Apertura regular season | 1 | Sat | 2021-01-16 | 17:00 | Millonarios | 1–0 | Envigado | | Estadio Palogrande | Bismark Santiago | Match Report | |
Apertura regular season | 1 | Sat | 2021-01-16 | 19:30 | Junior | 1–0 | Independiente | | Estadio Metropolitano Roberto Meléndez | Carlos Betancourt | Match Report | |
Apertura regular season | 1 | Sun | 2021-01-17 | 14:00 | Pasto | 2–2 | La Equidad | | Estadio Departamental Libertad | Jorge Tabares | Match Report | |
Apertura regular season | 1 | Sun | 2021-01-17 | 18:05 | Nacional | 2–0 | Santa Fe | | Estadio Atanasio Girardot | Nolberto Ararat | Match Report | |
Apertura regular season | 1 | Sun | 2021-01-17 | 20:10 | AD Cali | 1–0 | Jaguares | | Estadio Deportivo Cali | Jorge Duarte | Match Report | |
Apertura regular season | 1 | Mon | 2021-01-18 | 15:30 | Tolima | 1–1 | Once Caldas | | Estadio Guillermo Plazas Alcid | Wander Mosquera | Match Report | |
Apertura regular season | 1 | Tue | 2021-01-19 | 19:40 | CA Bucaramanga | 2–0 | Boyacá Chicó | | Estadio Alfonso López | Lisandro Castillo | Match Report | |
Apertura regular season | 1 | Wed | 2021-01-20 | 19:40 | Alianza | 2–2 | Pereira | | Estadio Daniel Villa Zapata | Jhon Hinestroza | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 2 | Fri | 2021-01-22 | 20:00 | Independiente | 2–1 | Boyacá Patriot | | Estadio Atanasio Girardot | Nicolás Gallo | Match Report | |
Apertura regular season | 2 | Sat | 2021-01-23 | 17:35 | Envigado | 0–1 | Pasto | | Estadio Polideportivo Sur | Mauricio Palencia | Match Report | |
Apertura regular season | 2 | Sun | 2021-01-24 | 16:00 | CD América | 1–1 | Rionegro | | Estadio Olímpico Pascual Guerrero | Carlos Ortega | Match Report | |
Apertura regular season | 2 | Sun | 2021-01-24 | 18:05 | Jaguares | 2–1 | CA Bucaramanga | | Estadio de Fútbol Jaraguay de Montería | Diego Escalante | Match Report | |
Apertura regular season | 2 | Sun | 2021-01-24 | 20:10 | Pereira | 0–1 | AD Cali | | Estadio Hernán Ramírez Villegas | Keiner Jiménez | Match Report | |
Apertura regular season | 2 | Mon | 2021-01-25 | 14:00 | La Equidad | 1–0 | Nacional | | Estadio Metropolitano de Techo | Ferney Trujillo | Match Report | |
Apertura regular season | 2 | Mon | 2021-01-25 | 17:30 | Once Caldas | 1–2 | Junior | | Estadio Palogrande | Wilmar Roldán | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 3 | Fri | 2021-01-29 | 18:00 | Jaguares | 2–0 | Alianza | | Estadio de Fútbol Jaraguay de Montería | Wander Mosquera | Match Report | |
Apertura regular season | 3 | Fri | 2021-01-29 | 20:00 | AD Cali | 1–1 | Envigado | | Estadio Deportivo Cali | Luis G. Matorel | Match Report | |
Apertura regular season | 3 | Sat | 2021-01-30 | 14:00 | Boyacá Patriot | 1–1 | Boyacá Chicó | | Estadio de la Independencia | Carlos Ortega | Match Report | |
Apertura regular season | 3 | Sat | 2021-01-30 | 16:00 | Rionegro | 0–2 | Santa Fe | | Estadio Alberto Grisales | Edilson Ariza | Match Report | |
Apertura regular season | 3 | Sat | 2021-01-30 | 18:05 | Nacional | 5–2 | Pereira | | Estadio Atanasio Girardot | Carlos Mario Herrera | Match Report | |
Apertura regular season | 3 | Sat | 2021-01-30 | 20:10 | Junior | 2–1 | CD América | | Estadio Metropolitano Roberto Meléndez | Jorge Tabares | Match Report | |
Apertura regular season | 3 | Sun | 2021-01-31 | 15:30 | Tolima | 1–0 | La Equidad | | Estadio Manuel Murillo Toro | Wilmar Roldán | Match Report | |
Apertura regular season | 3 | Sun | 2021-01-31 | 19:40 | CA Bucaramanga | 0–1 | Independiente | | Estadio Alfonso López | Jhon Hinestroza | Match Report | |
Apertura regular season | 3 | Mon | 2021-02-01 | 14:00 | Millonarios | 4–3 | Once Caldas | | Estadio Héctor El Zipa González | Éder Vergara | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 4 | Tue | 2021-02-02 | 16:00 | Envigado | 1–1 | Jaguares | | Estadio Polideportivo Sur | Héctor Rivera | Match Report | |
Apertura regular season | 4 | Tue | 2021-02-02 | 18:00 | Boyacá Chicó | 0–1 | AD Cali | | Estadio de la Independencia | Bismark Santiago | Match Report | |
Apertura regular season | 4 | Tue | 2021-02-02 | 20:05 | Pasto | 0–0 | Nacional | | Estadio Departamental Libertad | Carlos Betancourt | Match Report | |
Apertura regular season | 4 | Wed | 2021-02-03 | 14:00 | La Equidad | 1–0 | Junior | | Estadio Héctor El Zipa González | Diego Escalante | Match Report | |
Apertura regular season | 4 | Wed | 2021-02-03 | 16:00 | Pereira | 0–0 | Tolima | | Estadio Hernán Ramírez Villegas | Mauricio Palencia | Match Report | |
Apertura regular season | 4 | Wed | 2021-02-03 | 18:05 | Alianza | 1–2 | Rionegro | | Estadio Daniel Villa Zapata | Nolberto Ararat | Match Report | |
Apertura regular season | 4 | Wed | 2021-02-03 | 20:10 | CD América | 0–0 | CA Bucaramanga | | Estadio Olímpico Pascual Guerrero | Ferney Trujillo | Match Report | |
Apertura regular season | 4 | Thu | 2021-02-04 | 14:00 | Santa Fe | 1–0 | Boyacá Patriot | | Estadio Nemesio Camacho El Campín | Carlos Mario Herrera | Match Report | |
Apertura regular season | 4 | Thu | 2021-02-04 | 20:00 | Independiente | 0–0 | Millonarios | | Estadio Atanasio Girardot | Keiner Jiménez | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 5 | Sat | 2021-02-06 | 15:15 | Once Caldas | 3–1 | Envigado | | Estadio Palogrande | Lisandro Castillo | Match Report | |
Apertura regular season | 5 | Sat | 2021-02-06 | 17:30 | Junior | 2–0 | Alianza | | Estadio Metropolitano Roberto Meléndez | David Espinosa | Match Report | |
Apertura regular season | 5 | Sat | 2021-02-06 | 20:00 | Nacional | 2–0 | Boyacá Chicó | | Estadio Atanasio Girardot | Wander Mosquera | Match Report | |
Apertura regular season | 5 | Sun | 2021-02-07 | 14:00 | Millonarios | 3–2 | Pereira | | Estadio Nemesio Camacho El Campín | Jorge Tabares | Match Report | |
Apertura regular season | 5 | Sun | 2021-02-07 | 16:00 | Tolima | 2–1 | Independiente | | Estadio Manuel Murillo Toro | Éder Vergara | Match Report | |
Apertura regular season | 5 | Sun | 2021-02-07 | 18:05 | Boyacá Patriot | 0–1 | AD Cali | | Estadio de la Independencia | Diego Ruiz | Match Report | |
Apertura regular season | 5 | Sun | 2021-02-07 | 20:10 | Jaguares | 0–1 | Santa Fe | | Estadio de Fútbol Jaraguay de Montería | Wilmar Roldán | Match Report | |
Apertura regular season | 5 | Mon | 2021-02-08 | 20:00 | CA Bucaramanga | 0–0 | La Equidad | | Estadio Alfonso López | Carlos Mario Herrera | Match Report | |
Apertura regular season | 5 | Tue | 2021-02-09 | 19:40 | Rionegro | 1–1 | Pasto | | Estadio Alberto Grisales | Bismark Santiago | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 6 | Fri | 2021-02-12 | 16:00 | Pereira | 1–2 | Boyacá Patriot | | Estadio Hernán Ramírez Villegas | Wilmar Roldán | Match Report | |
Apertura regular season | 6 | Fri | 2021-02-12 | 18:00 | Alianza | 0–0 | Once Caldas | | Estadio Daniel Villa Zapata | Ferney Trujillo | Match Report | |
Apertura regular season | 6 | Fri | 2021-02-12 | 20:05 | Boyacá Chicó | 1–2 | CD América | | Estadio de la Independencia | Jorge Guzmán | Match Report | |
Apertura regular season | 6 | Sat | 2021-02-13 | 15:15 | La Equidad | 1–0 | Millonarios | | Estadio Metropolitano de Techo | Carlos Ortega | Match Report | |
Apertura regular season | 6 | Sat | 2021-02-13 | 17:30 | AD Cali | 1–0 | Rionegro | | Estadio Deportivo Cali | Keiner Jiménez | Match Report | |
Apertura regular season | 6 | Sat | 2021-02-13 | 20:00 | Envigado | 2–2 | Junior | | Estadio Polideportivo Sur | Jonathan Ortíz | Match Report | |
Apertura regular season | 6 | Sun | 2021-02-14 | 14:00 | Santa Fe | 2–0 | CA Bucaramanga | | Estadio Nemesio Camacho El Campín | Luis G. Matorel | Match Report | |
Apertura regular season | 6 | Sun | 2021-02-14 | 18:05 | Independiente | 1–0 | Jaguares | | Estadio Atanasio Girardot | Edilson Ariza | Match Report | |
Apertura regular season | 6 | Sun | 2021-02-14 | 20:10 | Pasto | 0–1 | Tolima | | Estadio Departamental Libertad | Jhon Hinestroza | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 7 | Tue | 2021-02-16 | 18:00 | Boyacá Patriot | 3–1 | Alianza | | Estadio de la Independencia | Diego Escalante | Match Report | |
