| Second qualifying round | | 17:00 | Laçi al | 0–2 | no Molde | 420 | Stadiumi Laçi | Kristo Tohver | Match Report | Leg 2 of 2; Molde won |
| Second qualifying round | | 17:30 | FK AS Trenčín sk | 4–1 | pl Górnik Zabrze | 1,897 | Futbalový štadión | Ola Nilsen | Match Report | Leg 2 of 2; FK AS Trenčín won |
| Second qualifying round | | 18:00 | Valletta FC mt | 1–2 | ba Zrinjski Mostar | 1,310 | MFA Centenary Stadium | Rade Obrenović | Match Report | Leg 2 of 2; Zrinjski Mostar won |
| Second qualifying round | | 18:30 | BK Häcken se | 1–1 | de RB Leipzig | 2,968 | Bravida Arena | Mete Kalkavan | Match Report | Leg 2 of 2; RB Leipzig won |
| Second qualifying round | | 18:30 | Lillestrøm no | 1–2 | at LASK | 1,975 | Åråsen Stadion | Vilhjálmur Alvar Þórarinsson | Match Report | Leg 2 of 2; LASK won |
| Second qualifying round | | 18:30 | AEK Larnaca cy | 4–0 | ie Dundalk FC | 3,991 | AEK Arena - George Karapatakis | Fran Jović | Match Report | Leg 2 of 2; AEK Larnaca won |
| Second qualifying round | | 19:00 | Sparta Prague cz | 2–1 | rs Spartak Subotica | 12,068 | Hřiště FC Přední Kopanina | Constantin Colțescu | Match Report | Leg 2 of 2; Spartak Subotica won |
| Second qualifying round | | 19:00 | Vaduz li | 1–1 | lt Žalgiris | 853 | Rheinpark Stadion | Anastasios Papapetrou | Match Report | Leg 2 of 2; Žalgiris won |
| Second qualifying round | | 19:00 | Alashkert am | 0–0 | me FK Sutjeska Nikšić | 6,735 | Vazgen Sargsyan anvan Hanrapetakan Marza... | Ivaylo Stoyanov | Match Report | Leg 2 of 2; Alashkert won |
| Second qualifying round | | 19:00 | Lincoln Red Imps FC gi | 1–1 | wls The New Saints FC | 546 | Victoria Stadium | Petri Viljanen | Match Report | Leg 2 of 2; The New Saints FC won |
| Second qualifying round | | 19:00 | Víkingur Gøta fo | 0–4 | ge FC Torpedo Kutaisi | 300 | Svangaskarð | Lee Evans | Match Report | Leg 2 of 2; FC Torpedo Kutaisi won |
| Second qualifying round | | 19:00 | Riteriai lt | 1–1 | rs Partizan | 1,980 | Vilniaus LFF stadionas | Stephan Klossner | Match Report | Leg 2 of 2; Partizan won |
| Second qualifying round | | 19:00 | Admira Wacker Mödling at | 1–3 | bg CSKA Sofia | 2,400 | BSFZ-Arena | Pol van Boekel | Match Report | Leg 2 of 2; CSKA Sofia won |
| Second qualifying round | | 19:00 | Slavia Sofia bg | 2–3 | hr Hajduk Split | 2,100 | Stadion Vasil Levski | Daniele Doveri | Match Report | Leg 2 of 2; Hajduk Split won |
| Second qualifying round | | 19:00 | FC Flora ee | 2–0 | cy APOEL FC | 801 | A. Le Coq Arena | Amaury Delerue | Match Report | Leg 2 of 2; APOEL FC won |
| Second qualifying round | | 19:00 | AIK Stockholm se | 0–1 | dk Nordsjælland | 10,946 | Stockholms Olympiastadion | Jérôme Brisard | Match Report | Leg 2 of 2; Nordsjælland won |
| Second qualifying round | | 19:00 | FC Progrès Niederkorn lu | 2–0 | hu Honvéd | 1,852 | Stade Parc des Sports | Karim Abed | Match Report | Leg 2 of 2; FC Progrès Niederkorn won |
| Second qualifying round | | 19:00 | Dinamo Minsk by | 4–1 | sk DAC | 9,450 | Stadyen Dynama | Antti Munukka | Match Report | Leg 2 of 2; Dinamo Minsk won |
| Second qualifying round | | 19:15 | FH is | 0–1 | il Hapoel Haifa FC | 1,136 | Kaplakrikavöllur | Sergey Tsinkevich | Match Report | Leg 2 of 2; Hapoel Haifa FC won |
| Second qualifying round | | 19:30 | Slovan Bratislava sk | 3–1 | mt Balzan FC | 4,176 | Štadión Pasienky | Alexandre Boucaut | Match Report | Leg 2 of 2; Slovan Bratislava won |
| Second qualifying round | | 19:45 | Burnley eng | 3–1 | sct Aberdeen | 17,404 | Turf Moor | Massimiliano Irrati | Match Report | Leg 2 of 2; Burnley won; Required Extra Time |
| Second qualifying round | | 19:45 | Rangers sct | 1–1 | hr Osijek | 48,202 | Ibrox Stadium | Dennis Higler | Match Report | Leg 2 of 2; Rangers won |
