| Sat | 2026-02-21 | 13:30 | St. Louis City | 1–1 | Charlotte | 22,423 | Energizer Park | Ismail Elfath | Match Report | |
| Sat | 2026-02-21 | 16:45 | FC Cincinnati | 2–0 | Atlanta Utd | 25,513 | TQL Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2026-02-21 | 16:30 | Vancouver W'caps | 1–0 | Real Salt Lake | 23,546 | BC Place Stadium | Drew Fischer | Match Report | |
| Sat | 2026-02-21 | 18:30 | LAFC | 3–0 | Inter Miami | 75,673 | United Airlines Field at the Los Angeles... | Pierre-Luc Lauziere | Match Report | |
| Sat | 2026-02-21 | 19:30 | D.C. United | 1–0 | Philadelphia Union | 18,003 | Audi Field | Guido Gonzalez Jr. | Match Report | |
| Sat | 2026-02-21 | 19:30 | Portland Timbers | 3–2 | Columbus Crew | 22,210 | Providence Park | Allen Chapman | Match Report | |
| Sat | 2026-02-21 | 19:30 | Houston Dynamo | 2–1 | Chicago Fire | 20,254 | Shell Energy Stadium | Filip Dujic | Match Report | |
| Sat | 2026-02-21 | 19:30 | FC Dallas | 3–2 | Toronto FC | 11,004 | Toyota Stadium | Tim Ford | Match Report | |
| Sat | 2026-02-21 | 19:30 | Nashville SC | 4–1 | NE Revolution | 25,044 | Geodis Park | Tori Penso | Match Report | |
| Sat | 2026-02-21 | 19:30 | Austin FC | 2–2 | Minnesota Utd | 20,738 | Q2 Stadium | Armando Villarreal | Match Report | |
| Sat | 2026-02-21 | 19:30 | Orlando City | 1–2 | RB New York | 24,453 | Inter&Co Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2026-02-21 | 19:30 | SJ Earthquakes | 3–0 | Sporting KC | 16,367 | PayPal Park | Alexis Da Silva | Match Report | |
| Sat | 2026-02-21 | 19:30 | San Diego FC | 5–0 | CF Montréal | 25,412 | Snapdragon Stadium | Joe Dickerson | Match Report | |
| Sun | 2026-02-22 | 16:00 | LA Galaxy | 1–1 | NYCFC | 25,025 | Dignity Health Sports Park | Victor Rivas | Match Report | |
| Sun | 2026-02-22 | 18:15 | Seattle Sounders | 2–0 | Colorado Rapids | 31,606 | Lumen Field | Malik Badawi | Match Report | |
| Sat | 2026-02-28 | 13:30 | Chicago Fire | 3–0 | CF Montréal | 20,872 | Soldier Field | Elijio Arreguin | Match Report | |
| Sat | 2026-02-28 | 14:30 | Colorado Rapids | 2–0 | Portland Timbers | 16,113 | Dick's Sporting Goods Park | Jair Marrufo | Match Report | |
| Sat | 2026-02-28 | 14:30 | RB New York | 1–0 | NE Revolution | 15,087 | Sports Illustrated Stadium | Ricardo Montero | Match Report | |
| Sat | 2026-02-28 | 15:30 | Minnesota Utd | 1–0 | FC Cincinnati | 19,609 | Allianz Field | Marcos de Oliveira | Match Report | |
| Sun | 2026-03-01 | 13:30 | Austin FC | 1–0 | D.C. United | 20,738 | Q2 Stadium | Lorenzo Hernandez | Match Report | |
| Sat | 2026-02-28 | 16:30 | SJ Earthquakes | 2–0 | Atlanta Utd | 16,159 | PayPal Park | Ricardo Fierro | Match Report | |
| Sun | 2026-03-01 | 16:30 | Philadelphia Union | 1–2 | NYCFC | 18,513 | Subaru Park | Chris Penso | Match Report | |
| Sat | 2026-02-28 | 17:30 | Real Salt Lake | 2–1 | Seattle Sounders | 20,660 | America First Field | Tori Penso | Match Report | |
| Sat | 2026-02-28 | 18:30 | Vancouver W'caps | 3–0 | Toronto FC | 24,533 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-02-28 | 19:30 | FC Dallas | 0–0 | Nashville SC | 11,004 | Toyota Stadium | Serhii Boiko | Match Report | |
| Sat | 2026-02-28 | 19:30 | Sporting KC | 2–2 | Columbus Crew | 18,522 | Children's Mercy Park | Sergii Demianchuk | Match Report | |
| Sat | 2026-02-28 | 19:30 | Houston Dynamo | 0–2 | LAFC | 20,853 | Shell Energy Stadium | Jon Freemon | Match Report | |
| Sat | 2026-02-28 | 19:30 | LA Galaxy | 3–0 | Charlotte | 20,205 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sun | 2026-03-01 | 18:15 | San Diego FC | 2–0 | St. Louis City | 21,969 | Snapdragon Stadium | Drew Fischer | Match Report | |
| Sun | 2026-03-01 | 19:00 | Orlando City | 2–4 | Inter Miami | 24,453 | Inter&Co Stadium | Ismail Elfath | Match Report | |
| Sat | 2026-03-07 | 14:30 | NYCFC | 5–0 | Orlando City | 25,055 | Yankee Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2026-03-07 | 16:30 | D.C. United | 1–2 | Inter Miami | 72,026 | M&T Bank Stadium | Filip Dujic | Match Report | |
| Sun | 2026-03-08 | 16:30 | RB New York | 0–3 | CF Montréal | 16,847 | Sports Illustrated Stadium | Serhii Boiko | Match Report | |
| Sun | 2026-03-08 | 19:00 | FC Cincinnati | 0–1 | Toronto FC | 25,513 | TQL Stadium | Alexis Da Silva | Match Report | |
| Sat | 2026-03-07 | 19:30 | Philadelphia Union | 0–1 | SJ Earthquakes | 17,410 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2026-03-07 | 19:30 | Columbus Crew | 0–0 | Chicago Fire | 20,121 | ScottsMiracle-Gro Field | Tori Penso | Match Report | |
| Sat | 2026-03-07 | 19:30 | Colorado Rapids | 4–1 | LA Galaxy | 14,568 | Dick's Sporting Goods Park | Allen Chapman | Match Report | |
| Sat | 2026-03-07 | 19:30 | St. Louis City | 0–1 | Seattle Sounders | 22,423 | Energizer Park | Tim Ford | Match Report | |
| Sat | 2026-03-07 | 19:30 | LAFC | 1–0 | FC Dallas | 22,130 | BMO Stadium | Drew Fischer | Match Report | |
| Sat | 2026-03-07 | 19:30 | Charlotte | 3–1 | Austin FC | 35,611 | Bank of America Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2026-03-07 | 19:30 | Atlanta Utd | 2–3 | Real Salt Lake | 53,862 | Mercedes-Benz Stadium | Jon Freemon | Match Report | |
| Sat | 2026-03-07 | 19:30 | Nashville SC | 3–1 | Minnesota Utd | 24,387 | Geodis Park | Pierre-Luc Lauziere | Match Report | |
| Sat | 2026-03-07 | 19:30 | Portland Timbers | 1–4 | Vancouver W'caps | 22,473 | Providence Park | Victor Rivas | Match Report | |
| Sat | 2026-03-07 | 19:30 | Sporting KC | 0–1 | San Diego FC | 14,294 | Children's Mercy Park | Malik Badawi | Match Report | |
| Sat | 2026-03-14 | 13:00 | Toronto FC | 1–1 | RB New York | 18,767 | BMO Field | Chris Penso | Match Report | |
| Sat | 2026-03-14 | 15:15 | Atlanta Utd | 3–1 | Philadelphia Union | 35,308 | Mercedes-Benz Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2026-03-14 | 18:15 | Columbus Crew | 0–1 | Nashville SC | 19,960 | ScottsMiracle-Gro Field | Fotis Bazakos | Match Report | |
| Sat | 2026-03-14 | 19:30 | NYCFC | 3–1 | Colorado Rapids | 18,079 | Yankee Stadium | Brandon Stevis | Match Report | |
| Sat | 2026-03-14 | 19:30 | Orlando City | 2–1 | CF Montréal | 18,035 | Inter&Co Stadium | Jair Marrufo | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-03-14 | 19:30 | Charlotte | 0–0 | Inter Miami | 34,780 | Bank of America Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2026-03-15 | 13:30 | Vancouver W'caps | 6–0 | Minnesota Utd | 23,885 | BC Place Stadium | Ricardo Fierro | Match Report | |
| Sun | 2026-03-15 | 14:30 | NE Revolution | 6–1 | FC Cincinnati | 15,627 | Gillette Stadium | Lorenzo Hernandez | Match Report | |
| Sun | 2026-03-15 | 16:00 | SJ Earthquakes | 0–1 | Seattle Sounders | 18,251 | PayPal Park | Victor Rivas | Match Report | |
| Sat | 2026-03-14 | 18:30 | LA Galaxy | 1–2 | Sporting KC | 18,232 | Dignity Health Sports Park | Ismail Elfath | Match Report | |
| Sat | 2026-03-14 | 19:30 | Real Salt Lake | 2–1 | Austin FC | 20,751 | America First Field | Elijio Arreguin | Match Report | |
| Sat | 2026-03-14 | 19:30 | FC Dallas | 3–3 | San Diego FC | 11,004 | Toyota Stadium | Ricardo Montero | Match Report | |