Apertura regular season | 7 | Tue | 2021-02-16 | 20:00 | Once Caldas | 0–1 | Nacional | | Estadio Palogrande | Bismark Santiago | Match Report | |
Apertura regular season | 7 | Wed | 2021-02-17 | 14:00 | CA Bucaramanga | 2–0 | Pereira | | Estadio Alfonso López | Lisandro Castillo | Match Report | |
Apertura regular season | 7 | Wed | 2021-02-17 | 16:00 | Rionegro | 1–1 | Envigado | | Estadio Alberto Grisales | Wilmar Roldán | Match Report | |
Apertura regular season | 7 | Wed | 2021-02-17 | 18:05 | Independiente | 1–0 | Boyacá Chicó | | Estadio Atanasio Girardot | Carlos Betancourt | Match Report | |
Apertura regular season | 7 | Wed | 2021-02-17 | 20:10 | Junior | 1–2 | AD Cali | | Estadio Metropolitano Roberto Meléndez | John J. Ospina | Match Report | |
Apertura regular season | 7 | Thu | 2021-02-18 | 16:00 | Jaguares | 2–1 | La Equidad | | Estadio de Fútbol Jaraguay de Montería | Jorge Tabares | Match Report | |
Apertura regular season | 7 | Thu | 2021-02-18 | 18:00 | Millonarios | 3–1 | Pasto | | Estadio Nemesio Camacho El Campín | Nolberto Ararat | Match Report | |
Apertura regular season | 7 | Thu | 2021-02-18 | 20:05 | CD América | 0–0 | Santa Fe | | Estadio Olímpico Pascual Guerrero | Éder Vergara | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 8 | Fri | 2021-02-19 | 20:00 | Tolima | 3–1 | Boyacá Patriot | | Estadio Manuel Murillo Toro | David Espinosa | Match Report | |
Apertura regular season | 8 | Sat | 2021-02-20 | 15:15 | Envigado | 1–0 | CA Bucaramanga | | Estadio Polideportivo Sur | Yahir Cárdenas | Match Report | |
Apertura regular season | 8 | Sat | 2021-02-20 | 17:30 | Pereira | 0–0 | Rionegro | | Estadio Hernán Ramírez Villegas | Carlos Ortega | Match Report | |
Apertura regular season | 8 | Sat | 2021-02-20 | 20:00 | Boyacá Chicó | 2–1 | Junior | | Estadio de la Independencia | Ferney Trujillo | Match Report | |
Apertura regular season | 8 | Sun | 2021-02-21 | 14:00 | La Equidad | 0–0 | Once Caldas | | Estadio Metropolitano de Techo | Jhon Hinestroza | Match Report | |
Apertura regular season | 8 | Sun | 2021-02-21 | 16:00 | Pasto | 2–2 | Jaguares | | Estadio Departamental Libertad | Diego Escalante | Match Report | |
Apertura regular season | 8 | Sun | 2021-02-21 | 18:05 | Santa Fe | 0–0 | Independiente | | Estadio Nemesio Camacho El Campín | Jonathan Ortíz | Match Report | |
Apertura regular season | 8 | Sun | 2021-02-21 | 20:10 | Nacional | 2–2 | CD América | | Estadio Atanasio Girardot | Jorge Guzmán | Match Report | |
Apertura regular season | 8 | Mon | 2021-02-22 | 20:00 | AD Cali | 1–1 | Alianza | | Estadio Deportivo Cali | Bismark Santiago | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 9 | Tue | 2021-02-23 | 20:00 | Junior | 2–0 | Millonarios | | Estadio Metropolitano Roberto Meléndez | Wilmar Roldán | Match Report | |
Apertura regular season | 9 | Wed | 2021-02-24 | 14:00 | CD América | 0–0 | Envigado | | Estadio Olímpico Pascual Guerrero | Jorge Duarte | Match Report | |
Apertura regular season | 9 | Wed | 2021-02-24 | 16:00 | Rionegro | 1–2 | La Equidad | | Estadio Alberto Grisales | Carlos Betancourt | Match Report | |
Apertura regular season | 9 | Wed | 2021-02-24 | 18:05 | CA Bucaramanga | 3–2 | Nacional | | Estadio Alfonso López | Mauricio Palencia | Match Report | |
Apertura regular season | 9 | Wed | 2021-02-24 | 20:10 | Santa Fe | 2–0 | Boyacá Chicó | | Estadio Nemesio Camacho El Campín | Nolberto Ararat | Match Report | |
Apertura regular season | 9 | Thu | 2021-02-25 | 14:00 | Once Caldas | 0–1 | Pasto | | Estadio Palogrande | Jorge Tabares | Match Report | |
Apertura regular season | 9 | Thu | 2021-02-25 | 16:00 | Jaguares | 2–0 | Pereira | | Estadio de Fútbol Jaraguay de Montería | John J. Ospina | Match Report | |
Apertura regular season | 9 | Thu | 2021-02-25 | 18:05 | Alianza | 0–5 | Tolima | | Estadio Daniel Villa Zapata | Luis G. Matorel | Match Report | |
Apertura regular season | 9 | Thu | 2021-02-25 | 20:10 | Independiente | 1–1 | AD Cali | | Estadio Atanasio Girardot | Éder Vergara | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 10 | Sat | 2021-02-27 | 17:30 | La Equidad | 2–1 | Boyacá Chicó | | Estadio Metropolitano de Techo | Carlos Mario Herrera | Match Report | |
Apertura regular season | 10 | Sat | 2021-02-27 | 20:00 | Boyacá Patriot | 1–0 | Junior | | Estadio de la Independencia | Carlos Ortega | Match Report | |
Apertura regular season | 10 | Sun | 2021-02-28 | 14:00 | Envigado | 1–1 | Independiente | | Estadio Polideportivo Sur | Diego Escalante | Match Report | |
Apertura regular season | 10 | Sun | 2021-02-28 | 16:00 | Tolima | 1–0 | Rionegro | | Estadio Manuel Murillo Toro | John J. Ospina | Match Report | |
Apertura regular season | 10 | Sun | 2021-02-28 | 18:05 | Pasto | 1–1 | CD América | | Estadio Departamental Libertad | Nicolás Gallo | Match Report | |
Apertura regular season | 10 | Sun | 2021-02-28 | 20:10 | AD Cali | 1–1 | Santa Fe | | Estadio Deportivo Cali | Wilmar Roldán | Match Report | |
Apertura regular season | 10 | Mon | 2021-03-01 | 18:00 | Pereira | 2–0 | Once Caldas | | Estadio Hernán Ramírez Villegas | Andrés Rojas | Match Report | |
Apertura regular season | 10 | Mon | 2021-03-01 | 20:00 | Millonarios | 0–2 | Jaguares | | Estadio Nemesio Camacho El Campín | Jhon Hinestroza | Match Report | |
Apertura regular season | 10 | Tue | 2021-03-02 | 20:00 | Nacional | 5–0 | Alianza | | Estadio Atanasio Girardot | Ferney Trujillo | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 1 | Wed | 2021-03-03 | 20:05 | Boyacá Patriot | 0–1 | CD América | | Estadio de la Independencia | Héctor Rivera | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 2 | Thu | 2021-03-04 | 18:00 | Boyacá Chicó | 0–1 | Millonarios | | Estadio de la Independencia | Nicolás Gallo | Match Report | |
Apertura regular season | 2 | Thu | 2021-03-04 | 20:05 | Santa Fe | 3–2 | Tolima | | Estadio Nemesio Camacho El Campín | Carlos Ortega | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 11 | Fri | 2021-03-05 | 18:00 | Independiente | 1–1 | La Equidad | | Estadio Atanasio Girardot | Nolberto Ararat | Match Report | |
Apertura regular season | 11 | Fri | 2021-03-05 | 20:00 | Junior | 1–1 | CA Bucaramanga | | Estadio Metropolitano Roberto Meléndez | Andrés Rojas | Match Report | |
Apertura regular season | 11 | Sat | 2021-03-06 | 17:30 | Once Caldas | 0–0 | AD Cali | | Estadio Palogrande | Stiven Camargo | Match Report | |
Apertura regular season | 11 | Sat | 2021-03-06 | 20:00 | Rionegro | 1–1 | Nacional | | Estadio Alberto Grisales | Wilmar Roldán | Match Report | |
Apertura regular season | 11 | Sun | 2021-03-07 | 15:30 | CD América | 1–0 | Pereira | | Estadio Olímpico Pascual Guerrero | Edilson Ariza | Match Report | |
Apertura regular season | 11 | Sun | 2021-03-07 | 17:40 | Jaguares | 3–2 | Boyacá Patriot | | Estadio de Fútbol Jaraguay de Montería | Jorge Duarte | Match Report | |
Apertura regular season | 11 | Sun | 2021-03-07 | 20:00 | Boyacá Chicó | 2–1 | Tolima | | Estadio de la Independencia | Wander Mosquera | Match Report | |
Apertura regular season | 11 | Mon | 2021-03-08 | 20:00 | Santa Fe | 2–2 | Pasto | | Estadio Nemesio Camacho El Campín | Éder Vergara | Match Report | |
Apertura regular season | 11 | Tue | 2021-03-09 | 20:00 | Alianza | 0–2 | Millonarios | | Estadio Daniel Villa Zapata | Diego Ruiz | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 12 | Thu | 2021-03-11 | 20:00 | AD Cali | 0–2 | CD América | | Estadio Deportivo Cali | Jhon Hinestroza | Match Report | |
Apertura regular season | 12 | Fri | 2021-03-12 | 15:15 | La Equidad | 3–1 | Envigado | | Estadio Metropolitano de Techo | Edilson Ariza | Match Report | |
Apertura regular season | 12 | Fri | 2021-03-12 | 20:00 | Tolima | 3–2 | Jaguares | | Estadio Manuel Murillo Toro | Nolberto Ararat | Match Report | |
Apertura regular season | 12 | Sat | 2021-03-13 | 17:30 | Pasto | 1–0 | Alianza | | Estadio Departamental Libertad | Diego Ulloa | Match Report | |
