | 4–0 | 0.3 | Zwolle | Stadion Feijenoord | Martin van den Kerkhof | Match Report | ||
| 13 | Sun | 2021-11-21 | 16:45 | RKC Waalwijk | 0.9 | 0–5 | 3.9 | Ajax | Mandemakers Stadion | Allard Lindhout | Match Report | ||
| 13 | Sun | 2021-11-21 | 20:00 | Cambuur | 1.7 | 2–1 | 1.3 | Utrecht | Cambuurstadion | Dennis Higler | Match Report | ||
| 14 | Fri | 2021-11-26 | 20:00 | NEC Nijmegen | 1.9 | 2–3 | 1.8 | Cambuur | Goffertstadion | Rob Dieperink | Match Report | ||
| 14 | Sat | 2021-11-27 | 18:45 | Fortuna Sittard | 1.1 | 1–4 | 1.8 | Groningen | Fortuna Sittard Stadion | Jeroen Manschot | Match Report | ||
| 14 | Sat | 2021-11-27 | 20:00 | Zwolle | 1.7 | 0–0 | 0.3 | RKC Waalwijk | MAC³PARK Stadion | Joey Kooij | Match Report | ||
| 14 | Sat | 2021-11-27 | 21:00 | Willem II | 1.0 | 0–1 | 0.3 | Go Ahead Eag | Koning Willem II Stadion | Laurens Gerrets | Match Report | ||
| 14 | Sun | 2021-11-28 | 12:15 | Sparta R'dam | 0.2 | 0–1 | 1.8 | Ajax | Sparta-Stadion Het Kasteel | Jochem Kamphuis | Match Report | ||
| 14 | Sun | 2021-11-28 | 14:30 | Utrecht | 2.6 | 1–0 | 0.5 | Heracles Almelo | Stadion Galgenwaard | Martin van den Kerkhof | Match Report | ||
| 14 | Sun | 2021-11-28 | 14:30 | Twente | 0.3 | 0–0 | 1.5 | Feyenoord | De Grolsch Veste | Serdar Gözübüyük | Match Report | ||
| 14 | Sun | 2021-11-28 | 16:45 | Heerenveen | 1.0 | 1–1 | 1.5 | PSV Eindhoven | Abe Lenstra Stadion | Allard Lindhout | Match Report | ||
| 14 | Sun | 2021-11-28 | 20:00 | Vitesse | 0.9 | 0–0 | 1.2 | AZ Alkmaar | GelreDome | Danny Makkelie | Match Report | ||
| 4 | Wed | 2021-12-01 | 20:00 | Feyenoord | 2.3 | 2–1 | 0.9 | Heracles Almelo | Stadion Feijenoord | Bas Nijhuis | Match Report | ||
| 2 | Thu | 2021-12-02 | 18:45 | AZ Alkmaar | 1.4 | 2–1 | 1.1 | Fortuna Sittard | AFAS Stadion | Dennis Higler | Match Report | ||
| 15 | Thu | 2021-12-02 | 21:00 | Ajax | 2.9 | 5–0 | 0.1 | Willem II | Johan Cruyff ArenA | Edwin van de Graaf | Match Report | ||
| 15 | Fri | 2021-12-03 | 20:00 | Groningen | 0.3 | 1–1 | 0.6 | Zwolle | Hitachi Capital Mobility Stadion | Richard Martens | Match Report | ||
| 15 | Sat | 2021-12-04 | 16:30 | PSV Eindhoven | 1.5 | 4–1 | 1.2 | Utrecht | Philips Stadion | Danny Makkelie | Match Report | ||
| 15 | Sat | 2021-12-04 | 18:45 | Cambuur | 1.1 | 1–6 | 2.8 | Vitesse | Cambuurstadion | Serdar Gözübüyük | Match Report | ||
| 15 | Sat | 2021-12-04 | 21:00 | Heracles Almelo | 0.9 | 0–1 | 1.0 | Heerenveen | Erve Asito | Pol van Boekel | Match Report | ||
| 15 | Sun | 2021-12-05 | 12:15 | RKC Waalwijk | 2.1 | 2–1 | 2.0 | NEC Nijmegen | Mandemakers Stadion | Dennis Higler | Match Report | ||
| 15 | Sun | 2021-12-05 | 14:30 | AZ Alkmaar | 2.5 | 3–1 | 1.0 | Sparta R'dam | AFAS Stadion | Sander Van der Eijk | Match Report | ||
| 15 | Sun | 2021-12-05 | 14:30 | Go Ahead Eag | 1.1 | 1–2 | 1.1 | Twente | De Adelaarshorst | Allard Lindhout | Match Report | ||
| 15 | Sun | 2021-12-05 | 16:45 | Feyenoord | 3.6 | 5–0 | 0.4 | Fortuna Sittard | Stadion Feijenoord | Rob Dieperink | Match Report | ||
| 16 | Fri | 2021-12-10 | 20:00 | Willem II | 0.8 | 1–3 | 2.0 | Cambuur | Koning Willem II Stadion | Martin van den Kerkhof | Match Report | ||
| 16 | Sat | 2021-12-11 | 18:45 | Utrecht | 2.0 | 0–0 | 0.3 | Go Ahead Eag | Stadion Galgenwaard | Joey Kooij | Match Report | ||
| 16 | Sat | 2021-12-11 | 20:00 | Heerenveen | 0.8 | 0–0 | 0.4 | Sparta R'dam | Abe Lenstra Stadion | Jannick van der Laan | Match Report | ||