| Sat | 2026-03-14 | 19:30 | LAFC | 2–0 | St. Louis City | 22,266 | BMO Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2026-03-14 | 19:30 | Houston Dynamo | 3–2 | Portland Timbers | 18,026 | Shell Energy Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2026-03-14 | 19:30 | Chicago Fire | 1–2 | D.C. United | 15,845 | Soldier Field | Sergii Demianchuk | Match Report | |
| Sat | 2026-03-21 | 13:00 | Toronto FC | 2–1 | Columbus Crew | 15,384 | BMO Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2026-03-21 | 16:30 | Philadelphia Union | 1–2 | Chicago Fire | 18,753 | Subaru Park | Nabil Bensalah | Match Report | |
| Sat | 2026-03-21 | 17:15 | Nashville SC | 5–0 | Orlando City | 27,167 | Geodis Park | Victor Rivas | Match Report | |
| Sat | 2026-03-21 | 19:30 | Atlanta Utd | 0–0 | D.C. United | 35,418 | Mercedes-Benz Stadium | Jair Marrufo | Match Report | |
| Sat | 2026-03-21 | 19:30 | Charlotte | 6–1 | RB New York | 27,166 | Bank of America Stadium | Allen Chapman | Match Report | |
| Sun | 2026-03-22 | 13:00 | FC Cincinnati | 4–3 | CF Montréal | 25,513 | TQL Stadium | Filip Dujic | Match Report | |
| Sun | 2026-03-22 | 13:00 | NYCFC | 2–3 | Inter Miami | 45,845 | Yankee Stadium | Armando Villarreal | Match Report | |
| Sun | 2026-03-22 | 13:30 | Minnesota Utd | 0–0 | Seattle Sounders | 19,637 | Allianz Field | Jon Freemon | Match Report | |
| Sun | 2026-03-22 | 13:45 | Portland Timbers | 1–1 | LA Galaxy | 23,075 | Providence Park | Drew Fischer | Match Report | |
| Sun | 2026-03-22 | 16:00 | San Diego FC | 2–2 | Real Salt Lake | 24,141 | Snapdragon Stadium | Alexis Da Silva | Match Report | |
| Sat | 2026-03-21 | 19:30 | Vancouver W'caps | 0–1 | SJ Earthquakes | 21,261 | BC Place Stadium | Chris Penso | Match Report | |
| Sat | 2026-03-21 | 19:30 | Sporting KC | 1–4 | Colorado Rapids | 17,037 | Children's Mercy Park | Fotis Bazakos | Match Report | |
| Sat | 2026-03-21 | 19:30 | FC Dallas | 4–3 | Houston Dynamo | 11,004 | Toyota Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2026-03-21 | 19:30 | St. Louis City | 3–1 | NE Revolution | 22,423 | Energizer Park | Serhii Boiko | Match Report | |
| Sat | 2026-03-21 | 19:45 | Austin FC | 0–0 | LAFC | 20,738 | Q2 Stadium | Rubiel Vazquez | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-04-04 | 13:00 | Toronto FC | 3–2 | Colorado Rapids | 14,442 | BMO Field | Ricardo Montero | Match Report | |
| Sat | 2026-04-04 | 14:30 | Real Salt Lake | 3–1 | Sporting KC | 20,290 | America First Field | Tim Ford | Match Report | |
| Sat | 2026-04-04 | 16:30 | NE Revolution | 3–0 | CF Montréal | 19,461 | Gillette Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2026-04-04 | 19:30 | NYCFC | 1–1 | St. Louis City | 20,867 | Citi Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2026-04-04 | 19:30 | RB New York | 4–2 | FC Cincinnati | 20,867 | Sports Illustrated Stadium | Victor Rivas | Match Report | |
| Sat | 2026-04-04 | 19:30 | D.C. United | 0–4 | FC Dallas | 19,215 | Audi Field | Rubiel Vazquez | Match Report | |
| Sat | 2026-04-04 | 19:30 | Atlanta Utd | 1–3 | Columbus Crew | 34,130 | Mercedes-Benz Stadium | Lorenzo Hernandez | Match Report | |
| Sat | 2026-04-04 | 19:30 | Inter Miami | 2–2 | Austin FC | 26,412 | Nu Stadium | Allen Chapman | Match Report | |
| Sat | 2026-04-04 | 19:30 | Charlotte | 2–1 | Philadelphia Union | 25,865 | Bank of America Stadium | Drew Fischer | Match Report | |
| Sat | 2026-04-04 | 18:30 | LAFC | 6–0 | Orlando City | 22,185 | BMO Stadium | Alexis Da Silva | Match Report | |
| Sat | 2026-04-04 | 19:30 | Vancouver W'caps | 3–2 | Portland Timbers | 25,465 | BC Place Stadium | Joe Dickerson | Match Report | |
| Sat | 2026-04-04 | 19:30 | Chicago Fire | 1–0 | Nashville SC | 15,932 | Soldier Field | Marcos de Oliveira | Match Report | |
| Sat | 2026-04-04 | 19:30 | SJ Earthquakes | 3–0 | San Diego FC | 18,251 | PayPal Park | Fotis Bazakos | Match Report | |
| Sat | 2026-04-04 | 19:30 | LA Galaxy | 1–2 | Minnesota Utd | 22,447 | Dignity Health Sports Park | Malik Badawi | Match Report | |
| Sat | 2026-04-04 | 20:00 | Houston Dynamo | 0–1 | Seattle Sounders | 17,253 | Shell Energy Stadium | Ismail Elfath | Match Report | |
| Sat | 2026-04-11 | 13:00 | Toronto FC | 1–1 | FC Cincinnati | 15,770 | BMO Field | Ricardo Fierro | Match Report | |
| Sat | 2026-04-11 | 13:30 | Austin FC | 1–2 | LA Galaxy | 20,738 | Q2 Stadium | Tori Penso | Match Report | |
| Sat | 2026-04-11 | 13:45 | Portland Timbers | 2–1 | LAFC | 24,686 | Providence Park | Armando Villarreal | Match Report | |
| Sat | 2026-04-11 | 14:30 | CF Montréal | 1–2 | Philadelphia Union | 14,028 | Stade Saputo | Alexis Da Silva | Match Report | |
| Sat | 2026-04-11 | 16:30 | Vancouver W'caps | 2–0 | NYCFC | 25,460 | BC Place Stadium | Jair Marrufo | Match Report | |
| Sat | 2026-04-11 | 19:30 | Charlotte | 1–2 | Nashville SC | 26,012 | Bank of America Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2026-04-11 | 19:30 | Inter Miami | 2–2 | RB New York | 26,277 | Nu Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2026-04-11 | 19:30 | NE Revolution | 1–0 | D.C. United | 15,454 | Gillette Stadium | Jon Freemon | Match Report | |
| Sun | 2026-04-12 | 19:00 | Columbus Crew | 1–1 | Orlando City | 19,834 | ScottsMiracle-Gro Field | Ricardo Montero | Match Report | |
| Sat | 2026-04-11 | 19:30 | FC Dallas | 1–1 | St. Louis City | 11,004 | Toyota Stadium | Filip Dujic | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-04-11 | 19:30 | Colorado Rapids | 6–2 | Houston Dynamo | 15,102 | Dick's Sporting Goods Park | Serhii Boiko | Match Report | |
| Sat | 2026-04-11 | 19:30 | Sporting KC | 1–3 | SJ Earthquakes | 16,921 | Children's Mercy Park | Allen Chapman | Match Report | |
| Sat | 2026-04-11 | 19:30 | San Diego FC | 1–2 | Minnesota Utd | 23,394 | Snapdragon Stadium | Victor Rivas | Match Report | |
| Sat | 2026-04-11 | 19:30 | Chicago Fire | 1–0 | Atlanta Utd | 17,764 | Soldier Field | Drew Fischer | Match Report | |
| Sat | 2026-04-18 | 13:00 | Toronto FC | 3–3 | Austin FC | 16,550 | BMO Field | Drew Fischer | Match Report | |
| Sat | 2026-04-18 | 14:30 | CF Montréal | 4–1 | RB New York | 12,568 | Stade Saputo | Sergii Demianchuk | Match Report | |
| Sat | 2026-04-18 | 14:30 | Colorado Rapids | 2–3 | Inter Miami | 75,824 | Empower Field at Mile High | Jon Freemon | Match Report | |
| Sat | 2026-04-18 | 19:30 | Philadelphia Union | 0–0 | D.C. United | 18,529 | Subaru Park | Lorenzo Hernandez | Match Report | |
| Sat | 2026-04-18 | 19:30 | NE Revolution | 2–1 | Columbus Crew | 16,257 | Gillette Stadium | Tim Ford | Match Report | |
| Sat | 2026-04-18 | 19:30 | FC Cincinnati | 3–3 | Chicago Fire | 25,513 | TQL Stadium | Malik Badawi | Match Report | |
| Sat | 2026-04-18 | 19:30 | NYCFC | 1–2 | Charlotte | 20,997 | Citi Field | Tori Penso | Match Report | |
| Sat | 2026-04-18 | 19:30 | Orlando City | 0–1 | Houston Dynamo | 19,243 | Inter&Co Stadium | Pierre-Luc Lauziere | Match Report | |
| Fri | 2026-04-17 | 19:30 | Vancouver W'caps | 3–0 | Sporting KC | 21,777 | BC Place Stadium | Elijio Arreguin | Match Report | |
| Sat | 2026-04-18 | 19:30 | Atlanta Utd | 0–2 | Nashville SC | 36,895 | Mercedes-Benz Stadium | Allen Chapman | Match Report | |