Apertura regular season | 12 | Sat | 2021-03-13 | 20:00 | Boyacá Patriot | 0–2 | Millonarios | | Estadio de la Independencia | Jorge Tabares | Match Report | |
Apertura regular season | 12 | Sun | 2021-03-14 | 17:35 | Rionegro | 0–2 | Independiente | | Estadio Alberto Grisales | Carlos Ortega | Match Report | |
Apertura regular season | 12 | Sun | 2021-03-14 | 20:00 | Nacional | 1–0 | Junior | | Estadio Atanasio Girardot | Ferney Trujillo | Match Report | |
Apertura regular season | 12 | Mon | 2021-03-15 | 20:00 | CA Bucaramanga | 1–1 | Once Caldas | | Estadio Alfonso López | Yahir Cárdenas | Match Report | |
Apertura regular season | 12 | Tue | 2021-03-16 | 20:00 | Pereira | 0–0 | Boyacá Chicó | | Estadio Hernán Ramírez Villegas | Andrés Rojas | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 13 | Fri | 2021-03-19 | 19:40 | Jaguares | 0–2 | Rionegro | | Estadio de Fútbol Jaraguay de Montería | Jhon Hinestroza | Match Report | |
Apertura regular season | 13 | Sat | 2021-03-20 | 15:30 | Envigado | 2–1 | Santa Fe | | Estadio Polideportivo Sur | Nolberto Ararat | Match Report | |
Apertura regular season | 13 | Sat | 2021-03-20 | 17:40 | Junior | 3–0 | Pereira | | Estadio Metropolitano Roberto Meléndez | Carlos Ortega | Match Report | |
Apertura regular season | 13 | Sat | 2021-03-20 | 20:00 | Once Caldas | 1–1 | CD América | | Estadio Palogrande | Wilmar Roldán | Match Report | |
Apertura regular season | 13 | Sun | 2021-03-21 | 15:30 | Independiente | 2–2 | Pasto | | Estadio Atanasio Girardot | Andrés Rojas | Match Report | |
Apertura regular season | 13 | Sun | 2021-03-21 | 17:40 | AD Cali | 0–0 | Tolima | | Estadio Deportivo Cali | Diego Escalante | Match Report | |
Apertura regular season | 13 | Sun | 2021-03-21 | 20:00 | Millonarios | 1–2 | Nacional | | Estadio Nemesio Camacho El Campín | Carlos Betancourt | Match Report | |
Apertura regular season | 13 | Mon | 2021-03-22 | 18:05 | Boyacá Patriot | 1–2 | La Equidad | | Estadio de la Independencia | Luis G. Matorel | Match Report | |
Apertura regular season | 13 | Mon | 2021-03-22 | 20:10 | Alianza | 1–3 | CA Bucaramanga | | Estadio Daniel Villa Zapata | Carlos Mario Herrera | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 14 | Tue | 2021-03-23 | 18:00 | Boyacá Chicó | 3–0 | Envigado | | Estadio de la Independencia | Carlos Betancourt | Match Report | |
Apertura regular season | 14 | Tue | 2021-03-23 | 20:00 | Santa Fe | 2–0 | Once Caldas | | Estadio Nemesio Camacho El Campín | Jorge Tabares | Match Report | |
Apertura regular season | 14 | Wed | 2021-03-24 | 15:15 | CD América | 1–2 | Independiente | | Estadio Olímpico Pascual Guerrero | Éder Vergara | Match Report | |
Apertura regular season | 14 | Wed | 2021-03-24 | 17:30 | Tolima | 0–1 | Junior | | Estadio Manuel Murillo Toro | Andrés Rojas | Match Report | |
Apertura regular season | 14 | Wed | 2021-03-24 | 20:00 | Nacional | 3–1 | Jaguares | | Estadio Atanasio Girardot | Bismark Santiago | Match Report | |
Apertura regular season | 14 | Thu | 2021-03-25 | 14:00 | Pasto | 1–0 | Boyacá Patriot | | Estadio Departamental Libertad | Edilson Ariza | Match Report | |
Apertura regular season | 14 | Thu | 2021-03-25 | 16:00 | La Equidad | 1–1 | Alianza | | Estadio Metropolitano de Techo | Wilmar Roldán | Match Report | |
Apertura regular season | 14 | Thu | 2021-03-25 | 18:05 | CA Bucaramanga | 1–0 | AD Cali | | Estadio Alfonso López | Wander Mosquera | Match Report | |
Apertura regular season | 14 | Thu | 2021-03-25 | 20:10 | Rionegro | 0–0 | Millonarios | | Estadio Alberto Grisales | Carlos Ortega | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 15 | Sat | 2021-03-27 | 14:00 | Envigado | 0–0 | Tolima | | Estadio Polideportivo Sur | Diego Ulloa | Match Report | |
Apertura regular season | 15 | Sat | 2021-03-27 | 16:00 | Once Caldas | 4–2 | Boyacá Chicó | | Estadio Palogrande | Bismark Santiago | Match Report | |
Apertura regular season | 15 | Sat | 2021-03-27 | 18:05 | Junior | 1–1 | Santa Fe | | Estadio Metropolitano Roberto Meléndez | Wilmar Roldán | Match Report | |
Apertura regular season | 15 | Sat | 2021-03-27 | 20:10 | Independiente | 0–0 | Nacional | | Estadio Atanasio Girardot | Carlos Mario Herrera | Match Report | |
Apertura regular season | 15 | Sun | 2021-03-28 | 14:00 | Pereira | 0–0 | La Equidad | | Estadio Hernán Ramírez Villegas | Carlos Betancourt | Match Report | |
Apertura regular season | 15 | Sun | 2021-03-28 | 16:00 | Alianza | 0–2 | CD América | | Estadio Daniel Villa Zapata | Héctor Rivera | Match Report | |
Apertura regular season | 15 | Sun | 2021-03-28 | 18:05 | Boyacá Patriot | 2–1 | Rionegro | | Estadio de la Independencia | Jorge Guzmán | Match Report | |
Apertura regular season | 15 | Sun | 2021-03-28 | 20:10 | Millonarios | 2–1 | CA Bucaramanga | | Estadio Nemesio Camacho El Campín | Diego Escalante | Match Report | |
Apertura regular season | 15 | Mon | 2021-03-29 | 20:00 | AD Cali | 1–1 | Pasto | | Estadio Deportivo Cali | David Espinosa | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 16 | Tue | 2021-03-30 | 18:00 | Tolima | 2–1 | Nacional | | Estadio Manuel Murillo Toro | Carlos Betancourt | Match Report | |
Apertura regular season | 16 | Tue | 2021-03-30 | 20:05 | Jaguares | 0–2 | Junior | | Estadio de Fútbol Jaraguay de Montería | Jorge Tabares | Match Report | |
Apertura regular season | 16 | Wed | 2021-03-31 | 15:30 | CD América | 2–1 | Millonarios | | Estadio Olímpico Pascual Guerrero | Wilmar Roldán | Match Report | |
Apertura regular season | 16 | Wed | 2021-03-31 | 17:40 | Envigado | 3–0 | Boyacá Patriot | | Estadio Polideportivo Sur | Lisandro Castillo | Match Report | |
Apertura regular season | 16 | Wed | 2021-03-31 | 20:00 | Rionegro | 2–2 | Once Caldas | | Estadio Alberto Grisales | Wander Mosquera | Match Report | |
Apertura regular season | 16 | Thu | 2021-04-01 | 18:00 | Boyacá Chicó | 2–0 | Alianza | | Estadio de la Independencia | Carlos Ortega | Match Report | |
Apertura regular season | 16 | Thu | 2021-04-01 | 20:05 | La Equidad | 2–5 | AD Cali | | Estadio Metropolitano de Techo | John J. Ospina | Match Report | |
Apertura regular season | 16 | Fri | 2021-04-02 | 19:40 | Santa Fe | 1–1 | Pereira | | Estadio Nemesio Camacho El Campín | Diego Escalante | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 17 | Sat | 2021-04-03 | 18:05 | Nacional | 3–0 | Envigado | | Estadio Atanasio Girardot | Éder Vergara | Match Report | |
Apertura regular season | 17 | Sat | 2021-04-03 | 20:10 | Millonarios | 0–0 | Tolima | | Estadio Nemesio Camacho El Campín | Jhon Hinestroza | Match Report | |
Apertura regular season | 17 | Sun | 2021-04-04 | 15:30 | CD América | 0–1 | La Equidad | | Estadio Olímpico Pascual Guerrero | Carlos Ortega | Match Report | |
Apertura regular season | 17 | Sun | 2021-04-04 | 17:40 | Boyacá Chicó | 0–0 | Pasto | | Estadio de la Independencia | Jorge Tabares | Match Report | |
Apertura regular season | 17 | Sun | 2021-04-04 | 20:00 | Junior | 0–0 | Rionegro | | Estadio Metropolitano Roberto Meléndez | Carlos Betancourt | Match Report | |
Apertura regular season | 17 | Mon | 2021-04-05 | 18:00 | CA Bucaramanga | 0–1 | Boyacá Patriot | | Estadio Alfonso López | Ferney Trujillo | Match Report | |
Apertura regular season | 17 | Mon | 2021-04-05 | 20:00 | Once Caldas | 1–2 | Jaguares | | Estadio Palogrande | Luis G. Matorel | Match Report | |
Apertura regular season | 17 | Tue | 2021-04-06 | 18:00 | Pereira | 1–0 | Independiente | | Estadio Hernán Ramírez Villegas | Edilson Ariza | Match Report | |
Apertura regular season | 17 | Tue | 2021-04-06 | 20:00 | Alianza | 0–3 | Santa Fe | | Estadio Daniel Villa Zapata | Jorge Guzmán | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 18 | Sat | 2021-04-10 | 15:30 | Independiente | 2–2 | Alianza | | Estadio Atanasio Girardot | Nolberto Ararat | Match Report | |
Apertura regular season | 18 | Sat | 2021-04-10 | 17:40 | Jaguares | 0–0 | CD América | | Estadio de Fútbol Jaraguay de Montería | Andrés Rojas | Match Report | |
Apertura regular season | 18 | Sat | 2021-04-10 | 20:00 | AD Cali | 1–0 | Nacional | | Estadio Deportivo Cali | Jhon Hinestroza | Match Report | |