| 16 | Sat | 2021-12-11 | 21:00 | Zwolle | 0.9 | 0–1 | 1.8 | Fortuna Sittard | MAC³PARK Stadion | Edwin van de Graaf | Match Report | ||
| 16 | Sun | 2021-12-12 | 12:15 | Twente | 2.9 | 2–1 | 0.6 | RKC Waalwijk | De Grolsch Veste | Pol van Boekel | Match Report | ||
| 16 | Sun | 2021-12-12 | 14:30 | Vitesse | 1.4 | 2–1 | 0.7 | Heracles Almelo | GelreDome | Jeroen Manschot | Match Report | ||
| 16 | Sun | 2021-12-12 | 14:30 | Groningen | 0.7 | 1–1 | 2.0 | Feyenoord | Hitachi Capital Mobility Stadion | Danny Makkelie | Match Report | ||
| 16 | Sun | 2021-12-12 | 16:45 | Ajax | 3.6 | 1–2 | 1.3 | AZ Alkmaar | Johan Cruyff ArenA | Bas Nijhuis | Match Report | ||
| 16 | Sun | 2021-12-12 | 20:00 | NEC Nijmegen | 1.1 | 1–2 | 3.9 | PSV Eindhoven | Goffertstadion | Serdar Gözübüyük | Match Report | ||
| 17 | Sat | 2021-12-18 | 16:30 | Fortuna Sittard | 0.8 | 2–2 | 2.9 | Utrecht | Fortuna Sittard Stadion | Martin Perez | Match Report | ||
| 17 | Sat | 2021-12-18 | 18:45 | Sparta R'dam | 1.5 | 2–2 | 0.4 | Vitesse | Sparta-Stadion Het Kasteel | Bas Nijhuis | Match Report | ||
| 17 | Sat | 2021-12-18 | 20:00 | Heracles Almelo | 2.3 | 4–2 | 0.5 | Groningen | Erve Asito | Serdar Gözübüyük | Match Report | ||
| 17 | Sat | 2021-12-18 | 20:00 | AZ Alkmaar | 2.3 | 4–1 | 1.9 | Willem II | AFAS Stadion | Allard Lindhout | Match Report | ||
| 17 | Sat | 2021-12-18 | 21:00 | Zwolle | 0.9 | 1–3 | 1.4 | Twente | MAC³PARK Stadion | Alex Bos | Match Report | ||
| 17 | Sun | 2021-12-19 | 12:15 | Cambuur | 0.9 | 1–2 | 3.2 | Heerenveen | Cambuurstadion | Danny Makkelie | Match Report | ||
| 17 | Sun | 2021-12-19 | 14:30 | Feyenoord | 1.0 | 0–2 | 1.0 | Ajax | Stadion Feijenoord | Dennis Higler | Match Report | ||
| 17 | Sun | 2021-12-19 | 14:30 | Go Ahead Eag | 1.6 | 0–2 | 1.5 | NEC Nijmegen | De Adelaarshorst | Erwin Blank | Match Report | ||
| 17 | Sun | 2021-12-19 | 16:45 | RKC Waalwijk | 0.5 | 1–4 | 3.0 | PSV Eindhoven | Mandemakers Stadion | Jeroen Manschot | Match Report | ||
| 18 | Tue | 2021-12-21 | 18:45 | Vitesse | 2.5 | 1–0 | 1.1 | Zwolle | GelreDome | Pol van Boekel | Match Report | ||
| 18 | Tue | 2021-12-21 | 21:00 | AZ Alkmaar | 0.9 | 1–0 | 0.9 | Groningen | AFAS Stadion | Martin van den Kerkhof | Match Report | ||
| 18 | Wed | 2021-12-22 | 18:45 | Heerenveen | 0.6 | 0–3 | 2.6 | Feyenoord | Abe Lenstra Stadion | Jeroen Manschot | Match Report | ||
| 18 | Wed | 2021-12-22 | 18:45 | Willem II | 0.5 | 0–1 | 1.4 | NEC Nijmegen | Koning Willem II Stadion | Danny Makkelie | Match Report | ||
| 18 | Wed | 2021-12-22 | 20:00 | Heracles Almelo | 3.2 | 1–1 | 0.5 | Cambuur | Erve Asito | Allard Lindhout | Match Report | ||
| 18 | Wed | 2021-12-22 | 21:00 | Ajax | 3.4 | 5–0 | 0.4 | Fortuna Sittard | Johan Cruyff ArenA | Marc Nagtegaal | Match Report | ||
| 18 | Wed | 2021-12-22 | 21:00 | Utrecht | 1.3 | 1–1 | 0.7 | Twente | Stadion Galgenwaard | Richard Martens | Match Report | ||
| 18 | Thu | 2021-12-23 | 18:45 | PSV Eindhoven | 2.7 | 2–0 | 0.2 | Go Ahead Eag | Philips Stadion | Dennis Higler | Match Report | ||
| 18 | Thu | 2021-12-23 | 21:00 | Sparta R'dam | 1.5 | 1–1 | 0.5 | RKC Waalwijk | Sparta-Stadion Het Kasteel | Edwin van de Graaf | Match Report | ||
| 19 | Fri | 2022-01-14 | 20:00 | Zwolle | 1.8 | 2–0 | 0.6 | Willem II | MAC³PARK Stadion | Jeroen Manschot | Match Report | ||
| 19 | Sat | 2022-01-15 | 18:45 | NEC Nijmegen | 1.1 | 0–0 | 0.7 | Heracles Almelo | Goffertstadion | Joey Kooij | Match Report | ||
| 19 | Sat | 2022-01-15 | 20:00 | Twente | 2.3 | 2–0 | 1.0 | Heerenveen | De Grolsch Veste | Pol van Boekel | Match Report | ||
