Scores & Fixtures 2022 Copa Libertadores
| Round | Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group stage | 1 | Tue | 2022-04-05 | 18:15 | Olimpia py | 1.1 | 0–0 | 1.2 | py Cerro Porteño | Estadio Defensores del Chaco | Anderson Daronco | Match Report | ||
| Group stage | 1 | Tue | 2022-04-05 | 18:15 | Caracas ve | 0.8 | 0–0 | 1.5 | br Ath Paranaense | Estadio Olímpico | Andrés Rojas | Match Report | ||
| Group stage | 1 | Tue | 2022-04-05 | 19:15 | Colón ar | 3.2 | 2–1 | 0.2 | uy Peñarol | Estadio Brigadier General Estanislao Lóp... | Wilton Sampaio | Match Report | ||
| Group stage | 1 | Wed | 2022-04-06 | 19:00 | América (MG) br | 1.0 | 0–2 | 2.5 | ec Independiente | Estádio Raimundo Sampaio | Fernando Rapallini | Match Report | ||
| Group stage | 1 | Wed | 2022-04-06 | 19:00 | Bragantino br | 1.9 | 2–0 | 1.0 | uy Nacional | Estádio Nabi Abi Chedid | Kevin Ortega | Match Report | ||
| Group stage | 1 | Wed | 2022-04-06 | 19:00 | Talleres ar | 1.2 | 1–0 | 0.5 | cl Univ Católica | Estadio Mario Alberto Kempes | Gustavo Tejera | Match Report | ||
| Group stage | 1 | Tue | 2022-04-05 | 19:30 | AD Cali co | 1.6 | 2–0 | 0.7 | ar Boca Juniors | 18,695 | Estadio Deportivo Cali | Jesús Valenzuela | Match Report | |
| Group stage | 1 | Tue | 2022-04-05 | 19:30 | Sporting Cristal pe | 1.1 | 0–2 | 0.7 | br Flamengo | Estadio Nacional | John J. Ospina | Match Report | ||
| Group stage | 1 | Tue | 2022-04-05 | 20:30 | Always Ready bo | 1.3 | 2–0 | 0.7 | br Corinthians | 4,536 | Estadio Hernando Siles | Piero Maza | Match Report | |
| Group stage | 1 | Thu | 2022-04-07 | 19:00 | Fortaleza br | 1.9 | 1–2 | 1.3 | cl Colo-Colo | Estádio Castelão | Andrés Cunha | Match Report | ||
| Group stage | 1 | Wed | 2022-04-06 | 19:00 | Alianza Lima pe | 0.3 | 0–1 | 1.3 | ar River Plate | Estadio Nacional | Wilmar Roldán | Match Report | ||
| Group stage | 1 | Wed | 2022-04-06 | 19:00 | Tolima co | 1.1 | 0–2 | 1.0 | br Atlético Mineiro | Estadio Manuel Murillo Toro | Alexis Herrera | Match Report | ||
| Group stage | 1 | Wed | 2022-04-06 | 20:00 | Dep Táchira ve | 0.9 | 0–4 | 2.5 | br Palmeiras | Estadio Polideportivo de Pueblo Nuevo | Darío Herrera | Match Report | ||
| Group stage | 1 | Wed | 2022-04-06 | 22:00 | Indep Petrolero bo | 0.7 | 1–1 | 1.0 | ec CS Emelec | Estadio Olímpico Patria | Cristián Garay | Match Report | ||
| Group stage | 1 | Thu | 2022-04-07 | 21:00 | Estudiantes ar | 3.2 | 4–1 | 1.9 | ar Vélez Sarsfield | 16,803 | Estadio Jorge Luis Hirschi | Eber Aquino | Match Report | |
| Group stage | 1 | Thu | 2022-04-07 | 22:00 | The Strongest bo | 1.9 | 1–1 | 0.6 | py Libertad | 6,079 | Estadio Hernando Siles | Nicolás Gamboa | Match Report | |
| Group stage | 2 | Tue | 2022-04-12 | 18:15 | Cerro Porteño py | 2.5 | 3–1 | 2.0 | ar Colón | Estadio General Pablo Rojas | Roberto Tobar | Match Report | ||
| Group stage | 2 | Tue | 2022-04-12 | 18:15 | Univ Católica cl | 0.9 | 2–1 | 1.6 | pe Sporting Cristal | Estadio San Carlos de Apoquindo | Leodán González | Match Report | ||
| Group stage | 2 | Tue | 2022-04-12 | 19:15 | Boca Juniors ar | 2.2 | 2–0 | 0.2 | bo Always Ready | Estadio Alberto José Armando | Gustavo Tejera | Match Report | ||
| Group stage | 2 | Wed | 2022-04-13 | 18:00 | Libertad py | 2.1 | 2–1 | 1.1 | ve Caracas | Estadio Defensores del Chaco | Facundo Tello | Match Report | ||
| Group stage | 2 | Wed | 2022-04-13 | 18:00 | Colo-Colo cl | 1.9 | 2–1 | 1.2 | pe Alianza Lima | Estadio Monumental David Arellano | Esteban Ostojich | Match Report | ||
| Group stage | 2 | Tue | 2022-04-12 | 21:30 | Flamengo br | 1.3 | 3–1 | 0.8 | ar Talleres | 42,915 | Estadio Jornalista Mário Filho | Jesús Valenzuela | Match Report | |
| Group stage | 2 | Tue | 2022-04-12 | 21:30 | Peñarol uy | 0.5 | 2–1 | 1.1 | py Olimpia | 19,813 | Estadio Campeón del Siglo | Raphael Claus | Match Report | |
| Group stage | 2 | Tue | 2022-04-12 | 21:30 | Palmeiras br | 2.5 | 8–1 | 0.1 | bo Indep Petrolero | 26,409 | Allianz Parque | Derlis López | Match Report | |
| Group stage | 2 | Thu | 2022-04-14 | 19:00 | Ath Paranaense br | 2.2 | 1–0 | 0.2 | bo The Strongest | Estádio Joaquim Américo Guimarães | Darío Herrera | Match Report | ||
| Group stage | 2 | Wed | 2022-04-13 | 21:00 | River Plate ar | 2.7 | 2–0 | 0.9 | br Fortaleza | Estadio Monumental Antonio Vespucio Libe... | Andrés Matonte | Match Report | ||
| Group stage | 2 | Wed | 2022-04-13 | 21:00 | Nacional uy | 1.9 | 0–0 | 1.2 | ar Estudiantes | 22,339 | Estadio Gran Parque Central | Wilmar Roldán | Match Report | |
| Group stage | 2 | Wed | 2022-04-13 | 21:00 | Independiente ec | 2.2 | 2–2 | 0.8 | co Tolima | 3,699 | Estadio banco Guayaquil | Kevin Ortega | Match Report | |
| Group stage | 2 | Wed | 2022-04-13 | 21:00 | Atlético Mineiro br | 2.6 | 1–1 | 0.2 | br América (MG) | 37,312 | Estádio Governador Magalhães Pinto | Patricio Loustau | Match Report | |
| Group stage | 2 | Wed | 2022-04-13 | 21:00 | Corinthians br | 1.5 | 1–0 | 0.4 | co AD Cali | 37,708 | Neo Química Arena | Eber Aquino | Match Report | |
| Group stage | 2 | Thu | 2022-04-14 | 21:00 | CS Emelec ec | 0.6 | 1–1 | 1.1 | ve Dep Táchira | Estadio Banco del Pacífico | Jhon Hinestroza | Match Report | ||
| Group stage | 2 | Thu | 2022-04-14 | 21:00 | Vélez Sarsfield ar | 1.5 | 2–2 | 0.6 | br Bragantino | 6,826 | Estadio José Amalfitani | John J. Ospina | Match Report | |
| Group stage | 3 | Tue | 2022-04-26 | 18:15 | Indep Petrolero bo | 1.4 | 1–2 | 1.9 | ve Dep Táchira | Estadio Olímpico Patria | Nicolás Gamboa | Match Report | ||
| Group stage | 3 | Tue | 2022-04-26 | 18:15 | Libertad py | 0.8 | 1–0 | 1.2 | br Ath Paranaense | Estadio Defensores del Chaco | Gustavo Tejera | Match Report | ||
| Group stage | 3 | Tue | 2022-04-26 | 19:15 | Vélez Sarsfield ar | 2.0 | 1–2 | 1.5 | uy Nacional | Estadio José Amalfitani | Eber Aquino | Match Report | ||