| Sun | 2026-04-19 | 16:00 | LAFC | 1–4 | SJ Earthquakes | 22,114 | BMO Stadium | Joe Dickerson | Match Report | |
| Sat | 2026-04-18 | 18:30 | Seattle Sounders | 4–1 | St. Louis City | 30,596 | Lumen Field | Chris Penso | Match Report | |
| Sat | 2026-04-18 | 19:30 | Minnesota Utd | 2–0 | Portland Timbers | 19,617 | Allianz Field | Nabil Bensalah | Match Report | |
| Sat | 2026-04-18 | 19:30 | FC Dallas | 2–2 | LA Galaxy | 11,004 | Toyota Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2026-04-18 | 19:30 | Real Salt Lake | 4–2 | San Diego FC | 20,852 | America First Field | Ismail Elfath | Match Report | |
| Wed | 2026-04-22 | 19:30 | RB New York | 4–4 | D.C. United | 13,309 | Sports Illustrated Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2026-04-22 | 19:30 | NYCFC | 4–4 | FC Cincinnati | 7,099 | Yankee Stadium | Serhii Boiko | Match Report | |
| Wed | 2026-04-22 | 19:30 | Toronto FC | 3–3 | Philadelphia Union | 15,461 | BMO Field | Fotis Bazakos | Match Report | |
| Wed | 2026-04-22 | 19:30 | Orlando City | 4–1 | Charlotte | 16,089 | Inter&Co Stadium | Filip Dujic | Match Report | |
| Wed | 2026-04-22 | 19:45 | Atlanta Utd | 1–2 | NE Revolution | 30,306 | Mercedes-Benz Stadium | Ricardo Montero | Match Report | |
| Wed | 2026-04-22 | 19:30 | FC Dallas | 0–1 | Minnesota Utd | 11,004 | Toyota Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2026-04-22 | 19:30 | Houston Dynamo | 1–0 | San Diego FC | 15,838 | Shell Energy Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2026-04-22 | 19:30 | Real Salt Lake | 0–2 | Inter Miami | 21,512 | America First Field | Pierre-Luc Lauziere | Match Report | |
| Wed | 2026-04-22 | 19:30 | LAFC | 0–0 | Colorado Rapids | 22,132 | BMO Stadium | Victor Rivas | Match Report | |
| Wed | 2026-04-22 | 19:30 | SJ Earthquakes | 5–1 | Austin FC | 12,276 | PayPal Park | Tim Ford | Match Report | |
| Wed | 2026-04-22 | 21:45 | Columbus Crew | 2–1 | LA Galaxy | 19,049 | ScottsMiracle-Gro Field | Rosendo Mendoza | Match Report | |
| Sat | 2026-04-25 | 13:00 | Toronto FC | 1–2 | Atlanta Utd | 13,754 | BMO Field | Ismail Elfath | Match Report | |
| Sat | 2026-04-25 | 14:30 | CF Montréal | 1–0 | NYCFC | 14,015 | Stade Saputo | Ramy Touchan | Match Report | |
| Sat | 2026-04-25 | 15:45 | Minnesota Utd | 0–1 | LAFC | 19,710 | Allianz Field | Guido Gonzalez Jr. | Match Report | |
| Sat | 2026-04-25 | 19:30 | FC Cincinnati | 2–0 | RB New York | 25,513 | TQL Stadium | Fotis Bazakos | Match Report | |
| Sat | 2026-04-25 | 19:30 | Columbus Crew | 2–0 | Philadelphia Union | 19,903 | ScottsMiracle-Gro Field | Filip Dujic | Match Report | |
| Sat | 2026-04-25 | 19:30 | D.C. United | 3–2 | Orlando City | 14,040 | Audi Field | Chris Penso | Match Report | |
| Sat | 2026-04-25 | 19:30 | Inter Miami | 1–1 | NE Revolution | 26,609 | Nu Stadium | Rubiel Vazquez | Match Report | |
| Sun | 2026-04-26 | 16:00 | LA Galaxy | 2–1 | Real Salt Lake | 19,773 | Dignity Health Sports Park | Victor Rivas | Match Report | |
| Sat | 2026-04-25 | 18:30 | San Diego FC | 1–2 | Portland Timbers | 22,369 | Snapdragon Stadium | Jon Freemon | Match Report | |
| Sat | 2026-04-25 | 19:30 | Vancouver W'caps | 3–1 | Colorado Rapids | 27,588 | BC Place Stadium | Lorenzo Hernandez | Match Report | |
| Sat | 2026-04-25 | 19:30 | St. Louis City | 2–3 | SJ Earthquakes | 22,423 | Energizer Park | Drew Fischer | Match Report | |
| Sat | 2026-04-25 | 19:30 | Austin FC | 2–0 | Houston Dynamo | 20,738 | Q2 Stadium | Alexis Da Silva | Match Report | |
| Sat | 2026-04-25 | 19:30 | Nashville SC | 4–2 | Charlotte | 30,109 | Geodis Park | Joe Dickerson | Match Report | |
| Sat | 2026-04-25 | 19:30 | Seattle Sounders | 2–1 | FC Dallas | 31,785 | Lumen Field | Jon Freemon | Match Report | |
| Sat | 2026-04-25 | 19:30 | Chicago Fire | 5–0 | Sporting KC | 17,892 | Soldier Field | Brandon Stevis | Match Report | |
| Sat | 2026-05-02 | 13:00 | Toronto FC | 1–1 | SJ Earthquakes | 19,021 | BMO Field | Michael Venne | Match Report | |
| Sat | 2026-05-02 | 13:30 | Sporting KC | 1–1 | Seattle Sounders | 16,378 | Children's Mercy Park | Sergii Demianchuk | Match Report | |
| Sat | 2026-05-02 | 14:45 | Real Salt Lake | 2–0 | Portland Timbers | 20,614 | America First Field | Rosendo Mendoza | Match Report | |
| Sat | 2026-05-02 | 19:15 | Inter Miami | 3–4 | Orlando City | 26,684 | Nu Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2026-05-02 | 19:30 | NE Revolution | 1–0 | Charlotte | 22,851 | Gillette Stadium | Pierre-Luc Lauziere | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-05-02 | 19:30 | Atlanta Utd | 3–1 | CF Montréal | 34,703 | Mercedes-Benz Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2026-05-02 | 19:30 | Columbus Crew | 2–3 | Minnesota Utd | 18,904 | ScottsMiracle-Gro Field | Serhii Boiko | Match Report | |
| Sat | 2026-05-02 | 19:30 | Philadelphia Union | 0–0 | Nashville SC | 17,430 | Subaru Park | Elijio Arreguin | Match Report | |
| Sat | 2026-05-02 | 19:30 | RB New York | 0–2 | FC Dallas | 20,414 | Sports Illustrated Stadium | Jair Marrufo | Match Report | |
| Sun | 2026-05-03 | 15:00 | NYCFC | 0–2 | D.C. United | 23,931 | Citi Field | Ismail Elfath | Match Report | |
| Sun | 2026-05-03 | 16:30 | Austin FC | 2–0 | St. Louis City | 20,738 | Q2 Stadium | Jon Freemon | Match Report | |
| Sat | 2026-05-02 | 18:30 | San Diego FC | 2–2 | LAFC | 28,459 | Snapdragon Stadium | Filip Dujic | Match Report | |
| Sat | 2026-05-02 | 19:30 | LA Galaxy | 1–1 | Vancouver W'caps | 19,429 | Dignity Health Sports Park | Alexis Da Silva | Match Report | |
| Sat | 2026-05-02 | 19:30 | Houston Dynamo | 1–0 | Colorado Rapids | 18,889 | Shell Energy Stadium | Allen Chapman | Match Report | |
| Sat | 2026-05-02 | 19:30 | Chicago Fire | 2–3 | FC Cincinnati | 18,639 | Soldier Field | Joe Dickerson | Match Report | |
| Sat | 2026-05-09 | 13:00 | Toronto FC | 2–4 | Inter Miami | 44,828 | BMO Field | Victor Rivas | Match Report | |
| Sat | 2026-05-09 | 13:30 | Chicago Fire | 1–3 | RB New York | 23,647 | Soldier Field | Allen Chapman | Match Report | |
| Sat | 2026-05-09 | 16:30 | CF Montréal | 2–0 | Orlando City | 14,044 | Stade Saputo | Marcos de Oliveira | Match Report | |
| Sat | 2026-05-09 | 19:30 | NE Revolution | 2–1 | Philadelphia Union | 18,561 | Gillette Stadium | Tori Penso | Match Report | |
| Sat | 2026-05-09 | 19:30 | Charlotte | 2–2 | FC Cincinnati | 26,252 | Bank of America Stadium | Ismail Elfath | Match Report | |
| Sat | 2026-05-09 | 19:30 | Atlanta Utd | 1–2 | LA Galaxy | 40,392 | Mercedes-Benz Stadium | Fotis Bazakos | Match Report | |
| Sun | 2026-05-10 | 16:30 | NYCFC | 3–0 | Columbus Crew | 17,770 | Yankee Stadium | Rubiel Vazquez | Match Report | |
| Sun | 2026-05-10 | 18:00 | Minnesota Utd | 2–2 | Austin FC | 18,749 | Allianz Field | Chris Penso | Match Report | |
| Sat | 2026-05-09 | 19:30 | FC Dallas | 3–1 | Real Salt Lake | 11,004 | Toyota Stadium | Joe Dickerson | Match Report | |
| Sat | 2026-05-09 | 19:30 | Seattle Sounders | 1–1 | San Diego FC | 31,528 | Lumen Field | Armando Villarreal | Match Report | |
| Sat | 2026-05-09 | 19:30 | Colorado Rapids | 0–1 | St. Louis City | 16,028 | Dick's Sporting Goods Park | Tim Ford | Match Report | |
| Sat | 2026-05-09 | 19:30 | Portland Timbers | 6–0 | Sporting KC | 22,384 | Providence Park | Ramy Touchan | Match Report | |