Apertura regular season | 18 | Sun | 2021-04-11 | 15:30 | Rionegro | 0–3 | Boyacá Chicó | | Estadio Alberto Grisales | Carlos Ortega | Match Report | |
Apertura regular season | 18 | Sun | 2021-04-11 | 15:30 | Envigado | 0–1 | Pereira | | Estadio Polideportivo Sur | Carlos Betancourt | Match Report | |
Apertura regular season | 18 | Sun | 2021-04-11 | 17:40 | Pasto | 0–0 | Junior | | Estadio Departamental Libertad | Wilmar Roldán | Match Report | |
Apertura regular season | 18 | Sun | 2021-04-11 | 20:00 | Santa Fe | 1–2 | Millonarios | | Estadio Nemesio Camacho El Campín | John J. Ospina | Match Report | |
Apertura regular season | 18 | Mon | 2021-04-12 | 20:00 | Tolima | 0–0 | CA Bucaramanga | | Estadio Manuel Murillo Toro | Bismark Santiago | Match Report | |
Apertura regular season | 18 | Tue | 2021-04-13 | 20:00 | Boyacá Patriot | 1–1 | Once Caldas | | Estadio de la Independencia | Diego Escalante | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 16 | Thu | 2021-04-15 | 19:40 | Pasto | 1–1 | CA Bucaramanga | | Estadio Departamental Libertad | Andrés Rojas | Match Report | |
| | | | | | | | | | | | |
Apertura regular season | 19 | Fri | 2021-04-16 | 19:40 | Alianza | 1–1 | Envigado | | Estadio Daniel Villa Zapata | Juan Alba | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 15:30 | Boyacá Chicó | 0–0 | Jaguares | | Estadio de la Independencia | Bismark Santiago | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 15:30 | La Equidad | 1–2 | Santa Fe | | Estadio Metropolitano de Techo | Andrés Rojas | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 15:30 | CA Bucaramanga | 4–1 | Rionegro | | Estadio Alfonso López | Jhon Hinestroza | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 15:30 | Pereira | 4–2 | Pasto | | Estadio Hernán Ramírez Villegas | Carlos Ortega | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 15:30 | Millonarios | 3–1 | AD Cali | | Estadio Nemesio Camacho El Campín | Edilson Ariza | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 15:30 | Nacional | 7–1 | Boyacá Patriot | | Estadio Atanasio Girardot | Nicolás Gallo | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 15:30 | CD América | 2–0 | Tolima | | Estadio Olímpico Pascual Guerrero | Wilmar Roldán | Match Report | |
Apertura regular season | 19 | Sun | 2021-04-18 | 16:30 | Once Caldas | 2–0 | Independiente | | Estadio Palogrande | John J. Ospina | Match Report | |
| | | | | | | | | | | | |
Quarter-finals | | Sat | 2021-04-24 | 15:30 | CD América | 1–2 | Millonarios | | Estadio Olímpico Pascual Guerrero | Carlos Ortega | Match Report | Leg 1 of 2 |
Quarter-finals | | Sun | 2021-04-25 | 15:30 | Junior | 3–1 | Santa Fe | | Estadio Metropolitano Roberto Meléndez | Wilmar Roldán | Match Report | Leg 1 of 2 |
Quarter-finals | | Sun | 2021-04-25 | 17:40 | Tolima | 3–0 | AD Cali | | Estadio Manuel Murillo Toro | Jorge Tabares | Match Report | Leg 1 of 2 |
Quarter-finals | | Sun | 2021-04-25 | 20:00 | La Equidad | 1–0 | Nacional | | Estadio Metropolitano de Techo | Jhon Hinestroza | Match Report | Leg 1 of 2 |
Quarter-finals | | Sat | 2021-05-01 | 18:00 | Millonarios | 0–0 | CD América | | Estadio Nemesio Camacho El Campín | Wilmar Roldán | Match Report | Leg 2 of 2; Millonarios won |
Quarter-finals | | Sun | 2021-05-02 | 13:00 | Santa Fe | 0–0 | Junior | | Estadio Nemesio Camacho El Campín | Carlos Ortega | Match Report | Leg 2 of 2; Junior won |
Quarter-finals | | Sun | 2021-05-02 | 15:30 | Nacional | 2–2 | La Equidad | | Estadio Atanasio Girardot | Carlos Betancourt | Match Report | Leg 2 of 2; La Equidad won |
Quarter-finals | | Fri | 2021-06-04 | 15:30 | AD Cali | 2–0 | Tolima | | Estadio Deportivo Cali | Jhon Hinestroza | Match Report | Leg 2 of 2; Tolima won |
Semi-finals | | Thu | 2021-06-10 | 16:00 | Junior | 3–2 | Millonarios | | Estadio Metropolitano Roberto Meléndez | Carlos Betancourt | Match Report | Leg 1 of 2 |
Semi-finals | | Thu | 2021-06-10 | 18:05 | Tolima | 1–1 | La Equidad | | Estadio Manuel Murillo Toro | Carlos Ortega | Match Report | Leg 1 of 2 |
Semi-finals | | Sun | 2021-06-13 | 13:30 | Millonarios | 2–0 | Junior | | Estadio Nemesio Camacho El Campín | Jorge Tabares | Match Report | Leg 2 of 2; Millonarios won |
Semi-finals | | Mon | 2021-06-14 | 19:00 | La Equidad | 1–2 | Tolima | | Estadio Metropolitano de Techo | Jhon Hinestroza | Match Report | Leg 2 of 2; Tolima won |
Final | | Thu | 2021-06-17 | 20:00 | Tolima | 1–1 | Millonarios | | Estadio Manuel Murillo Toro | Carlos Betancourt | Match Report | Leg 1 of 2 |
Final | | Sun | 2021-06-20 | 15:00 | Millonarios | 1–2 | Tolima | | Estadio Nemesio Camacho El Campín | Carlos Ortega | Match Report | Leg 2 of 2; Tolima won |
Finalización regular season | 1 | Fri | 2021-07-16 | 20:00 | Independiente | 1–1 | Rionegro | | Estadio Atanasio Girardot | Yahir Cárdenas | Match Report | |
Finalización regular season | 1 | Sat | 2021-07-17 | 15:30 | CD América | 3–1 | Junior | | Estadio Olímpico Pascual Guerrero | Éder Vergara | Match Report | |
Finalización regular season | 1 | Sat | 2021-07-17 | 17:40 | Deportes Quindío | 2–0 | Jaguares | | Estadio Centenario | Carlos Betancur | Match Report | |
Finalización regular season | 1 | Sat | 2021-07-17 | 20:00 | Santa Fe | 1–2 | AD Cali | | Estadio Nemesio Camacho El Campín | Jhon Hinestroza | Match Report | |
Finalización regular season | 1 | Sun | 2021-07-18 | 15:30 | Envigado | 2–2 | Nacional | | Estadio Polideportivo Sur | Bismark Santiago | Match Report | |
Finalización regular season | 1 | Sun | 2021-07-18 | 17:40 | Boyacá Patriot | 0–2 | CA Bucaramanga | | Estadio de la Independencia | Juan Mira | Match Report | |
Finalización regular season | 1 | Sun | 2021-07-18 | 20:00 | Pasto | 1–3 | Millonarios | | Estadio Departamental Libertad | Nolberto Ararat | Match Report | |
Finalización regular season | 1 | Mon | 2021-07-19 | 16:00 | Tolima | 1–0 | Pereira | | Estadio Manuel Murillo Toro | Luis G. Matorel | Match Report | |
Finalización regular season | 1 | Mon | 2021-07-19 | 18:00 | Once Caldas | 1–0 | Atlético Huila | | Estadio Palogrande | David Espinosa | Match Report | |
Finalización regular season | 1 | Mon | 2021-07-19 | 20:05 | Alianza | 1–0 | La Equidad | | Estadio Daniel Villa Zapata | Mauricio Palencia | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 2 | Wed | 2021-07-21 | 20:05 | Millonarios | 2–1 | Deportes Quindío | | Estadio Nemesio Camacho El Campín | Edilson Ariza | Match Report | |
Finalización regular season | 2 | Fri | 2021-07-23 | 19:40 | Atlético Huila | 2–2 | Boyacá Patriot | | Estadio Guillermo Plazas Alcid | Jorge Tabares | Match Report | |
Finalización regular season | 2 | Sat | 2021-07-24 | 15:30 | Rionegro | 1–3 | CD América | | Estadio Alberto Grisales | Bismark Santiago | Match Report | |
Finalización regular season | 2 | Sat | 2021-07-24 | 17:40 | Jaguares | 1–1 | Once Caldas | | Estadio de Fútbol Jaraguay de Montería | Wander Mosquera | Match Report | |
Finalización regular season | 2 | Sat | 2021-07-24 | 20:00 | Nacional | 1–0 | Tolima | | Estadio Atanasio Girardot | Carlos Ortega | Match Report | |
Finalización regular season | 2 | Sun | 2021-07-25 | 15:30 | CA Bucaramanga | 4–3 | Santa Fe | | Estadio Alfonso López | Éder Vergara | Match Report | |
Finalización regular season | 2 | Sun | 2021-07-25 | 17:40 | Junior | 1–0 | Envigado | | Estadio Metropolitano Roberto Meléndez | Carlos Betancourt | Match Report | |
Finalización regular season | 2 | Sun | 2021-07-25 | 20:00 | AD Cali | 0–0 | Independiente | | Estadio Deportivo Cali | John J. Ospina | Match Report | |
Finalización regular season | 2 | Mon | 2021-07-26 | 20:05 | Pereira | 0–2 | Alianza | | Estadio Hernán Ramírez Villegas | Diego Ruiz | Match Report | |
Finalización regular season | 2 | Tue | 2021-07-27 | 20:05 | La Equidad | 0–0 | Pasto | | Estadio Metropolitano de Techo | Ferney Trujillo | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 3 | Fri | 2021-07-30 | 20:00 | Deportes Quindío | 2–1 | Rionegro | | Estadio Centenario | Jhon Hinestroza | Match Report | |