| 19 | Sat | 2022-01-15 | 20:00 | Feyenoord | 1.0 | 0–1 | 1.6 | Vitesse | Stadion Feijenoord | Allard Lindhout | Match Report | ||
| 19 | Sat | 2022-01-15 | 21:00 | Go Ahead Eag | 0.8 | 0–2 | 1.1 | RKC Waalwijk | De Adelaarshorst | Sander Van der Eijk | Match Report | ||
| 19 | Sun | 2022-01-16 | 12:15 | Utrecht | 0.9 | 0–3 | 1.6 | Ajax | Stadion Galgenwaard | Serdar Gözübüyük | Match Report | ||
| 19 | Sun | 2022-01-16 | 14:30 | Groningen | 0.4 | 0–1 | 1.4 | PSV Eindhoven | Hitachi Capital Mobility Stadion | Bas Nijhuis | Match Report | ||
| 19 | Sun | 2022-01-16 | 14:30 | Cambuur | 1.0 | 1–1 | 1.0 | Sparta R'dam | Cambuurstadion | Dennis Higler | Match Report | ||
| 19 | Sun | 2022-01-16 | 16:45 | Fortuna Sittard | 1.5 | 1–2 | 1.7 | AZ Alkmaar | Fortuna Sittard Stadion | Rob Dieperink | Match Report | ||
| 20 | Sat | 2022-01-22 | 18:45 | Vitesse | 0.6 | 1–3 | 2.1 | Groningen | GelreDome | Dennis Higler | Match Report | ||
| 20 | Sat | 2022-01-22 | 20:00 | AZ Alkmaar | 1.9 | 0–0 | 0.3 | Cambuur | AFAS Stadion | Bas Nijhuis | Match Report | ||
| 20 | Sat | 2022-01-22 | 20:00 | Heerenveen | 1.4 | 0–1 | 1.5 | Zwolle | Abe Lenstra Stadion | Martin van den Kerkhof | Match Report | ||
| 20 | Sat | 2022-01-22 | 21:00 | Willem II | 0.4 | 0–1 | 0.9 | Twente | Koning Willem II Stadion | Edwin van de Graaf | Match Report | ||
| 20 | Sun | 2022-01-23 | 12:15 | NEC Nijmegen | 0.4 | 1–4 | 4.3 | Feyenoord | Goffertstadion | Pol van Boekel | Match Report | ||
| 20 | Sun | 2022-01-23 | 14:30 | PSV Eindhoven | 1.3 | 1–2 | 1.8 | Ajax | Philips Stadion | Danny Makkelie | Match Report | ||
| 20 | Sun | 2022-01-23 | 14:30 | Heracles Almelo | 2.1 | 1–1 | 1.7 | Go Ahead Eag | Erve Asito | Jannick van der Laan | Match Report | ||
| 20 | Sun | 2022-01-23 | 16:45 | Sparta R'dam | 0.6 | 0–3 | 2.6 | Utrecht | Sparta-Stadion Het Kasteel | Erwin Blank | Match Report | ||
| 20 | Sun | 2022-01-23 | 20:00 | RKC Waalwijk | 1.9 | 2–1 | 1.5 | Fortuna Sittard | Mandemakers Stadion | Serdar Gözübüyük | Match Report | ||
| 21 | Sat | 2022-02-05 | 16:30 | Utrecht | 1.5 | 3–2 | 1.8 | Cambuur | 8,000 | Stadion Galgenwaard | Edwin van de Graaf | Match Report | |
| 21 | Sat | 2022-02-05 | 18:45 | Fortuna Sittard | 1.1 | 2–0 | 1.2 | Heerenveen | 4,200 | Fortuna Sittard Stadion | Joey Kooij | Match Report | |
| 21 | Sat | 2022-02-05 | 20:00 | Zwolle | 1.6 | 1–1 | 1.2 | NEC Nijmegen | 4,500 | MAC³PARK Stadion | Jannick van der Laan | Match Report | |
| 21 | Sat | 2022-02-05 | 20:00 | PSV Eindhoven | 1.4 | 1–2 | 1.7 | AZ Alkmaar | 12,000 | Philips Stadion | Allard Lindhout | Match Report | |
| 21 | Sat | 2022-02-05 | 21:00 | Twente | 2.7 | 3–0 | 0.4 | Vitesse | De Grolsch Veste | Danny Makkelie | Match Report | ||
| 21 | Sun | 2022-02-06 | 12:15 | Feyenoord | 2.7 | 4–0 | 0.6 | Sparta R'dam | 17,039 | Stadion Feijenoord | Serdar Gözübüyük | Match Report | |
| 21 | Sun | 2022-02-06 | 14:30 | Groningen | 2.5 | 2–1 | 1.1 | Go Ahead Eag | 6,900 | Hitachi Capital Mobility Stadion | Alex Bos | Match Report | |
| 21 | Sun | 2022-02-06 | 14:30 | Willem II | 1.1 | 3–1 | 1.1 | RKC Waalwijk | 4,686 | Koning Willem II Stadion | Bas Nijhuis | Match Report | |
| 21 | Sun | 2022-02-06 | 16:45 | Ajax | 3.6 | 3–0 | 0.2 | Heracles Almelo | 15,750 | Johan Cruyff ArenA | Jeroen Manschot | Match Report | |
| 22 | Fri | 2022-02-11 | 20:00 | Heracles Almelo | 1.6 | 1–0 | 1.6 | Utrecht | 4,058 | Erve Asito | Rob Dieperink | Match Report | |