| Group stage | 3 | Tue | 2022-04-26 | 19:15 | Estudiantes ar | 2.3 | 2–0 | 0.5 | br Bragantino | Estadio Jorge Luis Hirschi | Kevin Ortega | Match Report | ||
| Group stage | 3 | Wed | 2022-04-27 | 19:00 | América (MG) br | 1.9 | 2–3 | 2.2 | co Tolima | 4,651 | Estádio Raimundo Sampaio | Andrés Cunha | Match Report | |
| Group stage | 3 | Wed | 2022-04-27 | 19:00 | Fortaleza br | 2.0 | 2–1 | 0.4 | pe Alianza Lima | 32,557 | Estádio Castelão | Carlos Betancourt | Match Report | |
| Group stage | 3 | Tue | 2022-04-26 | 19:30 | Independiente ec | 2.0 | 1–1 | 1.7 | br Atlético Mineiro | Estadio banco Guayaquil | Fernando Rapallini | Match Report | ||
| Group stage | 3 | Tue | 2022-04-26 | 21:30 | Corinthians br | 1.2 | 2–0 | 0.3 | ar Boca Juniors | Neo Química Arena | Andrés Matonte | Match Report | ||
| Group stage | 3 | Tue | 2022-04-26 | 21:30 | Talleres ar | 2.0 | 1–0 | 0.3 | pe Sporting Cristal | Estadio Mario Alberto Kempes | Mario Díaz de Vivar | Match Report | ||
| Group stage | 3 | Thu | 2022-04-28 | 18:00 | Univ Católica cl | 0.9 | 2–3 | 2.9 | br Flamengo | Estadio San Carlos de Apoquindo | José Argote | Match Report | ||
| Group stage | 3 | Wed | 2022-04-27 | 19:00 | CS Emelec ec | 0.9 | 1–3 | 2.3 | br Palmeiras | Estadio Banco del Pacífico | Patricio Loustau | Match Report | ||
| Group stage | 3 | Wed | 2022-04-27 | 20:00 | Cerro Porteño py | 1.1 | 1–0 | 0.8 | uy Peñarol | Estadio General Pablo Rojas | Wilmar Roldán | Match Report | ||
| Group stage | 3 | Wed | 2022-04-27 | 20:00 | Colo-Colo cl | 0.6 | 1–2 | 1.4 | ar River Plate | Estadio Monumental David Arellano | Alexis Herrera | Match Report | ||
| Group stage | 3 | Wed | 2022-04-27 | 22:00 | The Strongest bo | 3.1 | 1–1 | 0.9 | ve Caracas | Estadio Hernando Siles | Guillermo Guerrero | Match Report | ||
| Group stage | 3 | Thu | 2022-04-28 | 20:00 | Olimpia py | 2.1 | 0–0 | 1.6 | ar Colón | Estadio Defensores del Chaco | Jesús Valenzuela | Match Report | ||
| Group stage | 3 | Thu | 2022-04-28 | 22:00 | Always Ready bo | 2.7 | 2–2 | 2.4 | co AD Cali | Estadio Hernando Siles | Augusto Aragón | Match Report | ||
| Group stage | 4 | Tue | 2022-05-03 | 18:15 | Dep Táchira ve | 1.2 | 1–4 | 1.8 | ec CS Emelec | Estadio Polideportivo de Pueblo Nuevo | Pablo Echavarría | Match Report | ||
| Group stage | 4 | Tue | 2022-05-03 | 18:15 | Caracas ve | 1.8 | 1–0 | 1.0 | py Libertad | Estadio Olímpico | Andrés Matonte | Match Report | ||
| Group stage | 4 | Tue | 2022-05-03 | 18:15 | The Strongest bo | 2.6 | 5–0 | 0.8 | br Ath Paranaense | Estadio Hernando Siles | Augusto Menéndez | Match Report | ||
| Group stage | 4 | Wed | 2022-05-04 | 19:00 | Colón ar | 2.5 | 2–1 | 0.6 | py Cerro Porteño | Estadio Brigadier General Estanislao Lóp... | Raphael Claus | Match Report | ||
| Group stage | 4 | Wed | 2022-05-04 | 19:00 | Talleres ar | 1.0 | 2–2 | 0.5 | br Flamengo | Estadio Mario Alberto Kempes | Eber Aquino | Match Report | ||
| Group stage | 4 | Tue | 2022-05-03 | 20:30 | Indep Petrolero bo | 0.7 | 0–5 | 3.5 | br Palmeiras | Estadio Olímpico Patria | Nicolás Lamolina | Match Report | ||
| Group stage | 4 | Tue | 2022-05-03 | 21:30 | América (MG) br | 0.9 | 1–2 | 1.6 | br Atlético Mineiro | Estádio Raimundo Sampaio | Darío Herrera | Match Report | ||
| Group stage | 4 | Tue | 2022-05-03 | 21:30 | Estudiantes ar | 1.1 | 1–0 | 0.3 | uy Nacional | Estadio Jorge Luis Hirschi | Wilmar Roldán | Match Report | ||
| Group stage | 4 | Wed | 2022-05-04 | 19:00 | AD Cali co | 1.8 | 0–0 | 2.1 | br Corinthians | Estadio Deportivo Cali | Andrés Cunha | Match Report | ||
| Group stage | 4 | Thu | 2022-05-05 | 19:00 | Fortaleza br | 1.4 | 1–1 | 2.2 | ar River Plate | Estádio Castelão | Esteban Ostojich | Match Report | ||
| Group stage | 4 | Wed | 2022-05-04 | 20:00 | Olimpia py | 0.7 | 1–0 | 0.7 | uy Peñarol | Estadio Defensores del Chaco | Anderson Daronco | Match Report | ||
| Group stage | 4 | Wed | 2022-05-04 | 20:00 | Always Ready bo | 1.0 | 0–1 | 1.6 | ar Boca Juniors | Estadio Hernando Siles | Kevin Ortega | Match Report | ||
| Group stage | 4 | Wed | 2022-05-04 | 21:00 | Tolima co | 1.5 | 1–0 | 0.7 | ec Independiente | Estadio Manuel Murillo Toro | Patricio Loustau | Match Report | ||
| Group stage | 4 | Wed | 2022-05-04 | 21:00 | Sporting Cristal pe | 1.0 | 1–1 | 1.2 | cl Univ Católica | Estadio Nacional | Andrés Rojas | Match Report | ||
| Group stage | 4 | Thu | 2022-05-05 | 21:00 | Alianza Lima pe | 0.5 | 1–1 | 3.0 | cl Colo-Colo | Estadio Alejandro Villanueva | Carlos Betancourt | Match Report | ||
| Group stage | 4 | Thu | 2022-05-05 | 21:00 | Bragantino br | 0.9 | 1–1 | 1.0 | ar Vélez Sarsfield | Estádio Nabi Abi Chedid | John J. Ospina | Match Report | ||
| Group stage | 5 | Tue | 2022-05-17 | 18:15 | Caracas ve | 0.6 | 0–0 | 0.5 | bo The Strongest | Estadio Olímpico | Darío Herrera | Match Report | ||
| Group stage | 5 | Tue | 2022-05-17 | 19:15 | Bragantino br | 0.5 | 0–1 | 0.5 | ar Estudiantes | 4,769 | Estádio Nabi Abi Chedid | Juan Benítez | Match Report | |
| Group stage | 5 | Tue | 2022-05-17 | 19:15 | Peñarol uy | 1.5 | 0–0 | 0.5 | py Cerro Porteño | Estadio Campeón del Siglo | Wilton Sampaio | Match Report | ||
| Group stage | 5 | Wed | 2022-05-18 | 19:00 | Palmeiras br | 2.8 | 1–0 | 0.6 | ec CS Emelec | Allianz Parque | Nicolás Gamboa | Match Report | ||
| Group stage | 5 | Wed | 2022-05-18 | 19:00 | Ath Paranaense br | 1.3 | 2–0 | 0.5 | py Libertad | Estádio Joaquim Américo Guimarães | Patricio Loustau | Match Report | ||
| Group stage | 5 | Wed | 2022-05-18 | 19:00 | Nacional uy | 1.6 | 2–3 | 1.7 | ar Vélez Sarsfield | Estadio Gran Parque Central | Piero Maza | Match Report | ||
| Group stage | 5 | Tue | 2022-05-17 | 19:30 | Sporting Cristal pe | 0.8 | 0–0 | 0.8 | ar Talleres | Estadio Nacional | Luis Quiroz | Match Report | ||
| Group stage | 5 | Tue | 2022-05-17 | 21:30 | Flamengo br | 3.8 | 3–0 | 1.1 | cl Univ Católica | 43,532 | Estadio Jornalista Mário Filho | John J. Ospina | Match Report | |
