| Second qualifying round | | 17:00 | Santa Coloma ad | 3–0 | me FK Sutjeska Nikšić | 212 | Estadi Comunal d'Andorra la Vella | Kristoffer Karlsson | Match Report | Leg 2 of 2; Santa Coloma won; Required Extra Time |
| Second qualifying round | | 17:30 | Spartak Trnava sk | 4–1 | lv Futbola Klubs Alfa Rīga | 7,394 | City Arena Trnava | Luca Cibelli | Match Report | Leg 2 of 2; Spartak Trnava won |
| Second qualifying round | | 18:00 | Pogoń Szczecin pl | 3–2 | nir Linfield FC | 16,839 | Stadion Miejski im. Floriana Krygiera | Abdulkadir Bitigen | Match Report | Leg 2 of 2; Pogoń Szczecin won |
| Second qualifying round | | 18:45 | Zalaegerszeg hu | 1–2 | hr Osijek | 5,347 | ZTE-Aréna | Gal Leibovitz | Match Report | Leg 2 of 2; Osijek won |
| Second qualifying round | | 19:00 | Pyunik am | 2–1 | se Kalmar | 3,100 | Kotaik | Igor Stojchevski | Match Report | Leg 2 of 2; Pyunik won |
| Second qualifying round | | 19:00 | FK Panevėžys lt | 1–1 | il Hapoel Be'er Sheva FC | 920 | Hikvision Arena | Jan Petřík | Match Report | Leg 2 of 2; Hapoel Be'er Sheva FC won |
| Second qualifying round | | 19:00 | FK Kauno Žalgiris lt | 1–2 | pl Lech Poznań | 5,180 | S. Dariaus ir S. Girėno stadionas | Mads-Kristoffer Kristoffersen | Match Report | Leg 2 of 2; Lech Poznań won |
| Second qualifying round | | 19:00 | Rosenborg no | 3–2 | nir Crusaders FC | 11,288 | Lerkendal Stadion | Ádám Farkas | Match Report | Leg 2 of 2; Rosenborg won; Required Extra Time |
| Second qualifying round | | 19:00 | FC Tobol kz | 1–2 | ch Basel | 8,420 | Ortalıq Stadion | Miloš Milanović | Match Report | Leg 2 of 2; FC Tobol won |
| Second qualifying round | | 19:00 | KuPS fi | 3–3 | ie Derry City | 2,524 | Väre Areena | Dario Bel | Match Report | Leg 2 of 2; Derry City won |
| Second qualifying round | | 19:05 | Bohemians 1905 cz | 2–4 | no Bodø/Glimt | 12,089 | epet Arena | Marcel Bîrsan | Match Report | Leg 2 of 2; Bodø/Glimt won |
| Second qualifying round | | 19:15 | Hibernian sct | 6–1 | ad Inter d'Escaldes | 13,840 | Easter Road Stadium | Peter Kráľovič | Match Report | Leg 2 of 2; Hibernian won |
| Second qualifying round | | 19:30 | FC Progrès Niederkorn lu | 2–1 | dk Midtjylland | 1,780 | Stade Parc des Sports | Ferenc Karakó | Match Report | Leg 2 of 2; Midtjylland won; Required Extra Time |
| Second qualifying round | | 19:30 | Larne FC nir | 1–4 | xk KF Ballkani Therandë | 1,301 | Solitude | Vilhjálmur Þórarinsson | Match Report | Leg 2 of 2; KF Ballkani Therandë won |
| Second qualifying round | | 19:45 | Haverfordwest wls | 1–1 | fo B36 Tórshavn | 2,119 | Cardiff City Stadium | Christian-Petru Ciochirca | Match Report | Leg 2 of 2; B36 Tórshavn won; Required Extra Time |
| Second qualifying round | | 19:45 | Dundalk FC ie | 2–2 | is KA | 2,900 | Oriel Park | Walter Altmann | Match Report | Leg 2 of 2; KA won |
| Second qualifying round | | 20:00 | AC Omonia cy | 4–1 | az Qabala | 15,048 | Neo GSP | Adam Ladebäck | Match Report | Leg 2 of 2; AC Omonia won |
| Second qualifying round | | 20:00 | Hammarby se | 1–1 | nl Twente | 24,542 | Tele2 Arena | Manfredas Lukjančukas | Match Report | Leg 2 of 2; Twente won; Required Extra Time |
| Second qualifying round | | 20:00 | AGF dk | 1–0 | be Club Brugge | 12,651 | Ceres Park | Atilla Karaoğlan | Match Report | Leg 2 of 2; Club Brugge won |
| Second qualifying round | | 20:00 | Sabah FK az | 2–1 | lv FK Rīgas Futbola skola | 4,730 | Bank Respublika Arena | Fedayi San | Match Report | Leg 2 of 2; Sabah FK won |
| Second qualifying round | | 20:00 | FC Dinamo Tbilisi ge | 0–1 | mt Ħamrun Spartans FC | 2,500 | Boris Paichadze Stadioni | Viktor Shimusik | Match Report | Leg 2 of 2; Ħamrun Spartans FC won |
| Second qualifying round | | 20:00 | Sepsi Sfântu Gheorghe ro | 4–0 | bg CSKA Sofia | 8,270 | Stadionul Arena Sepsi | Eldorjan Hamiti | Match Report | Leg 2 of 2; Sepsi Sfântu Gheorghe won |
| Second qualifying round | | 20:00 | KF Drita xk | 1–2 | cz Viktoria Plzeň | 8,000 | Stadiumi Fadil Vokrri | Jakob Sundberg | Match Report | Leg 2 of 2; Viktoria Plzeň won |