| Sat | 2026-05-09 | 19:30 | SJ Earthquakes | 1–1 | Vancouver W'caps | 18,000 | PayPal Park | Malik Badawi | Match Report | |
| Sat | 2026-05-09 | 20:15 | Nashville SC | 2–2 | D.C. United | 28,384 | Geodis Park | Joshua Encarnacion | Match Report | |
| Sun | 2026-05-10 | 18:00 | LAFC | 1–4 | Houston Dynamo | 21,531 | BMO Stadium | Drew Fischer | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2026-05-13 | 19:15 | Charlotte | 0–1 | NYCFC | 23,903 | Bank of America Stadium | Jon Freemon | Match Report | |
| Wed | 2026-05-13 | 19:30 | NE Revolution | 0–3 | Nashville SC | | Gillette Stadium | Sergii Demianchuk | Match Report | |
| Wed | 2026-05-13 | 19:30 | D.C. United | 1–3 | Chicago Fire | | Audi Field | Ricardo Fierro | Match Report | |
| Wed | 2026-05-13 | 19:30 | FC Cincinnati | 3–5 | Inter Miami | 25,513 | TQL Stadium | Alexis Da Silva | Match Report | |
| Wed | 2026-05-13 | 19:30 | RB New York | 3–2 | Columbus Crew | | Sports Illustrated Stadium | Pierre-Luc Lauziere | Match Report | |
| Wed | 2026-05-13 | 19:30 | CF Montréal | 2–2 | Portland Timbers | 12,251 | Stade Saputo | Allen Chapman | Match Report | |
| Wed | 2026-05-13 | 19:30 | Orlando City | 4–3 | Philadelphia Union | 15,656 | Inter&Co Stadium | Serhii Boiko | Match Report | |
| Wed | 2026-05-13 | 18:30 | San Diego FC | 5–0 | Austin FC | 19,194 | Snapdragon Stadium | Malik Badawi | Match Report | |
| Wed | 2026-05-13 | 18:30 | Seattle Sounders | 3–2 | SJ Earthquakes | 28,726 | Lumen Field | Filip Dujic | Match Report | |
| Wed | 2026-05-13 | 19:30 | St. Louis City | 2–1 | LAFC | 22,423 | Energizer Park | Lorenzo Hernandez | Match Report | |
| Wed | 2026-05-13 | 19:30 | FC Dallas | 2–3 | Vancouver W'caps | 11,004 | Toyota Stadium | Rosendo Mendoza | Match Report | |
| Wed | 2026-05-13 | 19:30 | Minnesota Utd | 0–1 | Colorado Rapids | 18,458 | Allianz Field | Elijio Arreguin | Match Report | |
| Wed | 2026-05-13 | 19:30 | Sporting KC | 3–1 | LA Galaxy | | Children's Mercy Park | Ricardo Montero | Match Report | |
| Wed | 2026-05-13 | 19:30 | Real Salt Lake | 3–0 | Houston Dynamo | 20,429 | America First Field | Jair Marrufo | Match Report | |
| Sat | 2026-05-16 | 16:30 | CF Montréal | 0–2 | Chicago Fire | 16,018 | Stade Saputo | Fotis Bazakos | Match Report | |
| Sat | 2026-05-16 | 19:30 | RB New York | 1–1 | NYCFC | 25,219 | Sports Illustrated Stadium | Victor Rivas | Match Report | |
| Sat | 2026-05-16 | 19:30 | Charlotte | 3–1 | Toronto FC | 28,158 | Bank of America Stadium | Allen Chapman | Match Report | |
| Sat | 2026-05-16 | 19:30 | NE Revolution | 2–1 | Minnesota Utd | 26,358 | Gillette Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2026-05-16 | 19:30 | D.C. United | 1–1 | St. Louis City | 16,888 | Audi Field | Rodrigo Albuquerque | Match Report | |
| Sat | 2026-05-16 | 19:30 | Orlando City | 1–1 | Atlanta Utd | 20,074 | Inter&Co Stadium | Tori Penso | Match Report | |
| Sat | 2026-05-16 | 19:30 | Philadelphia Union | 1–1 | Columbus Crew | 17,505 | Subaru Park | Armando Villarreal | Match Report | |
| Sun | 2026-05-17 | 18:00 | Inter Miami | 2–0 | Portland Timbers | 26,715 | Nu Stadium | Drew Fischer | Match Report | |
| Sat | 2026-05-16 | 18:15 | Seattle Sounders | 0–2 | LA Galaxy | 35,659 | Lumen Field | Joe Dickerson | Match Report | |
| Sat | 2026-05-16 | 18:30 | San Diego FC | 3–3 | FC Cincinnati | 24,984 | Snapdragon Stadium | Tim Ford | Match Report | |
| Sat | 2026-05-16 | 19:30 | SJ Earthquakes | 2–3 | FC Dallas | 18,000 | PayPal Park | Chris Penso | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-05-16 | 19:30 | Real Salt Lake | 2–1 | Colorado Rapids | 21,424 | America First Field | Malik Badawi | Match Report | |
| Sat | 2026-05-16 | 19:30 | Houston Dynamo | 1–0 | Vancouver W'caps | 20,114 | Shell Energy Stadium | Ismail Elfath | Match Report | |
| Sat | 2026-05-16 | 19:30 | Austin FC | 1–2 | Sporting KC | 20,738 | Q2 Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2026-05-17 | 19:00 | Nashville SC | 3–2 | LAFC | 27,948 | Geodis Park | Rubiel Vazquez | Match Report | |
| Sat | 2026-05-23 | 13:45 | St. Louis City | 3–0 | Austin FC | 22,423 | Energizer Park | Pierre-Luc Lauziere | Match Report | |
| Sat | 2026-05-23 | 15:30 | Minnesota Utd | 1–1 | Real Salt Lake | 19,838 | Allianz Field | Tori Penso | Match Report | |
| Sat | 2026-05-23 | 19:30 | FC Cincinnati | 6–2 | Orlando City | | TQL Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2026-05-23 | 19:30 | Charlotte | 1–0 | NE Revolution | | Bank of America Stadium | Fotis Bazakos | Match Report | |
| Sat | 2026-05-23 | 19:30 | D.C. United | 4–4 | CF Montréal | | Audi Field | Filip Dujic | Match Report | |
| Sun | 2026-05-24 | 17:00 | Columbus Crew | 2–0 | Atlanta Utd | | ScottsMiracle-Gro Field | Chris Penso | Match Report | |
| Sat | 2026-05-23 | 18:30 | Portland Timbers | 1–3 | SJ Earthquakes | | Providence Park | Tim Ford | Match Report | |
| Sat | 2026-05-23 | 18:30 | San Diego FC | 2–4 | Vancouver W'caps | | Snapdragon Stadium | Drew Fischer | Match Report | |
| Sun | 2026-05-24 | 19:00 | Inter Miami | 6–4 | Philadelphia Union | | Nu Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2026-05-23 | 19:30 | Chicago Fire | 2–1 | Toronto FC | 26,752 | Soldier Field | Sergii Demianchuk | Match Report | |
| Sat | 2026-05-23 | 19:30 | Sporting KC | 1–2 | RB New York | 17,575 | Children's Mercy Park | Nabil Bensalah | Match Report | |
| Sat | 2026-05-23 | 19:30 | Colorado Rapids | 1–2 | FC Dallas | | Dick's Sporting Goods Park | Ismail Elfath | Match Report | |
| Sat | 2026-05-23 | 19:30 | Nashville SC | 2–1 | NYCFC | | Geodis Park | Alexis Da Silva | Match Report | |
| Sat | 2026-05-23 | 19:30 | LA Galaxy | 1–1 | Houston Dynamo | | Dignity Health Sports Park | Lorenzo Hernandez | Match Report | |
| Sun | 2026-05-24 | 18:15 | LAFC | 1–0 | Seattle Sounders | | BMO Stadium | Ramy Touchan | Match Report | |
| Thu | 2026-07-16 | 19:30 | CF Montréal | | Toronto FC | | Stade Saputo | | Head-to-Head | |
| Thu | 2026-07-16 | 19:30 | Seattle Sounders | | Portland Timbers | | Lumen Field | | Head-to-Head | |
| Thu | 2026-07-16 | 19:30 | Chicago Fire | | Vancouver W'caps | | Soldier Field | | Head-to-Head | |
| Thu | 2026-07-16 | 19:30 | St. Louis City | | Sporting KC | | Energizer Park | | Head-to-Head | |
| Fri | 2026-07-17 | 19:00 | Nashville SC | | Atlanta Utd | | Geodis Park | | Head-to-Head | |
| Fri | 2026-07-17 | 19:45 | LA Galaxy | | LAFC | | Dignity Health Sports Park | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2026-07-22 | 19:30 | NE Revolution | | Toronto FC | | Gillette Stadium | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Philadelphia Union | | RB New York | | Subaru Park | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Columbus Crew | | NYCFC | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | FC Cincinnati | | Vancouver W'caps | | TQL Stadium | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Inter Miami | | Chicago Fire | | Nu Stadium | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | SJ Earthquakes | | Orlando City | | PayPal Park | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Portland Timbers | | FC Dallas | | Providence Park | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | LA Galaxy | | St. Louis City | | Dignity Health Sports Park | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Sporting KC | | Minnesota Utd | | Children's Mercy Park | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | LAFC | | Real Salt Lake | | BMO Stadium | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Houston Dynamo | | D.C. United | | Shell Energy Stadium | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Austin FC | | Seattle Sounders | | Q2 Stadium | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Colorado Rapids | | San Diego FC | | Dick's Sporting Goods Park | | Head-to-Head | |