| Group stage | 5 | Tue | 2022-05-17 | 21:30 | Boca Juniors ar | 1.1 | 1–1 | 0.1 | br Corinthians | Estadio Alberto José Armando | Christian Ferreyra | Match Report | ||
| Group stage | 5 | Thu | 2022-05-19 | 19:00 | Atlético Mineiro br | 2.5 | 3–1 | 0.6 | ec Independiente | Estádio Governador Magalhães Pinto | Esteban Ostojich | Match Report | ||
| Group stage | 5 | Wed | 2022-05-18 | 19:00 | Tolima co | 2.0 | 2–2 | 1.4 | br América (MG) | Estadio Manuel Murillo Toro | Fernando Rapallini | Match Report | ||
| Group stage | 5 | Wed | 2022-05-18 | 20:00 | Dep Táchira ve | 2.5 | 3–0 | 0.3 | bo Indep Petrolero | Estadio Polideportivo de Pueblo Nuevo | Carlos Benítez | Match Report | ||
| Group stage | 5 | Wed | 2022-05-18 | 21:00 | Colón ar | 1.0 | 2–1 | 0.4 | py Olimpia | Estadio Brigadier General Estanislao Lóp... | Wilmar Roldán | Match Report | ||
| Group stage | 5 | Wed | 2022-05-18 | 21:00 | Alianza Lima pe | 1.0 | 0–2 | 2.3 | br Fortaleza | Estadio Alejandro Villanueva | Franklin Congo | Match Report | ||
| Group stage | 5 | Thu | 2022-05-19 | 21:00 | River Plate ar | 3.7 | 4–0 | 0.7 | cl Colo-Colo | Estadio Monumental Antonio Vespucio Libe... | Andrés Matonte | Match Report | ||
| Group stage | 5 | Thu | 2022-05-19 | 21:00 | AD Cali co | 3.0 | 3–0 | 0.6 | bo Always Ready | Estadio Deportivo Cali | Alexis Herrera | Match Report | ||
| Group stage | 6 | Tue | 2022-05-24 | 19:15 | Vélez Sarsfield ar | 1.9 | 4–0 | 0.9 | ar Estudiantes | Estadio José Amalfitani | Nicolás Gamboa | Match Report | ||
| Group stage | 6 | Tue | 2022-05-24 | 19:15 | Nacional uy | 3.1 | 3–0 | 0.9 | br Bragantino | Estadio Gran Parque Central | Wilmar Roldán | Match Report | ||
| Group stage | 6 | Wed | 2022-05-25 | 18:00 | Colo-Colo cl | 1.8 | 3–4 | 1.8 | br Fortaleza | Estadio Monumental David Arellano | Esteban Ostojich | Match Report | ||
| Group stage | 6 | Wed | 2022-05-25 | 19:00 | River Plate ar | 4.9 | 8–1 | 1.1 | pe Alianza Lima | Estadio Monumental Antonio Vespucio Libe... | John J. Ospina | Match Report | ||
| Group stage | 6 | Tue | 2022-05-24 | 19:30 | CS Emelec ec | 3.8 | 7–0 | 0.6 | bo Indep Petrolero | Estadio Banco del Pacífico | Carlos Ortega | Match Report | ||
| Group stage | 6 | Tue | 2022-05-24 | 20:30 | Univ Católica cl | 1.4 | 0–1 | 0.5 | ar Talleres | Estadio San Carlos de Apoquindo | Gery Vargas | Match Report | ||
| Group stage | 6 | Tue | 2022-05-24 | 21:30 | Palmeiras br | 2.9 | 4–1 | 0.9 | ve Dep Táchira | Allianz Parque | Kevin Ortega | Match Report | ||
| Group stage | 6 | Tue | 2022-05-24 | 21:30 | Flamengo br | 1.8 | 2–1 | 0.8 | pe Sporting Cristal | Estadio Jornalista Mário Filho | Alexis Herrera | Match Report | ||
| Group stage | 6 | Thu | 2022-05-26 | 18:00 | Libertad py | 2.4 | 4–1 | 0.9 | bo The Strongest | Estadio Defensores del Chaco | Facundo Tello | Match Report | ||
| Group stage | 6 | Thu | 2022-05-26 | 19:00 | Ath Paranaense br | 2.2 | 5–1 | 0.8 | ve Caracas | Estádio Joaquim Américo Guimarães | Nicolás Lamolina | Match Report | ||
| Group stage | 6 | Wed | 2022-05-25 | 19:00 | Independiente ec | 1.3 | 3–0 | 0.2 | br América (MG) | Estadio banco Guayaquil | Leodán González | Match Report | ||
| Group stage | 6 | Wed | 2022-05-25 | 20:00 | Cerro Porteño py | 0.9 | 0–1 | 0.7 | py Olimpia | Estadio General Pablo Rojas | Raphael Claus | Match Report | ||
| Group stage | 6 | Wed | 2022-05-25 | 21:00 | Atlético Mineiro br | 1.0 | 1–2 | 0.5 | co Tolima | Estádio Governador Magalhães Pinto | Patricio Loustau | Match Report | ||
| Group stage | 6 | Wed | 2022-05-25 | 21:00 | Peñarol uy | 0.8 | 2–1 | 0.7 | ar Colón | Estadio Campeón del Siglo | Anderson Daronco | Match Report | ||
| Group stage | 6 | Thu | 2022-05-26 | 21:00 | Boca Juniors ar | 1.0 | 1–0 | 0.5 | co AD Cali | Estadio Alberto José Armando | Piero Maza | Match Report | ||
| Group stage | 6 | Thu | 2022-05-26 | 21:00 | Corinthians br | 2.2 | 1–1 | 0.4 | bo Always Ready | Neo Química Arena | José Argote | Match Report | ||
| Round of 16 | Tue | 2022-06-28 | 17:15 | CS Emelec ec | 1.4 | 1–1 | 1.7 | br Atlético Mineiro | Estadio Banco del Pacífico | Fernando Rapallini | Match Report | Leg 1 of 2 | ||
| Round of 16 | Wed | 2022-06-29 | 18:15 | Cerro Porteño py | 0.4 | 0–3 | 4.0 | br Palmeiras | Estadio General Pablo Rojas | Wilmar Roldán | Match Report | Leg 1 of 2 | ||
| Round of 16 | Wed | 2022-06-29 | 19:15 | Talleres ar | 1.2 | 1–1 | 0.4 | ar Colón | Estadio Mario Alberto Kempes | Wilton Sampaio | Match Report | Leg 1 of 2 | ||
| Round of 16 | Tue | 2022-06-28 | 21:30 | Corinthians br | 1.7 | 0–0 | 0.7 | ar Boca Juniors | Neo Química Arena | Roberto Tobar | Match Report | Leg 1 of 2 | ||
| Round of 16 | Tue | 2022-06-28 | 21:30 | Ath Paranaense br | 1.4 | 2–1 | 1.3 | py Libertad | Estádio Joaquim Américo Guimarães | Alexis Herrera | Match Report | Leg 1 of 2 | ||
| Round of 16 | Wed | 2022-06-29 | 19:30 | Tolima co | 1.0 | 0–1 | 0.3 | br Flamengo | Estadio Manuel Murillo Toro | Jesús Valenzuela | Match Report | Leg 1 of 2 | ||
| Round of 16 | Wed | 2022-06-29 | 21:30 | Vélez Sarsfield ar | 1.8 | 1–0 | 0.5 | ar River Plate | Estadio José Amalfitani | Raphael Claus | Match Report | Leg 1 of 2 | ||
| Round of 16 | Thu | 2022-06-30 | 21:30 | Fortaleza br | 0.8 | 1–1 | 0.9 | ar Estudiantes | Estádio Castelão | Andrés Matonte | Match Report | Leg 1 of 2 | ||
| Round of 16 | Tue | 2022-07-05 | 19:15 | Atlético Mineiro br | 2.0 | 1–0 | 0.2 | ec CS Emelec | Estádio Governador Magalhães Pinto | Jesús Valenzuela | Match Report | Leg 2 of 2; Atlético Mineiro won | ||
| Round of 16 | Wed | 2022-07-06 | 19:15 | Colón ar | 0.2 | 0–2 | 1.5 | ar Talleres | 17,235 | Estadio Brigadier General Estanislao Lóp... | Anderson Daronco | Match Report | Leg 2 of 2; Talleres won | |
| Round of 16 | Wed | 2022-07-06 | 19:15 | Palmeiras br | 2.3 | 5–0 | 0.4 | py Cerro Porteño | 37,431 | Allianz Parque | Patricio Loustau | Match Report | Leg 2 of 2; Palmeiras won | |