| Second qualifying round | | 20:00 | Rīga FC lv | 3–1 | hu Kecskemét | 5,533 | Stadions Skonto | Iwan Arwel Griffith | Match Report | Leg 2 of 2; Rīga FC won; Required Extra Time |
| Round | Wk | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Second qualifying round | | 20:00 | Urartu am | 2–3 | ro Farul Constanța | 3,500 | Urartu Stadium | Tom Owen | Match Report | Leg 2 of 2; Farul Constanța won |
| Second qualifying round | | 20:00 | Shamrock Rovers ie | 0–2 | hu Ferencváros | 3,737 | Tallaght Stadium | Tomasz Musiał | Match Report | Leg 2 of 2; Ferencváros won |
| Second qualifying round | | 20:00 | Vojvodina rs | 1–2 | cy APOEL FC | 6,705 | Stadion Karađorđe | Vitālijs Spasjoņņikovs | Match Report | Leg 2 of 2; APOEL FC won |
| Second qualifying round | | 20:00 | Levski Sofia bg | 1–0 | mk FK Shkupi | 16,424 | Stadion Georgi Asparuhov | Lionel Tschudi | Match Report | Leg 2 of 2; Levski Sofia won |
| Second qualifying round | | 20:00 | MŠK Žilina sk | 2–5 | be Gent | 6,224 | Štadión Pod Dubňom | Dumitru Muntean | Match Report | Leg 2 of 2; Gent won |
| Second qualifying round | | 20:00 | KF Tirana al | 0–2 | tr Beşiktaş | 10,865 | Air Albania Stadium | Stuart Attwell | Match Report | Leg 2 of 2; Beşiktaş won |
| Second qualifying round | | 20:00 | FC Petrocub Sărata-Galbenă md | 0–2 | il Maccabi Tel Aviv FC | 5,348 | Stadionul Zimbru | Peter Kjaesgaard | Match Report | Leg 2 of 2; Maccabi Tel Aviv FC won |
| Second qualifying round | | 20:15 | Rijeka hr | 6–1 | xk KF Dukagjini Klinë | 6,827 | Stadion HNK Rijeka | Jamie Robinson | Match Report | Leg 2 of 2; Rijeka won |
| Second qualifying round | | 20:15 | Vitória Guimarães pt | (2) 0–1 (4) | si NK Celje | 18,639 | Estádio Dom Afonso Henriques | Viktor Kopievskii | Match Report | Leg 2 of 2; NK Celje won; NK Celje won on penalty kicks following extra time |
| Second qualifying round | | 20:30 | Beitar Jerusalem il | 1–4 | gr PAOK | 26,557 | Teddi Malcha Stadium | Benoît Millot | Match Report | Leg 2 of 2; PAOK won |
| Second qualifying round | | 20:30 | Borac Banja Luka ba | 1–2 | at Austria Wien | 8,653 | Gradski Stadion | Urs Schnyder | Match Report | Leg 2 of 2; Austria Wien won |
| Second qualifying round | | 20:30 | NK Maribor si | 4–3 | lu Differdange | 6,000 | Ljudski vrt | Krzysztof Jakubik | Match Report | Leg 2 of 2; NK Maribor won; Required Extra Time |
| Second qualifying round | | 20:45 | Luzern ch | 1–1 | se Djurgården | 13,374 | swissporarena | Genc Nuza | Match Report | Leg 2 of 2; Luzern won |
| Second qualifying round | | 21:00 | Legia Warsaw pl | 3–2 | kz FC Ordabasy | 23,517 | Stadion Miejski Legii Warszawa im. Marsz... | Kevin Clancy | Match Report | Leg 2 of 2; Legia Warsaw won |
| Second qualifying round | | 21:00 | Debrecen hu | (3) 1–2 (1) | am Alashkert | 10,708 | Nagyerdei Stadion | Robert Schröder | Match Report | Leg 2 of 2; Debrecen won; Debrecen won on penalty kicks following extra time |
| Second qualifying round | | 21:00 | FC Aktobe kz | 1–2 | ge FC Torpedo Kutaisi | 12,354 | Ortalıq Stadion | Trustin Farrugia Cann | Match Report | Leg 2 of 2; FC Aktobe won |
| Second qualifying round | | 21:00 | Neftçi az | 2–0 | ba Željezničar Sarajevo | 10,000 | Neftçi Arena | Balázs Berke | Match Report | Leg 2 of 2; Neftçi won |
| Second qualifying round | | 21:00 | Adana Demirspor tr | 2–1 | ro CFR Cluj | 22,256 | Yeni Adana Stadyumu | Nathan Verboomen | Match Report | Leg 2 of 2; Adana Demirspor won |
| Second qualifying round | | 21:00 | FC Dila Gori ge | 3–1 | ua Vorskla Poltava | 4,100 | Stadioni Tengiz Burjanadze | Simone Sozza | Match Report | Leg 2 of 2; FC Dila Gori won |
| Second qualifying round | | 21:15 | Aris gr | 1–0 | am Ararat-Armenia | 11,217 | Stadio Harilaou Kleánthis Vikelídis | Michael Fabbri | Match Report | Leg 2 of 2; Aris won |
| Second qualifying round | | 21:30 | FCSB ro | 3–2 | bg CSKA 1948 | | Stadionul Arcul de Triumf | Juxhin Xhaja | Match Report | Leg 2 of 2; FCSB won |
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