Scores & Fixtures 2021-2022 Liga MX
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Thu | 2021-07-22 | 21:00 | Querétaro | 0.4 | 0–0 | 1.4 | América | 10,221 | Estadio La Corregidora | Marco Ortíz | Match Report | |
| 1 | Sat | 2021-07-24 | 16:00 | Pachuca | 2.6 | 4–0 | 0.7 | León | Estadio Hidalgo | Alejandro Funk | Match Report | ||
| 1 | Fri | 2021-07-23 | 19:00 | Necaxa | 1.4 | 0–3 | 1.7 | Santos | 9,153 | Estadio Victoria de Aguascalientes | Jorge Pérez | Match Report | |
| 1 | Fri | 2021-07-23 | 20:00 | FC Juárez | 0.4 | 1–3 | 2.9 | Toluca | 7,345 | Estadio Olímpico Benito Juárez | Jorge Rojas | Match Report | |
| 1 | Sun | 2021-07-25 | 12:00 | UNAM | 0.6 | 0–0 | 1.3 | Atlas | Estadio Olímpico de Universitario | Luis Santander | Match Report | ||
| 1 | Sat | 2021-07-24 | 21:00 | Guadalajara | 1.7 | 1–2 | 0.8 | Atlético | 11,647 | Estadio Akron | Eduardo Basulto | Match Report | |
| 1 | Sun | 2021-07-25 | 19:06 | Monterrey | 1.5 | 1–1 | 1.2 | Puebla | 20,267 | Estadio BBVA Bancomer | Oscar Mejia | Match Report | |
| 1 | Sun | 2021-07-25 | 19:06 | Tijuana | 1.2 | 1–2 | 0.7 | UANL | 4,333 | Estadio Caliente | Óscar Macias | Match Report | |
| 1 | Mon | 2021-07-26 | 20:00 | Cruz Azul | 1.6 | 0–2 | 0.8 | Mazatlán | 9,598 | Estadio Azteca | Diego Montaño | Match Report | |
| 2 | Sat | 2021-07-31 | 17:00 | León | 2.8 | 2–1 | 2.1 | Tijuana | 8,863 | Estadio León | Jorge Pérez | Match Report | |
| 2 | Fri | 2021-07-30 | 18:00 | Mazatlán | 2.0 | 2–1 | 1.1 | Pachuca | 4,675 | Estadio de Mazatlán | Edgar Rangel | Match Report | |
| 2 | Fri | 2021-07-30 | 21:05 | Puebla | 0.9 | 0–2 | 0.6 | Guadalajara | 6,800 | Estadio Cuauhtémoc | Fernando Guerrero | Match Report | |
| 2 | Sun | 2021-08-01 | 12:00 | Toluca | 1.8 | 3–1 | 0.9 | UANL | 8,540 | Estadio Nemesio Díez | Victor Caceres | Match Report | |
| 2 | Sun | 2021-08-01 | 18:00 | Santos | 2.0 | 1–1 | 0.2 | Cruz Azul | 12,200 | Estadio Nuevo Corona | Jorge Rojas | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | América | 1.2 | 2–1 | 1.9 | Necaxa | 9,590 | Estadio Azteca | Fernando Hernández | Match Report | |
| 2 | Sat | 2021-07-31 | 21:00 | Monterrey | 1.9 | 2–0 | 0.6 | UNAM | 20,943 | Estadio BBVA Bancomer | Adonai Escobedo | Match Report | |
| 2 | Sat | 2021-07-31 | 21:00 | Atlas | 1.0 | 2–0 | 0.2 | FC Juárez | 7,859 | Estadio Jalisco | Oscar Mejia | Match Report | |
| 2 | Mon | 2021-08-02 | 21:00 | Atlético | 2.8 | 1–1 | 0.9 | Querétaro | 6,917 | Estadio Alfonso Lastras Ramírez | Luis Santander | Match Report | |
| 3 | Thu | 2021-08-05 | 21:00 | Querétaro | 1.1 | 0–1 | 1.3 | León | 10,031 | Estadio La Corregidora | Daniel Quintero | Match Report | |
| 3 | Sat | 2021-08-07 | 17:00 | Guadalajara | 1.8 | 2–2 | 1.4 | FC Juárez | 9,208 | Estadio Akron | Fernando Hernández | Match Report | |
| 3 | Fri | 2021-08-06 | 18:00 | Mazatlán | 0.7 | 1–1 | 1.1 | Monterrey | 6,543 | Estadio de Mazatlán | Mario Vargas | Match Report | |
| 3 | Fri | 2021-08-06 | 19:06 | Tijuana | 0.9 | 0–2 | 0.8 | Toluca | 5,333 | Estadio Caliente | Diego Montaño | Match Report | |
| 3 | Fri | 2021-08-06 | 21:05 | Necaxa | 1.8 | 1–2 | 1.0 | Cruz Azul | 13,187 | Estadio Victoria de Aguascalientes | Adonai Escobedo | Match Report | |
| 3 | Sun | 2021-08-08 | 12:00 | UNAM | 1.2 | 1–3 | 1.4 | Atlético | Estadio Olímpico de Universitario | Óscar Macias | Match Report | ||
| 3 | Sat | 2021-08-07 | 19:00 | América | 2.4 | 2–0 | 1.1 | Puebla | 8,567 | Estadio Azteca | César Arturo Ramos | Match Report | |
| 3 | Sat | 2021-08-07 | 21:00 | UANL | 1.0 | 1–1 | 1.8 | Santos | 14,350 | Estadio Universitario de Nuevo León | Marco Ortíz | Match Report | |
| 3 | Mon | 2021-08-09 | 21:00 | Pachuca | 1.5 | 0–1 | 1.4 | Atlas | Estadio Hidalgo | Guillermo Pacheco Larios | Match Report | ||
| 4 | Thu | 2021-08-12 | 21:00 | Atlético | 1.2 | 0–2 | 1.2 | Necaxa | 4,128 | Estadio Alfonso Lastras Ramírez | César Arturo Ramos | Match Report | |
| 4 | Sat | 2021-08-14 | 17:00 | UNAM | 1.3 | 0–0 | 1.3 | Querétaro | Estadio Olímpico de Universitario | Oscar Mejia | Match Report | ||
| 4 | Fri | 2021-08-13 | 19:00 | Puebla | 2.0 | 1–1 | 2.2 | UANL | 7,654 | Estadio Cuauhtémoc | Jorge Rojas | Match Report | |
| 4 | Fri | 2021-08-13 | 20:00 | FC Juárez | 1.9 | 1–1 | 0.3 | Tijuana | 7,806 | Estadio Olímpico Benito Juárez | Edgar Morales | Match Report | |
| 4 | Sun | 2021-08-15 | 17:00 | Atlas | 0.4 | 0–1 | 1.7 | América | 13,637 | Estadio Jalisco | Jorge Pérez | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | León | 2.4 | 3–0 | 0.5 | Mazatlán | 9,663 | Estadio León | Brian Gonzalez | Match Report | |
| 4 | Sat | 2021-08-14 | 21:00 | Cruz Azul | 1.3 | 4–0 | 0.8 | Toluca | 8,588 | Estadio Azteca | Fernando Guerrero | Match Report | |
| 4 | Sat | 2021-08-14 | 21:06 | Monterrey | 1.4 | 3–1 | 0.9 | Pachuca | 15,833 | Estadio BBVA Bancomer | Óscar Macias | Match Report | |
| 4 | Sun | 2021-08-15 | 19:06 | Santos | 0.9 | 0–0 | 1.0 | Guadalajara | 13,082 | Estadio Nuevo Corona | Luis Santander | Match Report | |
| 5 | Tue | 2021-08-17 | 17:00 | Toluca | 1.6 | 2–2 | 0.6 | Mazatlán | Estadio Nemesio Díez | Saul Silva | Match Report | ||
| 5 | Tue | 2021-08-17 | 19:00 | UANL | 1.1 | 3–0 | 0.2 | Querétaro | 9,264 | Estadio Universitario de Nuevo León | Diego Montaño | Match Report | |
| 5 | Tue | 2021-08-17 | 19:06 | Tijuana | 1.2 | 1–1 | 0.6 | Puebla | Estadio Caliente | Fernando Hernández | Match Report | ||
| 5 | Tue | 2021-08-17 | 21:00 | Necaxa | 1.4 | 3–0 | 0.6 | UNAM | 9,242 | Estadio Victoria de Aguascalientes | Eduardo Basulto | Match Report | |
| 5 | Wed | 2021-08-18 | 19:00 | Santos | 0.8 | 1–1 | 0.9 | Atlas | 11,998 | Estadio Nuevo Corona | Fernando Guerrero | Match Report | |
| 5 | Wed | 2021-08-18 | 19:00 | Cruz Azul | 1.5 | 1–1 | 1.2 | Monterrey | 7,720 | Estadio Azteca | Jorge Pérez | Match Report | |
| 5 | Wed | 2021-08-18 | 20:00 | FC Juárez | 0.8 | 1–2 | 2.3 | América | 13,992 | Estadio Olímpico Benito Juárez | Luis Santander | Match Report | |
| 5 | Wed | 2021-08-18 | 21:00 | Guadalajara | 1.1 | 0–3 | 1.6 | León | 10,892 | Estadio Akron | Adonai Escobedo | Match Report | |