| Round of 16 | Tue | 2022-07-05 | 20:30 | Libertad py | 1.8 | 1–1 | 1.6 | br Ath Paranaense | 12,735 | Estadio Defensores del Chaco | Andrés Cunha | Match Report | Leg 2 of 2; Ath Paranaense won | |
| Round of 16 | Tue | 2022-07-05 | 21:30 | Boca Juniors ar | 1.9 | (5) 0–0 (6) | 0.1 | br Corinthians | Estadio Alberto José Armando | Andrés Matonte | Match Report | Leg 2 of 2; Corinthians won; Corinthians won on penalty kicks following extra time | ||
| Round of 16 | Wed | 2022-07-06 | 21:30 | Flamengo br | 4.5 | 7–1 | 0.6 | co Tolima | 61,871 | Estadio Jornalista Mário Filho | Mario Díaz de Vivar | Match Report | Leg 2 of 2; Flamengo won | |
| Round of 16 | Wed | 2022-07-06 | 21:30 | River Plate ar | 1.2 | 0–0 | 0.7 | ar Vélez Sarsfield | Estadio Monumental Antonio Vespucio Libe... | Roberto Tobar | Match Report | Leg 2 of 2; Vélez Sarsfield won | ||
| Round of 16 | Thu | 2022-07-07 | 21:30 | Estudiantes ar | 2.0 | 3–0 | 0.1 | br Fortaleza | 19,942 | Estadio Jorge Luis Hirschi | Esteban Ostojich | Match Report | Leg 2 of 2; Estudiantes won | |
| Quarter-finals | Tue | 2022-08-02 | 21:30 | Corinthians br | 0.5 | 0–2 | 0.9 | br Flamengo | Neo Química Arena | Patricio Loustau | Match Report | Leg 1 of 2 | ||
| Quarter-finals | Wed | 2022-08-03 | 21:30 | Atlético Mineiro br | 2.2 | 2–2 | 2.2 | br Palmeiras | Estádio Governador Magalhães Pinto | Facundo Tello | Match Report | Leg 1 of 2 | ||
| Quarter-finals | Wed | 2022-08-03 | 21:30 | Vélez Sarsfield ar | 1.2 | 3–2 | 0.7 | ar Talleres | Estadio José Amalfitani | Wilmar Roldán | Match Report | Leg 1 of 2 | ||
| Quarter-finals | Thu | 2022-08-04 | 21:30 | Ath Paranaense br | 1.1 | 0–0 | 0.8 | ar Estudiantes | Estádio Joaquim Américo Guimarães | Jesús Valenzuela | Match Report | Leg 1 of 2 | ||
| Quarter-finals | Tue | 2022-08-09 | 21:30 | Flamengo br | 2.1 | 1–0 | 0.5 | br Corinthians | Estadio Jornalista Mário Filho | Esteban Ostojich | Match Report | Leg 2 of 2; Flamengo won | ||
| Quarter-finals | Wed | 2022-08-10 | 21:30 | Talleres ar | 0.5 | 0–1 | 0.8 | ar Vélez Sarsfield | Estadio Mario Alberto Kempes | Eber Aquino | Match Report | Leg 2 of 2; Vélez Sarsfield won | ||
| Quarter-finals | Wed | 2022-08-10 | 21:30 | Palmeiras br | 0.6 | (6) 0–0 (5) | 0.5 | br Atlético Mineiro | Allianz Parque | Wilmar Roldán | Match Report | Leg 2 of 2; Palmeiras won; Palmeiras won on penalty kicks following extra time | ||
| Quarter-finals | Thu | 2022-08-11 | 21:30 | Estudiantes ar | 1.4 | 0–1 | 0.4 | br Ath Paranaense | Estadio Jorge Luis Hirschi | Andrés Matonte | Match Report | Leg 2 of 2; Ath Paranaense won | ||
| Semi-finals | Tue | 2022-08-30 | 21:30 | Ath Paranaense br | 1.0 | 1–0 | 0.8 | br Palmeiras | 38,963 | Estádio Joaquim Américo Guimarães | Roberto Tobar | Match Report | Leg 1 of 2 | |
| Round | Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Semi-finals | Wed | 2022-08-31 | 21:30 | Vélez Sarsfield ar | 0.4 | 0–4 | 2.8 | br Flamengo | Estadio José Amalfitani | Wilmar Roldán | Match Report | Leg 1 of 2 | ||
| Semi-finals | Tue | 2022-09-06 | 21:30 | Palmeiras br | 1.3 | 2–2 | 1.2 | br Ath Paranaense | Allianz Parque | Esteban Ostojich | Match Report | Leg 2 of 2; Ath Paranaense won | ||
| Semi-finals | Wed | 2022-09-07 | 21:30 | Flamengo br | 1.4 | 2–1 | 0.7 | ar Vélez Sarsfield | Estadio Jornalista Mário Filho | Piero Maza | Match Report | Leg 2 of 2; Flamengo won | ||
| Final | Sat | 2022-10-29 | 15:00 | Flamengo br | 1.4 | 1–0 | 0.4 | br Ath Paranaense | Estadio Monumental Isidro Romero Carbo (Neutral Site) | Patricio Loustau | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First qualifying stage | Wed | 2022-02-09 | 18:15 | Deportivo Lara ve | 1.5 | 2–3 | 1.2 | bo Bolívar | Estadio Rafael Agustín Tovar | Eber Aquino | Match Report | Leg 1 of 2 | |
| First qualifying stage | Tue | 2022-02-08 | 21:30 | Torque uy | 1.3 | 1–1 | 1.5 | ec Barcelona SC | Estadio Centenario | Darío Herrera | Match Report | Leg 1 of 2 | |
| First qualifying stage | Wed | 2022-02-09 | 19:30 | U César Vallejo pe | 0.8 | 0–1 | 1.7 | py Olimpia | 2,177 | Estadio Mansiche | Jesús Valenzuela | Match Report | Leg 1 of 2 |
| First qualifying stage | Wed | 2022-02-16 | 18:15 | Bolívar bo | 2.8 | 4–0 | 0.1 | ve Deportivo Lara | Estadio Hernando Siles | Wilton Sampaio | Match Report | Leg 2 of 2; Bolívar won | |
| First qualifying stage | Tue | 2022-02-15 | 19:30 | Barcelona SC ec | 1.1 | (8) 0–0 (7) | 0.8 | uy Torque | Estadio Monumental Isidro Romero Carbo | Anderson Daronco | Match Report | Leg 2 of 2; Barcelona SC won; Barcelona SC won on penalty kicks following extra time | |
| First qualifying stage | Wed | 2022-02-16 | 21:30 | Olimpia py | 3.9 | 2–0 | 0.3 | pe U César Vallejo | 19,539 | Estadio Manuel Ferreira | Facundo Tello | Match Report | Leg 2 of 2; Olimpia won |
| Second qualifying stage | Tue | 2022-02-22 | 19:15 | CD Everton cl | 1.8 | 3–0 | 0.2 | ve Monagas | Estadio Sausalito | Ivo Méndez | Match Report | Leg 1 of 2 | |
| Second qualifying stage | Wed | 2022-02-23 | 18:15 | Bolívar bo | 1.9 | 1–1 | 1.0 | ec Univ Católica | 12,038 | Estadio Hernando Siles | Piero Maza | Match Report | Leg 1 of 2 |
| Second qualifying stage | Wed | 2022-02-23 | 19:15 | América (MG) br | 1.3 | 0–1 | 0.4 | py Guaraní | 6,409 | Estádio Raimundo Sampaio | Wilmar Roldán | Match Report | Leg 1 of 2 |
| Second qualifying stage | Tue | 2022-02-22 | 19:30 | Millonarios co | 1.2 | 1–2 | 2.7 | br Fluminense | Estadio Nemesio Camacho El Campín | Darío Herrera | Match Report | Leg 1 of 2 | |
| Second qualifying stage | Tue | 2022-02-22 | 21:30 | Plaza Colonia uy | 3.1 | 2–0 | 0.8 | bo The Strongest | Estadio Centenario | Bruno Arleu de Araujo | Match Report | Leg 1 of 2 | |
| Second qualifying stage | Wed | 2022-02-23 | 19:30 | Barcelona SC ec | 2.5 | 2–0 | 0.2 | pe Universitario | Estadio Monumental Isidro Romero Carbo | José Argote | Match Report | Leg 1 of 2 | |