Finalización regular season | 3 | Sat | 2021-07-31 | 16:00 | Tolima | 1–1 | Alianza | | Estadio Manuel Murillo Toro | Nolberto Ararat | Match Report | |
Finalización regular season | 3 | Sat | 2021-07-31 | 18:05 | AD Cali | 1–2 | CA Bucaramanga | | Estadio Deportivo Cali | Wilmar Roldán | Match Report | |
Finalización regular season | 3 | Sat | 2021-07-31 | 20:10 | Independiente | 0–0 | Junior | | Estadio Atanasio Girardot | Edilson Ariza | Match Report | |
Finalización regular season | 3 | Sun | 2021-08-01 | 14:00 | Boyacá Patriot | 1–0 | La Equidad | | Estadio de la Independencia | Bismark Santiago | Match Report | |
Finalización regular season | 3 | Sun | 2021-08-01 | 16:00 | Envigado | 1–0 | CD América | | Estadio Polideportivo Sur | Diego Ruiz | Match Report | |
Finalización regular season | 3 | Sun | 2021-08-01 | 18:05 | Once Caldas | 0–2 | Millonarios | | Estadio Palogrande | Carlos Mario Herrera | Match Report | |
Finalización regular season | 3 | Sun | 2021-08-01 | 20:10 | Jaguares | 2–0 | Atlético Huila | | Estadio de Fútbol Jaraguay de Montería | Luis G. Matorel | Match Report | |
Finalización regular season | 3 | Mon | 2021-08-02 | 20:00 | Pasto | 1–2 | Pereira | | Estadio Departamental Libertad | Diego Escalante | Match Report | |
Finalización regular season | 3 | Tue | 2021-08-03 | 20:00 | Santa Fe | 0–1 | Nacional | | Estadio Nemesio Camacho El Campín | Carlos Betancourt | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 4 | Fri | 2021-08-06 | 20:05 | Atlético Huila | 0–0 | Deportes Quindío | | Estadio Guillermo Plazas Alcid | Bismark Santiago | Match Report | |
Finalización regular season | 4 | Sat | 2021-08-07 | 15:00 | CD América | 1–0 | Once Caldas | | Estadio Olímpico Pascual Guerrero | Jhon Hinestroza | Match Report | |
Finalización regular season | 4 | Sat | 2021-08-07 | 17:30 | Nacional | 2–0 | AD Cali | | Estadio Atanasio Girardot | Edilson Ariza | Match Report | |
Finalización regular season | 4 | Sat | 2021-08-07 | 20:00 | Millonarios | 0–1 | Santa Fe | | Estadio Nemesio Camacho El Campín | Andrés Rojas | Match Report | |
Finalización regular season | 4 | Sun | 2021-08-08 | 16:00 | La Equidad | 0–0 | Independiente | | Estadio Metropolitano de Techo | Nolberto Ararat | Match Report | |
Finalización regular season | 4 | Sun | 2021-08-08 | 18:05 | Junior | 0–0 | Tolima | | Estadio Metropolitano Roberto Meléndez | Wilmar Roldán | Match Report | |
Finalización regular season | 4 | Sun | 2021-08-08 | 20:10 | Alianza | 2–0 | Pasto | | Estadio Daniel Villa Zapata | David Espinosa | Match Report | |
Finalización regular season | 4 | Mon | 2021-08-09 | 19:40 | CA Bucaramanga | 0–1 | Jaguares | | Estadio Alfonso López | Diego Escalante | Match Report | |
Finalización regular season | 4 | Tue | 2021-08-10 | 18:00 | Rionegro | 1–0 | Boyacá Patriot | | Estadio Alberto Grisales | Diego Ruiz | Match Report | |
Finalización regular season | 4 | Tue | 2021-08-10 | 20:00 | Pereira | 0–1 | Envigado | | Estadio Hernán Ramírez Villegas | Carlos Betancourt | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 5 | Fri | 2021-08-13 | 19:40 | Tolima | 1–0 | Pasto | | Estadio Manuel Murillo Toro | Diego Ulloa | Match Report | |
Finalización regular season | 5 | Sat | 2021-08-14 | 15:00 | Envigado | 2–1 | Alianza | | Estadio Polideportivo Sur | Ferney Trujillo | Match Report | |
Finalización regular season | 5 | Sat | 2021-08-14 | 17:40 | Independiente | 2–0 | CD América | | Estadio Atanasio Girardot | Andrés Rojas | Match Report | |
Finalización regular season | 5 | Sat | 2021-08-14 | 20:00 | AD Cali | 2–2 | Millonarios | | Estadio Deportivo Cali | Bismark Santiago | Match Report | |
Finalización regular season | 5 | Sun | 2021-08-15 | 16:00 | Jaguares | 1–1 | Junior | | Estadio de Fútbol Jaraguay de Montería | Nolberto Ararat | Match Report | |
Finalización regular season | 5 | Sun | 2021-08-15 | 18:05 | Boyacá Patriot | 0–3 | Nacional | | Estadio de la Independencia | Luis G. Matorel | Match Report | |
Finalización regular season | 5 | Sun | 2021-08-15 | 20:10 | Once Caldas | 0–1 | Pereira | | Estadio Palogrande | Edilson Ariza | Match Report | |
Finalización regular season | 5 | Mon | 2021-08-16 | 17:10 | Atlético Huila | 0–2 | Rionegro | | Estadio Guillermo Plazas Alcid | Lisandro Castillo | Match Report | |
Finalización regular season | 5 | Mon | 2021-08-16 | 19:30 | Santa Fe | 0–2 | La Equidad | | Estadio Nemesio Camacho El Campín | Carlos Betancourt | Match Report | |
Finalización regular season | 5 | Tue | 2021-08-17 | 20:00 | Deportes Quindío | 2–3 | CA Bucaramanga | | Estadio Centenario | Carlos Mario Herrera | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 6 | Fri | 2021-08-20 | 19:30 | CD América | 0–0 | Boyacá Patriot | | Estadio Olímpico Pascual Guerrero | Mauricio Palencia | Match Report | |
Finalización regular season | 6 | Sat | 2021-08-21 | 14:00 | Pereira | 1–1 | Santa Fe | | Estadio Hernán Ramírez Villegas | Wilmar Roldán | Match Report | |
Finalización regular season | 6 | Sat | 2021-08-21 | 16:00 | Nacional | 1–0 | Deportes Quindío | | Estadio Polideportivo Sur | Jhon Hinestroza | Match Report | |
Finalización regular season | 6 | Sat | 2021-08-21 | 18:05 | Junior | 4–2 | Once Caldas | | Estadio Metropolitano Roberto Meléndez | Andrés Rojas | Match Report | |
Finalización regular season | 6 | Sat | 2021-08-21 | 20:10 | Millonarios | 2–0 | Independiente | | Estadio Nemesio Camacho El Campín | Ferney Trujillo | Match Report | |
Finalización regular season | 6 | Sun | 2021-08-22 | 14:00 | La Equidad | 1–1 | Tolima | | Estadio Metropolitano de Techo | Diego Escalante | Match Report | |
Finalización regular season | 6 | Sun | 2021-08-22 | 16:00 | Rionegro | 1–2 | Jaguares | | Estadio Alberto Grisales | Edilson Ariza | Match Report | |
Finalización regular season | 6 | Sun | 2021-08-22 | 18:05 | Alianza | 2–3 | AD Cali | | Estadio Daniel Villa Zapata | Luis G. Matorel | Match Report | |
Finalización regular season | 6 | Sun | 2021-08-22 | 20:10 | Pasto | 0–2 | Envigado | | Estadio Departamental Libertad | Alexander Ortiz | Match Report | |
Finalización regular season | 6 | Mon | 2021-08-23 | 20:00 | CA Bucaramanga | 1–1 | Atlético Huila | | Estadio Alfonso López | Bismark Santiago | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 7 | Fri | 2021-08-27 | 19:40 | Deportes Quindío | 2–1 | Once Caldas | | Estadio Centenario | Wilmar Roldán | Match Report | |
Finalización regular season | 7 | Sat | 2021-08-28 | 16:00 | Envigado | 3–2 | La Equidad | | Estadio Polideportivo Sur | Jorge Duarte | Match Report | |
Finalización regular season | 7 | Sat | 2021-08-28 | 18:05 | Pereira | 1–0 | Millonarios | | Estadio Hernán Ramírez Villegas | Luis G. Matorel | Match Report | |
Finalización regular season | 7 | Sat | 2021-08-28 | 20:10 | Atlético Huila | 3–1 | Independiente | | Estadio Guillermo Plazas Alcid | Edilson Ariza | Match Report | |
Finalización regular season | 7 | Sun | 2021-08-29 | 14:00 | Boyacá Patriot | 0–0 | Pasto | | Estadio de la Independencia | Yahir Cárdenas | Match Report | |
Finalización regular season | 7 | Sun | 2021-08-29 | 16:00 | AD Cali | 1–1 | Junior | | Estadio Deportivo Cali | Jorge Tabares | Match Report | |
Finalización regular season | 7 | Sun | 2021-08-29 | 18:05 | Santa Fe | 1–1 | CD América | | Estadio Nemesio Camacho El Campín | Diego Escalante | Match Report | |
Finalización regular season | 7 | Sun | 2021-08-29 | 20:10 | Jaguares | 0–3 | Tolima | | Estadio de Fútbol Jaraguay de Montería | Jonathan Ortíz | Match Report | |
Finalización regular season | 7 | Mon | 2021-08-30 | 18:00 | Nacional | 1–0 | Rionegro | | Estadio Atanasio Girardot | Andrés Rojas | Match Report | |
Finalización regular season | 7 | Mon | 2021-08-30 | 20:05 | CA Bucaramanga | 1–2 | Alianza | | Estadio Alfonso López | Carlos Ortega | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 8 | Sat | 2021-09-04 | 16:00 | CD América | 0–1 | Deportes Quindío | | Estadio Olímpico Pascual Guerrero | Jorge Tabares | Match Report | |
Finalización regular season | 8 | Sat | 2021-09-04 | 18:05 | La Equidad | 1–0 | Jaguares | | Estadio Metropolitano de Techo | Wilmar Roldán | Match Report | |
