Scores & Fixtures 2021-2022 La Liga
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-08-13 | 21:00 | Valencia | 1.5 | 1–0 | 1.4 | Getafe | 9,868 | Estadio de Mestalla | Jesús Gil | Match Report | |
| 1 | Sat | 2021-08-14 | 19:30 | Mallorca | 0.5 | 1–1 | 0.6 | Betis | 6,279 | Iberostar Estadi | Antonio Matéu Lahoz | Match Report | |
| 1 | Sat | 2021-08-14 | 19:30 | Cádiz | 0.6 | 1–1 | 0.9 | Levante | 6,941 | Estadio Nuevo Mirandilla | Santiago Jaime | Match Report | |
| 1 | Sat | 2021-08-14 | 22:00 | Alavés | 1.7 | 1–4 | 1.7 | Real Madrid | 3,968 | Estadio de Mendizorroza | César Soto | Match Report | |
| 1 | Sat | 2021-08-14 | 22:00 | Osasuna | 0.9 | 0–0 | 0.5 | Espanyol | 6,715 | Estadio El Sadar | Miguel Ángel Ortiz Arias | Match Report | |
| 1 | Sun | 2021-08-15 | 17:30 | Celta Vigo | 2.3 | 1–2 | 1.5 | Atlético Madrid | 5,401 | Estadio de Balaídos | José Luis Munuera | Match Report | |
| 1 | Sun | 2021-08-15 | 20:00 | Barcelona | 2.8 | 4–2 | 0.8 | Real Sociedad | 20,384 | Camp Nou | Alejandro Hernández | Match Report | |
| 1 | Sun | 2021-08-15 | 22:15 | Sevilla | 3.7 | 3–0 | 0.4 | Rayo Vallecano | 13,962 | Estadio Ramón Sánchez Pizjuán | Isidro Díaz de Mera | Match Report | |
| 1 | Mon | 2021-08-16 | 20:00 | Villarreal | 1.1 | 0–0 | 0.3 | Granada | 7,837 | Estadio de la Cerámica | Pablo González | Match Report | |
| 1 | Mon | 2021-08-16 | 22:00 | Elche | 1.1 | 0–0 | 0.6 | Athletic Club | 9,145 | Estadio Manuel Martínez Valero | Adrián Cordero | Match Report | |
| 2 | Fri | 2021-08-20 | 21:00 | Betis | 1.1 | 1–1 | 1.6 | Cádiz | 23,745 | Estadio Benito Villamarín | Valentín Pizarro | Match Report | |
| 2 | Sat | 2021-08-21 | 17:00 | Alavés | 0.5 | 0–1 | 0.7 | Mallorca | 2,896 | Estadio de Mendizorroza | Alejandro Muñíz | Match Report | |
| 2 | Sat | 2021-08-21 | 19:30 | Espanyol | 1.3 | 0–0 | 0.6 | Villarreal | 11,095 | RCDE Stadium | Jorge Figueroa | Match Report | |
| 2 | Sat | 2021-08-21 | 19:30 | Granada | 1.1 | 1–1 | 1.5 | Valencia | 6,267 | Estadio Nuevo Los Cármenes | Carlos del Cerro | Match Report | |
| 2 | Sat | 2021-08-21 | 22:00 | Athletic Club | 1.4 | 1–1 | 1.0 | Barcelona | 9,394 | San Mamés | Juan Martínez | Match Report | |
| 2 | Sun | 2021-08-22 | 17:00 | Real Sociedad | 1.9 | 1–0 | 0.5 | Rayo Vallecano | 7,652 | Estadio Municipal de Anoeta | Santiago Jaime | Match Report | |
| 2 | Sun | 2021-08-22 | 19:30 | Atlético Madrid | 1.2 | 1–0 | 0.2 | Elche | 24,926 | Estadio Wanda Metropolitano | Ricardo de Burgos | Match Report | |
| 2 | Sun | 2021-08-22 | 22:00 | Levante | 1.9 | 3–3 | 1.6 | Real Madrid | 9,838 | Estadio Ciudad de Valencia | Guillermo Cuadra | Match Report | |
| 2 | Mon | 2021-08-23 | 20:00 | Getafe | 0.5 | 0–1 | 1.2 | Sevilla | 4,810 | Coliseum Alfonso Pérez | José Sánchez | Match Report | |
| 2 | Mon | 2021-08-23 | 22:00 | Osasuna | 2.0 | 0–0 | 0.1 | Celta Vigo | 7,189 | Estadio El Sadar | Alberola Rojas | Match Report | |
| 3 | Fri | 2021-08-27 | 20:00 | Mallorca | 1.0 | 1–0 | 0.4 | Espanyol | 7,529 | Iberostar Estadi | Isidro Díaz de Mera | Match Report | |
| 3 | Fri | 2021-08-27 | 22:15 | Valencia | 1.6 | 3–0 | 0.4 | Alavés | 10,627 | Estadio de Mestalla | Miguel Ángel Ortiz Arias | Match Report | |
| 3 | Sat | 2021-08-28 | 17:00 | Celta Vigo | 1.1 | 0–1 | 1.4 | Athletic Club | 5,492 | Estadio de Balaídos | Antonio Matéu Lahoz | Match Report | |
| 3 | Sat | 2021-08-28 | 19:30 | Real Sociedad | 1.0 | 1–0 | 0.4 | Levante | 7,758 | Estadio Municipal de Anoeta | José Luis Munuera | Match Report | |
| 3 | Sat | 2021-08-28 | 19:30 | Elche | 0.5 | 1–1 | 1.3 | Sevilla | 10,385 | Estadio Manuel Martínez Valero | Valentín Pizarro | Match Report | |