| 6 | Sat | 2021-08-21 | 17:00 | Atlas | 1.5 | 0–0 | 2.4 | Toluca | 7,239 | Estadio Jalisco | Marco Ortíz | Match Report | |
| 6 | Fri | 2021-08-20 | 20:00 | Mazatlán | 0.6 | 0–3 | 1.8 | UANL | 7,733 | Estadio de Mazatlán | Eduardo Basulto | Match Report | |
| 6 | Sun | 2021-08-22 | 12:00 | UNAM | 2.2 | 2–0 | 0.9 | Puebla | Estadio Olímpico de Universitario | Brian Gonzalez | Match Report | ||
| 6 | Sun | 2021-08-22 | 17:00 | América | 1.5 | 2–0 | 0.2 | Tijuana | Estadio Azteca | Jorge Rojas | Match Report | ||
| 6 | Sat | 2021-08-21 | 19:00 | León | 2.8 | 1–1 | 2.0 | Santos | 9,239 | Estadio León | Fernando Hernández | Match Report | |
| 6 | Sat | 2021-08-21 | 21:00 | Atlético | 1.4 | 0–0 | 0.1 | Cruz Azul | 3,909 | Estadio Alfonso Lastras Ramírez | Oscar Mejia | Match Report | |
| 6 | Sat | 2021-08-21 | 21:36 | Monterrey | 0.5 | 0–0 | 0.5 | Guadalajara | 15,467 | Estadio BBVA Bancomer | Diego Montaño | Match Report | |
| 6 | Sun | 2021-08-22 | 19:00 | Necaxa | 0.9 | 1–0 | 0.4 | FC Juárez | 8,983 | Estadio Victoria de Aguascalientes | Daniel Quintero | Match Report | |
| 6 | Sun | 2021-08-22 | 21:00 | Querétaro | 1.4 | 0–2 | 1.4 | Pachuca | 5,190 | Estadio La Corregidora | César Arturo Ramos | Match Report | |
| 7 | Sat | 2021-08-28 | 17:00 | Guadalajara | 1.5 | 2–1 | 1.3 | Necaxa | 9,603 | Estadio Akron | Jorge Rojas | Match Report | |
| 7 | Fri | 2021-08-27 | 18:00 | Mazatlán | 1.2 | 2–2 | 2.0 | Atlético | 5,477 | Estadio de Mazatlán | Adonai Escobedo | Match Report | |
| 7 | Fri | 2021-08-27 | 19:06 | Tijuana | 1.5 | 2–2 | 0.9 | Monterrey | 3,333 | Estadio Caliente | Fernando Guerrero | Match Report | |
| 7 | Fri | 2021-08-27 | 21:00 | Puebla | 0.8 | 1–0 | 1.0 | Querétaro | 6,086 | Estadio Cuauhtémoc | Erick Miranda | Match Report | |
| 7 | Sun | 2021-08-29 | 12:00 | Toluca | 2.5 | 2–1 | 1.3 | UNAM | 9,566 | Estadio Nemesio Díez | César Arturo Ramos | Match Report | |
| 7 | Sun | 2021-08-29 | 18:00 | Santos | 1.4 | 2–0 | 0.2 | FC Juárez | 11,691 | Estadio Nuevo Corona | Óscar Macias | Match Report | |
| 7 | Sat | 2021-08-28 | 19:00 | UANL | 1.9 | 1–1 | 1.0 | Atlas | 11,225 | Estadio Universitario de Nuevo León | Luis Santander | Match Report | |
| 7 | Sat | 2021-08-28 | 21:00 | León | 1.5 | 1–1 | 1.0 | América | 12,719 | Estadio León | Marco Ortíz | Match Report | |
| 7 | Sun | 2021-08-29 | 20:00 | Cruz Azul | 1.1 | 1–1 | 0.8 | Pachuca | 14,626 | Estadio Azteca | Alejandro Funk | Match Report | |
| 8 | Sat | 2021-09-11 | 17:00 | Atlas | 1.4 | 2–1 | 0.5 | Monterrey | 5,568 | Estadio Jalisco | Óscar Macias | Match Report | |
| 8 | Fri | 2021-09-10 | 19:00 | Puebla | 1.2 | 2–2 | 1.2 | Atlético | 3,370 | Estadio Cuauhtémoc | Juan Esquivel | Match Report | |
| 8 | Fri | 2021-09-10 | 19:06 | Tijuana | 3.1 | 2–1 | 0.6 | Santos | 6,333 | Estadio Caliente | Luis Santander | Match Report | |
| 8 | Fri | 2021-09-10 | 20:00 | FC Juárez | 0.9 | 2–1 | 1.1 | Cruz Azul | 11,623 | Estadio Olímpico Benito Juárez | Marco Ortíz | Match Report | |
| 8 | Sun | 2021-09-12 | 17:00 | UNAM | 0.8 | 0–0 | 1.9 | Guadalajara | Estadio Olímpico de Universitario | Fernando Guerrero | Match Report | ||
| 8 | Sat | 2021-09-11 | 19:00 | UANL | 0.5 | 2–2 | 2.6 | León | 12,962 | Estadio Universitario de Nuevo León | Jorge Pérez | Match Report | |
| 8 | Sat | 2021-09-11 | 21:00 | América | 1.6 | 2–0 | 0.0 | Mazatlán | 14,637 | Estadio Azteca | Diego Montaño | Match Report | |
| 8 | Sun | 2021-09-12 | 19:00 | Querétaro | 0.4 | 3–0 | 1.1 | Necaxa | 5,704 | Estadio La Corregidora | Fernando Hernández | Match Report | |
| 8 | Mon | 2021-09-13 | 21:00 | Pachuca | 1.5 | 1–2 | 0.6 | Toluca | Estadio Hidalgo | Oscar Mejia | Match Report | ||
| 9 | Thu | 2021-09-16 | 19:00 | Atlético | 3.1 | 4–1 | 1.0 | Tijuana | 3,038 | Estadio Alfonso Lastras Ramírez | Oscar Mejia | Match Report | |
| 9 | Sat | 2021-09-18 | 17:00 | León | 1.4 | 0–1 | 0.6 | FC Juárez | 10,078 | Estadio León | Adonai Escobedo | Match Report | |
| 9 | Fri | 2021-09-17 | 21:00 | Necaxa | 0.9 | 0–3 | 1.2 | Atlas | 11,020 | Estadio Victoria de Aguascalientes | Fernando Guerrero | Match Report | |
| 9 | Sat | 2021-09-18 | 19:00 | Toluca | 2.0 | 3–1 | 1.2 | América | 10,297 | Estadio Nemesio Díez | Jorge Rojas | Match Report | |
| 9 | Sat | 2021-09-18 | 20:00 | Mazatlán | 1.2 | 2–2 | 2.0 | UNAM | 7,902 | Estadio de Mazatlán | Erick Miranda | Match Report | |
| 9 | Sat | 2021-09-18 | 21:00 | Guadalajara | 1.2 | 1–0 | 1.4 | Pachuca | 11,135 | Estadio Akron | Diego Montaño | Match Report | |
| 9 | Sun | 2021-09-19 | 19:00 | Cruz Azul | 2.1 | 2–0 | 0.4 | Querétaro | 14,882 | Estadio Azteca | Edgar Morales | Match Report | |
| 9 | Sun | 2021-09-19 | 19:06 | Monterrey | 1.7 | 2–0 | 1.2 | UANL | 26,755 | Estadio BBVA Bancomer | Fernando Hernández | Match Report | |
| 9 | Sun | 2021-09-19 | 21:06 | Santos | 1.2 | 1–1 | 0.9 | Puebla | 11,431 | Estadio Nuevo Corona | César Arturo Ramos | Match Report | |
| 14 | Tue | 2021-09-21 | 20:00 | FC Juárez | 1.1 | 1–0 | 0.8 | Atlético | 11,906 | Estadio Olímpico Benito Juárez | Eduardo Basulto | Match Report | |
| 11 | Wed | 2021-09-22 | 19:06 | Monterrey | 2.8 | 2–0 | 1.4 | Toluca | 19,836 | Estadio BBVA Bancomer | Erick Miranda | Match Report | |
| 10 | Thu | 2021-09-23 | 21:00 | Pachuca | 0.9 | 1–0 | 0.5 | Necaxa | 4,710 | Estadio Hidalgo | Jorge Pérez | Match Report | |
| 10 | Sat | 2021-09-25 | 17:00 | Atlas | 1.4 | 2–0 | 1.0 | León | 8,832 | Estadio Jalisco | Jorge Rojas | Match Report | |
| 10 | Fri | 2021-09-24 | 19:06 | Tijuana | 0.7 | 0–0 | 0.6 | Mazatlán | 7,333 | Estadio Caliente | Adonai Escobedo | Match Report | |
| 10 | Fri | 2021-09-24 | 20:00 | Puebla | 1.9 | 1–1 | 1.7 | Cruz Azul | 14,782 | Estadio Cuauhtémoc | Oscar Mejia | Match Report | |
| 10 | Sun | 2021-09-26 | 12:00 | Toluca | 2.4 | 1–2 | 1.9 | Atlético | 6,833 | Estadio Nemesio Díez | Luis Santander | Match Report | |
| 10 | Sat | 2021-09-25 | 19:00 | UANL | 1.0 | 0–0 | 1.9 | UNAM | 15,581 | Estadio Universitario de Nuevo León | Óscar Macias | Match Report | |