| Wed | 2026-07-22 | 19:30 | Nashville SC | | CF Montréal | | Geodis Park | | Head-to-Head | |
| Wed | 2026-07-22 | 20:15 | Charlotte | | Atlanta Utd | | Bank of America Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 18:30 | RB New York | | Charlotte | | Sports Illustrated Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 19:00 | Columbus Crew | | FC Cincinnati | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | Orlando City | | Nashville SC | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | NE Revolution | | Atlanta Utd | | Gillette Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | CF Montréal | | Inter Miami | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | D.C. United | | Toronto FC | | Audi Field | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | Philadelphia Union | | Seattle Sounders | | Subaru Park | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | NYCFC | | Chicago Fire | | Yankee Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 18:30 | San Diego FC | | FC Dallas | | Snapdragon Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | St. Louis City | | Colorado Rapids | | Energizer Park | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-07-25 | 19:30 | Houston Dynamo | | Austin FC | | Shell Energy Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | LAFC | | Sporting KC | | BMO Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | Portland Timbers | | Real Salt Lake | | Providence Park | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | SJ Earthquakes | | LA Galaxy | | Stanford Stadium | | Head-to-Head | |
| Sat | 2026-07-25 | 19:30 | Minnesota Utd | | Vancouver W'caps | | Allianz Field | | Head-to-Head | |
| Fri | 2026-07-31 | 19:30 | NYCFC | | Toronto FC | | Yankee Stadium | | Head-to-Head | |
| Sat | 2026-08-01 | 16:30 | Vancouver W'caps | | LAFC | | BC Place Stadium | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | D.C. United | | Nashville SC | | Audi Field | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | Inter Miami | | Columbus Crew | | Nu Stadium | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | RB New York | | Orlando City | | Sports Illustrated Stadium | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | FC Cincinnati | | SJ Earthquakes | | TQL Stadium | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | CF Montréal | | NE Revolution | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | Philadelphia Union | | Atlanta Utd | | Subaru Park | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | Minnesota Utd | | San Diego FC | | Allianz Field | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | LA Galaxy | | FC Dallas | | Dignity Health Sports Park | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | Colorado Rapids | | Austin FC | | Dick's Sporting Goods Park | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | Chicago Fire | | Charlotte | | Soldier Field | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | Sporting KC | | Houston Dynamo | | Children's Mercy Park | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | Portland Timbers | | Seattle Sounders | | Providence Park | | Head-to-Head | |
| Sat | 2026-08-01 | 19:30 | St. Louis City | | Real Salt Lake | | Energizer Park | | Head-to-Head | |
| Sat | 2026-08-08 | 16:30 | NE Revolution | | Houston Dynamo | | Gillette Stadium | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | Orlando City | | FC Cincinnati | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | Toronto FC | | NE Revolution | | BMO Field | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | CF Montréal | | D.C. United | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | Charlotte | | Columbus Crew | | Bank of America Stadium | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-08-15 | 19:30 | Atlanta Utd | | RB New York | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sun | 2026-08-16 | 17:30 | Chicago Fire | | Portland Timbers | | Soldier Field | | Head-to-Head | |
| Sun | 2026-08-16 | 18:30 | NYCFC | | Philadelphia Union | | Yankee Stadium | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | SJ Earthquakes | | St. Louis City | | PayPal Park | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | Colorado Rapids | | Sporting KC | | Dick's Sporting Goods Park | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | Nashville SC | | Inter Miami | | Geodis Park | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | LAFC | | San Diego FC | | BMO Stadium | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | Real Salt Lake | | Minnesota Utd | | America First Field | | Head-to-Head | |
| Sat | 2026-08-15 | 19:30 | Houston Dynamo | | LA Galaxy | | Shell Energy Stadium | | Head-to-Head | |
| Sun | 2026-08-16 | 18:00 | Seattle Sounders | | Vancouver W'caps | | Lumen Field | | Head-to-Head | |
| Sun | 2026-08-16 | 19:30 | Austin FC | | FC Dallas | | Q2 Stadium | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Columbus Crew | | CF Montréal | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Orlando City | | Chicago Fire | | Inter&Co Stadium | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | RB New York | | Nashville SC | | Sports Illustrated Stadium | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | D.C. United | | NE Revolution | | Audi Field | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Toronto FC | | Charlotte | | BMO Field | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | FC Cincinnati | | NYCFC | | TQL Stadium | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Philadelphia Union | | Inter Miami | | Subaru Park | | Head-to-Head | |
| Wed | 2026-08-19 | 18:30 | Seattle Sounders | | Austin FC | | Lumen Field | | Head-to-Head | |
| Wed | 2026-08-19 | 19:00 | Sporting KC | | St. Louis City | | Children's Mercy Park | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Portland Timbers | | San Diego FC | | Providence Park | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | LA Galaxy | | SJ Earthquakes | | Dignity Health Sports Park | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Colorado Rapids | | LAFC | | Dick's Sporting Goods Park | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Real Salt Lake | | FC Dallas | | America First Field | | Head-to-Head | |