| 3 | Sat | 2021-08-28 | 22:00 | Betis | 0.6 | 0–1 | 0.9 | Real Madrid | 22,590 | Estadio Benito Villamarín | Alejandro Hernández | Match Report | |
| 3 | Sun | 2021-08-29 | 17:00 | Barcelona | 1.1 | 2–1 | 0.4 | Getafe | 26,543 | Camp Nou | Pablo González | Match Report | |
| 3 | Sun | 2021-08-29 | 19:30 | Rayo Vallecano | 2.2 | 4–0 | 0.5 | Granada | 583 | Estadio del Rayo Vallecano | Jesús Gil | Match Report | |
| 3 | Sun | 2021-08-29 | 19:30 | Cádiz | 1.6 | 2–3 | 2.4 | Osasuna | 7,452 | Estadio Nuevo Mirandilla | Adrián Cordero | Match Report | |
| 3 | Sun | 2021-08-29 | 22:00 | Atlético Madrid | 1.7 | 2–2 | 0.3 | Villarreal | 26,840 | Estadio Wanda Metropolitano | César Soto | Match Report | |
| 4 | Sat | 2021-09-11 | 18:30 | Levante | 1.0 | 1–1 | 2.2 | Rayo Vallecano | 12,974 | Estadio Ciudad de Valencia | Alberola Rojas | Match Report | |
| 4 | Sat | 2021-09-11 | 21:00 | Athletic Club | 1.4 | 2–0 | 0.2 | Mallorca | 14,566 | San Mamés | Jorge Figueroa | Match Report | |
| 4 | Sun | 2021-09-12 | 14:00 | Espanyol | 0.4 | 1–2 | 0.8 | Atlético Madrid | 15,321 | RCDE Stadium | Juan Martínez | Match Report | |
| 4 | Sun | 2021-09-12 | 16:15 | Osasuna | 0.6 | 1–4 | 0.9 | Valencia | 13,940 | Estadio El Sadar | Ricardo de Burgos | Match Report | |
| 4 | Sun | 2021-09-12 | 18:30 | Cádiz | 0.3 | 0–2 | 1.9 | Real Sociedad | 11,826 | Estadio Nuevo Mirandilla | Alejandro Muñíz | Match Report | |
| 4 | Sun | 2021-09-12 | 21:00 | Real Madrid | 3.2 | 5–2 | 1.8 | Celta Vigo | 19,874 | Estadio Santiago Bernabéu | José Sánchez | Match Report | |
| 4 | Mon | 2021-09-13 | 20:00 | Getafe | 0.3 | 0–1 | 0.8 | Elche | 6,853 | Coliseum Alfonso Pérez | Mario Melero | Match Report | |
| 4 | Mon | 2021-09-13 | 22:00 | Granada | 0.6 | 1–2 | 2.3 | Betis | 10,201 | Estadio Nuevo Los Cármenes | Guillermo Cuadra | Match Report | |
| 5 | Fri | 2021-09-17 | 21:00 | Celta Vigo | 1.0 | 1–2 | 1.1 | Cádiz | 6,754 | Estadio de Balaídos | Isidro Díaz de Mera | Match Report | |
| 5 | Sat | 2021-09-18 | 14:00 | Rayo Vallecano | 2.2 | 3–0 | 1.1 | Getafe | 3,280 | Estadio del Rayo Vallecano | Adrián Cordero | Match Report | |
| 5 | Sat | 2021-09-18 | 16:15 | Atlético Madrid | 0.9 | 0–0 | 1.0 | Athletic Club | 38,798 | Estadio Wanda Metropolitano | Jesús Gil | Match Report | |
| 5 | Sat | 2021-09-18 | 18:30 | Elche | 0.4 | 1–1 | 1.1 | Levante | 11,507 | Estadio Manuel Martínez Valero | Miguel Ángel Ortiz Arias | Match Report | |
| 5 | Sat | 2021-09-18 | 21:00 | Alavés | 0.5 | 0–2 | 1.4 | Osasuna | 8,176 | Estadio de Mendizorroza | Alejandro Hernández | Match Report | |
| 5 | Sun | 2021-09-19 | 14:00 | Mallorca | 0.5 | 0–0 | 1.4 | Villarreal | 9,168 | Iberostar Estadi | Carlos del Cerro | Match Report | |
| 5 | Sun | 2021-09-19 | 16:15 | Real Sociedad | 1.3 | 0–0 | 0.5 | Sevilla | 23,757 | Estadio Municipal de Anoeta | Antonio Matéu Lahoz | Match Report | |
| 5 | Sun | 2021-09-19 | 18:30 | Betis | 1.9 | 2–2 | 1.1 | Espanyol | 30,189 | Estadio Benito Villamarín | César Soto | Match Report | |
| 5 | Sun | 2021-09-19 | 21:00 | Valencia | 0.9 | 1–2 | 1.3 | Real Madrid | 26,689 | Estadio de Mestalla | Pablo González | Match Report | |
| 5 | Mon | 2021-09-20 | 21:00 | Barcelona | 1.8 | 1–1 | 0.8 | Granada | 27,097 | Camp Nou | Santiago Jaime | Match Report | |
| 6 | Tue | 2021-09-21 | 19:30 | Getafe | 0.3 | 1–2 | 1.1 | Atlético Madrid | 8,950 | Coliseum Alfonso Pérez | Guillermo Cuadra | Match Report | |
| 6 | Tue | 2021-09-21 | 22:00 | Levante | 1.7 | 0–2 | 0.7 | Celta Vigo | 11,989 | Estadio Ciudad de Valencia | Jorge Figueroa | Match Report | |
| 6 | Tue | 2021-09-21 | 22:00 | Athletic Club | 0.9 | 1–2 | 1.0 | Rayo Vallecano | 16,236 | San Mamés | José Luis Munuera | Match Report | |