| 10 | Sat | 2021-09-25 | 21:00 | América | 0.9 | 0–0 | 0.5 | Guadalajara | 42,862 | Estadio Azteca | César Arturo Ramos | Match Report | |
| 10 | Sun | 2021-09-26 | 19:06 | Santos | 1.5 | 1–2 | 2.5 | Monterrey | 14,484 | Estadio Nuevo Corona | Marco Ortíz | Match Report | |
| 11 | Tue | 2021-09-28 | 17:00 | Necaxa | 1.6 | 3–0 | 0.8 | Tijuana | 7,251 | Estadio Victoria de Aguascalientes | Guillermo Pacheco Larios | Match Report | |
| 11 | Wed | 2021-09-29 | 17:00 | Atlético | 1.1 | 0–3 | 1.7 | UANL | 9,545 | Estadio Alfonso Lastras Ramírez | Jorge Rojas | Match Report | |
| 11 | Tue | 2021-09-28 | 18:00 | Mazatlán | 0.3 | 3–1 | 0.9 | FC Juárez | 5,880 | Estadio de Mazatlán | Jorge Pérez | Match Report | |
| 11 | Tue | 2021-09-28 | 21:00 | Atlas | 2.0 | 0–1 | 0.7 | Puebla | 9,902 | Estadio Jalisco | Fernando Hernández | Match Report | |
| 11 | Tue | 2021-09-28 | 21:05 | Pachuca | 0.9 | 1–1 | 1.5 | América | 7,454 | Estadio Hidalgo | Fernando Guerrero | Match Report | |
| 11 | Wed | 2021-09-29 | 21:15 | Querétaro | 1.1 | 1–0 | 1.1 | Guadalajara | 6,812 | Estadio La Corregidora | Luis Santander | Match Report | |
| 12 | Sat | 2021-10-02 | 17:00 | León | 0.9 | 0–0 | 0.9 | Atlético | 9,675 | Estadio León | Victor Caceres | Match Report | |
| 12 | Fri | 2021-10-01 | 19:00 | Puebla | 1.8 | 1–2 | 1.2 | Pachuca | 5,906 | Estadio Cuauhtémoc | Daniel Quintero | Match Report | |
| 12 | Fri | 2021-10-01 | 20:00 | FC Juárez | 1.0 | 3–1 | 1.2 | Monterrey | 9,608 | Estadio Olímpico Benito Juárez | Fernando Hernández | Match Report | |
| 12 | Sun | 2021-10-03 | 12:00 | Toluca | 1.6 | 1–1 | 1.8 | Querétaro | 6,585 | Estadio Nemesio Díez | Oscar Mejia | Match Report | |
| 12 | Sun | 2021-10-03 | 17:00 | América | 1.3 | 2–0 | 0.8 | UNAM | 27,571 | Estadio Azteca | Jorge Pérez | Match Report | |
| 12 | Sat | 2021-10-02 | 19:06 | Santos | 1.6 | 1–0 | 0.3 | Mazatlán | 11,293 | Estadio Nuevo Corona | Erick Miranda | Match Report | |
| 12 | Sat | 2021-10-02 | 21:00 | Guadalajara | 0.5 | 0–1 | 1.2 | Atlas | 21,709 | Estadio Akron | Fernando Guerrero | Match Report | |
| 12 | Sun | 2021-10-03 | 19:00 | UANL | 0.9 | 0–0 | 0.8 | Necaxa | 15,797 | Estadio Universitario de Nuevo León | Marco Ortíz | Match Report | |
| 12 | Sun | 2021-10-03 | 19:06 | Tijuana | 1.1 | 0–1 | 1.0 | Cruz Azul | 10,333 | Estadio Caliente | Luis Santander | Match Report | |
| 10 | Fri | 2021-10-08 | 18:00 | FC Juárez | 1.5 | 0–0 | 0.9 | Querétaro | 10,646 | Estadio Olímpico Benito Juárez | Marco Ortíz | Match Report | |
| 13 | Thu | 2021-10-14 | 20:00 | Querétaro | 2.2 | 1–1 | 0.5 | Tijuana | 8,471 | Estadio La Corregidora | Eduardo Basulto | Match Report | |
| 13 | Sat | 2021-10-16 | 17:00 | Monterrey | 1.7 | 0–1 | 0.3 | León | 26,078 | Estadio BBVA Bancomer | César Arturo Ramos | Match Report | |
| 13 | Fri | 2021-10-15 | 19:00 | Necaxa | 1.8 | 0–1 | 1.8 | Puebla | 8,723 | Estadio Victoria de Aguascalientes | Fernando Guerrero | Match Report | |
| 13 | Fri | 2021-10-15 | 20:00 | Mazatlán | 2.3 | 1–0 | 1.1 | Atlas | 8,120 | Estadio de Mazatlán | Mario Vargas | Match Report | |
| 13 | Sun | 2021-10-17 | 12:00 | UNAM | 0.8 | 1–0 | 1.2 | FC Juárez | 9,000 | Estadio Olímpico de Universitario | Adonai Escobedo | Match Report | |
| 13 | Sun | 2021-10-17 | 17:00 | Guadalajara | 0.8 | 2–0 | 0.4 | Toluca | 15,019 | Estadio Akron | Fernando Hernández | Match Report | |
| 13 | Sat | 2021-10-16 | 19:00 | Atlético | 0.5 | 0–1 | 0.9 | América | 16,373 | Estadio Alfonso Lastras Ramírez | Diego Montaño | Match Report | |
| 13 | Sat | 2021-10-16 | 19:05 | Pachuca | 2.3 | 1–1 | 2.0 | Santos | 5,503 | Estadio Hidalgo | Oscar Mejia | Match Report | |
| 13 | Sat | 2021-10-16 | 21:00 | Cruz Azul | 0.5 | 1–1 | 1.1 | UANL | 20,894 | Estadio Azteca | Jorge Pérez | Match Report | |
| 14 | Tue | 2021-10-19 | 17:00 | Querétaro | 1.1 | 1–0 | 1.4 | Monterrey | 10,595 | Estadio La Corregidora | Fernando Guerrero | Match Report | |
| 14 | Tue | 2021-10-19 | 19:00 | Puebla | 2.9 | 2–0 | 0.3 | Mazatlán | 5,624 | Estadio Cuauhtémoc | Jorge Pérez | Match Report | |
| 14 | Tue | 2021-10-19 | 19:05 | América | 1.2 | 2–1 | 1.2 | Santos | 16,918 | Estadio Azteca | Marco Ortíz | Match Report | |
| 14 | Tue | 2021-10-19 | 21:05 | Atlas | 0.7 | 0–0 | 0.8 | Cruz Azul | 9,604 | Estadio Jalisco | Jorge Rojas | Match Report | |
| 14 | Wed | 2021-10-20 | 19:00 | León | 2.5 | 1–2 | 0.9 | UNAM | 12,333 | Estadio León | Erick Miranda | Match Report | |
| 14 | Wed | 2021-10-20 | 19:00 | Toluca | 0.8 | 1–1 | 1.3 | Necaxa | 10,090 | Estadio Nemesio Díez | César Arturo Ramos | Match Report | |
| 14 | Wed | 2021-10-20 | 19:06 | Tijuana | 0.9 | 0–0 | 0.6 | Guadalajara | 10,333 | Estadio Caliente | Juan Esquivel | Match Report | |
| 14 | Wed | 2021-10-20 | 21:00 | UANL | 2.3 | 3–0 | 1.4 | Pachuca | 24,153 | Estadio Universitario de Nuevo León | Luis Santander | Match Report | |
| 15 | Sat | 2021-10-23 | 17:00 | Puebla | 0.7 | 0–1 | 1.3 | León | 15,101 | Estadio Cuauhtémoc | Eduardo Basulto | Match Report | |
| 15 | Sat | 2021-10-23 | 17:06 | Monterrey | 0.9 | 0–1 | 1.9 | Necaxa | 23,077 | Estadio BBVA Bancomer | Luis Santander | Match Report | |
| 15 | Fri | 2021-10-22 | 20:00 | Mazatlán | 0.6 | 2–1 | 1.1 | Querétaro | 9,107 | Estadio de Mazatlán | Óscar Macias | Match Report | |
| 15 | Sun | 2021-10-24 | 12:00 | UNAM | 1.8 | 3–1 | 0.7 | Tijuana | 11,981 | Estadio Olímpico de Universitario | Fernando Hernández | Match Report | |
| 15 | Sat | 2021-10-23 | 19:00 | América | 1.0 | 1–0 | 0.8 | UANL | 32,675 | Estadio Azteca | Fernando Guerrero | Match Report | |
| 15 | Sat | 2021-10-23 | 21:00 | Guadalajara | 0.4 | 1–1 | 1.1 | Cruz Azul | 20,492 | Estadio Akron | Marco Ortíz | Match Report | |
| 15 | Sun | 2021-10-24 | 19:00 | Atlético | 1.2 | 2–6 | 2.7 | Atlas | 9,309 | Estadio Alfonso Lastras Ramírez | César Arturo Ramos | Match Report | |
| 15 | Sun | 2021-10-24 | 19:06 | Santos | 2.4 | 2–2 | 1.2 | Toluca | 12,511 | Estadio Nuevo Corona | Jorge Rojas | Match Report | |
| 15 | Sun | 2021-10-24 | 21:00 | Pachuca | 1.6 | 1–1 | 0.9 | FC Juárez | 2,747 | Estadio Hidalgo | Diego Montaño | Match Report | |