| Wed | 2026-08-19 | 19:30 | Minnesota Utd | | Atlanta Utd | | Allianz Field | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2026-08-19 | 19:30 | Vancouver W'caps | | Houston Dynamo | | BC Place Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | Charlotte | | D.C. United | | Bank of America Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | Orlando City | | Real Salt Lake | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | RB New York | | Chicago Fire | | Sports Illustrated Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | CF Montréal | | LA Galaxy | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | FC Cincinnati | | Seattle Sounders | | TQL Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | Inter Miami | | Toronto FC | | Nu Stadium | | Head-to-Head | |
| Sun | 2026-08-23 | 16:30 | NE Revolution | | NYCFC | | Gillette Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 18:30 | Vancouver W'caps | | FC Dallas | | BC Place Stadium | | Head-to-Head | |
| Sun | 2026-08-23 | 19:00 | Atlanta Utd | | Sporting KC | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | St. Louis City | | Houston Dynamo | | Energizer Park | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | Nashville SC | | Columbus Crew | | Geodis Park | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | LAFC | | Portland Timbers | | BMO Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | Austin FC | | Philadelphia Union | | Q2 Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | San Diego FC | | Colorado Rapids | | Snapdragon Stadium | | Head-to-Head | |
| Sat | 2026-08-22 | 19:30 | SJ Earthquakes | | Minnesota Utd | | PayPal Park | | Head-to-Head | |
| Sat | 2026-08-29 | 13:30 | Seattle Sounders | | Chicago Fire | | Lumen Field | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Inter Miami | | CF Montréal | | Nu Stadium | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Toronto FC | | NYCFC | | BMO Field | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | D.C. United | | LAFC | | Audi Field | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Columbus Crew | | NE Revolution | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Atlanta Utd | | Charlotte | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | RB New York | | Philadelphia Union | | Sports Illustrated Stadium | | Head-to-Head | |
| Sun | 2026-08-30 | 18:00 | St. Louis City | | FC Dallas | | Energizer Park | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Colorado Rapids | | Real Salt Lake | | Dick's Sporting Goods Park | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-08-29 | 19:30 | Portland Timbers | | Austin FC | | Providence Park | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Minnesota Utd | | Orlando City | | Allianz Field | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | San Diego FC | | LA Galaxy | | Snapdragon Stadium | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Sporting KC | | Vancouver W'caps | | Children's Mercy Park | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Houston Dynamo | | SJ Earthquakes | | Shell Energy Stadium | | Head-to-Head | |
| Sat | 2026-08-29 | 19:30 | Nashville SC | | FC Cincinnati | | Geodis Park | | Head-to-Head | |
| Fri | 2026-09-04 | 19:30 | NYCFC | | Nashville SC | | Yankee Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Orlando City | | San Diego FC | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Columbus Crew | | Colorado Rapids | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | FC Cincinnati | | D.C. United | | TQL Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Charlotte | | Houston Dynamo | | Bank of America Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Inter Miami | | Atlanta Utd | | Nu Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Philadelphia Union | | CF Montréal | | Subaru Park | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Toronto FC | | Chicago Fire | | BMO Field | | Head-to-Head | |
| Sat | 2026-09-05 | 17:30 | Seattle Sounders | | RB New York | | Lumen Field | | Head-to-Head | |
| Sat | 2026-09-05 | 18:30 | LA Galaxy | | NE Revolution | | Dignity Health Sports Park | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | FC Dallas | | Sporting KC | | Toyota Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Vancouver W'caps | | St. Louis City | | BC Place Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Austin FC | | SJ Earthquakes | | Q2 Stadium | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Real Salt Lake | | LAFC | | America First Field | | Head-to-Head | |
| Sat | 2026-09-05 | 19:30 | Portland Timbers | | Minnesota Utd | | Providence Park | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Toronto FC | | Nashville SC | | BMO Field | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Philadelphia Union | | FC Cincinnati | | Subaru Park | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | NYCFC | | NE Revolution | | Citi Field | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | CF Montréal | | Charlotte | | Stade Saputo | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2026-09-09 | 19:30 | Atlanta Utd | | Orlando City | | Mercedes-Benz Stadium | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | D.C. United | | Columbus Crew | | Audi Field | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Chicago Fire | | Inter Miami | | Soldier Field | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Portland Timbers | | St. Louis City | | Providence Park | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Minnesota Utd | | FC Dallas | | Allianz Field | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Houston Dynamo | | Real Salt Lake | | Shell Energy Stadium | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | San Diego FC | | SJ Earthquakes | | Snapdragon Stadium | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | LAFC | | RB New York | | BMO Stadium | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Austin FC | | Colorado Rapids | | Q2 Stadium | | Head-to-Head | |
| Wed | 2026-09-09 | 19:30 | Vancouver W'caps | | LA Galaxy | | BC Place Stadium | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | D.C. United | | Atlanta Utd | | Audi Field | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | FC Cincinnati | | Charlotte | | TQL Stadium | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | Inter Miami | | Nashville SC | | Nu Stadium | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | Orlando City | | Toronto FC | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | Columbus Crew | | RB New York | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Sun | 2026-09-13 | 15:30 | Vancouver W'caps | | Austin FC | | BC Place Stadium | | Head-to-Head | |
| Sun | 2026-09-13 | 17:30 | Chicago Fire | | NE Revolution | | Soldier Field | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | Real Salt Lake | | NYCFC | | America First Field | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | FC Dallas | | Portland Timbers | | Toyota Stadium | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | LA Galaxy | | Seattle Sounders | | Dignity Health Sports Park | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | St. Louis City | | Minnesota Utd | | Energizer Park | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | Colorado Rapids | | CF Montréal | | Dick's Sporting Goods Park | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | SJ Earthquakes | | Houston Dynamo | | PayPal Park | | Head-to-Head | |