Finalización regular season | 8 | Sun | 2021-09-05 | 11:00 | Once Caldas | 1–1 | CA Bucaramanga | | Estadio Palogrande | Mauricio Palencia | Match Report | |
Finalización regular season | 8 | Sun | 2021-09-05 | 13:00 | Pasto | 2–0 | AD Cali | 6,000 | Estadio Departamental Libertad | Diego Escalante | Match Report | |
Finalización regular season | 8 | Sun | 2021-09-05 | 15:00 | Independiente | 0–0 | Santa Fe | | Estadio Atanasio Girardot | Diego Ruiz | Match Report | |
Finalización regular season | 8 | Sun | 2021-09-05 | 20:10 | Alianza | 1–3 | Nacional | | Estadio Daniel Villa Zapata | Bismark Santiago | Match Report | |
Finalización regular season | 8 | Mon | 2021-09-06 | 16:00 | Rionegro | 0–1 | Pereira | | Estadio Alberto Grisales | Carlos Ortega | Match Report | |
Finalización regular season | 8 | Mon | 2021-09-06 | 18:00 | Tolima | 2–0 | Envigado | | Estadio Manuel Murillo Toro | Éder Vergara | Match Report | |
Finalización regular season | 8 | Mon | 2021-09-06 | 20:05 | Millonarios | 1–0 | Boyacá Patriot | | Estadio Nemesio Camacho El Campín | Juan Alba | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 9 | Fri | 2021-09-10 | 19:40 | Jaguares | 0–1 | Independiente | | Estadio de Fútbol Jaraguay de Montería | Carlos Mario Herrera | Match Report | |
Finalización regular season | 9 | Sat | 2021-09-11 | 14:00 | Boyacá Patriot | 0–0 | Envigado | | Estadio de la Independencia | Wander Mosquera | Match Report | |
Finalización regular season | 9 | Sat | 2021-09-11 | 16:00 | Once Caldas | 2–3 | Rionegro | | Estadio Palogrande | Diego Ruiz | Match Report | |
Finalización regular season | 9 | Sat | 2021-09-11 | 18:05 | AD Cali | 0–1 | CD América | | Estadio Deportivo Cali | Wilmar Roldán | Match Report | |
Finalización regular season | 9 | Sat | 2021-09-11 | 20:10 | Santa Fe | 1–1 | Alianza | | Estadio Nemesio Camacho El Campín | Jorge Tabares | Match Report | |
Finalización regular season | 9 | Sun | 2021-09-12 | 14:00 | CA Bucaramanga | 3–4 | Millonarios | | Estadio Alfonso López | John J. Ospina | Match Report | |
Finalización regular season | 9 | Sun | 2021-09-12 | 16:00 | Pereira | 1–1 | Junior | | Estadio Hernán Ramírez Villegas | Carlos Betancourt | Match Report | |
Finalización regular season | 9 | Sun | 2021-09-12 | 18:05 | Nacional | 2–0 | La Equidad | | Estadio Atanasio Girardot | Nolberto Ararat | Match Report | |
Finalización regular season | 9 | Mon | 2021-09-13 | 18:00 | Deportes Quindío | 1–2 | Pasto | | Estadio Centenario | Luis G. Matorel | Match Report | |
Finalización regular season | 9 | Mon | 2021-09-13 | 20:00 | Atlético Huila | 1–2 | Tolima | | Estadio Guillermo Plazas Alcid | Carlos Ortega | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 10 | Fri | 2021-09-17 | 20:00 | Independiente | 3–1 | Once Caldas | | Estadio Atanasio Girardot | Lisandro Castillo | Match Report | |
Finalización regular season | 10 | Sat | 2021-09-18 | 14:00 | Envigado | 1–1 | Deportes Quindío | | Estadio Polideportivo Sur | Carlos Betancourt | Match Report | |
Finalización regular season | 10 | Sat | 2021-09-18 | 16:00 | CD América | 2–3 | Jaguares | | Estadio Olímpico Pascual Guerrero | Bismark Santiago | Match Report | |
Finalización regular season | 10 | Sat | 2021-09-18 | 18:05 | Junior | 1–3 | Nacional | | Estadio Metropolitano Roberto Meléndez | Carlos Ortega | Match Report | |
Finalización regular season | 10 | Sat | 2021-09-18 | 20:10 | Millonarios | 3–1 | Atlético Huila | | Estadio Nemesio Camacho El Campín | Alexander Ortiz | Match Report | |
Finalización regular season | 10 | Sun | 2021-09-19 | 16:00 | Tolima | 1–1 | AD Cali | | Estadio Manuel Murillo Toro | Wander Mosquera | Match Report | |
Finalización regular season | 10 | Sun | 2021-09-19 | 18:05 | Pasto | 0–1 | Santa Fe | | Estadio Departamental Libertad | John J. Ospina | Match Report | |
Finalización regular season | 10 | Sun | 2021-09-19 | 20:10 | Rionegro | 3–0 | CA Bucaramanga | | Estadio Alberto Grisales | Nolberto Ararat | Match Report | |
Finalización regular season | 10 | Mon | 2021-09-20 | 18:00 | La Equidad | 1–1 | Pereira | | Estadio Metropolitano de Techo | Edilson Ariza | Match Report | |
Finalización regular season | 10 | Mon | 2021-09-20 | 20:00 | Alianza | 3–0 | Boyacá Patriot | | Estadio Daniel Villa Zapata | Diego Escalante | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 8 | Wed | 2021-09-22 | 20:00 | Junior | 3–0 | Atlético Huila | | Estadio Metropolitano Roberto Meléndez | Luis G. Matorel | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 11 | Fri | 2021-09-24 | 18:00 | AD Cali | 2–1 | Pereira | 5,000 | Estadio Deportivo Cali | Carlos Ortega | Match Report | |
Finalización regular season | 11 | Fri | 2021-09-24 | 20:00 | Once Caldas | 1–1 | Alianza | 2,500 | Estadio Palogrande | Carlos Betancourt | Match Report | |
Finalización regular season | 11 | Sat | 2021-09-25 | 14:00 | Santa Fe | 3–1 | Envigado | | Estadio Nemesio Camacho El Campín | Yahir Cárdenas | Match Report | |
Finalización regular season | 11 | Sat | 2021-09-25 | 16:00 | Rionegro | 1–2 | Junior | | Estadio Alberto Grisales | Lisandro Castillo | Match Report | |
Finalización regular season | 11 | Sat | 2021-09-25 | 18:05 | Nacional | 1–1 | Pasto | | Estadio Atanasio Girardot | Stiven Camargo | Match Report | |
Finalización regular season | 11 | Sat | 2021-09-25 | 20:10 | CA Bucaramanga | 2–1 | CD América | | Estadio Alfonso López | David Espinosa | Match Report | |
Finalización regular season | 11 | Sun | 2021-09-26 | 14:00 | Boyacá Patriot | 0–0 | Tolima | | Estadio de la Independencia | Diego Ulloa | Match Report | |
Finalización regular season | 11 | Sun | 2021-09-26 | 16:00 | Jaguares | 4–3 | Millonarios | | Estadio de Fútbol Jaraguay de Montería | Wilmar Roldán | Match Report | |
Finalización regular season | 11 | Sun | 2021-09-26 | 20:10 | Deportes Quindío | 1–0 | Independiente | | Estadio Centenario | Andrés Rojas | Match Report | |
Finalización regular season | 11 | Mon | 2021-09-27 | 20:00 | Atlético Huila | 1–1 | La Equidad | | Estadio Guillermo Plazas Alcid | Diego Escalante | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 12 | Thu | 2021-09-30 | 19:40 | Pasto | 0–1 | Once Caldas | | Estadio Departamental Libertad | Jorge Tabares | Match Report | |
Finalización regular season | 12 | Fri | 2021-10-01 | 18:00 | Tolima | 0–0 | Santa Fe | | Estadio Manuel Murillo Toro | Wilmar Roldán | Match Report | |
Finalización regular season | 12 | Fri | 2021-10-01 | 20:05 | Junior | 1–0 | Boyacá Patriot | | Estadio Metropolitano Roberto Meléndez | John J. Ospina | Match Report | |
Finalización regular season | 12 | Sat | 2021-10-02 | 14:00 | La Equidad | 1–0 | Deportes Quindío | | Estadio Metropolitano de Techo | Bismark Santiago | Match Report | |
Finalización regular season | 12 | Sat | 2021-10-02 | 16:00 | Envigado | 1–2 | AD Cali | | Estadio Polideportivo Sur | Edilson Ariza | Match Report | |
Finalización regular season | 12 | Sat | 2021-10-02 | 18:05 | Pereira | 3–2 | Nacional | | Estadio Hernán Ramírez Villegas | Nicolás Gallo | Match Report | |
Finalización regular season | 12 | Sat | 2021-10-02 | 20:10 | CD América | 1–0 | Atlético Huila | | Estadio Olímpico Pascual Guerrero | Jhon Hinestroza | Match Report | |
Finalización regular season | 12 | Sun | 2021-10-03 | 16:00 | Millonarios | 1–0 | Rionegro | | Estadio Nemesio Camacho El Campín | Carlos Ortega | Match Report | |
Finalización regular season | 12 | Sun | 2021-10-03 | 18:05 | Independiente | 1–0 | CA Bucaramanga | | Estadio Atanasio Girardot | Carlos Betancourt | Match Report | |
Finalización regular season | 12 | Sun | 2021-10-03 | 20:10 | Alianza | 1–1 | Jaguares | | Estadio Daniel Villa Zapata | Andrés Rojas | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 13 | Fri | 2021-10-08 | 16:00 | Jaguares | 4–1 | Pasto | | Estadio de Fútbol Jaraguay de Montería | Ferney Trujillo | Match Report | |
Finalización regular season | 13 | Fri | 2021-10-08 | 18:00 | Rionegro | 1–0 | Alianza | | Estadio Alberto Grisales | Héctor Rivera | Match Report | |