| 16 | Thu | 2021-10-28 | 19:00 | Atlas | 1.0 | 0–2 | 1.1 | Tijuana | 10,299 | Estadio Jalisco | Óscar Macias | Match Report | |
| 16 | Sat | 2021-10-30 | 17:00 | Querétaro | 2.4 | 2–3 | 2.6 | Santos | 13,254 | Estadio La Corregidora | Jorge Pérez | Match Report | |
| 16 | Fri | 2021-10-29 | 19:00 | Necaxa | 2.7 | 2–1 | 1.3 | Mazatlán | 10,809 | Estadio Victoria de Aguascalientes | Oscar Mejia | Match Report | |
| 16 | Fri | 2021-10-29 | 20:00 | FC Juárez | 0.5 | 0–2 | 1.6 | Puebla | 10,942 | Estadio Olímpico Benito Juárez | Erick Miranda | Match Report | |
| 16 | Sun | 2021-10-31 | 12:00 | Toluca | 0.3 | 0–0 | 1.0 | León | 11,210 | Estadio Nemesio Díez | Marco Ortíz | Match Report | |
| 16 | Sun | 2021-10-31 | 17:05 | Cruz Azul | 1.1 | 2–1 | 0.5 | América | 31,257 | Estadio Azteca | Luis Santander | Match Report | |
| 16 | Sat | 2021-10-30 | 20:06 | Pachuca | 2.5 | 1–1 | 0.7 | UNAM | 6,887 | Estadio Hidalgo | Fernando Guerrero | Match Report | |
| 16 | Sat | 2021-10-30 | 21:10 | UANL | 0.9 | 2–1 | 1.1 | Guadalajara | 25,523 | Estadio Universitario de Nuevo León | Diego Montaño | Match Report | |
| 16 | Sun | 2021-10-31 | 19:05 | Atlético | 0.6 | 1–1 | 0.4 | Monterrey | 7,690 | Estadio Alfonso Lastras Ramírez | Adonai Escobedo | Match Report | |
| 5 | Wed | 2021-11-03 | 19:00 | Pachuca | 2.7 | 0–0 | 1.5 | Atlético | 10,683 | Estadio Hidalgo | Erick Miranda | Match Report | |
| 11 | Wed | 2021-11-03 | 21:00 | Cruz Azul | 1.5 | 0–1 | 0.7 | León | 17,928 | Estadio Azteca | Fernando Guerrero | Match Report | |
| 11 | Thu | 2021-11-04 | 19:00 | UNAM | 1.6 | 0–3 | 1.3 | Santos | 14,190 | Estadio Olímpico de Universitario | Adonai Escobedo | Match Report | |
| 17 | Thu | 2021-11-04 | 21:00 | Atlas | 2.3 | 2–0 | 0.3 | Querétaro | 10,421 | Estadio Jalisco | Guillermo Pacheco Larios | Match Report | |
| 17 | Sat | 2021-11-06 | 17:00 | León | 2.1 | 3–0 | 1.1 | Necaxa | 11,240 | Estadio León | Luis Santander | Match Report | |
| 17 | Fri | 2021-11-05 | 19:00 | Puebla | 1.9 | 1–0 | 1.2 | Toluca | 16,136 | Estadio Cuauhtémoc | Jorge Pérez | Match Report | |
| 17 | Fri | 2021-11-05 | 20:00 | Mazatlán | 0.5 | 0–1 | 0.4 | Guadalajara | 12,830 | Estadio de Mazatlán | Jorge Rojas | Match Report | |
| 17 | Sun | 2021-11-07 | 17:00 | UNAM | 2.0 | 4–3 | 2.0 | Cruz Azul | 23,573 | Estadio Olímpico de Universitario | Marco Ortíz | Match Report | |
| 17 | Sat | 2021-11-06 | 19:00 | América | 0.5 | 0–0 | 0.4 | Monterrey | 25,654 | Estadio Azteca | Diego Montaño | Match Report | |
| 17 | Sat | 2021-11-06 | 20:06 | Tijuana | 2.0 | 3–2 | 2.6 | Pachuca | 6,333 | Estadio Caliente | Eduardo Basulto | Match Report | |
| 17 | Sat | 2021-11-06 | 21:00 | UANL | 2.0 | 3–0 | 0.4 | FC Juárez | 26,243 | Estadio Universitario de Nuevo León | Óscar Macias | Match Report | |
| 17 | Sun | 2021-11-07 | 19:06 | Santos | 1.7 | 0–0 | 0.9 | Atlético | 14,658 | Estadio Nuevo Corona | Fernando Guerrero | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reclassification | Sun | 2021-11-21 | 17:00 | Toluca | 1.9 | 1–2 | 1.6 | UNAM | 22,595 | Estadio Nemesio Díez | Fernando Hernández | Match Report | |
| Reclassification | Sat | 2021-11-20 | 19:00 | Santos | 2.1 | 2–0 | 0.5 | Atlético | 10,048 | Estadio Corona | César Arturo Ramos | Match Report | |
| Reclassification | Sat | 2021-11-20 | 21:00 | Puebla | 1.5 | (6) 2–2 (5) | 0.9 | Guadalajara | 34,530 | Estadio Cuauhtémoc | Marco Ortíz | Match Report | Puebla won on penalty kicks following extra time |
| Reclassification | Sun | 2021-11-21 | 19:15 | Cruz Azul | 1.6 | 1–4 | 1.8 | Monterrey | Estadio Azteca | Fernando Guerrero | Match Report | ||
| Quarter-finals | Wed | 2021-11-24 | 19:00 | UNAM | 0.6 | 0–0 | 0.1 | América | 42,784 | Estadio Olímpico Universitario de Colima | Jorge Pérez | Match Report | Leg 1 of 2 |
| Quarter-finals | Wed | 2021-11-24 | 21:05 | Monterrey | 0.6 | 0–0 | 0.6 | Atlas | 27,105 | Estadio BBVA Bancomer | Jorge Rojas | Match Report | Leg 1 of 2 |
| Quarter-finals | Thu | 2021-11-25 | 19:00 | Puebla | 1.7 | 2–1 | 0.9 | León | 27,259 | Estadio Cuauhtémoc | Erick Miranda | Match Report | Leg 1 of 2 |
| Quarter-finals | Thu | 2021-11-25 | 21:05 | Santos | 1.0 | 2–1 | 1.0 | UANL | 15,310 | Estadio Corona | Óscar Macias | Match Report | Leg 1 of 2 |
| Quarter-finals | Sat | 2021-11-27 | 19:00 | América | 2.0 | 1–3 | 1.7 | UNAM | 51,302 | Estadio Azteca | Marco Ortíz | Match Report | Leg 2 of 2; UNAM won |
| Quarter-finals | Sat | 2021-11-27 | 21:05 | Atlas | 1.1 | 1–1 | 0.4 | Monterrey | 21,210 | Estadio Jalisco | César Arturo Ramos | Match Report | Leg 2 of 2; Monterrey won |
| Quarter-finals | Sun | 2021-11-28 | 18:00 | UANL | 1.1 | 1–0 | 0.3 | Santos | 37,438 | Estadio Universitario de Nuevo León | Luis Santander | Match Report | Leg 2 of 2; UANL won |
| Quarter-finals | Sun | 2021-11-28 | 20:05 | León | 2.2 | 2–0 | 0.6 | Puebla | 13,307 | Estadio León | Jorge Pérez | Match Report | Leg 2 of 2; León won |
| Semi-finals | Wed | 2021-12-01 | 21:00 | UANL | 2.7 | 2–1 | 0.3 | León | 37,785 | Estadio Universitario de Nuevo León | Marco Ortíz | Match Report | Leg 1 of 2 |
| Semi-finals | Thu | 2021-12-02 | 21:00 | UNAM | 1.3 | 0–1 | 0.4 | Atlas | 48,976 | Estadio Olímpico de Universitario | Jorge Rojas | Match Report | Leg 1 of 2 |
| Semi-finals | Sat | 2021-12-04 | 21:00 | León | 2.2 | 2–1 | 1.2 | UANL | 23,570 | Estadio León | César Arturo Ramos | Match Report | Leg 2 of 2; León won |
| Semi-finals | Sun | 2021-12-05 | 19:00 | Atlas | 2.1 | 0–1 | 0.9 | UNAM | 42,962 | Estadio Jalisco | Jorge Pérez | Match Report | Leg 2 of 2; Atlas won |
| Finals | Thu | 2021-12-09 | 21:00 | León | 1.6 | 3–2 | 0.4 | Atlas | 23,513 | Estadio León | Luis Santander | Match Report | Leg 1 of 2 |
| Finals | Sun | 2021-12-12 | 20:15 | Atlas | 2.8 | (4) 1–0 (3) | 0.8 | León | 47,548 | Estadio Jalisco | Marco Ortíz | Match Report | Leg 2 of 2; Atlas won; Atlas won on penalty kicks following extra time |
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Thu | 2022-01-06 | 21:00 | Atlético | 0.7 | 0–2 | 2.3 | Pachuca | 6,841 | Estadio Alfonso Lastras Ramírez | Óscar Macias | Match Report | |