| 6 | Wed | 2021-09-22 | 19:30 | Sevilla | 1.0 | 3–1 | 0.4 | Valencia | 23,654 | Estadio Ramón Sánchez Pizjuán | José Sánchez | Match Report | |
| 6 | Wed | 2021-09-22 | 19:30 | Espanyol | 1.7 | 1–0 | 0.5 | Alavés | 14,254 | RCDE Stadium | Mario Melero | Match Report | |
| 6 | Wed | 2021-09-22 | 22:00 | Real Madrid | 2.6 | 6–1 | 1.4 | Mallorca | 20,113 | Estadio Santiago Bernabéu | Alberola Rojas | Match Report | |
| 6 | Wed | 2021-09-22 | 22:00 | Villarreal | 3.2 | 4–1 | 1.2 | Elche | 8,234 | Estadio de la Cerámica | Alejandro Muñíz | Match Report | |
| 6 | Thu | 2021-09-23 | 19:30 | Osasuna | 1.0 | 1–3 | 2.4 | Betis | 13,758 | Estadio El Sadar | Juan Martínez | Match Report | |
| 6 | Thu | 2021-09-23 | 19:30 | Granada | 1.3 | 2–3 | 1.7 | Real Sociedad | 9,552 | Estadio Nuevo Los Cármenes | Valentín Pizarro | Match Report | |
| 6 | Thu | 2021-09-23 | 22:00 | Cádiz | 1.3 | 0–0 | 0.4 | Barcelona | 12,180 | Estadio Nuevo Mirandilla | Carlos del Cerro | Match Report | |
| 7 | Sat | 2021-09-25 | 14:00 | Alavés | 0.7 | 1–0 | 0.7 | Atlético Madrid | 9,836 | Estadio de Mendizorroza | Antonio Matéu Lahoz | Match Report | |
| 7 | Sat | 2021-09-25 | 16:15 | Valencia | 0.9 | 1–1 | 0.8 | Athletic Club | 13,680 | Estadio de Mestalla | Alejandro Hernández | Match Report | |
| 7 | Sat | 2021-09-25 | 18:30 | Sevilla | 1.8 | 2–0 | 0.7 | Espanyol | 23,956 | Estadio Ramón Sánchez Pizjuán | Pablo González | Match Report | |
| 7 | Sat | 2021-09-25 | 21:00 | Real Madrid | 1.1 | 0–0 | 0.5 | Villarreal | 23,985 | Estadio Santiago Bernabéu | Jesús Gil | Match Report | |
| 7 | Sun | 2021-09-26 | 14:00 | Mallorca | 2.6 | 2–3 | 0.9 | Osasuna | 9,359 | Iberostar Estadi | Miguel Ángel Ortiz Arias | Match Report | |
| 7 | Sun | 2021-09-26 | 16:15 | Barcelona | 2.9 | 3–0 | 0.8 | Levante | 35,334 | Camp Nou | Isidro Díaz de Mera | Match Report | |
| 7 | Sun | 2021-09-26 | 18:30 | Rayo Vallecano | 1.3 | 3–1 | 1.0 | Cádiz | 5,903 | Estadio del Rayo Vallecano | Ricardo de Burgos | Match Report | |
| 7 | Sun | 2021-09-26 | 18:30 | Real Sociedad | 2.4 | 1–0 | 0.5 | Elche | 23,941 | Estadio Municipal de Anoeta | Adrián Cordero | Match Report | |
| 7 | Sun | 2021-09-26 | 21:00 | Betis | 1.9 | 2–0 | 0.6 | Getafe | 29,825 | Estadio Benito Villamarín | Santiago Jaime | Match Report | |
| 7 | Mon | 2021-09-27 | 21:00 | Celta Vigo | 1.3 | 1–0 | 0.8 | Granada | 6,375 | Estadio de Balaídos | César Soto | Match Report | |
| 8 | Fri | 2021-10-01 | 21:00 | Athletic Club | 2.0 | 1–0 | 0.9 | Alavés | 28,665 | San Mamés | Carlos del Cerro | Match Report | |
| 8 | Sat | 2021-10-02 | 14:00 | Osasuna | 0.5 | 1–0 | 0.2 | Rayo Vallecano | 19,238 | Estadio El Sadar | Mario Melero | Match Report | |
| 8 | Sat | 2021-10-02 | 16:15 | Mallorca | 0.6 | 1–0 | 1.2 | Levante | 11,803 | Iberostar Estadi | Alejandro Muñíz | Match Report | |
| 8 | Sat | 2021-10-02 | 18:30 | Cádiz | 0.2 | 0–0 | 1.1 | Valencia | 14,794 | Estadio Nuevo Mirandilla | Valentín Pizarro | Match Report | |
| 8 | Sat | 2021-10-02 | 21:00 | Atlético Madrid | 1.2 | 2–0 | 0.7 | Barcelona | 60,594 | Estadio Wanda Metropolitano | César Soto | Match Report | |
| 8 | Sun | 2021-10-03 | 14:00 | Elche | 1.3 | 1–0 | 0.5 | Celta Vigo | 11,299 | Estadio Manuel Martínez Valero | José Luis Munuera | Match Report | |
| 8 | Sun | 2021-10-03 | 16:15 | Espanyol | 1.2 | 2–1 | 1.6 | Real Madrid | 23,377 | RCDE Stadium | Guillermo Cuadra | Match Report | |
| 8 | Sun | 2021-10-03 | 18:30 | Getafe | 0.7 | 1–1 | 0.7 | Real Sociedad | 8,463 | Coliseum Alfonso Pérez | Jorge Figueroa | Match Report | |
| 8 | Sun | 2021-10-03 | 18:30 | Villarreal | 2.6 | 2–0 | 0.5 | Betis | 16,719 | Estadio de la Cerámica | José Sánchez | Match Report | |