Finalización regular season | 13 | Fri | 2021-10-08 | 20:05 | Independiente | 0–0 | Envigado | | Estadio Atanasio Girardot | Nolberto Ararat | Match Report | |
Finalización regular season | 13 | Sat | 2021-10-09 | 14:00 | Once Caldas | 0–2 | Tolima | | Estadio Palogrande | Keiner Jiménez | Match Report | |
Finalización regular season | 13 | Sat | 2021-10-09 | 16:00 | AD Cali | 2–2 | La Equidad | | Estadio Deportivo Cali | Jorge Tabares | Match Report | |
Finalización regular season | 13 | Sat | 2021-10-09 | 18:05 | Millonarios | 0–0 | CD América | | Estadio Nemesio Camacho El Campín | Edilson Ariza | Match Report | |
Finalización regular season | 13 | Sat | 2021-10-09 | 20:10 | Atlético Huila | 1–4 | Nacional | | Estadio Guillermo Plazas Alcid | Carlos Betancourt | Match Report | |
Finalización regular season | 13 | Mon | 2021-10-11 | 18:00 | Boyacá Patriot | 0–1 | Santa Fe | | Estadio de la Independencia | Carlos Ortega | Match Report | |
Finalización regular season | 13 | Mon | 2021-10-11 | 20:05 | CA Bucaramanga | 1–1 | Junior | | Estadio Alfonso López | Andrés Rojas | Match Report | |
Finalización regular season | 13 | Tue | 2021-10-12 | 20:05 | Deportes Quindío | 2–3 | Pereira | | Estadio Centenario | Wilmar Roldán | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 14 | Fri | 2021-10-15 | 19:40 | Tolima | 1–0 | Atlético Huila | | Estadio Manuel Murillo Toro | Mauricio Palencia | Match Report | |
Finalización regular season | 14 | Sat | 2021-10-16 | 14:00 | La Equidad | 1–3 | Boyacá Patriot | | Estadio Metropolitano de Techo | Diego Ruiz | Match Report | |
Finalización regular season | 14 | Sat | 2021-10-16 | 16:00 | CD América | 1–1 | AD Cali | | Estadio Olímpico Pascual Guerrero | Carlos Betancourt | Match Report | |
Finalización regular season | 14 | Sat | 2021-10-16 | 18:05 | Pereira | 3–0 | Once Caldas | | Estadio Hernán Ramírez Villegas | Diego Escalante | Match Report | |
Finalización regular season | 14 | Sat | 2021-10-16 | 20:10 | Nacional | 1–1 | Independiente | | Estadio Atanasio Girardot | Wilmar Roldán | Match Report | |
Finalización regular season | 14 | Sun | 2021-10-17 | 14:00 | Pasto | 1–0 | Deportes Quindío | | Estadio Departamental Libertad | Lisandro Castillo | Match Report | |
Finalización regular season | 14 | Sun | 2021-10-17 | 16:00 | Alianza | 2–0 | CA Bucaramanga | | Estadio Daniel Villa Zapata | John J. Ospina | Match Report | |
Finalización regular season | 14 | Sun | 2021-10-17 | 18:05 | Santa Fe | 0–2 | Millonarios | | Estadio Nemesio Camacho El Campín | Andrés Rojas | Match Report | |
Finalización regular season | 14 | Sun | 2021-10-17 | 20:10 | Junior | 2–1 | Jaguares | | Estadio Metropolitano Roberto Meléndez | Carlos Ortega | Match Report | |
Finalización regular season | 14 | Mon | 2021-10-18 | 16:00 | Envigado | 4–1 | Rionegro | | Estadio Polideportivo Sur | Jhon Hinestroza | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 15 | Thu | 2021-10-21 | 18:00 | Once Caldas | 2–1 | La Equidad | | Estadio Palogrande | Héctor Rivera | Match Report | |
Finalización regular season | 15 | Fri | 2021-10-22 | 17:00 | Jaguares | 1–1 | Envigado | | Estadio de Fútbol Jaraguay de Montería | Carlos Betancourt | Match Report | |
Finalización regular season | 15 | Fri | 2021-10-22 | 19:00 | Deportes Quindío | 1–0 | Alianza | | Estadio Centenario | Ferney Trujillo | Match Report | |
Finalización regular season | 15 | Sat | 2021-10-23 | 14:00 | Boyacá Patriot | 1–2 | Pereira | | Estadio de la Independencia | Jhon Hinestroza | Match Report | |
Finalización regular season | 15 | Sat | 2021-10-23 | 16:00 | CA Bucaramanga | 2–1 | Pasto | | Estadio Alfonso López | Wander Mosquera | Match Report | |
Finalización regular season | 15 | Sat | 2021-10-23 | 18:05 | Independiente | 2–2 | Tolima | | Estadio Atanasio Girardot | Diego Ruiz | Match Report | |
Finalización regular season | 15 | Sat | 2021-10-23 | 20:10 | Millonarios | 4–1 | Junior | | Estadio Nemesio Camacho El Campín | Wilmar Roldán | Match Report | |
Finalización regular season | 15 | Sun | 2021-10-24 | 16:00 | Rionegro | 1–2 | AD Cali | | Estadio Alberto Grisales | Nicolás Gallo | Match Report | |
Finalización regular season | 15 | Sun | 2021-10-24 | 18:05 | CD América | 0–2 | Nacional | | Estadio Olímpico Pascual Guerrero | Andrés Rojas | Match Report | |
Finalización regular season | 15 | Sun | 2021-10-24 | 20:10 | Atlético Huila | 1–2 | Santa Fe | | Estadio Guillermo Plazas Alcid | Diego Escalante | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 16 | Tue | 2021-10-26 | 16:00 | Envigado | 2–1 | Millonarios | | Estadio Polideportivo Sur | John J. Ospina | Match Report | |
Finalización regular season | 16 | Tue | 2021-10-26 | 18:00 | Alianza | 3–0 | Independiente | | Estadio Daniel Villa Zapata | Luis G. Matorel | Match Report | |
Finalización regular season | 16 | Tue | 2021-10-26 | 20:05 | Pereira | 1–1 | CA Bucaramanga | | Estadio Hernán Ramírez Villegas | Bismark Santiago | Match Report | |
Finalización regular season | 16 | Wed | 2021-10-27 | 16:00 | La Equidad | 2–2 | Rionegro | | Estadio Metropolitano de Techo | Nolberto Ararat | Match Report | |
Finalización regular season | 16 | Wed | 2021-10-27 | 18:00 | AD Cali | 2–0 | Boyacá Patriot | | Estadio Deportivo Cali | Wilmar Roldán | Match Report | |
Finalización regular season | 16 | Wed | 2021-10-27 | 20:05 | Nacional | 2–0 | Once Caldas | | Estadio Atanasio Girardot | Yahir Cárdenas | Match Report | |
Finalización regular season | 16 | Thu | 2021-10-28 | 14:00 | Pasto | 1–0 | Atlético Huila | | Estadio Departamental Libertad | Nicolás Gallo | Match Report | |
Finalización regular season | 16 | Thu | 2021-10-28 | 16:00 | Santa Fe | 3–1 | Jaguares | | Estadio Nemesio Camacho El Campín | Jhon Hinestroza | Match Report | |
Finalización regular season | 16 | Thu | 2021-10-28 | 18:05 | Junior | 0–0 | Deportes Quindío | | Estadio Metropolitano Roberto Meléndez | Andrés Rojas | Match Report | |
Finalización regular season | 16 | Thu | 2021-10-28 | 20:10 | Tolima | 0–1 | CD América | | Estadio Manuel Murillo Toro | Lisandro Castillo | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 17 | Sat | 2021-10-30 | 18:05 | CA Bucaramanga | 2–1 | Envigado | | Estadio Alfonso López | Héctor Rivera | Match Report | |
Finalización regular season | 17 | Sat | 2021-10-30 | 20:10 | Millonarios | 0–1 | La Equidad | | Estadio Nemesio Camacho El Campín | Luis G. Matorel | Match Report | |
Finalización regular season | 17 | Sun | 2021-10-31 | 14:00 | Once Caldas | 1–1 | Boyacá Patriot | | Estadio Palogrande | Bismark Santiago | Match Report | |
Finalización regular season | 17 | Sun | 2021-10-31 | 16:00 | Jaguares | 0–0 | Nacional | | Estadio de Fútbol Jaraguay de Montería | Edilson Ariza | Match Report | |
Finalización regular season | 17 | Sun | 2021-10-31 | 18:05 | Independiente | 0–0 | Pereira | | Estadio Atanasio Girardot | Nicolás Gallo | Match Report | |
Finalización regular season | 17 | Sun | 2021-10-31 | 20:10 | CD América | 1–1 | Alianza | | Estadio Olímpico Pascual Guerrero | John J. Ospina | Match Report | |
Finalización regular season | 17 | Mon | 2021-11-01 | 16:00 | Junior | 2–1 | Pasto | | Estadio Metropolitano Roberto Meléndez | Carlos Betancourt | Match Report | |
Finalización regular season | 17 | Mon | 2021-11-01 | 18:05 | Atlético Huila | 0–5 | AD Cali | | Estadio Guillermo Plazas Alcid | Diego Ruiz | Match Report | |
Finalización regular season | 17 | Mon | 2021-11-01 | 20:10 | Deportes Quindío | 1–1 | Santa Fe | | Estadio Centenario | Wilmar Roldán | Match Report | |
Finalización regular season | 17 | Tue | 2021-11-02 | 20:00 | Rionegro | 1–1 | Tolima | | Estadio Alberto Grisales | Juan Alba | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 18 | Fri | 2021-11-05 | 20:00 | Pereira | 0–0 | Jaguares | | Estadio Hernán Ramírez Villegas | Andrés Rojas | Match Report | |
Finalización regular season | 18 | Sat | 2021-11-06 | 13:45 | Envigado | 1–2 | Once Caldas | | Estadio Polideportivo Sur | Lisandro Castillo | Match Report | |