| Second qualifying stage | Wed | 2022-02-23 | 21:30 | Audax Italiano cl | 0.6 | 1–0 | 1.8 | ar Estudiantes | Estadio CODELCO-El Teniente | Christian Ferreyra | Match Report | Leg 1 of 2 | |
| Second qualifying stage | Thu | 2022-02-24 | 21:30 | Olimpia py | 1.6 | 3–1 | 2.7 | co Nacional | Estadio Defensores del Chaco | Néstor Pitana | Match Report | Leg 1 of 2 | |
| Second qualifying stage | Tue | 2022-03-01 | 18:15 | Monagas ve | 1.2 | 1–0 | 0.6 | cl CD Everton | Estadio Monumental de Maturín | Gery Vargas | Match Report | Leg 2 of 2; CD Everton won | |
| Second qualifying stage | Wed | 2022-03-02 | 17:15 | Univ Católica ec | 0.9 | 2–0 | 0.7 | bo Bolívar | Estadio Olímpico Atahualpa | Raphael Claus | Match Report | Leg 2 of 2; Univ Católica won | |
| Second qualifying stage | Wed | 2022-03-02 | 19:15 | Guaraní py | 1.2 | (4) 2–3 (5) | 1.9 | br América (MG) | Estadio Defensores del Chaco | Facundo Tello | Match Report | Leg 2 of 2; América (MG) won; América (MG) won on penalty kicks following extra time | |
| Second qualifying stage | Tue | 2022-03-01 | 20:30 | The Strongest bo | 2.1 | 3–0 | 0.3 | uy Plaza Colonia | Estadio Hernando Siles | John J. Ospina | Match Report | Leg 2 of 2; The Strongest won | |
| Second qualifying stage | Tue | 2022-03-01 | 21:30 | Fluminense br | 1.4 | 2–0 | 0.9 | co Millonarios | Estádio Club de Regatas Vasco da Gama | Fernando Rapallini | Match Report | Leg 2 of 2; Fluminense won | |
| Second qualifying stage | Wed | 2022-03-02 | 19:30 | Universitario pe | 1.8 | 0–1 | 1.1 | ec Barcelona SC | Estadio Nacional | Andrés Matonte | Match Report | Leg 2 of 2; Barcelona SC won | |
| Second qualifying stage | Wed | 2022-03-02 | 21:30 | Estudiantes ar | 1.7 | 2–0 | 0.5 | cl Audax Italiano | Estadio Jorge Luis Hirschi | Wilton Sampaio | Match Report | Leg 2 of 2; Estudiantes won | |
| Second qualifying stage | Thu | 2022-03-03 | 19:30 | Nacional co | 0.8 | 1–1 | 0.7 | py Olimpia | Estadio Atanasio Girardot | Patricio Loustau | Match Report | Leg 2 of 2; Olimpia won | |
| Third qualifying stage | Wed | 2022-03-09 | 19:15 | CD Everton cl | 0.6 | 0–1 | 1.4 | ar Estudiantes | Estadio Sausalito | Bruno Arleu de Araujo | Match Report | Leg 1 of 2 | |
| Third qualifying stage | Tue | 2022-03-08 | 21:30 | América (MG) br | 1.0 | 0–0 | 1.1 | ec Barcelona SC | Estádio Raimundo Sampaio | Darío Herrera | Match Report | Leg 1 of 2 | |
| Third qualifying stage | Wed | 2022-03-09 | 21:30 | Fluminense br | 2.4 | 3–1 | 0.9 | py Olimpia | 31,799 | Estádio Nilton Santos | Facundo Tello | Match Report | Leg 1 of 2 |
| Third qualifying stage | Thu | 2022-03-10 | 19:30 | Univ Católica ec | 1.2 | 0–0 | 0.1 | bo The Strongest | Estadio Olímpico Atahualpa | Andrés Matonte | Match Report | Leg 1 of 2 | |
| Third qualifying stage | Wed | 2022-03-16 | 19:15 | Estudiantes ar | 0.7 | 1–0 | 0.1 | cl CD Everton | Estadio Jorge Luis Hirschi | Jesús Valenzuela | Match Report | Leg 2 of 2; Estudiantes won | |
| Third qualifying stage | Tue | 2022-03-15 | 19:30 | Barcelona SC ec | 0.8 | (4) 0–0 (5) | 0.5 | br América (MG) | Estadio Monumental Isidro Romero Carbo | Patricio Loustau | Match Report | Leg 2 of 2; América (MG) won; América (MG) won on penalty kicks following extra time | |
| Third qualifying stage | Wed | 2022-03-16 | 21:30 | Olimpia py | 1.9 | (4) 2–0 (1) | 0.7 | br Fluminense | Estadio Defensores del Chaco | Roberto Tobar | Match Report | Leg 2 of 2; Olimpia won; Olimpia won on penalty kicks following extra time | |
| Third qualifying stage | Thu | 2022-03-17 | 20:30 | The Strongest bo | 0.7 | 2–1 | 0.6 | ec Univ Católica | Estadio Hernando Siles | Wilton Sampaio | Match Report | Leg 2 of 2; The Strongest won |
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tue | 2022-04-05 | 18:15 | Olimpia py | 1.1 | 0–0 | 1.2 | py Cerro Porteño | Estadio Defensores del Chaco | Anderson Daronco | Match Report | ||
| 1 | Tue | 2022-04-05 | 18:15 | Caracas ve | 0.8 | 0–0 | 1.5 | br Ath Paranaense | Estadio Olímpico | Andrés Rojas | Match Report | ||
| 1 | Tue | 2022-04-05 | 19:15 | Colón ar | 3.2 | 2–1 | 0.2 | uy Peñarol | Estadio Brigadier General Estanislao Lóp... | Wilton Sampaio | Match Report | ||
| 1 | Wed | 2022-04-06 | 19:00 | Bragantino br | 1.9 | 2–0 | 1.0 | uy Nacional | Estádio Nabi Abi Chedid | Kevin Ortega | Match Report | ||
| 1 | Wed | 2022-04-06 | 19:00 | Talleres ar | 1.2 | 1–0 | 0.5 | cl Univ Católica | Estadio Mario Alberto Kempes | Gustavo Tejera | Match Report | ||
| 1 | Wed | 2022-04-06 | 19:00 | América (MG) br | 1.0 | 0–2 | 2.5 | ec Independiente | Estádio Raimundo Sampaio | Fernando Rapallini | Match Report | ||
| 1 | Tue | 2022-04-05 | 19:30 | Sporting Cristal pe | 1.1 | 0–2 | 0.7 | br Flamengo | Estadio Nacional | John J. Ospina | Match Report | ||
| 1 | Tue | 2022-04-05 | 19:30 | AD Cali co | 1.6 | 2–0 | 0.7 | ar Boca Juniors | 18,695 | Estadio Deportivo Cali | Jesús Valenzuela | Match Report | |
| 1 | Tue | 2022-04-05 | 20:30 | Always Ready bo | 1.3 | 2–0 | 0.7 | br Corinthians | 4,536 | Estadio Hernando Siles | Piero Maza | Match Report | |
| 1 | Thu | 2022-04-07 | 19:00 | Fortaleza br | 1.9 | 1–2 | 1.3 | cl Colo-Colo | Estádio Castelão | Andrés Cunha | Match Report | ||
| 1 | Wed | 2022-04-06 | 19:00 | Alianza Lima pe | 0.3 | 0–1 | 1.3 | ar River Plate | Estadio Nacional | Wilmar Roldán | Match Report | ||
| 1 | Wed | 2022-04-06 | 19:00 | Tolima co | 1.1 | 0–2 | 1.0 | br Atlético Mineiro | Estadio Manuel Murillo Toro | Alexis Herrera | Match Report | ||
| 1 | Wed | 2022-04-06 | 20:00 | Dep Táchira ve | 0.9 | 0–4 | 2.5 | br Palmeiras | Estadio Polideportivo de Pueblo Nuevo | Darío Herrera | Match Report | ||
| 1 | Wed | 2022-04-06 | 22:00 | Indep Petrolero bo | 0.7 | 1–1 | 1.0 | ec CS Emelec | Estadio Olímpico Patria | Cristián Garay | Match Report | ||
| 1 | Thu | 2022-04-07 | 21:00 | Estudiantes ar | 3.2 | 4–1 | 1.9 | ar Vélez Sarsfield | 16,803 | Estadio Jorge Luis Hirschi | Eber Aquino | Match Report | |