| 8 | Sun | 2021-10-03 | 21:00 | Granada | 0.1 | 1–0 | 1.3 | Sevilla | 12,334 | Estadio Nuevo Los Cármenes | Alberola Rojas | Match Report | |
| 9 | Sat | 2021-10-16 | 18:30 | Levante | 0.9 | 0–0 | 0.6 | Getafe | 14,551 | Estadio Ciudad de Valencia | Mario Melero | Match Report | |
| 9 | Sat | 2021-10-16 | 21:00 | Real Sociedad | 0.4 | 1–0 | 0.2 | Mallorca | 30,831 | Estadio Municipal de Anoeta | Pablo González | Match Report | |
| 9 | Sun | 2021-10-17 | 14:00 | Rayo Vallecano | 1.2 | 2–1 | 0.4 | Elche | 6,989 | Estadio del Rayo Vallecano | Santiago Jaime | Match Report | |
| 9 | Sun | 2021-10-17 | 16:15 | Celta Vigo | 1.2 | 0–1 | 1.0 | Sevilla | 10,774 | Estadio de Balaídos | Ricardo de Burgos | Match Report | |
| 9 | Sun | 2021-10-17 | 18:30 | Villarreal | 0.5 | 1–2 | 0.6 | Osasuna | 14,831 | Estadio de la Cerámica | Adrián Cordero | Match Report | |
| 9 | Sun | 2021-10-17 | 21:00 | Barcelona | 1.9 | 3–1 | 0.4 | Valencia | 47,317 | Camp Nou | Jesús Gil | Match Report | |
| 9 | Mon | 2021-10-18 | 19:00 | Alavés | 0.9 | 0–1 | 1.4 | Betis | 10,227 | Estadio de Mendizorroza | Miguel Ángel Ortiz Arias | Match Report | |
| 9 | Mon | 2021-10-18 | 21:00 | Espanyol | 1.3 | 2–0 | 0.4 | Cádiz | 15,678 | RCDE Stadium | Antonio Matéu Lahoz | Match Report | |
| 10 | Fri | 2021-10-22 | 21:00 | Osasuna | 1.0 | 1–1 | 0.5 | Granada | 21,128 | Estadio El Sadar | Alejandro Muñíz | Match Report | |
| 10 | Sat | 2021-10-23 | 14:00 | Valencia | 1.8 | 2–2 | 0.6 | Mallorca | 29,139 | Estadio de Mestalla | Carlos del Cerro | Match Report | |
| 10 | Sat | 2021-10-23 | 16:15 | Cádiz | 1.5 | 0–2 | 1.3 | Alavés | 13,790 | Estadio Nuevo Mirandilla | Alberola Rojas | Match Report | |
| 10 | Sat | 2021-10-23 | 18:30 | Elche | 0.9 | 2–2 | 0.8 | Espanyol | 13,449 | Estadio Manuel Martínez Valero | Jorge Figueroa | Match Report | |
| 10 | Sat | 2021-10-23 | 21:00 | Athletic Club | 2.8 | 2–1 | 0.5 | Villarreal | 38,698 | San Mamés | Guillermo Cuadra | Match Report | |
| 10 | Sun | 2021-10-24 | 14:00 | Sevilla | 1.6 | 5–3 | 1.9 | Levante | 30,601 | Estadio Ramón Sánchez Pizjuán | Valentín Pizarro | Match Report | |
| 10 | Sun | 2021-10-24 | 16:15 | Barcelona | 1.6 | 1–2 | 1.5 | Real Madrid | 86,422 | Camp Nou | José Sánchez | Match Report | |
| 10 | Sun | 2021-10-24 | 18:30 | Betis | 1.4 | 3–2 | 1.0 | Rayo Vallecano | 45,362 | Estadio Benito Villamarín | Ricardo de Burgos | Match Report | |
| 10 | Sun | 2021-10-24 | 21:00 | Atlético Madrid | 1.7 | 2–2 | 0.8 | Real Sociedad | 50,032 | Estadio Wanda Metropolitano | José Luis Munuera | Match Report | |
| 10 | Mon | 2021-10-25 | 21:00 | Getafe | 0.5 | 0–3 | 1.6 | Celta Vigo | 7,630 | Coliseum Alfonso Pérez | Juan Martínez | Match Report | |
| 11 | Tue | 2021-10-26 | 19:00 | Alavés | 1.7 | 1–0 | 0.3 | Elche | 10,206 | Estadio de Mendizorroza | Jesús Gil | Match Report | |
| 11 | Tue | 2021-10-26 | 21:00 | Espanyol | 1.3 | 1–1 | 3.3 | Athletic Club | 16,196 | RCDE Stadium | Miguel Ángel Ortiz Arias | Match Report | |
| 11 | Tue | 2021-10-26 | 21:30 | Villarreal | 1.7 | 3–3 | 1.4 | Cádiz | 12,190 | Estadio de la Cerámica | Alejandro Hernández | Match Report | |
| 11 | Wed | 2021-10-27 | 19:00 | Rayo Vallecano | 0.8 | 1–0 | 2.5 | Barcelona | 9,340 | Estadio del Rayo Vallecano | Antonio Matéu Lahoz | Match Report | |
| 11 | Wed | 2021-10-27 | 19:00 | Mallorca | 1.5 | 1–1 | 0.8 | Sevilla | 15,125 | Iberostar Estadi | Santiago Jaime | Match Report | |
| 11 | Wed | 2021-10-27 | 20:00 | Betis | 2.0 | 4–1 | 1.6 | Valencia | 43,123 | Estadio Benito Villamarín | Isidro Díaz de Mera | Match Report | |
| 11 | Wed | 2021-10-27 | 21:30 | Real Madrid | 0.7 | 0–0 | 0.5 | Osasuna | 35,691 | Estadio Santiago Bernabéu | César Soto | Match Report | |