| Second qualifying round | | 20:00 | Apollon Limassol cy | 3–1 | ba Željezničar | 3,400 | Neo GSP | Nikola Popov | Match Report | Leg 2 of 2; Apollon Limassol won |
| Second qualifying round | | 20:00 | Rio Ave pt | 4–4 | pl Jagiellonia | 5,930 | Estádio do Rio Ave Futebol Clube | Marco Di Bello | Match Report | Leg 2 of 2; Jagiellonia won |
| Round | Wk | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Second qualifying round | | 20:00 | Vitesse nl | 3–1 | ro Viitorul Constanța | 9,876 | GelreDome | Kevin Clancy | Match Report | Leg 2 of 2; Vitesse won |
| Second qualifying round | | 20:00 | Crusaders FC nir | 1–1 | si NK Olimpija Ljubljana | 1,080 | Seaview | Oliver Drachta | Match Report | Leg 2 of 2; NK Olimpija Ljubljana won |
| Second qualifying round | | 20:00 | FC Copenhagen dk | 5–0 | is Stjarnan | 8,726 | Telia Parken | Paul Tierney | Match Report | Leg 2 of 2; FC Copenhagen won |
| Second qualifying round | | 20:00 | FC Mariupol ua | 2–1 | se Djurgården | 5,077 | Stadion Chornomorets | Robert Harvey | Match Report | Leg 2 of 2; FC Mariupol won; Required Extra Time |
| Second qualifying round | | 20:00 | Valur is | 3–0 | ad Santa Coloma | 825 | Origo Völlurinn | Irfan Peljto | Match Report | Leg 2 of 2; Valur won |
| Second qualifying round | | 20:15 | NK Maribor si | 2–0 | ge FC Chikhura Sachkhere | 7,166 | Ljudski vrt | Halil Meler | Match Report | Leg 2 of 2; NK Maribor won |
| Second qualifying round | | 20:15 | Sarajevo ba | 0–8 | it Atalanta | 23,820 | Olimpijski Stadion Asim Ferhatović Hase | Stuart Attwell | Match Report | Leg 2 of 2; Atalanta won |
| Second qualifying round | | 20:15 | Atromitos gr | 1–1 | by FC Dinamo Brest | 2,420 | Stadio Peristeriou | Eitan Shmuelevich | Match Report | Leg 2 of 2; FC Dinamo Brest won |
| Second qualifying round | | 20:30 | NK Domžale si | 1–1 | ru Ufa | 2,500 | Športni park | Arnold Hunter | Match Report | Leg 2 of 2; Ufa won |
| Second qualifying round | | 20:45 | Bordeaux fr | 2–1 | lv FK Ventspils | 15,863 | Stade Matmut-Atlantique | Hugo Miguel | Match Report | Leg 2 of 2; Bordeaux won |
| Second qualifying round | | 20:45 | Lech Poznań pl | 3–1 | by Shakhtyor | 16,507 | INEA stadion | Christian Dingert | Match Report | Leg 2 of 2; Lech Poznań won; Required Extra Time |
| Second qualifying round | | 20:45 | S.P. La Fiorita sm | 0–3 | lv Spartaks Jūrmala | 224 | Stadio Tullo Morgagni | Alan Sant | Match Report | Leg 2 of 2; Spartaks Jūrmala won |
| Second qualifying round | | 20:45 | KF Drita xk | 1–1 | lu F91 Dudelange | 2,200 | Stadiumi Olimpik Adem Jashari | Michael Tykgaard | Match Report | Leg 2 of 2; F91 Dudelange won |
| Second qualifying round | | 20:45 | Sarpsborg 08 no | 1–0 | ch St. Gallen | 5,460 | Sarpsborg Stadion | Franck Schneider | Match Report | Leg 2 of 2; Sarpsborg 08 won |
| Second qualifying round | | 20:45 | AZ Alkmaar nl | 2–1 | kz FC Kairat | 9,437 | AFAS Stadion | Dimitar Mečkarovski | Match Report | Leg 2 of 2; FC Kairat won |
| Second qualifying round | | 21:00 | Asteras Tripoli gr | 1–1 | sct Hibernian | 3,870 | Stadio Theodoros Kolokotronis | Benoît Millot | Match Report | Leg 2 of 2; Hibernian won |
| Second qualifying round | | 21:00 | Radnički Niš rs | 2–2 | il Maccabi Tel Aviv FC | 7,588 | Gradski Stadion Čair | Radu Petrescu | Match Report | Leg 2 of 2; Maccabi Tel Aviv FC won |
| Second qualifying round | | 21:00 | Újpest hu | 1–3 | es Sevilla | 9,785 | Szusza Ferenc Stadion | Kirill Levnikov | Match Report | Leg 2 of 2; Sevilla won |
| Second qualifying round | | 21:00 | Beşiktaş tr | 6–0 | fo B36 Tórshavn | 23,929 | Vodafone Arena | Carlos Xistra | Match Report | Leg 2 of 2; Beşiktaş won |
| Second qualifying round | | 21:30 | FCSB ro | 4–0 | si Rudar Velenje | 7,030 | Arena Naţională | Sergey Ivanov | Match Report | Leg 2 of 2; FCSB won |
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