| 1 | Thu | 2022-04-07 | 22:00 | The Strongest bo | 1.9 | 1–1 | 0.6 | py Libertad | 6,079 | Estadio Hernando Siles | Nicolás Gamboa | Match Report | |
| 2 | Tue | 2022-04-12 | 18:15 | Cerro Porteño py | 2.5 | 3–1 | 2.0 | ar Colón | Estadio General Pablo Rojas | Roberto Tobar | Match Report | ||
| 2 | Tue | 2022-04-12 | 18:15 | Univ Católica cl | 0.9 | 2–1 | 1.6 | pe Sporting Cristal | Estadio San Carlos de Apoquindo | Leodán González | Match Report | ||
| 2 | Tue | 2022-04-12 | 19:15 | Boca Juniors ar | 2.2 | 2–0 | 0.2 | bo Always Ready | Estadio Alberto José Armando | Gustavo Tejera | Match Report | ||
| 2 | Wed | 2022-04-13 | 18:00 | Libertad py | 2.1 | 2–1 | 1.1 | ve Caracas | Estadio Defensores del Chaco | Facundo Tello | Match Report | ||
| 2 | Wed | 2022-04-13 | 18:00 | Colo-Colo cl | 1.9 | 2–1 | 1.2 | pe Alianza Lima | Estadio Monumental David Arellano | Esteban Ostojich | Match Report | ||
| 2 | Tue | 2022-04-12 | 21:30 | Palmeiras br | 2.5 | 8–1 | 0.1 | bo Indep Petrolero | 26,409 | Allianz Parque | Derlis López | Match Report | |
| 2 | Tue | 2022-04-12 | 21:30 | Flamengo br | 1.3 | 3–1 | 0.8 | ar Talleres | 42,915 | Estadio Jornalista Mário Filho | Jesús Valenzuela | Match Report | |
| 2 | Tue | 2022-04-12 | 21:30 | Peñarol uy | 0.5 | 2–1 | 1.1 | py Olimpia | 19,813 | Estadio Campeón del Siglo | Raphael Claus | Match Report | |
| 2 | Thu | 2022-04-14 | 19:00 | Ath Paranaense br | 2.2 | 1–0 | 0.2 | bo The Strongest | Estádio Joaquim Américo Guimarães | Darío Herrera | Match Report | ||
| 2 | Wed | 2022-04-13 | 21:00 | Nacional uy | 1.9 | 0–0 | 1.2 | ar Estudiantes | 22,339 | Estadio Gran Parque Central | Wilmar Roldán | Match Report | |
| 2 | Wed | 2022-04-13 | 21:00 | River Plate ar | 2.7 | 2–0 | 0.9 | br Fortaleza | Estadio Monumental Antonio Vespucio Libe... | Andrés Matonte | Match Report | ||
| 2 | Wed | 2022-04-13 | 21:00 | Corinthians br | 1.5 | 1–0 | 0.4 | co AD Cali | 37,708 | Neo Química Arena | Eber Aquino | Match Report | |
| 2 | Wed | 2022-04-13 | 21:00 | Atlético Mineiro br | 2.6 | 1–1 | 0.2 | br América (MG) | 37,312 | Estádio Governador Magalhães Pinto | Patricio Loustau | Match Report | |
| 2 | Wed | 2022-04-13 | 21:00 | Independiente ec | 2.2 | 2–2 | 0.8 | co Tolima | 3,699 | Estadio banco Guayaquil | Kevin Ortega | Match Report | |
| 2 | Thu | 2022-04-14 | 21:00 | CS Emelec ec | 0.6 | 1–1 | 1.1 | ve Dep Táchira | Estadio Banco del Pacífico | Jhon Hinestroza | Match Report | ||
| 2 | Thu | 2022-04-14 | 21:00 | Vélez Sarsfield ar | 1.5 | 2–2 | 0.6 | br Bragantino | 6,826 | Estadio José Amalfitani | John J. Ospina | Match Report | |
| 3 | Tue | 2022-04-26 | 18:15 | Libertad py | 0.8 | 1–0 | 1.2 | br Ath Paranaense | Estadio Defensores del Chaco | Gustavo Tejera | Match Report | ||
| 3 | Tue | 2022-04-26 | 18:15 | Indep Petrolero bo | 1.4 | 1–2 | 1.9 | ve Dep Táchira | Estadio Olímpico Patria | Nicolás Gamboa | Match Report | ||
| 3 | Tue | 2022-04-26 | 19:15 | Estudiantes ar | 2.3 | 2–0 | 0.5 | br Bragantino | Estadio Jorge Luis Hirschi | Kevin Ortega | Match Report | ||
| 3 | Tue | 2022-04-26 | 19:15 | Vélez Sarsfield ar | 2.0 | 1–2 | 1.5 | uy Nacional | Estadio José Amalfitani | Eber Aquino | Match Report | ||
| 3 | Wed | 2022-04-27 | 19:00 | América (MG) br | 1.9 | 2–3 | 2.2 | co Tolima | 4,651 | Estádio Raimundo Sampaio | Andrés Cunha | Match Report | |
| 3 | Wed | 2022-04-27 | 19:00 | Fortaleza br | 2.0 | 2–1 | 0.4 | pe Alianza Lima | 32,557 | Estádio Castelão | Carlos Betancourt | Match Report | |
| 3 | Tue | 2022-04-26 | 19:30 | Independiente ec | 2.0 | 1–1 | 1.7 | br Atlético Mineiro | Estadio banco Guayaquil | Fernando Rapallini | Match Report | ||
| 3 | Tue | 2022-04-26 | 21:30 | Corinthians br | 1.2 | 2–0 | 0.3 | ar Boca Juniors | Neo Química Arena | Andrés Matonte | Match Report | ||
| 3 | Tue | 2022-04-26 | 21:30 | Talleres ar | 2.0 | 1–0 | 0.3 | pe Sporting Cristal | Estadio Mario Alberto Kempes | Mario Díaz de Vivar | Match Report | ||
| 3 | Thu | 2022-04-28 | 18:00 | Univ Católica cl | 0.9 | 2–3 | 2.9 | br Flamengo | Estadio San Carlos de Apoquindo | José Argote | Match Report | ||
| 3 | Wed | 2022-04-27 | 19:00 | CS Emelec ec | 0.9 | 1–3 | 2.3 | br Palmeiras | Estadio Banco del Pacífico | Patricio Loustau | Match Report | ||
| 3 | Wed | 2022-04-27 | 20:00 | Colo-Colo cl | 0.6 | 1–2 | 1.4 | ar River Plate | Estadio Monumental David Arellano | Alexis Herrera | Match Report | ||
| 3 | Wed | 2022-04-27 | 20:00 | Cerro Porteño py | 1.1 | 1–0 | 0.8 | uy Peñarol | Estadio General Pablo Rojas | Wilmar Roldán | Match Report | ||
| 3 | Wed | 2022-04-27 | 22:00 | The Strongest bo | 3.1 | 1–1 | 0.9 | ve Caracas | Estadio Hernando Siles | Guillermo Guerrero | Match Report | ||
| 3 | Thu | 2022-04-28 | 20:00 | Olimpia py | 2.1 | 0–0 | 1.6 | ar Colón | Estadio Defensores del Chaco | Jesús Valenzuela | Match Report | ||
| 3 | Thu | 2022-04-28 | 22:00 | Always Ready bo | 2.7 | 2–2 | 2.4 | co AD Cali | Estadio Hernando Siles | Augusto Aragón | Match Report | ||
| 4 | Tue | 2022-05-03 | 18:15 | Dep Táchira ve | 1.2 | 1–4 | 1.8 | ec CS Emelec | Estadio Polideportivo de Pueblo Nuevo | Pablo Echavarría | Match Report | ||
| 4 | Tue | 2022-05-03 | 18:15 | The Strongest bo | 2.6 | 5–0 | 0.8 | br Ath Paranaense | Estadio Hernando Siles | Augusto Menéndez | Match Report | ||
| 4 | Tue | 2022-05-03 | 18:15 | Caracas ve | 1.8 | 1–0 | 1.0 | py Libertad | Estadio Olímpico | Andrés Matonte | Match Report | ||
| 4 | Wed | 2022-05-04 | 19:00 | Colón ar | 2.5 | 2–1 | 0.6 | py Cerro Porteño | Estadio Brigadier General Estanislao Lóp... | Raphael Claus | Match Report | ||
| 4 | Wed | 2022-05-04 | 19:00 | Talleres ar | 1.0 | 2–2 | 0.5 | br Flamengo | Estadio Mario Alberto Kempes | Eber Aquino | Match Report | ||
| 4 | Tue | 2022-05-03 | 20:30 | Indep Petrolero bo | 0.7 | 0–5 | 3.5 | br Palmeiras | Estadio Olímpico Patria | Nicolás Lamolina | Match Report | ||