| 11 | Thu | 2021-10-28 | 19:00 | Celta Vigo | 1.4 | 0–2 | 1.7 | Real Sociedad | 8,726 | Estadio de Balaídos | Mario Melero | Match Report | |
| 11 | Thu | 2021-10-28 | 20:00 | Granada | 2.0 | 1–1 | 0.4 | Getafe | 13,651 | Estadio Nuevo Los Cármenes | Adrián Cordero | Match Report | |
| 11 | Thu | 2021-10-28 | 21:30 | Levante | 1.8 | 2–2 | 0.9 | Atlético Madrid | 16,298 | Estadio Ciudad de Valencia | Pablo González | Match Report | |
| 12 | Sat | 2021-10-30 | 14:00 | Elche | 1.1 | 1–2 | 1.1 | Real Madrid | 23,010 | Estadio Manuel Martínez Valero | Ricardo de Burgos | Match Report | |
| 12 | Sat | 2021-10-30 | 16:15 | Sevilla | 2.0 | 2–0 | 0.6 | Osasuna | 20,335 | Estadio Ramón Sánchez Pizjuán | Carlos del Cerro | Match Report | |
| 12 | Sat | 2021-10-30 | 18:30 | Valencia | 1.1 | 2–0 | 0.8 | Villarreal | 31,487 | Estadio de Mestalla | José Luis Munuera | Match Report | |
| 12 | Sat | 2021-10-30 | 21:00 | Barcelona | 1.3 | 1–1 | 0.9 | Alavés | 37,278 | Camp Nou | Jorge Figueroa | Match Report | |
| 12 | Sun | 2021-10-31 | 14:00 | Cádiz | 1.7 | 1–1 | 0.9 | Mallorca | 11,790 | Estadio Nuevo Mirandilla | Valentín Pizarro | Match Report | |
| 12 | Sun | 2021-10-31 | 16:15 | Atlético Madrid | 2.3 | 3–0 | 0.5 | Betis | 56,838 | Estadio Wanda Metropolitano | Alberola Rojas | Match Report | |
| 12 | Sun | 2021-10-31 | 18:30 | Getafe | 0.8 | 2–1 | 0.6 | Espanyol | 4,721 | Coliseum Alfonso Pérez | Alejandro Muñíz | Match Report | |
| 12 | Sun | 2021-10-31 | 21:00 | Real Sociedad | 1.1 | 1–1 | 1.0 | Athletic Club | 37,066 | Estadio Municipal de Anoeta | Juan Martínez | Match Report | |
| 12 | Mon | 2021-11-01 | 18:30 | Rayo Vallecano | 0.6 | 0–0 | 0.6 | Celta Vigo | 9,580 | Estadio del Rayo Vallecano | Adrián Cordero | Match Report | |
| 12 | Mon | 2021-11-01 | 21:00 | Levante | 1.1 | 0–3 | 1.0 | Granada | 14,512 | Estadio Ciudad de Valencia | José Sánchez | Match Report | |
| 13 | Fri | 2021-11-05 | 21:00 | Athletic Club | 0.5 | 0–1 | 0.5 | Cádiz | 37,581 | San Mamés | Santiago Jaime | Match Report | |
| 13 | Sat | 2021-11-06 | 14:00 | Espanyol | 1.6 | 2–0 | 2.0 | Granada | 19,050 | RCDE Stadium | Isidro Díaz de Mera | Match Report | |
| 13 | Sat | 2021-11-06 | 16:15 | Celta Vigo | 1.5 | 3–3 | 0.9 | Barcelona | 13,146 | Estadio de Balaídos | Alejandro Hernández | Match Report | |
| 13 | Sat | 2021-11-06 | 18:30 | Alavés | 1.5 | 2–1 | 0.8 | Levante | 12,176 | Estadio de Mendizorroza | Adrián Cordero | Match Report | |
| 13 | Sat | 2021-11-06 | 21:00 | Real Madrid | 2.1 | 2–1 | 1.4 | Rayo Vallecano | 43,283 | Estadio Santiago Bernabéu | Pablo González | Match Report | |
| 13 | Sun | 2021-11-07 | 14:00 | Villarreal | 1.4 | 1–0 | 0.2 | Getafe | 13,504 | Estadio de la Cerámica | Jesús Gil | Match Report | |
| 13 | Sun | 2021-11-07 | 16:15 | Valencia | 1.1 | 3–3 | 2.3 | Atlético Madrid | 37,472 | Estadio de Mestalla | César Soto | Match Report | |
| 13 | Sun | 2021-11-07 | 18:30 | Osasuna | 0.4 | 0–2 | 1.5 | Real Sociedad | 21,741 | Estadio El Sadar | Miguel Ángel Ortiz Arias | Match Report | |
| 13 | Sun | 2021-11-07 | 18:30 | Mallorca | 2.3 | 2–2 | 0.8 | Elche | 12,933 | Iberostar Estadi | Mario Melero | Match Report | |
| 13 | Sun | 2021-11-07 | 21:00 | Betis | 0.3 | 0–2 | 1.7 | Sevilla | 50,534 | Estadio Benito Villamarín | Antonio Matéu Lahoz | Match Report | |
| 14 | Fri | 2021-11-19 | 21:00 | Levante | 0.5 | 0–0 | 0.5 | Athletic Club | 15,230 | Estadio Ciudad de Valencia | José Luis Munuera | Match Report | |
| 14 | Sat | 2021-11-20 | 14:00 | Celta Vigo | 1.0 | 1–1 | 2.8 | Villarreal | 10,086 | Estadio de Balaídos | Alberola Rojas | Match Report | |
| 14 | Sat | 2021-11-20 | 16:15 | Sevilla | 1.8 | 2–2 | 1.1 | Alavés | 25,208 | Estadio Ramón Sánchez Pizjuán | Alejandro Muñíz | Match Report | |