| 22 | Sat | 2022-02-12 | 18:45 | Groningen | 1.8 | 0–1 | 0.8 | Fortuna Sittard | 7,200 | Hitachi Capital Mobility Stadion | Edwin van de Graaf | Match Report | |
| 22 | Sat | 2022-02-12 | 18:45 | Cambuur | 1.6 | 3–4 | 2.4 | Zwolle | 3,300 | Cambuurstadion | Ingmar Oostrom | Match Report | |
| 22 | Sat | 2022-02-12 | 20:00 | Vitesse | 1.2 | 0–5 | 4.5 | PSV Eindhoven | 9,177 | GelreDome | Serdar Gözübüyük | Match Report | |
| 22 | Sun | 2022-02-13 | 12:15 | Go Ahead Eag | 1.2 | 1–4 | 3.4 | AZ Alkmaar | 3,746 | De Adelaarshorst | Marc Nagtegaal | Match Report | |
| 22 | Sun | 2022-02-13 | 12:15 | Sparta R'dam | 1.2 | 1–0 | 0.6 | Willem II | 3,500 | Sparta-Stadion Het Kasteel | Danny Makkelie | Match Report | |
| 22 | Sun | 2022-02-13 | 14:30 | RKC Waalwijk | 0.9 | 0–2 | 1.4 | Feyenoord | 2,126 | Mandemakers Stadion | Jeroen Manschot | Match Report | |
| 22 | Sun | 2022-02-13 | 14:30 | Heerenveen | 1.4 | 0–1 | 0.5 | NEC Nijmegen | 8,321 | Abe Lenstra Stadion | Richard Martens | Match Report | |
| 22 | Sun | 2022-02-13 | 16:45 | Ajax | 4.8 | 5–0 | 0.5 | Twente | 17,859 | Johan Cruyff ArenA | Allard Lindhout | Match Report | |
| 23 | Sat | 2022-02-19 | 16:30 | NEC Nijmegen | 1.7 | 1–1 | 1.3 | RKC Waalwijk | 11,802 | Goffertstadion | Erwin Blank | Match Report | |
| 23 | Sat | 2022-02-19 | 18:45 | Willem II | 0.6 | 0–1 | 2.4 | Ajax | 14,412 | Koning Willem II Stadion | Pol van Boekel | Match Report | |
| 23 | Sat | 2022-02-19 | 21:00 | AZ Alkmaar | 1.7 | 2–1 | 0.3 | Heracles Almelo | 13,616 | AFAS Stadion | Ingmar Oostrom | Match Report | |
| 23 | Sun | 2022-02-20 | 12:15 | Zwolle | 0.9 | 1–1 | 1.4 | Groningen | 13,620 | MAC³PARK Stadion | Jeroen Manschot | Match Report | |
| 23 | Sun | 2022-02-20 | 14:30 | Feyenoord | 2.5 | 3–1 | 0.4 | Cambuur | 44,779 | Stadion Feijenoord | Jochem Kamphuis | Match Report | |
| 23 | Sun | 2022-02-20 | 14:30 | Twente | 1.9 | 2–2 | 0.6 | Go Ahead Eag | 26,100 | De Grolsch Veste | Martin van den Kerkhof | Match Report | |
| 23 | Sun | 2022-02-20 | 16:45 | Utrecht | 2.2 | 1–1 | 1.1 | Vitesse | 16,886 | Stadion Galgenwaard | Allard Lindhout | Match Report | |
| 23 | Sun | 2022-02-20 | 16:45 | PSV Eindhoven | 1.8 | 3–1 | 1.6 | Heerenveen | 35,000 | Philips Stadion | Dennis Higler | Match Report | |
| 24 | Fri | 2022-02-25 | 20:00 | RKC Waalwijk | 1.0 | 1–2 | 3.1 | Twente | 5,364 | Mandemakers Stadion | Martin Perez | Match Report | |
| 24 | Sat | 2022-02-26 | 16:30 | Heracles Almelo | 2.1 | 2–0 | 1.1 | Zwolle | 6,788 | Erve Asito | Allard Lindhout | Match Report | |
| 24 | Sat | 2022-02-26 | 18:45 | Groningen | 1.7 | 1–0 | 1.0 | Willem II | 17,977 | Hitachi Capital Mobility Stadion | Martin van den Kerkhof | Match Report | |
| 24 | Sat | 2022-02-26 | 21:00 | Cambuur | 1.7 | 2–1 | 1.0 | Fortuna Sittard | 9,780 | Cambuurstadion | Jannick van der Laan | Match Report | |
| 24 | Sun | 2022-02-27 | 12:15 | AZ Alkmaar | 2.0 | 2–1 | 1.5 | Feyenoord | 16,241 | AFAS Stadion | Dennis Higler | Match Report | |
| 24 | Sun | 2022-02-27 | 12:15 | Vitesse | 2.3 | 4–1 | 1.1 | NEC Nijmegen | 13,877 | GelreDome | Danny Makkelie | Match Report | |
| 24 | Sun | 2022-02-27 | 14:30 | Sparta R'dam | 0.8 | 1–2 | 2.3 | PSV Eindhoven | 10,020 | Sparta-Stadion Het Kasteel | Jeroen Manschot | Match Report | |
| 24 | Sun | 2022-02-27 | 16:45 | Go Ahead Eag | 1.0 | 2–1 | 1.9 | Ajax | 9,200 | De Adelaarshorst | Jochem Kamphuis | Match Report | |
| 24 | Sun | 2022-02-27 | 20:00 | Heerenveen | 1.3 | 1–2 | 1.2 | Utrecht | 19,200 | Abe Lenstra Stadion | Serdar Gözübüyük | Match Report | |