| 4 | Tue | 2022-05-03 | 21:30 | América (MG) br | 0.9 | 1–2 | 1.6 | br Atlético Mineiro | Estádio Raimundo Sampaio | Darío Herrera | Match Report | ||
| 4 | Tue | 2022-05-03 | 21:30 | Estudiantes ar | 1.1 | 1–0 | 0.3 | uy Nacional | Estadio Jorge Luis Hirschi | Wilmar Roldán | Match Report | ||
| 4 | Thu | 2022-05-05 | 19:00 | Fortaleza br | 1.4 | 1–1 | 2.2 | ar River Plate | Estádio Castelão | Esteban Ostojich | Match Report | ||
| 4 | Wed | 2022-05-04 | 19:00 | AD Cali co | 1.8 | 0–0 | 2.1 | br Corinthians | Estadio Deportivo Cali | Andrés Cunha | Match Report | ||
| 4 | Wed | 2022-05-04 | 20:00 | Olimpia py | 0.7 | 1–0 | 0.7 | uy Peñarol | Estadio Defensores del Chaco | Anderson Daronco | Match Report | ||
| 4 | Wed | 2022-05-04 | 20:00 | Always Ready bo | 1.0 | 0–1 | 1.6 | ar Boca Juniors | Estadio Hernando Siles | Kevin Ortega | Match Report | ||
| 4 | Wed | 2022-05-04 | 21:00 | Tolima co | 1.5 | 1–0 | 0.7 | ec Independiente | Estadio Manuel Murillo Toro | Patricio Loustau | Match Report | ||
| 4 | Wed | 2022-05-04 | 21:00 | Sporting Cristal pe | 1.0 | 1–1 | 1.2 | cl Univ Católica | Estadio Nacional | Andrés Rojas | Match Report | ||
| 4 | Thu | 2022-05-05 | 21:00 | Alianza Lima pe | 0.5 | 1–1 | 3.0 | cl Colo-Colo | Estadio Alejandro Villanueva | Carlos Betancourt | Match Report | ||
| 4 | Thu | 2022-05-05 | 21:00 | Bragantino br | 0.9 | 1–1 | 1.0 | ar Vélez Sarsfield | Estádio Nabi Abi Chedid | John J. Ospina | Match Report | ||
| 5 | Tue | 2022-05-17 | 18:15 | Caracas ve | 0.6 | 0–0 | 0.5 | bo The Strongest | Estadio Olímpico | Darío Herrera | Match Report | ||
| 5 | Tue | 2022-05-17 | 19:15 | Bragantino br | 0.5 | 0–1 | 0.5 | ar Estudiantes | 4,769 | Estádio Nabi Abi Chedid | Juan Benítez | Match Report | |
| 5 | Tue | 2022-05-17 | 19:15 | Peñarol uy | 1.5 | 0–0 | 0.5 | py Cerro Porteño | Estadio Campeón del Siglo | Wilton Sampaio | Match Report | ||
| 5 | Wed | 2022-05-18 | 19:00 | Nacional uy | 1.6 | 2–3 | 1.7 | ar Vélez Sarsfield | Estadio Gran Parque Central | Piero Maza | Match Report | ||
| 5 | Wed | 2022-05-18 | 19:00 | Palmeiras br | 2.8 | 1–0 | 0.6 | ec CS Emelec | Allianz Parque | Nicolás Gamboa | Match Report | ||
| 5 | Wed | 2022-05-18 | 19:00 | Ath Paranaense br | 1.3 | 2–0 | 0.5 | py Libertad | Estádio Joaquim Américo Guimarães | Patricio Loustau | Match Report | ||
| 5 | Tue | 2022-05-17 | 19:30 | Sporting Cristal pe | 0.8 | 0–0 | 0.8 | ar Talleres | Estadio Nacional | Luis Quiroz | Match Report | ||
| 5 | Tue | 2022-05-17 | 21:30 | Flamengo br | 3.8 | 3–0 | 1.1 | cl Univ Católica | 43,532 | Estadio Jornalista Mário Filho | John J. Ospina | Match Report | |
| 5 | Tue | 2022-05-17 | 21:30 | Boca Juniors ar | 1.1 | 1–1 | 0.1 | br Corinthians | Estadio Alberto José Armando | Christian Ferreyra | Match Report | ||
| 5 | Wed | 2022-05-18 | 19:00 | Tolima co | 2.0 | 2–2 | 1.4 | br América (MG) | Estadio Manuel Murillo Toro | Fernando Rapallini | Match Report | ||
| 5 | Thu | 2022-05-19 | 19:00 | Atlético Mineiro br | 2.5 | 3–1 | 0.6 | ec Independiente | Estádio Governador Magalhães Pinto | Esteban Ostojich | Match Report | ||
| 5 | Wed | 2022-05-18 | 20:00 | Dep Táchira ve | 2.5 | 3–0 | 0.3 | bo Indep Petrolero | Estadio Polideportivo de Pueblo Nuevo | Carlos Benítez | Match Report | ||
| 5 | Wed | 2022-05-18 | 21:00 | Colón ar | 1.0 | 2–1 | 0.4 | py Olimpia | Estadio Brigadier General Estanislao Lóp... | Wilmar Roldán | Match Report | ||
| 5 | Wed | 2022-05-18 | 21:00 | Alianza Lima pe | 1.0 | 0–2 | 2.3 | br Fortaleza | Estadio Alejandro Villanueva | Franklin Congo | Match Report | ||
| 5 | Thu | 2022-05-19 | 21:00 | AD Cali co | 3.0 | 3–0 | 0.6 | bo Always Ready | Estadio Deportivo Cali | Alexis Herrera | Match Report | ||
| 5 | Thu | 2022-05-19 | 21:00 | River Plate ar | 3.7 | 4–0 | 0.7 | cl Colo-Colo | Estadio Monumental Antonio Vespucio Libe... | Andrés Matonte | Match Report | ||
| 6 | Tue | 2022-05-24 | 19:15 | Vélez Sarsfield ar | 1.9 | 4–0 | 0.9 | ar Estudiantes | Estadio José Amalfitani | Nicolás Gamboa | Match Report | ||
| 6 | Tue | 2022-05-24 | 19:15 | Nacional uy | 3.1 | 3–0 | 0.9 | br Bragantino | Estadio Gran Parque Central | Wilmar Roldán | Match Report | ||
| 6 | Wed | 2022-05-25 | 18:00 | Colo-Colo cl | 1.8 | 3–4 | 1.8 | br Fortaleza | Estadio Monumental David Arellano | Esteban Ostojich | Match Report | ||
| 6 | Wed | 2022-05-25 | 19:00 | River Plate ar | 4.9 | 8–1 | 1.1 | pe Alianza Lima | Estadio Monumental Antonio Vespucio Libe... | John J. Ospina | Match Report | ||
| 6 | Tue | 2022-05-24 | 19:30 | CS Emelec ec | 3.8 | 7–0 | 0.6 | bo Indep Petrolero | Estadio Banco del Pacífico | Carlos Ortega | Match Report | ||
| 6 | Tue | 2022-05-24 | 20:30 | Univ Católica cl | 1.4 | 0–1 | 0.5 | ar Talleres | Estadio San Carlos de Apoquindo | Gery Vargas | Match Report | ||
| 6 | Tue | 2022-05-24 | 21:30 | Palmeiras br | 2.9 | 4–1 | 0.9 | ve Dep Táchira | Allianz Parque | Kevin Ortega | Match Report | ||
| 6 | Tue | 2022-05-24 | 21:30 | Flamengo br | 1.8 | 2–1 | 0.8 | pe Sporting Cristal | Estadio Jornalista Mário Filho | Alexis Herrera | Match Report | ||
| 6 | Thu | 2022-05-26 | 18:00 | Libertad py | 2.4 | 4–1 | 0.9 | bo The Strongest | Estadio Defensores del Chaco | Facundo Tello | Match Report | ||
| 6 | Thu | 2022-05-26 | 19:00 | Ath Paranaense br | 2.2 | 5–1 | 0.8 | ve Caracas | Estádio Joaquim Américo Guimarães | Nicolás Lamolina | Match Report | ||
| 6 | Wed | 2022-05-25 | 19:00 | Independiente ec | 1.3 | 3–0 | 0.2 | br América (MG) | Estadio banco Guayaquil | Leodán González | Match Report | ||
| 6 | Wed | 2022-05-25 | 20:00 | Cerro Porteño py | 0.9 | 0–1 | 0.7 | py Olimpia | Estadio General Pablo Rojas | Raphael Claus | Match Report | ||
| 6 | Wed | 2022-05-25 | 21:00 | Peñarol uy | 0.8 | 2–1 | 0.7 | ar Colón | Estadio Campeón del Siglo | Anderson Daronco | Match Report | ||