| 1 | Fri | 2022-01-07 | 18:00 | FC Juárez | 2.4 | 2–1 | 0.9 | Necaxa | 7,731 | Estadio Olímpico Benito Juárez | Luis Santander | Match Report | |
| 1 | Fri | 2022-01-07 | 21:00 | Puebla | 1.0 | 1–1 | 0.7 | América | 35,040 | Estadio Cuauhtémoc | Oscar Mejia | Match Report | |
| 1 | Sat | 2022-01-08 | 19:06 | Monterrey | 2.1 | 0–0 | 0.7 | Querétaro | 18,926 | Estadio BBVA Bancomer | Edgar Morales | Match Report | |
| 1 | Sat | 2022-01-08 | 21:00 | Cruz Azul | 0.7 | 2–0 | 1.3 | Tijuana | 16,271 | Estadio Azteca | Daniel Quintero | Match Report | |
| 1 | Sun | 2022-01-09 | 18:00 | Guadalajara | 2.0 | 3–0 | 0.6 | Mazatlán | 19,565 | Estadio Akron | César Arturo Ramos | Match Report | |
| 1 | Mon | 2022-01-10 | 21:00 | UNAM | 3.5 | 5–0 | 0.3 | Toluca | 8,493 | Estadio Olímpico Universitario de Colima | Diego Montaño | Match Report | |
| 1 | Wed | 2022-01-12 | 20:06 | Santos | 0.3 | 1–1 | 0.7 | UANL | 9,377 | Estadio Nuevo Corona | Adonai Escobedo | Match Report | |
| 2 | Sat | 2022-01-15 | 17:00 | Atlas | 0.4 | 1–0 | 0.6 | Atlético | 13,353 | Estadio Jalisco | Brian Gonzalez | Match Report | |
| 2 | Fri | 2022-01-14 | 19:00 | Querétaro | 1.2 | 1–3 | 0.7 | UNAM | 13,569 | Estadio La Corregidora | Erick Miranda | Match Report | |
| 2 | Fri | 2022-01-14 | 21:00 | Necaxa | 0.4 | 0–4 | 2.0 | Monterrey | 8,921 | Estadio Victoria de Aguascalientes | Fernando Hernández | Match Report | |
| 2 | Sun | 2022-01-16 | 12:00 | Toluca | 2.2 | 3–1 | 1.0 | Santos | 10,023 | Estadio Nemesio Díez | César Arturo Ramos | Match Report | |
| 2 | Sun | 2022-01-16 | 17:00 | Pachuca | 0.8 | 2–1 | 0.9 | Guadalajara | 6,692 | Estadio Hidalgo | Adonai Escobedo | Match Report | |
| 2 | Sat | 2022-01-15 | 19:00 | UANL | 2.2 | 0–2 | 1.4 | Puebla | 14,829 | Estadio Universitario de Nuevo León | Luis Santander | Match Report | |
| 2 | Sat | 2022-01-15 | 19:06 | Tijuana | 1.2 | 1–1 | 0.7 | León | 8,333 | Estadio Caliente | Oscar Mejia | Match Report | |
| 2 | Sat | 2022-01-15 | 21:00 | Cruz Azul | 0.7 | 1–0 | 0.2 | FC Juárez | 13,801 | Estadio Azteca | Guillermo Pacheco Larios | Match Report | |
| 1 | Wed | 2022-01-19 | 21:00 | León | 1.3 | 1–1 | 1.3 | Atlas | 8,997 | Estadio León | Fernando Hernández | Match Report | |
| 3 | Thu | 2022-01-20 | 21:00 | Atlético | 0.6 | 0–1 | 2.1 | FC Juárez | 5,397 | Estadio Alfonso Lastras Ramírez | Erick Miranda | Match Report | |
| 3 | Sat | 2022-01-22 | 17:00 | Guadalajara | 0.7 | 1–1 | 0.3 | Querétaro | 15,193 | Estadio Akron | Diego Montaño | Match Report | |
| 3 | Fri | 2022-01-21 | 20:00 | Mazatlán | 1.3 | 1–2 | 1.1 | Toluca | 8,517 | Estadio de Mazatlán | Óscar Macias | Match Report | |
| 3 | Sun | 2022-01-23 | 12:00 | UNAM | 1.0 | 1–2 | 1.6 | UANL | 18,805 | Estadio Olímpico Universitario de Colima | Oscar Mejia | Match Report | |
| 3 | Sat | 2022-01-22 | 19:00 | León | 1.3 | 2–1 | 0.9 | Pachuca | 9,463 | Estadio León | Daniel Quintero | Match Report | |
| 3 | Sat | 2022-01-22 | 21:00 | América | 0.9 | 0–2 | 0.1 | Atlas | 20,825 | Estadio Azteca | Marco Ortíz | Match Report | |
| 3 | Sat | 2022-01-22 | 21:06 | Monterrey | 1.2 | 2–2 | 1.1 | Cruz Azul | 16,508 | Estadio BBVA Bancomer | César Arturo Ramos | Match Report | |
| 3 | Sun | 2022-01-23 | 19:00 | Santos | 0.5 | 1–4 | 1.6 | Necaxa | 9,630 | Estadio Nuevo Corona | Victor Caceres | Match Report | |
| 3 | Fri | 2022-01-28 | 21:00 | Puebla | 2.8 | 3–1 | 0.5 | Tijuana | 11,180 | Estadio Cuauhtémoc | Guillermo Pacheco Larios | Match Report | |
| 4 | Sat | 2022-02-05 | 17:00 | Necaxa | 2.8 | 1–3 | 2.7 | Pachuca | 9,238 | Estadio Victoria de Aguascalientes | Marco Ortíz | Match Report | |
| 4 | Sun | 2022-02-06 | 16:00 | Querétaro | 2.9 | 0–2 | 2.8 | Puebla | 13,622 | Estadio La Corregidora | Ismael Lopez | Match Report | |
| 4 | Sat | 2022-02-05 | 19:00 | América | 2.2 | 2–3 | 2.9 | Atlético | 16,968 | Estadio Azteca | Adonai Escobedo | Match Report | |
| 4 | Sat | 2022-02-05 | 19:06 | Tijuana | 3.9 | 1–0 | 0.9 | UNAM | 11,633 | Estadio Caliente | Diego Montaño | Match Report | |
| 4 | Sun | 2022-02-06 | 18:00 | Atlas | 1.1 | 2–1 | 1.3 | Santos | 17,346 | Estadio Jalisco | Jorge Pérez | Match Report | |
| 4 | Sun | 2022-02-06 | 20:00 | UANL | 4.1 | 4–3 | 2.4 | Mazatlán | 10,497 | Estadio Universitario de Nuevo León | Fernando Hernández | Match Report | |
| 4 | Mon | 2022-02-07 | 21:05 | León | 1.7 | 0–1 | 1.1 | Cruz Azul | 14,097 | Estadio León | Victor Caceres | Match Report | |
| 4 | Wed | 2022-02-09 | 18:00 | FC Juárez | 1.0 | 1–3 | 1.1 | Guadalajara | 7,801 | Estadio Olímpico Benito Juárez | Brian Gonzalez | Match Report | |
| 5 | Sat | 2022-02-12 | 17:00 | Guadalajara | 0.9 | 1–3 | 2.1 | UANL | 22,564 | Estadio Akron | Jorge Pérez | Match Report | |
| 5 | Sat | 2022-02-12 | 17:00 | Atlético | 2.4 | 0–1 | 0.3 | Toluca | 5,574 | Estadio Alfonso Lastras Ramírez | Daniel Quintero | Match Report | |
| 5 | Fri | 2022-02-11 | 18:00 | Mazatlán | 1.6 | 2–0 | 1.2 | Tijuana | 8,221 | Estadio de Mazatlán | Fernando Guerrero | Match Report | |
| 5 | Fri | 2022-02-11 | 21:00 | Puebla | 1.5 | 1–1 | 1.9 | Atlas | 23,170 | Estadio Cuauhtémoc | Victor Caceres | Match Report | |
| 5 | Sun | 2022-02-13 | 12:00 | UNAM | 0.8 | 2–1 | 1.3 | León | 15,079 | Estadio Olímpico Universitario de Colima | Guillermo Pacheco Larios | Match Report | |
| 5 | Sat | 2022-02-12 | 19:00 | Cruz Azul | 1.3 | 1–2 | 0.8 | Necaxa | 26,967 | Estadio Azteca | Erick Miranda | Match Report | |
| 5 | Sat | 2022-02-12 | 21:00 | Santos | 0.6 | 2–3 | 2.1 | América | 18,774 | Estadio Nuevo Corona | Luis Santander | Match Report | |
| 5 | Mon | 2022-02-14 | 21:00 | Pachuca | 0.9 | 2–2 | 1.6 | Querétaro | 5,584 | Estadio Hidalgo | Jorge Camacho | Match Report | |
| 2 | Wed | 2022-02-16 | 18:00 | Mazatlán | 1.2 | 2–1 | 1.2 | América | 13,934 | Estadio de Mazatlán | Jorge Pérez | Match Report | |
| 6 | Sat | 2022-02-19 | 17:00 | Querétaro | 1.4 | 2–0 | 0.3 | Mazatlán | 7,458 | Estadio La Corregidora | Luis Santander | Match Report | |
| 6 | Fri | 2022-02-18 | 19:00 | Puebla | 0.8 | 1–0 | 2.1 | Monterrey | 25,934 | Estadio Cuauhtémoc | Oscar Mejia | Match Report | |