| 25 | Sat | 2022-03-05 | 16:30 | Willem II | 0.8 | 0–0 | 1.4 | Heerenveen | 13,082 | Koning Willem II Stadion | Jochem Kamphuis | Match Report | |
| 25 | Sat | 2022-03-05 | 18:45 | Go Ahead Eag | 0.8 | 1–1 | 2.4 | Utrecht | 9,924 | De Adelaarshorst | Danny Makkelie | Match Report | |
| 25 | Sat | 2022-03-05 | 21:00 | Feyenoord | 2.5 | 1–1 | 0.8 | Groningen | 45,395 | Stadion Feijenoord | Pol van Boekel | Match Report | |
| 25 | Sun | 2022-03-06 | 12:15 | PSV Eindhoven | 3.0 | 3–1 | 0.4 | Heracles Almelo | 33,247 | Philips Stadion | Edwin van de Graaf | Match Report | |
| 25 | Sun | 2022-03-06 | 14:30 | Twente | 3.3 | 1–0 | 0.4 | Cambuur | 26,800 | De Grolsch Veste | Sander Van der Eijk | Match Report | |
| 25 | Sun | 2022-03-06 | 16:45 | NEC Nijmegen | 1.6 | 1–3 | 1.1 | AZ Alkmaar | 12,000 | Goffertstadion | Bas Nijhuis | Match Report | |
| 25 | Sun | 2022-03-06 | 16:45 | Ajax | 6.1 | 3–2 | 1.0 | RKC Waalwijk | 53,467 | Johan Cruyff ArenA | Dennis Higler | Match Report | |
| 25 | Sun | 2022-03-06 | 20:00 | Fortuna Sittard | 1.3 | 0–1 | 1.3 | Zwolle | 8,279 | Fortuna Sittard Stadion | Serdar Gözübüyük | Match Report | |
| 26 | Fri | 2022-03-11 | 20:00 | Cambuur | 1.6 | 2–3 | 3.3 | Ajax | 9,822 | Cambuurstadion | Allard Lindhout | Match Report | |
| 26 | Sat | 2022-03-12 | 16:30 | Sparta R'dam | 1.8 | 1–0 | 0.4 | Go Ahead Eag | 10,011 | Sparta-Stadion Het Kasteel | Richard Martens | Match Report | |
| 26 | Sat | 2022-03-12 | 18:45 | Groningen | 2.0 | 4–3 | 1.6 | NEC Nijmegen | 20,600 | Hitachi Capital Mobility Stadion | Sander van der Eijk | Match Report | |
| 26 | Sat | 2022-03-12 | 21:00 | RKC Waalwijk | 0.8 | 0–0 | 1.4 | Heerenveen | 4,203 | Mandemakers Stadion | Jeroen Manschot | Match Report | |
| 26 | Sun | 2022-03-13 | 12:15 | Fortuna Sittard | 1.7 | 1–0 | 1.6 | Willem II | 5,812 | Fortuna Sittard Stadion | Dennis Higler | Match Report | |
| 26 | Sun | 2022-03-13 | 14:30 | Utrecht | 0.4 | 0–1 | 2.3 | PSV Eindhoven | 22,269 | Stadion Galgenwaard | Bas Nijhuis | Match Report | |
| 26 | Sun | 2022-03-13 | 14:30 | Heracles Almelo | 1.1 | 0–0 | 0.5 | Vitesse | 7,035 | Erve Asito | Jochem Kamphuis | Match Report | |
| 26 | Sun | 2022-03-13 | 16:45 | Zwolle | 0.7 | 1–2 | 1.5 | Feyenoord | 14,000 | MAC³PARK Stadion | Martin van den Kerkhof | Match Report | |
| 26 | Sun | 2022-03-13 | 20:00 | AZ Alkmaar | 0.8 | 0–1 | 0.5 | Twente | 15,349 | AFAS Stadion | Pol van Boekel | Match Report | |
| 27 | Fri | 2022-03-18 | 20:00 | Heerenveen | 1.7 | 2–0 | 0.5 | Heracles Almelo | 17,980 | Abe Lenstra Stadion | Alex Bos | Match Report | |
| 27 | Sat | 2022-03-19 | 18:45 | Go Ahead Eag | 1.9 | 3–0 | 0.0 | Cambuur | 9,631 | De Adelaarshorst | Serdar Gözübüyük | Match Report | |
| 27 | Sat | 2022-03-19 | 20:00 | Twente | 1.9 | 1–0 | 0.8 | Zwolle | 28,000 | De Grolsch Veste | Edwin van de Graaf | Match Report | |
| 27 | Sat | 2022-03-19 | 21:00 | NEC Nijmegen | 1.2 | 0–0 | 0.2 | Sparta R'dam | 12,000 | Goffertstadion | Jochem Kamphuis | Match Report | |
| 27 | Sun | 2022-03-20 | 12:15 | Utrecht | 1.5 | 1–3 | 1.6 | Groningen | 21,221 | Stadion Galgenwaard | Dennis Higler | Match Report | |
| 27 | Sun | 2022-03-20 | 14:30 | Ajax | 2.2 | 3–2 | 1.6 | Feyenoord | Johan Cruyff ArenA | Danny Makkelie | Match Report | ||
| 27 | Sun | 2022-03-20 | 16:45 | Vitesse | 2.3 | 1–2 | 1.1 | RKC Waalwijk | 13,625 | GelreDome | Joey Kooij | Match Report | |
| 27 | Sun | 2022-03-20 | 16:45 | PSV Eindhoven | 4.0 | 5–0 | 0.2 | Fortuna Sittard | 33,491 | Philips Stadion | Allard Lindhout | Match Report | |