Finalización regular season | 18 | Sat | 2021-11-06 | 15:45 | Alianza | 1–0 | Atlético Huila | | Estadio Daniel Villa Zapata | Juan Alba | Match Report | |
Finalización regular season | 18 | Sat | 2021-11-06 | 18:00 | La Equidad | 2–1 | CD América | | Estadio Metropolitano de Techo | Carlos Ortega | Match Report | |
Finalización regular season | 18 | Sat | 2021-11-06 | 20:05 | Nacional | 0–0 | CA Bucaramanga | | Estadio Atanasio Girardot | Jhon Hinestroza | Match Report | |
Finalización regular season | 18 | Sun | 2021-11-07 | 14:00 | Boyacá Patriot | 0–1 | Independiente | | Estadio de la Independencia | Carlos Betancourt | Match Report | |
Finalización regular season | 18 | Sun | 2021-11-07 | 16:00 | Santa Fe | 1–1 | Junior | | Estadio Nemesio Camacho El Campín | Edilson Ariza | Match Report | |
Finalización regular season | 18 | Sun | 2021-11-07 | 18:05 | Tolima | 3–2 | Millonarios | | Estadio Manuel Murillo Toro | Nicolás Gallo | Match Report | |
Finalización regular season | 18 | Sun | 2021-11-07 | 20:10 | AD Cali | 1–0 | Deportes Quindío | | Estadio Deportivo Cali | Luis G. Matorel | Match Report | |
Finalización regular season | 18 | Mon | 2021-11-08 | 20:00 | Pasto | 0–2 | Rionegro | | Estadio Departamental Libertad | Jorge Duarte | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 19 | Fri | 2021-11-12 | 20:00 | Jaguares | 1–0 | AD Cali | | Estadio de Fútbol Jaraguay de Montería | Edilson Ariza | Match Report | |
Finalización regular season | 19 | Sat | 2021-11-13 | 18:05 | CD América | 3–0 | Pasto | | Estadio Olímpico Pascual Guerrero | Lisandro Castillo | Match Report | |
Finalización regular season | 19 | Sat | 2021-11-13 | 20:10 | Rionegro | 1–1 | Envigado | | Estadio Alberto Grisales | Nicolás Gallo | Match Report | |
Finalización regular season | 19 | Sun | 2021-11-14 | 14:00 | Deportes Quindío | 0–3 | Boyacá Patriot | | Estadio Centenario | Andrés Rojas | Match Report | |
Finalización regular season | 19 | Sun | 2021-11-14 | 16:00 | Independiente | 0–0 | Nacional | | Estadio Atanasio Girardot | Bismark Santiago | Match Report | |
Finalización regular season | 19 | Sun | 2021-11-14 | 18:05 | Millonarios | 1–1 | Alianza | | Estadio Nemesio Camacho El Campín | Jorge Tabares | Match Report | |
Finalización regular season | 19 | Sun | 2021-11-14 | 20:10 | Atlético Huila | 0–2 | Pereira | | Estadio Guillermo Plazas Alcid | Ferney Trujillo | Match Report | |
Finalización regular season | 19 | Mon | 2021-11-15 | 15:30 | CA Bucaramanga | 1–1 | Tolima | | Estadio Alfonso López | Carlos Betancourt | Match Report | |
Finalización regular season | 19 | Mon | 2021-11-15 | 20:05 | Once Caldas | 2–1 | Santa Fe | | Estadio Palogrande | Carlos Ortega | Match Report | |
Finalización regular season | 19 | Wed | 2021-11-17 | 20:05 | Junior | 1–0 | La Equidad | 6,215 | Estadio Metropolitano Roberto Meléndez | Juan Alba | Match Report | |
| | | | | | | | | | | | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Tolima | 3–1 | Deportes Quindío | | Estadio Manuel Murillo Toro | Jorge Tabares | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Pereira | 1–5 | CD América | | Estadio Hernán Ramírez Villegas | Bismark Santiago | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Envigado | 0–1 | Atlético Huila | | Estadio Polideportivo Sur | Carlos Ortega | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Pasto | 1–1 | Independiente | | Estadio Departamental Libertad | Edilson Ariza | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Santa Fe | 0–1 | Rionegro | | Estadio Nemesio Camacho El Campín | Jhon Hinestroza | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Nacional | 1–3 | Millonarios | | Estadio Atanasio Girardot | Carlos Betancourt | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Alianza | 1–1 | Junior | | Estadio Daniel Villa Zapata | Andrés Rojas | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | AD Cali | 0–0 | Once Caldas | | Estadio Deportivo Cali | Lisandro Castillo | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | Boyacá Patriot | 3–0 | Jaguares | | Estadio de la Independencia | Nicolás Gallo | Match Report | |
Finalización regular season | 20 | Sun | 2021-11-21 | 15:30 | La Equidad | 2–0 | CA Bucaramanga | | Estadio Metropolitano de Techo | John J. Ospina | Match Report | |
| | | | | | | | | | | | |
Semi-finals | 1 | Sat | 2021-11-27 | 18:00 | AD Cali | 2–1 | Pereira | | Estadio Deportivo Cali | Edilson Ariza | Match Report | |
Semi-finals | 1 | Sat | 2021-11-27 | 20:05 | Nacional | 1–1 | Junior | | Estadio Atanasio Girardot | Carlos Ortega | Match Report | |
Semi-finals | 1 | Sun | 2021-11-28 | 18:00 | CD América | 2–1 | Millonarios | | Estadio Romelio Martínez | Wilmar Roldán | Match Report | |
Semi-finals | 1 | Sun | 2021-11-28 | 20:05 | Alianza | 1–4 | Tolima | | Estadio Daniel Villa Zapata | Jhon Hinestroza | Match Report | |
| | | | | | | | | | | | |
Semi-finals | 2 | Wed | 2021-12-01 | 18:00 | Pereira | 1–1 | Nacional | | Estadio Hernán Ramírez Villegas | John J. Ospina | Match Report | |
Semi-finals | 2 | Wed | 2021-12-01 | 20:05 | Junior | 2–2 | AD Cali | | Estadio Metropolitano Roberto Meléndez | Wilmar Roldán | Match Report | |
Semi-finals | 2 | Thu | 2021-12-02 | 18:00 | Tolima | 2–0 | CD América | | Estadio Manuel Murillo Toro | Andrés Rojas | Match Report | |
Semi-finals | 2 | Thu | 2021-12-02 | 20:05 | Millonarios | 3–0 | Alianza | | Estadio Nemesio Camacho El Campín | Nicolás Gallo | Match Report | |
| | | | | | | | | | | | |
Semi-finals | 3 | Sat | 2021-12-04 | 17:30 | Pereira | 2–2 | Junior | | Estadio Hernán Ramírez Villegas | Carlos Betancourt | Match Report | |
Semi-finals | 3 | Sat | 2021-12-04 | 20:00 | AD Cali | 3–1 | Nacional | | Estadio Deportivo Cali | Jhon Hinestroza | Match Report | |
Semi-finals | 3 | Sun | 2021-12-05 | 16:00 | Alianza | 2–1 | CD América | | Estadio Daniel Villa Zapata | Bismark Santiago | Match Report | |
Semi-finals | 3 | Sun | 2021-12-05 | 18:05 | Tolima | 1–1 | Millonarios | | Estadio Manuel Murillo Toro | Carlos Ortega | Match Report | |
| | | | | | | | | | | | |
Semi-finals | 4 | Wed | 2021-12-08 | 17:00 | Junior | 3–0 | Pereira | 7,625 | Estadio Metropolitano Roberto Meléndez | Andrés Rojas | Match Report | |
Semi-finals | 4 | Wed | 2021-12-08 | 19:30 | Nacional | 1–2 | AD Cali | | Estadio Atanasio Girardot | John J. Ospina | Match Report | |
Semi-finals | 4 | Thu | 2021-12-09 | 18:00 | CD América | 2–1 | Alianza | | Estadio Olímpico Pascual Guerrero | Carlos Ortega | Match Report | |
Semi-finals | 4 | Thu | 2021-12-09 | 20:05 | Millonarios | 1–1 | Tolima | | Estadio Nemesio Camacho El Campín | Wilmar Roldán | Match Report | |
| | | | | | | | | | | | |
Semi-finals | 5 | Sat | 2021-12-11 | 17:45 | AD Cali | 2–0 | Junior | | Estadio Deportivo Cali | Wilmar Roldán | Match Report | |
Semi-finals | 5 | Sat | 2021-12-11 | 20:30 | Nacional | 5–1 | Pereira | | Estadio Atanasio Girardot | Lisandro Castillo | Match Report | |
Semi-finals | 5 | Sun | 2021-12-12 | 17:00 | Alianza | 0–1 | Millonarios | | Estadio Daniel Villa Zapata | John J. Ospina | Match Report | |
Semi-finals | 5 | Mon | 2021-12-13 | 11:00 | CD América | 0–1 | Tolima | | Estadio Olímpico Pascual Guerrero | Jhon Hinestroza | Match Report | |
| | | | | | | | | | | | |
Semi-finals | 6 | Wed | 2021-12-15 | 18:00 | Junior | 1–1 | Nacional | | Estadio Metropolitano Roberto Meléndez | Carlos Betancourt | Match Report | |
Semi-finals | 6 | Wed | 2021-12-15 | 20:05 | Pereira | 1–0 | AD Cali | | Estadio Hernán Ramírez Villegas | Jorge Tabares | Match Report | |
Semi-finals | 6 | Thu | 2021-12-16 | 19:45 | Tolima | 2–2 | Alianza | | Estadio Manuel Murillo Toro | Bismark Santiago | Match Report | |
Semi-finals | 6 | Thu | 2021-12-16 | 19:45 | Millonarios | 2–1 | CD América | | Estadio Nemesio Camacho El Campín | Nicolás Gallo | Match Report | |
| | | | | | | | | | | | |
Final | | Sun | 2021-12-19 | 18:00 | AD Cali | 1–1 | Tolima | | Estadio Deportivo Cali | Wilmar Roldán | Match Report | Leg 1 of 2 |
Final | | Wed | 2021-12-22 | 19:30 | Tolima | 1–2 | AD Cali | | Estadio Manuel Murillo Toro | John J. Ospina | Match Report | Leg 2 of 2; AD Cali won |