| 14 | Sat | 2021-11-20 | 18:30 | Atlético Madrid | 1.0 | 1–0 | 0.5 | Osasuna | 53,261 | Estadio Wanda Metropolitano | José Sánchez | Match Report | |
| 14 | Sat | 2021-11-20 | 21:00 | Barcelona | 1.4 | 1–0 | 1.0 | Espanyol | 74,418 | Camp Nou | Carlos del Cerro | Match Report | |
| 14 | Sun | 2021-11-21 | 14:00 | Getafe | 1.2 | 4–0 | 0.4 | Cádiz | 8,825 | Coliseum Alfonso Pérez | Ricardo de Burgos | Match Report | |
| 14 | Sun | 2021-11-21 | 16:15 | Granada | 0.7 | 1–4 | 3.5 | Real Madrid | 17,460 | Estadio Nuevo Los Cármenes | Juan Martínez | Match Report | |
| 14 | Sun | 2021-11-21 | 18:30 | Elche | 0.8 | 0–3 | 1.9 | Betis | 16,127 | Estadio Manuel Martínez Valero | Valentín Pizarro | Match Report | |
| 14 | Sun | 2021-11-21 | 21:00 | Real Sociedad | 0.3 | 0–0 | 0.7 | Valencia | 28,635 | Estadio Municipal de Anoeta | Mario Melero | Match Report | |
| 14 | Mon | 2021-11-22 | 21:00 | Rayo Vallecano | 2.4 | 3–1 | 0.7 | Mallorca | 6,708 | Estadio del Rayo Vallecano | Jorge Figueroa | Match Report | |
| 15 | Fri | 2021-11-26 | 21:00 | Athletic Club | 1.1 | 2–2 | 1.1 | Granada | 32,651 | San Mamés | Adrián Cordero | Match Report | |
| 15 | Sat | 2021-11-27 | 14:00 | Alavés | 0.9 | 1–2 | 1.2 | Celta Vigo | 10,093 | Estadio de Mendizorroza | Pablo González | Match Report | |
| 15 | Sat | 2021-11-27 | 16:15 | Valencia | 1.6 | 1–1 | 1.2 | Rayo Vallecano | 30,030 | Estadio de Mestalla | Alejandro Hernández | Match Report | |
| 15 | Sat | 2021-11-27 | 18:30 | Mallorca | 0.4 | 0–0 | 0.8 | Getafe | 8,635 | Iberostar Estadi | Santiago Jaime | Match Report | |
| 15 | Sat | 2021-11-27 | 21:00 | Villarreal | 1.1 | 1–3 | 3.2 | Barcelona | 19,050 | Estadio de la Cerámica | César Soto | Match Report | |
| 15 | Sun | 2021-11-28 | 14:00 | Betis | 2.6 | 3–1 | 0.3 | Levante | 45,012 | Estadio Benito Villamarín | Miguel Ángel Ortiz Arias | Match Report | |
| 15 | Sun | 2021-11-28 | 16:15 | Espanyol | 0.4 | 1–0 | 1.7 | Real Sociedad | 19,935 | RCDE Stadium | Antonio Matéu Lahoz | Match Report | |
| 15 | Sun | 2021-11-28 | 18:30 | Cádiz | 1.0 | 1–4 | 3.8 | Atlético Madrid | 16,861 | Estadio Nuevo Mirandilla | Jesús Gil | Match Report | |
| 15 | Sun | 2021-11-28 | 21:00 | Real Madrid | 1.2 | 2–1 | 0.7 | Sevilla | 45,281 | Estadio Santiago Bernabéu | José Sánchez | Match Report | |
| 15 | Mon | 2021-11-29 | 21:00 | Osasuna | 1.8 | 1–1 | 1.4 | Elche | 16,485 | Estadio El Sadar | Isidro Díaz de Mera | Match Report | |
| 9 | Wed | 2021-12-01 | 21:00 | Real Madrid | 1.8 | 1–0 | 2.4 | Athletic Club | 33,627 | Estadio Santiago Bernabéu | Isidro Díaz de Mera | Match Report | |
| 16 | Fri | 2021-12-03 | 21:00 | Granada | 1.0 | 2–1 | 2.1 | Alavés | 13,511 | Estadio Nuevo Los Cármenes | Alberola Rojas | Match Report | |
| 16 | Sat | 2021-12-04 | 14:00 | Sevilla | 0.4 | 1–0 | 1.7 | Villarreal | 30,865 | Estadio Ramón Sánchez Pizjuán | Carlos del Cerro | Match Report | |
| 16 | Sat | 2021-12-04 | 16:15 | Barcelona | 1.0 | 0–1 | 0.6 | Betis | 66,529 | Camp Nou | Pablo González | Match Report | |
| 16 | Sat | 2021-12-04 | 18:30 | Atlético Madrid | 1.5 | 1–2 | 0.6 | Mallorca | 51,009 | Estadio Wanda Metropolitano | Juan Martínez | Match Report | |
| 16 | Sat | 2021-12-04 | 21:00 | Real Sociedad | 0.7 | 0–2 | 1.6 | Real Madrid | 35,765 | Estadio Municipal de Anoeta | Jesús Gil | Match Report | |
| 16 | Sun | 2021-12-05 | 14:00 | Rayo Vallecano | 0.4 | 1–0 | 0.6 | Espanyol | 8,679 | Estadio del Rayo Vallecano | José Luis Munuera | Match Report | |
| 16 | Sun | 2021-12-05 | 16:15 | Elche | 2.4 | 3–1 | 1.7 | Cádiz | 11,879 | Estadio Manuel Martínez Valero | Alejandro Muñíz | Match Report | |
| 16 | Sun | 2021-12-05 | 18:30 | Levante | 0.5 | 0–0 | 0.3 | Osasuna | 15,361 | Estadio Ciudad de Valencia | Valentín Pizarro | Match Report | |