| 27 | Sun | 2022-03-20 | 20:00 | Willem II | 1.5 | 2–2 | 1.8 | AZ Alkmaar | 13,064 | Koning Willem II Stadion | Rob Dieperink | Match Report | |
| 28 | Sat | 2022-04-02 | 16:30 | Groningen | 0.6 | 1–3 | 2.3 | Ajax | 22,525 | Hitachi Capital Mobility Stadion | Bas Nijhuis | Match Report | |
| 28 | Sat | 2022-04-02 | 18:45 | Twente | 3.3 | 3–3 | 1.5 | PSV Eindhoven | 30,000 | De Grolsch Veste | Serdar Gözübüyük | Match Report | |
| 28 | Sat | 2022-04-02 | 20:00 | RKC Waalwijk | 0.6 | 1–1 | 1.5 | Utrecht | 6,389 | Mandemakers Stadion | Marc Nagtegaal | Match Report | |
| 28 | Sat | 2022-04-02 | 20:00 | AZ Alkmaar | 1.6 | 3–1 | 1.7 | Vitesse | 17,406 | AFAS Stadion | Jeroen Manschot | Match Report | |
| 28 | Sat | 2022-04-02 | 21:00 | Feyenoord | 2.8 | 2–0 | 0.6 | Willem II | 47,500 | Stadion Feijenoord | Edwin van de Graaf | Match Report | |
| 28 | Sun | 2022-04-03 | 12:15 | Zwolle | 1.3 | 0–1 | 1.3 | Go Ahead Eag | 14,000 | MAC³PARK Stadion | Danny Makkelie | Match Report | |
| 28 | Sun | 2022-04-03 | 14:30 | Sparta R'dam | 1.9 | 1–1 | 0.7 | Heerenveen | 10,210 | Sparta-Stadion Het Kasteel | Allard Lindhout | Match Report | |
| 28 | Sun | 2022-04-03 | 14:30 | Fortuna Sittard | 0.8 | 0–2 | 1.0 | Heracles Almelo | 10,067 | Fortuna Sittard Stadion | Martin van den Kerkhof | Match Report | |
| 28 | Sun | 2022-04-03 | 16:45 | Cambuur | 1.4 | 1–2 | 0.5 | NEC Nijmegen | 10,000 | Cambuurstadion | Pol van Boekel | Match Report | |
| 29 | Fri | 2022-04-08 | 20:00 | Go Ahead Eag | 2.5 | 4–0 | 0.9 | Willem II | 9,821 | De Adelaarshorst | Bas Nijhuis | Match Report | |
| 29 | Sat | 2022-04-09 | 18:45 | Utrecht | 2.8 | 1–1 | 1.7 | Fortuna Sittard | 21,216 | Stadion Galgenwaard | Sander van der Eijk | Match Report | |
| 29 | Sat | 2022-04-09 | 20:00 | Ajax | 2.6 | 2–1 | 0.8 | Sparta R'dam | 54,254 | Johan Cruyff ArenA | Pol van Boekel | Match Report | |
| 29 | Sat | 2022-04-09 | 21:00 | NEC Nijmegen | 0.6 | 0–2 | 1.7 | Twente | 12,390 | Goffertstadion | Dennis Higler | Match Report | |
| 29 | Sun | 2022-04-10 | 12:15 | Heerenveen | 1.1 | 3–1 | 0.6 | Groningen | 22,500 | Abe Lenstra Stadion | Danny Makkelie | Match Report | |
| 29 | Sun | 2022-04-10 | 14:30 | Vitesse | 3.1 | 1–0 | 0.2 | Cambuur | 14,970 | GelreDome | Edwin van de Graaf | Match Report | |
| 29 | Sun | 2022-04-10 | 14:30 | PSV Eindhoven | 1.5 | 2–0 | 0.6 | RKC Waalwijk | 33,000 | Philips Stadion | Rob Dieperink | Match Report | |
| 29 | Sun | 2022-04-10 | 16:45 | Heracles Almelo | 1.4 | 1–4 | 2.2 | Feyenoord | 7,461 | Erve Asito | Jeroen Manschot | Match Report | |
| 29 | Sun | 2022-04-10 | 20:00 | Zwolle | 1.4 | 2–1 | 0.7 | AZ Alkmaar | 12,876 | MAC³PARK Stadion | Allard Lindhout | Match Report | |
| 23 | Sat | 2022-04-16 | 18:45 | Fortuna Sittard | 1.1 | 3–0 | 0.5 | Sparta R'dam | 10,032 | Fortuna Sittard Stadion | Serdar Gözübüyük | Match Report | |
| 25 | Tue | 2022-04-19 | 18:45 | Vitesse | 1.3 | 0–1 | 1.2 | Sparta R'dam | 9,771 | GelreDome | Bas Nijhuis | Match Report | |
| 30 | Fri | 2022-04-22 | 20:00 | Twente | 1.7 | 2–0 | 0.3 | Sparta R'dam | 29,100 | De Grolsch Veste | Danny Makkelie | Match Report | |
| 30 | Sat | 2022-04-23 | 16:30 | NEC Nijmegen | 1.2 | 0–1 | 2.8 | Ajax | 12,390 | Goffertstadion | Jeroen Manschot | Match Report | |
| 30 | Sat | 2022-04-23 | 18:45 | AZ Alkmaar | 2.7 | 2–1 | 1.5 | Heerenveen | 17,198 | AFAS Stadion | Martin van den Kerkhof | Match Report | |
| 30 | Sat | 2022-04-23 | 20:00 | RKC Waalwijk | 1.1 | 0–2 | 1.3 | Zwolle | 5,236 | Mandemakers Stadion | Jochem Kamphuis | Match Report | |