| 6 | Wed | 2022-05-25 | 21:00 | Atlético Mineiro br | 1.0 | 1–2 | 0.5 | co Tolima | Estádio Governador Magalhães Pinto | Patricio Loustau | Match Report | ||
| 6 | Thu | 2022-05-26 | 21:00 | Corinthians br | 2.2 | 1–1 | 0.4 | bo Always Ready | Neo Química Arena | José Argote | Match Report | ||
| 6 | Thu | 2022-05-26 | 21:00 | Boca Juniors ar | 1.0 | 1–0 | 0.5 | co AD Cali | Estadio Alberto José Armando | Piero Maza | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Round of 16 | Tue | 2022-06-28 | 17:15 | CS Emelec ec | 1.4 | 1–1 | 1.7 | br Atlético Mineiro | Estadio Banco del Pacífico | Fernando Rapallini | Match Report | Leg 1 of 2 | |
| Round of 16 | Wed | 2022-06-29 | 18:15 | Cerro Porteño py | 0.4 | 0–3 | 4.0 | br Palmeiras | Estadio General Pablo Rojas | Wilmar Roldán | Match Report | Leg 1 of 2 | |
| Round of 16 | Wed | 2022-06-29 | 19:15 | Talleres ar | 1.2 | 1–1 | 0.4 | ar Colón | Estadio Mario Alberto Kempes | Wilton Sampaio | Match Report | Leg 1 of 2 | |
| Round of 16 | Tue | 2022-06-28 | 21:30 | Corinthians br | 1.7 | 0–0 | 0.7 | ar Boca Juniors | Neo Química Arena | Roberto Tobar | Match Report | Leg 1 of 2 | |
| Round of 16 | Tue | 2022-06-28 | 21:30 | Ath Paranaense br | 1.4 | 2–1 | 1.3 | py Libertad | Estádio Joaquim Américo Guimarães | Alexis Herrera | Match Report | Leg 1 of 2 | |
| Round of 16 | Wed | 2022-06-29 | 19:30 | Tolima co | 1.0 | 0–1 | 0.3 | br Flamengo | Estadio Manuel Murillo Toro | Jesús Valenzuela | Match Report | Leg 1 of 2 | |
| Round of 16 | Wed | 2022-06-29 | 21:30 | Vélez Sarsfield ar | 1.8 | 1–0 | 0.5 | ar River Plate | Estadio José Amalfitani | Raphael Claus | Match Report | Leg 1 of 2 | |
| Round of 16 | Thu | 2022-06-30 | 21:30 | Fortaleza br | 0.8 | 1–1 | 0.9 | ar Estudiantes | Estádio Castelão | Andrés Matonte | Match Report | Leg 1 of 2 | |
| Round of 16 | Tue | 2022-07-05 | 19:15 | Atlético Mineiro br | 2.0 | 1–0 | 0.2 | ec CS Emelec | Estádio Governador Magalhães Pinto | Jesús Valenzuela | Match Report | Leg 2 of 2; Atlético Mineiro won | |
| Round of 16 | Wed | 2022-07-06 | 19:15 | Colón ar | 0.2 | 0–2 | 1.5 | ar Talleres | 17,235 | Estadio Brigadier General Estanislao Lóp... | Anderson Daronco | Match Report | Leg 2 of 2; Talleres won |
| Round of 16 | Wed | 2022-07-06 | 19:15 | Palmeiras br | 2.3 | 5–0 | 0.4 | py Cerro Porteño | 37,431 | Allianz Parque | Patricio Loustau | Match Report | Leg 2 of 2; Palmeiras won |
| Round of 16 | Tue | 2022-07-05 | 20:30 | Libertad py | 1.8 | 1–1 | 1.6 | br Ath Paranaense | 12,735 | Estadio Defensores del Chaco | Andrés Cunha | Match Report | Leg 2 of 2; Ath Paranaense won |
| Round of 16 | Tue | 2022-07-05 | 21:30 | Boca Juniors ar | 1.9 | (5) 0–0 (6) | 0.1 | br Corinthians | Estadio Alberto José Armando | Andrés Matonte | Match Report | Leg 2 of 2; Corinthians won; Corinthians won on penalty kicks following extra time | |
| Round of 16 | Wed | 2022-07-06 | 21:30 | Flamengo br | 4.5 | 7–1 | 0.6 | co Tolima | 61,871 | Estadio Jornalista Mário Filho | Mario Díaz de Vivar | Match Report | Leg 2 of 2; Flamengo won |
| Round of 16 | Wed | 2022-07-06 | 21:30 | River Plate ar | 1.2 | 0–0 | 0.7 | ar Vélez Sarsfield | Estadio Monumental Antonio Vespucio Libe... | Roberto Tobar | Match Report | Leg 2 of 2; Vélez Sarsfield won | |
| Round of 16 | Thu | 2022-07-07 | 21:30 | Estudiantes ar | 2.0 | 3–0 | 0.1 | br Fortaleza | 19,942 | Estadio Jorge Luis Hirschi | Esteban Ostojich | Match Report | Leg 2 of 2; Estudiantes won |
| Quarter-finals | Tue | 2022-08-02 | 21:30 | Corinthians br | 0.5 | 0–2 | 0.9 | br Flamengo | Neo Química Arena | Patricio Loustau | Match Report | Leg 1 of 2 | |
| Quarter-finals | Wed | 2022-08-03 | 21:30 | Atlético Mineiro br | 2.2 | 2–2 | 2.2 | br Palmeiras | Estádio Governador Magalhães Pinto | Facundo Tello | Match Report | Leg 1 of 2 | |
| Quarter-finals | Wed | 2022-08-03 | 21:30 | Vélez Sarsfield ar | 1.2 | 3–2 | 0.7 | ar Talleres | Estadio José Amalfitani | Wilmar Roldán | Match Report | Leg 1 of 2 | |
| Quarter-finals | Thu | 2022-08-04 | 21:30 | Ath Paranaense br | 1.1 | 0–0 | 0.8 | ar Estudiantes | Estádio Joaquim Américo Guimarães | Jesús Valenzuela | Match Report | Leg 1 of 2 | |
| Quarter-finals | Tue | 2022-08-09 | 21:30 | Flamengo br | 2.1 | 1–0 | 0.5 | br Corinthians | Estadio Jornalista Mário Filho | Esteban Ostojich | Match Report | Leg 2 of 2; Flamengo won | |
| Quarter-finals | Wed | 2022-08-10 | 21:30 | Talleres ar | 0.5 | 0–1 | 0.8 | ar Vélez Sarsfield | Estadio Mario Alberto Kempes | Eber Aquino | Match Report | Leg 2 of 2; Vélez Sarsfield won | |
| Quarter-finals | Wed | 2022-08-10 | 21:30 | Palmeiras br | 0.6 | (6) 0–0 (5) | 0.5 | br Atlético Mineiro | Allianz Parque | Wilmar Roldán | Match Report | Leg 2 of 2; Palmeiras won; Palmeiras won on penalty kicks following extra time | |
| Quarter-finals | Thu | 2022-08-11 | 21:30 | Estudiantes ar | 1.4 | 0–1 | 0.4 | br Ath Paranaense | Estadio Jorge Luis Hirschi | Andrés Matonte | Match Report | Leg 2 of 2; Ath Paranaense won | |
| Semi-finals | Tue | 2022-08-30 | 21:30 | Ath Paranaense br | 1.0 | 1–0 | 0.8 | br Palmeiras | 38,963 | Estádio Joaquim Américo Guimarães | Roberto Tobar | Match Report | Leg 1 of 2 |
| Semi-finals | Wed | 2022-08-31 | 21:30 | Vélez Sarsfield ar | 0.4 | 0–4 | 2.8 | br Flamengo | Estadio José Amalfitani | Wilmar Roldán | Match Report | Leg 1 of 2 | |
| Semi-finals | Tue | 2022-09-06 | 21:30 | Palmeiras br | 1.3 | 2–2 | 1.2 | br Ath Paranaense | Allianz Parque | Esteban Ostojich | Match Report | Leg 2 of 2; Ath Paranaense won | |
| Semi-finals | Wed | 2022-09-07 | 21:30 | Flamengo br | 1.4 | 2–1 | 0.7 | ar Vélez Sarsfield | Estadio Jornalista Mário Filho | Piero Maza | Match Report | Leg 2 of 2; Flamengo won | |
| Final | Sat | 2022-10-29 | 15:00 | Flamengo br | 1.4 | 1–0 | 0.4 | br Ath Paranaense | Estadio Monumental Isidro Romero Carbo (Neutral Site) | Patricio Loustau | Match Report |
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