| 6 | Fri | 2022-02-18 | 19:06 | Tijuana | 1.8 | 1–1 | 0.3 | Necaxa | 10,333 | Estadio Caliente | Ismael Lopez | Match Report | |
| 6 | Fri | 2022-02-18 | 20:00 | FC Juárez | 0.3 | 0–0 | 0.6 | Santos | 7,355 | Estadio Olímpico Benito Juárez | Fernando Hernández | Match Report | |
| 6 | Sun | 2022-02-20 | 16:00 | América | 1.4 | 1–3 | 1.6 | Pachuca | 27,858 | Estadio Azteca | Diego Montaño | Match Report | |
| 6 | Sat | 2022-02-19 | 19:00 | UANL | 1.3 | 2–1 | 0.3 | Atlético | 20,850 | Estadio Universitario de Nuevo León | Marco Ortíz | Match Report | |
| 6 | Sat | 2022-02-19 | 21:00 | León | 1.2 | 2–1 | 1.2 | Guadalajara | 16,204 | Estadio León | Fernando Guerrero | Match Report | |
| 6 | Sun | 2022-02-20 | 18:05 | Toluca | 0.8 | 1–4 | 2.3 | Cruz Azul | 22,438 | Estadio Nemesio Díez | Jorge Pérez | Match Report | |
| 6 | Sun | 2022-02-20 | 20:05 | Atlas | 0.6 | 0–0 | 0.6 | UNAM | 20,436 | Estadio Jalisco | Daniel Quintero | Match Report | |
| 7 | Thu | 2022-02-24 | 19:00 | Pachuca | 1.3 | 3–1 | 0.4 | Mazatlán | 6,875 | Estadio Hidalgo | Ismael Lopez | Match Report | |
| 7 | Thu | 2022-02-24 | 21:05 | Querétaro | 0.4 | 1–1 | 1.5 | Toluca | 11,524 | Estadio La Corregidora | Oscar Mejia | Match Report | |
| 7 | Sat | 2022-02-26 | 17:06 | Monterrey | 1.3 | 0–2 | 1.2 | Atlético | 24,507 | Estadio BBVA Bancomer | Diego Montaño | Match Report | |
| 7 | Fri | 2022-02-25 | 19:00 | Necaxa | 1.1 | 0–1 | 1.2 | León | 12,781 | Estadio Victoria de Aguascalientes | Óscar Macias | Match Report | |
| 7 | Fri | 2022-02-25 | 19:06 | Tijuana | 1.0 | 2–0 | 0.7 | Atlas | 14,333 | Estadio Caliente | Jorge Pérez | Match Report | |
| 7 | Fri | 2022-02-25 | 20:00 | FC Juárez | 1.0 | 2–3 | 2.9 | UANL | 10,113 | Estadio Olímpico Benito Juárez | Daniel Quintero | Match Report | |
| 7 | Sat | 2022-02-26 | 19:00 | Guadalajara | 1.9 | 2–3 | 1.5 | Puebla | 19,747 | Estadio Akron | Fernando Hernández | Match Report | |
| 7 | Sat | 2022-02-26 | 21:00 | UNAM | 0.4 | 0–0 | 0.8 | América | 42,650 | Estadio Olímpico Universitario de Colima | Fernando Guerrero | Match Report | |
| 7 | Sun | 2022-02-27 | 19:00 | Cruz Azul | 2.6 | 1–2 | 1.0 | Santos | 33,924 | Estadio Azteca | César Arturo Ramos | Match Report | |
| 8 | Tue | 2022-03-01 | 19:00 | Puebla | 0.6 | 1–1 | 0.5 | FC Juárez | 26,100 | Estadio Cuauhtémoc | Ismael Lopez | Match Report | |
| 8 | Tue | 2022-03-01 | 19:00 | Toluca | 1.1 | 1–2 | 0.7 | Tijuana | 12,523 | Estadio Nemesio Díez | Jorge Camacho | Match Report | |
| 8 | Tue | 2022-03-01 | 20:00 | Mazatlán | 0.6 | 0–0 | 0.6 | Necaxa | 9,414 | Estadio de Mazatlán | Diego Montaño | Match Report | |
| 8 | Tue | 2022-03-01 | 21:00 | América | 0.7 | 1–1 | 0.9 | Querétaro | 17,414 | Estadio Azteca | Fernando Hernández | Match Report | |
| 8 | Tue | 2022-03-01 | 21:00 | León | 1.5 | 0–0 | 1.9 | Monterrey | 10,581 | Estadio León | Luis Santander | Match Report | |
| 8 | Wed | 2022-03-02 | 19:00 | Atlas | 0.7 | 0–1 | 1.7 | Pachuca | 14,421 | Estadio Jalisco | Brian Gonzalez | Match Report | |
| 8 | Wed | 2022-03-02 | 19:00 | UANL | 2.8 | 2–2 | 1.0 | Cruz Azul | 36,978 | Estadio Universitario de Nuevo León | Victor Caceres | Match Report | |
| 8 | Wed | 2022-03-02 | 21:00 | Atlético | 1.5 | 2–2 | 0.6 | Guadalajara | 14,630 | Estadio Alfonso Lastras Ramírez | César Arturo Ramos | Match Report | |
| 8 | Wed | 2022-03-02 | 21:00 | Santos | 2.1 | 3–2 | 1.3 | UNAM | 12,238 | Estadio Nuevo Corona | Óscar Macias | Match Report | |
| 9 | Sat | 2022-03-05 | 17:00 | Querétaro | 0–3 | Atlas | Estadio La Corregidora | Fernando Guerrero | Match Report | Match awarded to Atlas | |||
| 9 | Fri | 2022-03-04 | 19:00 | Necaxa | 0.5 | 0–1 | 0.9 | Toluca | 11,783 | Estadio Victoria de Aguascalientes | Guillermo Pacheco Larios | Match Report | |
| 9 | Fri | 2022-03-04 | 20:00 | FC Juárez | 0.4 | 0–1 | 0.8 | León | 9,307 | Estadio Olímpico Benito Juárez | Oscar Mejia | Match Report | |
| 9 | Sat | 2022-03-05 | 19:06 | Monterrey | 1.8 | 2–1 | 1.2 | América | 40,327 | Estadio BBVA Bancomer | Erick Miranda | Match Report | |
| 9 | Sat | 2022-03-05 | 21:00 | Guadalajara | 1.0 | 1–0 | 0.4 | Santos | 18,522 | Estadio Akron | Victor Caceres | Match Report | |
| 9 | Sat | 2022-03-05 | 21:00 | Cruz Azul | 0.7 | 1–3 | 1.3 | Puebla | 29,336 | Estadio Azteca | Jorge Pérez | Match Report | |
| 10 | Sat | 2022-03-12 | 17:00 | León | 1.5 | 0–3 | 1.4 | UANL | 16,242 | Estadio León | Fernando Guerrero | Match Report | |
| 10 | Fri | 2022-03-11 | 19:00 | Necaxa | 1.2 | 1–0 | 0.8 | Querétaro | Estadio Victoria de Aguascalientes | Oscar Mejia | Match Report | ||
| 10 | Fri | 2022-03-11 | 20:00 | FC Juárez | 0.4 | 1–2 | 1.0 | Atlas | 9,002 | Estadio Olímpico Benito Juárez | Erick Miranda | Match Report | |
| 10 | Fri | 2022-03-11 | 21:06 | Monterrey | 1.9 | 2–1 | 1.0 | Mazatlán | 27,012 | Estadio BBVA Bancomer | Daniel Quintero | Match Report | |
| 10 | Sun | 2022-03-13 | 12:00 | Toluca | 0.6 | 0–3 | 2.1 | Pachuca | 10,044 | Estadio Nemesio Díez | César Arturo Ramos | Match Report | |
| 10 | Sun | 2022-03-13 | 17:00 | Atlético | 1.9 | 2–1 | 1.8 | Puebla | 5,904 | Estadio Alfonso Lastras Ramírez | Luis Santander | Match Report | |
| 10 | Sat | 2022-03-12 | 19:00 | Cruz Azul | 0.9 | 2–1 | 1.2 | UNAM | 12,686 | Estadio Azteca | Fernando Hernández | Match Report | |
| 10 | Sat | 2022-03-12 | 21:00 | Guadalajara | 0.7 | 0–0 | 0.3 | América | 33,047 | Estadio Akron | Jorge Pérez | Match Report | |
| 10 | Sun | 2022-03-13 | 19:00 | Santos | 2.0 | 4–0 | 0.9 | Tijuana | 9,895 | Estadio Nuevo Corona | Brian Gonzalez | Match Report | |
| 5 | Tue | 2022-03-15 | 21:06 | Monterrey | 1.9 | 3–0 | 0.3 | FC Juárez | 29,052 | Estadio BBVA Bancomer | Victor Caceres | Match Report | |
| 11 | Thu | 2022-03-17 | 21:05 | Querétaro | 1.4 | 2–1 | 2.0 | Atlético | Estadio La Corregidora | Fernando Hernández | Match Report | ||
| 11 | Sat | 2022-03-19 | 17:00 | UNAM | 0.7 | 1–3 | 2.4 | Necaxa | 10,380 | Estadio Olímpico Universitario de Colima | Adonai Escobedo | Match Report | |