| Sat | 2026-09-12 | 19:30 | Sporting KC | | LAFC | | Children's Mercy Park | | Head-to-Head | |
| Sun | 2026-09-13 | 18:00 | San Diego FC | | Philadelphia Union | | Snapdragon Stadium | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Fri | 2026-09-18 | 19:30 | NYCFC | | RB New York | | Yankee Stadium | | Head-to-Head | |
| Sat | 2026-09-19 | 16:30 | SJ Earthquakes | | LAFC | | Levi's Stadium | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | CF Montréal | | Columbus Crew | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | NE Revolution | | Orlando City | | Gillette Stadium | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | D.C. United | | Charlotte | | Audi Field | | Head-to-Head | |
| Sun | 2026-09-20 | 19:00 | Inter Miami | | San Diego FC | | Nu Stadium | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | St. Louis City | | Toronto FC | | Energizer Park | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | Sporting KC | | Philadelphia Union | | Children's Mercy Park | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | Real Salt Lake | | Vancouver W'caps | | America First Field | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | Houston Dynamo | | FC Cincinnati | | Shell Energy Stadium | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | Portland Timbers | | Atlanta Utd | | Providence Park | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | Minnesota Utd | | LA Galaxy | | Allianz Field | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | FC Dallas | | Austin FC | | Toyota Stadium | | Head-to-Head | |
| Sat | 2026-09-19 | 19:30 | Colorado Rapids | | Seattle Sounders | | Dick's Sporting Goods Park | | Head-to-Head | |
| Sat | 2026-09-19 | 20:30 | Nashville SC | | Chicago Fire | | Geodis Park | | Head-to-Head | |
| Wed | 2026-09-23 | 18:30 | Seattle Sounders | | Real Salt Lake | | Lumen Field | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | Philadelphia Union | | Orlando City | | Subaru Park | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | RB New York | | St. Louis City | | Sports Illustrated Stadium | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | CF Montréal | | FC Cincinnati | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | Atlanta Utd | | NYCFC | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | Charlotte | | Chicago Fire | | Bank of America Stadium | | Head-to-Head | |
| Sat | 2026-09-26 | 17:30 | Seattle Sounders | | Minnesota Utd | | Lumen Field | | Head-to-Head | |
| Sun | 2026-09-27 | 19:00 | Columbus Crew | | Inter Miami | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | SJ Earthquakes | | Portland Timbers | | PayPal Park | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | Austin FC | | San Diego FC | | Q2 Stadium | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-09-26 | 19:30 | Nashville SC | | Toronto FC | | Geodis Park | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | LA Galaxy | | Colorado Rapids | | Dignity Health Sports Park | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | Houston Dynamo | | Sporting KC | | Shell Energy Stadium | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | FC Dallas | | LAFC | | Toyota Stadium | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | Real Salt Lake | | NE Revolution | | America First Field | | Head-to-Head | |
| Sat | 2026-09-26 | 19:30 | Vancouver W'caps | | D.C. United | | BC Place Stadium | | Head-to-Head | |
| Thu | 2026-10-01 | 18:30 | Seattle Sounders | | Sporting KC | | Lumen Field | | Head-to-Head | |
| Sat | 2026-10-10 | 13:00 | Toronto FC | | CF Montréal | | BMO Field | | Head-to-Head | |
| Sat | 2026-10-10 | 13:30 | Chicago Fire | | NYCFC | | Soldier Field | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Atlanta Utd | | FC Cincinnati | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | NE Revolution | | Seattle Sounders | | Gillette Stadium | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Charlotte | | FC Dallas | | Bank of America Stadium | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Orlando City | | Columbus Crew | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Philadelphia Union | | Real Salt Lake | | Subaru Park | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Inter Miami | | D.C. United | | Nu Stadium | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | RB New York | | San Diego FC | | Sports Illustrated Stadium | | Head-to-Head | |
| Sun | 2026-10-11 | 18:00 | St. Louis City | | LA Galaxy | | Energizer Park | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | LAFC | | Vancouver W'caps | | BMO Stadium | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Sporting KC | | Portland Timbers | | Children's Mercy Park | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Colorado Rapids | | SJ Earthquakes | | Dick's Sporting Goods Park | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Minnesota Utd | | Houston Dynamo | | Allianz Field | | Head-to-Head | |
| Sat | 2026-10-10 | 19:30 | Austin FC | | Nashville SC | | Q2 Stadium | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | FC Cincinnati | | NE Revolution | | TQL Stadium | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | Toronto FC | | Orlando City | | BMO Field | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | Columbus Crew | | Charlotte | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2026-10-14 | 19:30 | CF Montréal | | Atlanta Utd | | Stade Saputo | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | D.C. United | | RB New York | | Audi Field | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | Inter Miami | | NYCFC | | Nu Stadium | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | St. Louis City | | Vancouver W'caps | | Energizer Park | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | FC Dallas | | Seattle Sounders | | Toyota Stadium | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | Colorado Rapids | | Minnesota Utd | | Dick's Sporting Goods Park | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | Chicago Fire | | Philadelphia Union | | Soldier Field | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | LAFC | | Austin FC | | BMO Stadium | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | Real Salt Lake | | SJ Earthquakes | | America First Field | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | Nashville SC | | Sporting KC | | Geodis Park | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | San Diego FC | | Houston Dynamo | | Snapdragon Stadium | | Head-to-Head | |
| Wed | 2026-10-14 | 19:30 | LA Galaxy | | Portland Timbers | | Dignity Health Sports Park | | Head-to-Head | |
| Sat | 2026-10-17 | 14:30 | Philadelphia Union | | Charlotte | | Subaru Park | | Head-to-Head | |