| 16 | Sun | 2021-12-05 | 21:00 | Celta Vigo | 0.9 | 1–2 | 1.3 | Valencia | 11,361 | Estadio de Balaídos | Ricardo de Burgos | Match Report | |
| 16 | Mon | 2021-12-06 | 21:00 | Getafe | 1.2 | 0–0 | 0.5 | Athletic Club | 9,176 | Coliseum Alfonso Pérez | Jorge Figueroa | Match Report | |
| 17 | Fri | 2021-12-10 | 21:00 | Mallorca | 0.8 | 0–0 | 1.0 | Celta Vigo | 10,655 | Iberostar Estadi | Isidro Díaz de Mera | Match Report | |
| 17 | Sat | 2021-12-11 | 14:00 | Espanyol | 2.3 | 4–3 | 2.9 | Levante | 15,193 | RCDE Stadium | Adrián Cordero | Match Report | |
| 17 | Sat | 2021-12-11 | 16:15 | Alavés | 0.7 | 1–1 | 1.0 | Getafe | 10,065 | Estadio de Mendizorroza | César Soto | Match Report | |
| 17 | Sat | 2021-12-11 | 18:30 | Valencia | 1.6 | 2–1 | 0.9 | Elche | 31,662 | Estadio de Mestalla | Santiago Jaime | Match Report | |
| 17 | Sat | 2021-12-11 | 21:00 | Athletic Club | 1.4 | 0–1 | 0.2 | Sevilla | 36,737 | San Mamés | Alejandro Hernández | Match Report | |
| 17 | Sun | 2021-12-12 | 14:00 | Villarreal | 2.4 | 2–0 | 1.5 | Rayo Vallecano | 13,133 | Estadio de la Cerámica | Mario Melero | Match Report | |
| 17 | Sun | 2021-12-12 | 16:15 | Osasuna | 0.3 | 2–2 | 0.9 | Barcelona | 21,427 | Estadio El Sadar | Juan Martínez | Match Report | |
| 17 | Sun | 2021-12-12 | 18:30 | Betis | 1.6 | 4–0 | 0.9 | Real Sociedad | 52,158 | Estadio Benito Villamarín | José Sánchez | Match Report | |
| 17 | Sun | 2021-12-12 | 21:00 | Real Madrid | 0.4 | 2–0 | 0.7 | Atlético Madrid | 51,024 | Estadio Santiago Bernabéu | Antonio Matéu Lahoz | Match Report | |
| 17 | Mon | 2021-12-13 | 21:00 | Cádiz | 0.7 | 1–1 | 1.0 | Granada | 13,052 | Estadio Nuevo Mirandilla | Miguel Ángel Ortiz Arias | Match Report | |
| 18 | Fri | 2021-12-17 | 21:00 | Celta Vigo | 1.2 | 3–1 | 0.4 | Espanyol | 9,526 | Estadio de Balaídos | Valentín Pizarro | Match Report | |
| 18 | Sat | 2021-12-18 | 14:00 | Rayo Vallecano | 1.8 | 2–0 | 0.2 | Alavés | 7,911 | Estadio del Rayo Vallecano | Antonio Matéu Lahoz | Match Report | |
| 18 | Sat | 2021-12-18 | 16:15 | Real Sociedad | 0.9 | 1–3 | 2.9 | Villarreal | 29,679 | Estadio Municipal de Anoeta | Jorge Figueroa | Match Report | |
| 18 | Sat | 2021-12-18 | 18:30 | Barcelona | 2.7 | 3–2 | 1.3 | Elche | 41,664 | Camp Nou | Alberola Rojas | Match Report | |
| 18 | Sat | 2021-12-18 | 21:00 | Sevilla | 0.5 | 2–1 | 1.0 | Atlético Madrid | 33,241 | Estadio Ramón Sánchez Pizjuán | Ricardo de Burgos | Match Report | |
| 18 | Sun | 2021-12-19 | 14:00 | Granada | 1.9 | 4–1 | 0.9 | Mallorca | 13,014 | Estadio Nuevo Los Cármenes | Alejandro Muñíz | Match Report | |
| 18 | Sun | 2021-12-19 | 16:15 | Athletic Club | 1.3 | 3–2 | 2.1 | Betis | 38,002 | San Mamés | Jesús Gil | Match Report | |
| 18 | Sun | 2021-12-19 | 18:30 | Getafe | 1.1 | 1–0 | 0.6 | Osasuna | 8,126 | Coliseum Alfonso Pérez | José Luis Munuera | Match Report | |
| 18 | Sun | 2021-12-19 | 21:00 | Real Madrid | 2.0 | 0–0 | 0.2 | Cádiz | 38,818 | Estadio Santiago Bernabéu | Santiago Jaime | Match Report | |
| 18 | Mon | 2021-12-20 | 21:00 | Levante | 2.7 | 3–4 | 2.1 | Valencia | 18,851 | Estadio Ciudad de Valencia | Pablo González | Match Report | |
| 4 | Tue | 2021-12-21 | 19:00 | Villarreal | 3.3 | 5–2 | 0.8 | Alavés | 12,530 | Estadio de la Cerámica | Valentín Pizarro | Match Report | |
| 4 | Tue | 2021-12-21 | 21:30 | Sevilla | 0.3 | 1–1 | 1.8 | Barcelona | 31,358 | Estadio Ramón Sánchez Pizjuán | Carlos del Cerro | Match Report | |
| 9 | Wed | 2021-12-22 | 19:00 | Granada | 0.6 | 2–1 | 1.5 | Atlético Madrid | 13,304 | Estadio Nuevo Los Cármenes | Alejandro Hernández | Match Report | |