| 11 | Fri | 2022-03-18 | 21:00 | Puebla | 2.0 | 2–2 | 1.6 | Santos | 19,713 | Estadio Cuauhtémoc | Fernando Guerrero | Match Report | |
| 11 | Sun | 2022-03-20 | 17:00 | América | 2.6 | 3–0 | 0.2 | Toluca | 34,571 | Estadio Azteca | Oscar Mejia | Match Report | |
| 11 | Sat | 2022-03-19 | 19:00 | UANL | 0.5 | 2–0 | 0.5 | Monterrey | 41,473 | Estadio Universitario de Nuevo León | Jorge Pérez | Match Report | |
| 11 | Sat | 2022-03-19 | 21:00 | Pachuca | 0.9 | 1–0 | 0.7 | Cruz Azul | 11,367 | Estadio Hidalgo | Brian Gonzalez | Match Report | |
| 11 | Sun | 2022-03-20 | 19:00 | Atlas | 0.8 | 1–1 | 0.9 | Guadalajara | 19,017 | Estadio Jalisco | César Arturo Ramos | Match Report | |
| 11 | Sun | 2022-03-20 | 20:00 | Mazatlán | 1.1 | 1–2 | 1.3 | León | 9,566 | Estadio de Mazatlán | Ismael Lopez | Match Report | |
| 11 | Sun | 2022-03-20 | 20:06 | Tijuana | 1.4 | 1–0 | 1.8 | FC Juárez | 17,333 | Estadio Caliente | Luis Santander | Match Report | |
| 9 | Sat | 2022-03-26 | 17:00 | UNAM | 1.5 | 1–1 | 0.4 | Mazatlán | 9,289 | Estadio Olímpico Universitario de Colima | Luis Santander | Match Report | |
| 12 | Sat | 2022-04-02 | 17:00 | Cruz Azul | 0.4 | 1–0 | 0.8 | Atlas | 21,644 | Estadio Azteca | Luis Santander | Match Report | |
| 12 | Fri | 2022-04-01 | 20:00 | Atlético | 1.3 | 1–0 | 0.3 | Mazatlán | 5,803 | Estadio Alfonso Lastras Ramírez | César Arturo Ramos | Match Report | |
| 12 | Sun | 2022-04-03 | 12:00 | Toluca | 1.1 | 2–1 | 1.4 | Puebla | 9,215 | Estadio Nemesio Díez | Fernando Hernández | Match Report | |
| 12 | Sun | 2022-04-03 | 17:00 | León | 1.0 | 1–1 | 1.3 | Querétaro | Estadio León | Guillermo Pacheco Larios | Match Report | ||
| 12 | Sat | 2022-04-02 | 19:00 | Necaxa | 0.3 | 0–1 | 1.5 | América | 19,485 | Estadio Victoria de Aguascalientes | Daniel Quintero | Match Report | |
| 12 | Sat | 2022-04-02 | 21:00 | FC Juárez | 0.7 | 0–1 | 1.3 | UNAM | 11,748 | Estadio Olímpico Benito Juárez | Fernando Guerrero | Match Report | |
| 12 | Sun | 2022-04-03 | 19:00 | UANL | 2.3 | 2–0 | 0.8 | Tijuana | 37,691 | Estadio Universitario de Nuevo León | Óscar Macias | Match Report | |
| 12 | Sun | 2022-04-03 | 19:00 | Santos | 2.2 | 3–1 | 1.2 | Pachuca | 12,908 | Estadio Nuevo Corona | Adonai Escobedo | Match Report | |
| 4 | Wed | 2022-04-06 | 19:00 | Toluca | 1.3 | 2–2 | 1.9 | Monterrey | 10,150 | Estadio Nemesio Díez | Eduardo Galván | Match Report | |
| 9 | Wed | 2022-04-06 | 19:06 | Tijuana | 2.6 | 1–1 | 1.2 | Atlético | 13,533 | Estadio Caliente | Jesus Lopez | Match Report | |
| 9 | Thu | 2022-04-07 | 19:00 | Pachuca | 1.7 | 2–1 | 0.6 | UANL | 10,664 | Estadio Hidalgo | Ismael Lopez | Match Report | |
| 13 | Thu | 2022-04-07 | 21:00 | Atlas | 1.9 | 2–1 | 0.6 | Necaxa | 12,588 | Estadio Jalisco | Jorge Pérez | Match Report | |
| 13 | Sat | 2022-04-09 | 17:00 | Atlético | 1.7 | 2–0 | 2.0 | León | 6,102 | Estadio Alfonso Lastras Ramírez | Luis Santander | Match Report | |
| 13 | Fri | 2022-04-08 | 19:00 | Puebla | 1.4 | 2–2 | 2.2 | UNAM | 28,115 | Estadio Cuauhtémoc | Brian Gonzalez | Match Report | |
| 13 | Fri | 2022-04-08 | 20:00 | Mazatlán | 0.9 | 1–1 | 2.2 | Cruz Azul | 15,206 | Estadio de Mazatlán | Erick Miranda | Match Report | |
| 13 | Sat | 2022-04-09 | 19:00 | Toluca | 0.8 | 1–1 | 0.8 | Guadalajara | 20,166 | Estadio Nemesio Díez | Óscar Macias | Match Report | |
| 13 | Sat | 2022-04-09 | 19:06 | Monterrey | 2.1 | 1–0 | 0.8 | Santos | 29,769 | Estadio BBVA Bancomer | Marco Ortíz | Match Report | |
| 13 | Sat | 2022-04-09 | 21:00 | América | 1.5 | 3–0 | 0.5 | FC Juárez | 19,757 | Estadio Azteca | César Arturo Ramos | Match Report | |
| 13 | Sun | 2022-04-10 | 19:00 | Querétaro | 1.7 | 0–1 | 0.3 | UANL | Estadio La Corregidora | Diego Montaño | Match Report | ||
| 13 | Mon | 2022-04-11 | 21:00 | Pachuca | 2.7 | 0–0 | 0.2 | Tijuana | 9,191 | Estadio Hidalgo | Daniel Quintero | Match Report | |
| 12 | Wed | 2022-04-13 | 20:05 | Guadalajara | 1.3 | 1–3 | 1.8 | Monterrey | 24,247 | Estadio Akron | Diego Montaño | Match Report | |
| 14 | Thu | 2022-04-14 | 21:00 | Atlas | 1.6 | 1–2 | 1.4 | Mazatlán | 18,316 | Estadio Jalisco | Ismael Lopez | Match Report | |
| 14 | Sat | 2022-04-16 | 17:00 | León | 1.7 | 0–1 | 2.2 | Puebla | 12,859 | Estadio León | Eduardo Galván | Match Report | |
| 14 | Fri | 2022-04-15 | 19:00 | Necaxa | 1.6 | 4–2 | 1.9 | Atlético | 12,804 | Estadio Victoria de Aguascalientes | Oscar Mejia | Match Report | |
| 14 | Fri | 2022-04-15 | 19:06 | Tijuana | 0.4 | 1–3 | 3.1 | América | 27,333 | Estadio Caliente | Luis Santander | Match Report | |
| 14 | Fri | 2022-04-15 | 20:00 | FC Juárez | 0.7 | 1–2 | 0.7 | Pachuca | 8,568 | Estadio Olímpico Benito Juárez | Óscar Macias | Match Report | |
| 14 | Sun | 2022-04-17 | 12:00 | UNAM | 1.4 | 2–0 | 1.7 | Monterrey | 17,167 | Estadio Olímpico Universitario de Colima | Erick Miranda | Match Report | |
| 14 | Sat | 2022-04-16 | 19:00 | Santos | 1.8 | 1–1 | 1.4 | Querétaro | Estadio Nuevo Corona | César Arturo Ramos | Match Report | ||
| 14 | Sat | 2022-04-16 | 19:00 | UANL | 2.8 | 3–0 | 0.4 | Toluca | 36,658 | Estadio Universitario de Nuevo León | Marco Ortíz | Match Report | |
| 14 | Sat | 2022-04-16 | 21:00 | Cruz Azul | 0.5 | 0–1 | 1.3 | Guadalajara | 21,280 | Estadio Azteca | Jorge Pérez | Match Report | |
| 15 | Tue | 2022-04-19 | 19:00 | Pachuca | 1.2 | 1–0 | 1.1 | Puebla | 10,427 | Estadio Hidalgo | Oscar Mejia | Match Report | |
| 15 | Tue | 2022-04-19 | 19:00 | Necaxa | 0.7 | 2–0 | 1.1 | UANL | Estadio Victoria de Aguascalientes | Jesus Lopez | Match Report | ||
| 15 | Tue | 2022-04-19 | 20:00 | Mazatlán | 0.9 | 1–0 | 1.5 | Santos | 10,960 | Estadio de Mazatlán | Fernando Hernández | Match Report | |
| 15 | Tue | 2022-04-19 | 21:00 | Guadalajara | 0.9 | 2–1 | 0.9 | Tijuana | 20,945 | Estadio Akron | Adonai Escobedo | Match Report | |
| 15 | Tue | 2022-04-19 | 21:00 | Toluca | 1.4 | 0–1 | 1.2 | FC Juárez | 9,211 | Estadio Nemesio Díez | Victor Caceres | Match Report | |
| 15 | Wed | 2022-04-20 | 19:00 | Atlético | 1.7 | 2–0 | 0.5 | UNAM | 14,948 | Estadio Alfonso Lastras Ramírez | Marco Ortíz | Match Report | |