| Sat | 2026-10-17 | 15:30 | Minnesota Utd | | St. Louis City | | Allianz Field | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | NE Revolution | | Chicago Fire | | Gillette Stadium | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | Orlando City | | D.C. United | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | RB New York | | Toronto FC | | Sports Illustrated Stadium | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | Atlanta Utd | | Inter Miami | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sun | 2026-10-18 | 19:00 | FC Cincinnati | | Columbus Crew | | TQL Stadium | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | Austin FC | | Vancouver W'caps | | Q2 Stadium | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | Houston Dynamo | | FC Dallas | | Shell Energy Stadium | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | SJ Earthquakes | | Nashville SC | | PayPal Park | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | LA Galaxy | | San Diego FC | | Dignity Health Sports Park | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | Portland Timbers | | Colorado Rapids | | Providence Park | | Head-to-Head | |
| Sat | 2026-10-17 | 19:30 | Seattle Sounders | | CF Montréal | | Lumen Field | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-10-17 | 19:30 | Sporting KC | | Real Salt Lake | | Children's Mercy Park | | Head-to-Head | |
| Sat | 2026-10-24 | 13:30 | CF Montréal | | Nashville SC | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-10-24 | 15:30 | Columbus Crew | | Toronto FC | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Sat | 2026-10-24 | 17:30 | RB New York | | Inter Miami | | Sports Illustrated Stadium | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | Philadelphia Union | | NE Revolution | | Subaru Park | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | Atlanta Utd | | Chicago Fire | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | Orlando City | | NYCFC | | Inter&Co Stadium | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | D.C. United | | FC Cincinnati | | Audi Field | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | Real Salt Lake | | St. Louis City | | America First Field | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | Portland Timbers | | Charlotte | | Providence Park | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | San Diego FC | | Seattle Sounders | | Snapdragon Stadium | | Head-to-Head | |
| Sat | 2026-10-24 | 19:30 | Colorado Rapids | | Vancouver W'caps | | Dick's Sporting Goods Park | | Head-to-Head | |
| Sat | 2026-10-24 | 20:30 | Houston Dynamo | | Minnesota Utd | | Shell Energy Stadium | | Head-to-Head | |
| Sat | 2026-10-24 | 20:30 | FC Dallas | | SJ Earthquakes | | Toyota Stadium | | Head-to-Head | |
| Sat | 2026-10-24 | 20:30 | Sporting KC | | Austin FC | | Children's Mercy Park | | Head-to-Head | |
| Sun | 2026-10-25 | 18:00 | LAFC | | LA Galaxy | | BMO Stadium | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | NE Revolution | | RB New York | | Gillette Stadium | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Inter Miami | | FC Cincinnati | | Nu Stadium | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | NYCFC | | Atlanta Utd | | Yankee Stadium | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Charlotte | | CF Montréal | | Bank of America Stadium | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Toronto FC | | D.C. United | | BMO Field | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Minnesota Utd | | Sporting KC | | Allianz Field | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | FC Dallas | | Columbus Crew | | Toyota Stadium | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | St. Louis City | | Portland Timbers | | Energizer Park | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Austin FC | | Real Salt Lake | | Q2 Stadium | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2026-10-28 | 19:30 | Vancouver W'caps | | San Diego FC | | BC Place Stadium | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Seattle Sounders | | Houston Dynamo | | Lumen Field | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Chicago Fire | | Orlando City | | Soldier Field | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | Nashville SC | | Philadelphia Union | | Geodis Park | | Head-to-Head | |
| Wed | 2026-10-28 | 19:30 | SJ Earthquakes | | Colorado Rapids | | PayPal Park | | Head-to-Head | |
| Sat | 2026-10-31 | | FC Cincinnati | | Philadelphia Union | | TQL Stadium | | Head-to-Head | |
| Sat | 2026-10-31 | 13:00 | Charlotte | | Orlando City | | Bank of America Stadium | | Head-to-Head | |
| Sat | 2026-10-31 | 14:00 | Columbus Crew | | D.C. United | | ScottsMiracle-Gro Field | | Head-to-Head | |
| Sat | 2026-10-31 | 14:00 | LA Galaxy | | Austin FC | | Dignity Health Sports Park | | Head-to-Head | |
| Sat | 2026-10-31 | 14:00 | Sporting KC | | FC Dallas | | Children's Mercy Park | | Head-to-Head | |
| Sun | 2026-11-01 | | SJ Earthquakes | | Real Salt Lake | | PayPal Park | | Head-to-Head | |
| Sun | 2026-11-01 | | LAFC | | Minnesota Utd | | BMO Stadium | | Head-to-Head | |
| Sun | 2026-11-01 | | NYCFC | | CF Montréal | | Yankee Stadium | | Head-to-Head | |
| Sun | 2026-11-01 | | St. Louis City | | San Diego FC | | Energizer Park | | Head-to-Head | |
| Sun | 2026-11-01 | 13:30 | Vancouver W'caps | | Seattle Sounders | | BC Place Stadium | | Head-to-Head | |
| Sun | 2026-11-01 | 15:30 | Nashville SC | | RB New York | | Geodis Park | | Head-to-Head | |
| Sun | 2026-11-01 | 16:30 | Atlanta Utd | | Toronto FC | | Mercedes-Benz Stadium | | Head-to-Head | |
| Sun | 2026-11-01 | 18:00 | NE Revolution | | Inter Miami | | Gillette Stadium | | Head-to-Head | |
| Sat | 2026-10-31 | 19:30 | Colorado Rapids | | Chicago Fire | | Dick's Sporting Goods Park | | Head-to-Head | |
| Sun | 2026-11-01 | 17:00 | Portland Timbers | | Houston Dynamo | | Providence Park | | Head-to-Head | |
| Wed | 2026-11-04 | 19:30 | NYCFC | | LAFC | | Citi Field | | Head-to-Head | |
| Sat | 2026-11-07 | 15:00 | Chicago Fire | | Columbus Crew | | SeatGeek Stadium | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | Inter Miami | | Charlotte | | Nu Stadium | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | Philadelphia Union | | Toronto FC | | Subaru Park | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | Orlando City | | NE Revolution | | Inter&Co Stadium | | Head-to-Head | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2026-11-07 | 16:00 | RB New York | | Atlanta Utd | | Sports Illustrated Stadium | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | D.C. United | | NYCFC | | Audi Field | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | FC Cincinnati | | Nashville SC | | TQL Stadium | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | CF Montréal | | Vancouver W'caps | | Stade Saputo | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | San Diego FC | | Sporting KC | | Snapdragon Stadium | | Head-to-Head | |
| Sat | 2026-11-07 | 16:00 | Seattle Sounders | | LAFC | | Lumen Field | | Head-to-Head | |
| Sat | 2026-11-07 | 17:00 | Real Salt Lake | | LA Galaxy | | America First Field | | Head-to-Head | |
| Sat | 2026-11-07 | 18:00 | Minnesota Utd | | SJ Earthquakes | | Allianz Field | | Head-to-Head | |
| Sat | 2026-11-07 | 18:00 | Austin FC | | Portland Timbers | | Q2 Stadium | | Head-to-Head | |
| Sat | 2026-11-07 | 18:00 | Houston Dynamo | | St. Louis City | | Shell Energy Stadium | | Head-to-Head | |
| Sat | 2026-11-07 | 18:00 | FC Dallas | | Colorado Rapids | | Toyota Stadium | | Head-to-Head | |
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