Third qualifying stage (April 6, 2021 to April 15, 2021)

Apr 6
San Lorenzo
Santos
Apr 13
Santos
San Lorenzo
Santos won on aggregate score over two legs and advance to Group stage.
Apr 7
Libertad
Atlético Nacional
Apr 14
Atlético Nacional
Libertad
Atlético Nacional won on aggregate score over two legs and advance to Group stage.
Apr 9
Independiente
Grêmio
Apr 14
Grêmio
Independiente
Independiente won on aggregate score over two legs and advance to Group stage.
Apr 8
Bolívar
Junior
Apr 15
Junior
Bolívar
Junior won on aggregate score over two legs and advance to Group stage.

Second qualifying stage (March 9, 2021 to March 18, 2021)

Mar 10
Univ Católica
Libertad
Mar 17
Libertad
Univ Católica
Libertad won on aggregate score over two legs and advance to Third qualifying stage.
5–2
Mar 10
Caracas
Junior
Mar 17
Junior
Caracas
Junior won on aggregate score over two legs and advance to Third qualifying stage.
Mar 9
Santos
Deportivo Lara
Mar 16
Deportivo Lara
Santos
Santos won on aggregate score over two legs and advance to Third qualifying stage.
Mar 11
Guaraní
Atlético Nacional
Mar 18
Atlético Nacional
Guaraní
Atlético Nacional won on aggregate score over two legs and advance to Third qualifying stage.
Mar 9
Montevideo Wanderers
Bolívar
Mar 16
Bolívar
Montevideo Wanderers
Bolívar won on aggregate score over two legs and advance to Third qualifying stage.
Mar 10
Universidad de Chile
San Lorenzo
Mar 17
San Lorenzo
Universidad de Chile
San Lorenzo won on aggregate score over two legs and advance to Third qualifying stage.
Mar 9
Unión Española
Independiente
Mar 16
Independiente
Unión Española
Independiente won on aggregate score over two legs and advance to Third qualifying stage.
Mar 10
Grêmio
Ayacucho
Mar 16
Ayacucho
Grêmio
Grêmio won on aggregate score over two legs and advance to Third qualifying stage.

First qualifying stage (February 23, 2021 to March 3, 2021)

Feb 24
Universidad César Vallejo
Caracas
Mar 3
Caracas
Universidad César Vallejo
Caracas won on aggregate score over two legs and advance to Second qualifying stage.
Feb 23
Liverpool
Univ Católica
Mar 2
Univ Católica
Liverpool
Univ Católica won on aggregate score over two legs and advance to Second qualifying stage.
Feb 24
Royal Parí
Guaraní
Mar 3
Guaraní
Royal Parí
Guaraní won on aggregate score over two legs and advance to Second qualifying stage.

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FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.

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