| 30 | Sat | 2022-04-23 | 21:00 | Cambuur | 1.0 | 1–2 | 2.8 | PSV Eindhoven | 10,000 | Cambuurstadion | Dennis Higler | Match Report | |
| 30 | Sun | 2022-04-24 | 12:15 | Willem II | 0.5 | 1–0 | 0.8 | Vitesse | 14,500 | Koning Willem II Stadion | Serdar Gözübüyük | Match Report | |
| 30 | Sun | 2022-04-24 | 14:30 | Feyenoord | 1.5 | 2–1 | 0.6 | Utrecht | 47,500 | Stadion Feijenoord | Bas Nijhuis | Match Report | |
| 30 | Sun | 2022-04-24 | 14:30 | Groningen | 0.5 | 0–1 | 0.9 | Heracles Almelo | 20,471 | Hitachi Capital Mobility Stadion | Edwin van de Graaf | Match Report | |
| 30 | Sun | 2022-04-24 | 16:45 | Fortuna Sittard | 1.2 | 1–0 | 0.3 | Go Ahead Eag | 7,557 | Fortuna Sittard Stadion | Joey Kooij | Match Report | |
| 31 | Fri | 2022-04-29 | 20:00 | Utrecht | 2.6 | 1–0 | 0.6 | NEC Nijmegen | 20,665 | Stadion Galgenwaard | Danny Makkelie | Match Report | |
| 31 | Sat | 2022-04-30 | 18:45 | Ajax | 2.3 | 3–0 | 1.3 | Zwolle | 54,102 | Johan Cruyff ArenA | Rob Dieperink | Match Report | |
| 31 | Sat | 2022-04-30 | 20:00 | Heracles Almelo | 1.3 | 1–1 | 0.9 | Twente | 7,845 | Erve Asito | Sander van der Eijk | Match Report | |
| 31 | Sat | 2022-04-30 | 21:00 | Sparta R'dam | 1.5 | 1–1 | 2.0 | AZ Alkmaar | 10,010 | Sparta-Stadion Het Kasteel | Edwin van de Graaf | Match Report | |
| 31 | Sun | 2022-05-01 | 12:15 | Heerenveen | 2.9 | 3–3 | 1.7 | Cambuur | 25,100 | Abe Lenstra Stadion | Bas Nijhuis | Match Report | |
| 31 | Sun | 2022-05-01 | 14:30 | Go Ahead Eag | 1.6 | 1–2 | 1.9 | Vitesse | 9,814 | De Adelaarshorst | Jeroen Manschot | Match Report | |
| 31 | Sun | 2022-05-01 | 14:30 | PSV Eindhoven | 1.6 | 4–2 | 1.4 | Willem II | 33,100 | Philips Stadion | Jochem Kamphuis | Match Report | |
| 31 | Sun | 2022-05-01 | 16:45 | Fortuna Sittard | 1.0 | 1–3 | 4.2 | Feyenoord | 10,512 | Fortuna Sittard Stadion | Allard Lindhout | Match Report | |
| 31 | Sun | 2022-05-01 | 20:00 | RKC Waalwijk | 1.5 | 3–1 | 2.3 | Groningen | 6,348 | Mandemakers Stadion | Serdar Gözübüyük | Match Report | |
| 32 | Fri | 2022-05-06 | 20:00 | Cambuur | 1.8 | 1–1 | 1.8 | RKC Waalwijk | 10,000 | Cambuurstadion | Joey Kooij | Match Report | |
| 32 | Sat | 2022-05-07 | 18:45 | Twente | 2.3 | 1–2 | 1.2 | Fortuna Sittard | 29,500 | De Grolsch Veste | Jochem Kamphuis | Match Report | |
| 32 | Sat | 2022-05-07 | 20:00 | Zwolle | 1.4 | 1–1 | 1.9 | Utrecht | 14,000 | MAC³PARK Stadion | Pol van Boekel | Match Report | |
| 32 | Sat | 2022-05-07 | 20:00 | Willem II | 2.4 | 2–0 | 0.2 | Heracles Almelo | 14,408 | Koning Willem II Stadion | Allard Lindhout | Match Report | |
| 32 | Sat | 2022-05-07 | 21:00 | Groningen | 1.3 | 1–2 | 1.4 | Sparta R'dam | 20,400 | Hitachi Capital Mobility Stadion | Jeroen Manschot | Match Report | |
| 32 | Sun | 2022-05-08 | 12:15 | NEC Nijmegen | 1.7 | 1–0 | 0.5 | Go Ahead Eag | 12,390 | Goffertstadion | Ingmar Oostrom | Match Report | |
| 32 | Sun | 2022-05-08 | 14:30 | AZ Alkmaar | 1.8 | 2–2 | 1.9 | Ajax | 18,033 | AFAS Stadion | Dennis Higler | Match Report | |
| 32 | Sun | 2022-05-08 | 14:30 | Vitesse | 1.4 | 1–2 | 1.7 | Heerenveen | 14,710 | GelreDome | Richard Martens | Match Report | |