| 15 | Wed | 2022-04-20 | 21:00 | América | 1.7 | 2–0 | 0.5 | León | 36,210 | Estadio Azteca | Diego Montaño | Match Report | |
| 15 | Wed | 2022-04-20 | 21:06 | Monterrey | 1.7 | 0–0 | 0.4 | Atlas | 31,426 | Estadio BBVA Bancomer | César Arturo Ramos | Match Report | |
| 15 | Thu | 2022-04-21 | 21:00 | Querétaro | 1.1 | 0–1 | 1.6 | Cruz Azul | Estadio La Corregidora | Fernando Guerrero | Match Report | ||
| 16 | Sat | 2022-04-23 | 17:00 | Pachuca | 0.8 | 3–0 | 0.9 | Monterrey | 8,041 | Estadio Hidalgo | Luis Santander | Match Report | |
| 16 | Fri | 2022-04-22 | 19:00 | Puebla | 1.1 | 0–1 | 1.4 | Necaxa | 16,320 | Estadio Cuauhtémoc | Ismael Lopez | Match Report | |
| 16 | Fri | 2022-04-22 | 20:00 | FC Juárez | 0.1 | 0–2 | 0.6 | Mazatlán | 7,688 | Estadio Olímpico Benito Juárez | Oscar Mejia | Match Report | |
| 16 | Sun | 2022-04-24 | 12:00 | Toluca | 2.5 | 2–4 | 3.1 | Atlas | 10,765 | Estadio Nemesio Díez | Fernando Guerrero | Match Report | |
| 16 | Sun | 2022-04-24 | 17:00 | Cruz Azul | 0.9 | 0–1 | 0.7 | Atlético | 17,222 | Estadio Azteca | Jesus Lopez | Match Report | |
| 16 | Sat | 2022-04-23 | 19:00 | UANL | 0.5 | 0–2 | 1.6 | América | 38,810 | Estadio Universitario de Nuevo León | Fernando Hernández | Match Report | |
| 16 | Sat | 2022-04-23 | 21:00 | Guadalajara | 1.3 | 3–1 | 0.6 | UNAM | 31,767 | Estadio Akron | Óscar Macias | Match Report | |
| 16 | Sun | 2022-04-24 | 19:00 | Santos | 2.0 | 1–1 | 1.5 | León | 11,345 | Estadio Nuevo Corona | Adonai Escobedo | Match Report | |
| 16 | Sun | 2022-04-24 | 19:06 | Tijuana | 2.9 | 2–2 | 1.6 | Querétaro | Estadio Caliente | Marco Ortíz | Match Report | ||
| 17 | Sat | 2022-04-30 | 17:00 | Querétaro | 2.4 | 4–0 | 1.2 | FC Juárez | Estadio La Corregidora | Adonai Escobedo | Match Report | ||
| 17 | Fri | 2022-04-29 | 19:00 | Necaxa | 0.6 | 0–1 | 0.8 | Guadalajara | 20,537 | Estadio Victoria de Aguascalientes | César Arturo Ramos | Match Report | |
| 17 | Fri | 2022-04-29 | 20:05 | Mazatlán | 2.4 | 2–1 | 1.4 | Puebla | 15,729 | Estadio de Mazatlán | Jorge Pérez | Match Report | |
| 17 | Sun | 2022-05-01 | 12:00 | UNAM | 1.5 | 2–0 | 0.6 | Pachuca | 14,286 | Estadio Olímpico Universitario de Colima | Fernando Hernández | Match Report | |
| 17 | Sun | 2022-05-01 | 16:00 | Atlético | 1.6 | 1–3 | 1.0 | Santos | 10,364 | Estadio Alfonso Lastras Ramírez | Ismael Lopez | Match Report | |
| 17 | Sat | 2022-04-30 | 19:00 | Atlas | 0.5 | 1–1 | 1.5 | UANL | 21,968 | Estadio Jalisco | Oscar Mejia | Match Report | |
| 17 | Sat | 2022-04-30 | 19:06 | Monterrey | 2.3 | 2–0 | 1.0 | Tijuana | 28,642 | Estadio BBVA Bancomer | Daniel Quintero | Match Report | |
| 17 | Sat | 2022-04-30 | 21:00 | América | 1.2 | 0–0 | 0.3 | Cruz Azul | 52,630 | Estadio Azteca | Marco Ortíz | Match Report | |
| 17 | Sun | 2022-05-01 | 20:06 | León | 3.0 | 4–4 | 0.7 | Toluca | 18,732 | Estadio León | Luis Santander | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reclassification | Sat | 2022-05-07 | 17:45 | Cruz Azul | 1.9 | (3) 1–1 (1) | 1.1 | Necaxa | 29,073 | Estadio Azteca | Fernando Guerrero | Match Report | Cruz Azul won on penalty kicks following extra time |
| Reclassification | Sun | 2022-05-08 | 17:00 | Puebla | 0.8 | (3) 2–2 (1) | 2.1 | Mazatlán | 29,105 | Estadio Cuauhtémoc | César Arturo Ramos | Match Report | Puebla won on penalty kicks following extra time |
| Reclassification | Sat | 2022-05-07 | 20:06 | Monterrey | 1.4 | (1) 2–2 (3) | 0.9 | Atlético | 38,614 | Estadio BBVA Bancomer | Jorge Pérez | Match Report | Atlético won on penalty kicks following extra time |
| Reclassification | Sun | 2022-05-08 | 19:15 | Guadalajara | 1.1 | 4–1 | 0.5 | UNAM | 37,508 | Estadio Akron | Marco Ortíz | Match Report | |
| Quarter-finals | Wed | 2022-05-11 | 19:00 | Atlético | 1.9 | 2–2 | 0.5 | Pachuca | 16,605 | Estadio Alfonso Lastras Ramírez | Oscar Mejia | Match Report | Leg 1 of 2 |
| Quarter-finals | Wed | 2022-05-11 | 21:05 | Puebla | 0.3 | 1–1 | 0.8 | América | 43,921 | Estadio Cuauhtémoc | Luis Santander | Match Report | Leg 1 of 2 |
| Quarter-finals | Thu | 2022-05-12 | 19:00 | Cruz Azul | 0.5 | 0–1 | 0.5 | UANL | 28,974 | Estadio Azteca | Fernando Hernández | Match Report | Leg 1 of 2 |
| Quarter-finals | Thu | 2022-05-12 | 21:05 | Guadalajara | 0.8 | 1–2 | 1.1 | Atlas | 34,780 | Estadio Akron | Jorge Pérez | Match Report | Leg 1 of 2 |
| Quarter-finals | Sat | 2022-05-14 | 18:00 | América | 3.7 | 3–2 | 1.8 | Puebla | 51,186 | Estadio Azteca | Fernando Guerrero | Match Report | Leg 2 of 2; América won |
| Quarter-finals | Sun | 2022-05-15 | 18:00 | Atlas | 0.6 | 1–1 | 1.1 | Guadalajara | 32,746 | Estadio Jalisco | Fernando Hernández | Match Report | Leg 2 of 2; Atlas won |
| Quarter-finals | Sat | 2022-05-14 | 20:05 | Pachuca | 3.3 | 3–2 | 1.1 | Atlético | 9,565 | Estadio Hidalgo | Marco Ortíz | Match Report | Leg 2 of 2; Pachuca won |
| Quarter-finals | Sun | 2022-05-15 | 20:05 | UANL | 1.6 | 0–1 | 0.7 | Cruz Azul | 40,161 | Estadio Universitario de Nuevo León | César Arturo Ramos | Match Report | Leg 2 of 2; UANL won |
| Semi-finals | Wed | 2022-05-18 | 21:00 | Atlas | 1.3 | 3–0 | 0.8 | UANL | 20,684 | Estadio Jalisco | Marco Ortíz | Match Report | Leg 1 of 2 |
| Semi-finals | Thu | 2022-05-19 | 20:00 | América | 1.0 | 1–1 | 1.1 | Pachuca | 62,633 | Estadio Azteca | Jorge Pérez | Match Report | Leg 1 of 2 |
| Semi-finals | Sat | 2022-05-21 | 20:00 | UANL | 3.5 | 4–2 | 1.9 | Atlas | 41,635 | Estadio Universitario de Nuevo León | César Arturo Ramos | Match Report | Leg 2 of 2; Atlas won |
| Semi-finals | Sun | 2022-05-22 | 20:06 | Pachuca | 1.7 | 3–0 | 1.1 | América | 19,310 | Estadio Hidalgo | Fernando Hernández | Match Report | Leg 2 of 2; Pachuca won |
| Finals | Thu | 2022-05-26 | 21:00 | Atlas | 1.3 | 2–0 | 1.3 | Pachuca | 37,841 | Estadio Jalisco | Marco Ortíz | Match Report | Leg 1 of 2 |
| Finals | Sun | 2022-05-29 | 20:10 | Pachuca | 1.0 | 2–1 | 1.1 | Atlas | 22,038 | Estadio Hidalgo | Fernando Hernández | Match Report | Leg 2 of 2; Atlas won |
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