| 32 | Sun | 2022-05-08 | 16:45 | Feyenoord | 2.7 | 2–2 | 1.4 | PSV Eindhoven | 47,500 | Stadion Feijenoord | Serdar Gözübüyük | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | Go Ahead Eag | 0.8 | 0–1 | 0.6 | Feyenoord | 9,802 | De Adelaarshorst | Danny Makkelie | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | Utrecht | 1.8 | 2–2 | 1.3 | AZ Alkmaar | 20,085 | Stadion Galgenwaard | Jochem Kamphuis | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | PSV Eindhoven | 2.1 | 3–2 | 2.1 | NEC Nijmegen | 34,274 | Philips Stadion | Bas Nijhuis | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | Cambuur | 1.0 | 1–1 | 1.2 | Willem II | 10,000 | Cambuurstadion | Erwin Blank | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | Fortuna Sittard | 1.8 | 1–2 | 1.3 | Vitesse | 10,883 | Fortuna Sittard Stadion | Pol van Boekel | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | RKC Waalwijk | 1.9 | 2–0 | 0.9 | Heracles Almelo | 6,126 | Mandemakers Stadion | Marc Nagtegaal | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | Ajax | 4.1 | 5–0 | 0.2 | Heerenveen | 54,335 | Johan Cruyff ArenA | Allard Lindhout | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | Sparta R'dam | 0.7 | 2–0 | 1.9 | Zwolle | 10,606 | Sparta-Stadion Het Kasteel | Dennis Higler | Match Report | |
| 33 | Wed | 2022-05-11 | 20:00 | Twente | 2.3 | 3–0 | 0.5 | Groningen | 29,100 | De Grolsch Veste | Martin van den Kerkhof | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | Heerenveen | 1.8 | 3–1 | 0.6 | Go Ahead Eag | 23,200 | Abe Lenstra Stadion | Serdar Gözübüyük | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | Groningen | 1.3 | 2–3 | 1.6 | Cambuur | 21,286 | Hitachi Capital Mobility Stadion | Rob Dieperink | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | AZ Alkmaar | 1.6 | 1–3 | 1.4 | RKC Waalwijk | 17,568 | AFAS Stadion | Sander van der Eijk | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | Vitesse | 2.4 | 2–2 | 2.0 | Ajax | 18,920 | GelreDome | Bas Nijhuis | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | Feyenoord | 1.1 | 1–2 | 1.8 | Twente | 47,500 | Stadion Feijenoord | Jeroen Manschot | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | Zwolle | 2.2 | 1–2 | 2.5 | PSV Eindhoven | 14,000 | MAC³PARK Stadion | Edwin van de Graaf | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | Heracles Almelo | 1.9 | 1–3 | 1.4 | Sparta R'dam | 7,954 | Erve Asito | Danny Makkelie | Match Report | |
| 34 | Sun | 2022-05-15 | 14:30 | Willem II | 2.4 | 3–0 | 1.1 | Utrecht | Koning Willem II Stadion | Martin van den Kerkhof | Match Report | ||
| 34 | Sun | 2022-05-15 | 14:30 | NEC Nijmegen | 2.1 | 0–1 | 1.1 | Fortuna Sittard | 12,390 | Goffertstadion | Dennis Higler | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Semi-finals | Thu | 2022-05-19 | 18:45 | Heerenveen | 1.1 | 3–2 | 0.9 | AZ Alkmaar | 18,000 | Abe Lenstra Stadion | Jeroen Manschot | Match Report | Leg 1 of 2 |
| Semi-finals | Thu | 2022-05-19 | 21:00 | Utrecht | 1.3 | 3–1 | 0.9 | Vitesse | 17,524 | Stadion Galgenwaard | Dennis Higler | Match Report | Leg 1 of 2 |
| Semi-finals | Sun | 2022-05-22 | 14:30 | AZ Alkmaar | 1.5 | 2–0 | 0.6 | Heerenveen | 11,521 | AFAS Stadion | Danny Makkelie | Match Report | Leg 2 of 2; AZ Alkmaar won |
| Semi-finals | Sun | 2022-05-22 | 18:00 | Vitesse | 1.3 | 3–0 | 1.0 | Utrecht | 13,675 | GelreDome | Allard Lindhout | Match Report | Leg 2 of 2; Vitesse won; Required Extra Time |
| Finals | Thu | 2022-05-26 | 20:00 | Vitesse | 0.6 | 2–1 | 0.8 | AZ Alkmaar | 17,547 | GelreDome | Pol van Boekel | Match Report | Leg 1 of 2 |
| Finals | Sun | 2022-05-29 | 14:30 | AZ Alkmaar | 4.0 | 6–1 | 2.1 | Vitesse | 15,222 | AFAS Stadion | Bas Nijhuis | Match Report | Leg 2 of 2; AZ Alkmaar won |
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