| 21 | Wed | 2021-12-22 | 21:30 | Athletic Club | 1.0 | 1–2 | 1.1 | Real Madrid | 42,722 | San Mamés | César Soto | Match Report | |
| 19 | Fri | 2021-12-31 | 16:15 | Valencia | 0.7 | 1–2 | 2.0 | Espanyol | 29,566 | Estadio de Mestalla | José Sánchez | Match Report | |
| 19 | Sun | 2022-01-02 | 14:00 | Getafe | 0.9 | 1–0 | 0.7 | Real Madrid | 11,890 | Coliseum Alfonso Pérez | Mario Melero | Match Report | |
| 19 | Sun | 2022-01-02 | 16:15 | Atlético Madrid | 1.7 | 2–0 | 0.1 | Rayo Vallecano | 43,029 | Estadio Wanda Metropolitano | Jorge Figueroa | Match Report | |
| 19 | Sun | 2022-01-02 | 16:15 | Elche | 1.2 | 0–0 | 1.1 | Granada | 12,160 | Estadio Manuel Martínez Valero | Adrián Cordero | Match Report | |
| 19 | Sun | 2022-01-02 | 18:30 | Alavés | 1.7 | 1–1 | 0.9 | Real Sociedad | 13,498 | Estadio de Mendizorroza | Carlos del Cerro | Match Report | |
| 19 | Sun | 2022-01-02 | 18:30 | Betis | 1.4 | 0–2 | 2.6 | Celta Vigo | 41,656 | Estadio Benito Villamarín | César Soto | Match Report | |
| 19 | Sun | 2022-01-02 | 21:00 | Mallorca | 0.8 | 0–1 | 1.3 | Barcelona | 14,654 | Iberostar Estadi | Antonio Matéu Lahoz | Match Report | |
| 19 | Mon | 2022-01-03 | 19:00 | Villarreal | 3.4 | 5–0 | 0.4 | Levante | 13,462 | Estadio de la Cerámica | Alejandro Hernández | Match Report | |
| 19 | Mon | 2022-01-03 | 21:00 | Osasuna | 0.9 | 1–3 | 1.4 | Athletic Club | 16,206 | Estadio El Sadar | Miguel Ángel Ortiz Arias | Match Report | |
| 19 | Mon | 2022-01-03 | 21:15 | Cádiz | 0.2 | 0–1 | 0.9 | Sevilla | 14,342 | Estadio Nuevo Mirandilla | Alberola Rojas | Match Report | |
| 20 | Sat | 2022-01-08 | 14:00 | Levante | 1.2 | 2–0 | 1.2 | Mallorca | 13,330 | Estadio Ciudad de Valencia | Jorge Figueroa | Match Report | |
| 20 | Sat | 2022-01-08 | 16:15 | Real Sociedad | 1.7 | 1–0 | 0.4 | Celta Vigo | 27,938 | Estadio Municipal de Anoeta | Guillermo Cuadra | Match Report | |
| 20 | Sat | 2022-01-08 | 18:30 | Granada | 0.9 | 1–1 | 0.6 | Barcelona | 14,442 | Estadio Nuevo Los Cármenes | Pablo González | Match Report | |
| 20 | Sat | 2022-01-08 | 21:00 | Real Madrid | 3.9 | 4–1 | 1.3 | Valencia | 40,617 | Estadio Santiago Bernabéu | Alejandro Hernández | Match Report | |
| 20 | Sun | 2022-01-09 | 14:00 | Rayo Vallecano | 1.2 | 1–1 | 1.3 | Betis | 8,395 | Estadio del Rayo Vallecano | Alejandro Muñíz | Match Report | |
| 20 | Sun | 2022-01-09 | 16:15 | Sevilla | 0.7 | 1–0 | 0.1 | Getafe | 30,801 | Estadio Ramón Sánchez Pizjuán | Juan Martínez | Match Report | |
| 20 | Sun | 2022-01-09 | 18:30 | Osasuna | 2.2 | 2–0 | 0.2 | Cádiz | 16,292 | Estadio El Sadar | Ricardo de Burgos | Match Report | |
| 20 | Sun | 2022-01-09 | 18:30 | Alavés | 0.5 | 0–0 | 0.8 | Athletic Club | 14,103 | Estadio de Mendizorroza | Santiago Jaime | Match Report | |
| 20 | Sun | 2022-01-09 | 21:00 | Villarreal | 2.1 | 2–2 | 0.7 | Atlético Madrid | 14,127 | Estadio de la Cerámica | Alberola Rojas | Match Report | |
| 20 | Mon | 2022-01-10 | 21:00 | Espanyol | 1.3 | 1–2 | 1.0 | Elche | 11,870 | RCDE Stadium | Jesús Gil | Match Report | |
| 21 | Sun | 2022-01-16 | 14:00 | Elche | 0.2 | 1–0 | 0.6 | Villarreal | 12,433 | Estadio Manuel Martínez Valero | Valentín Pizarro | Match Report | |
| 21 | Tue | 2022-01-18 | 20:00 | Betis | 2.4 | 4–0 | 0.3 | Alavés | 38,753 | Estadio Benito Villamarín | José Sánchez | Match Report | |
| 21 | Tue | 2022-01-18 | 21:30 | Cádiz | 0.9 | 2–2 | 1.7 | Espanyol | 10,755 | Estadio Nuevo Mirandilla | Alejandro Muñíz | Match Report | |
| 21 | Wed | 2022-01-19 | 19:00 | Celta Vigo | 1.2 | 2–0 | 0.5 | Osasuna | 8,837 | Estadio de Balaídos | Adrián Cordero | Match Report | |
| 21 | Wed | 2022-01-19 | 21:30 | Valencia | 0.5 | 1–1 | 0.9 | Sevilla | 26,049 | Estadio de Mestalla | César Soto | Match Report | |
| 21 | Thu | 2022-01-20 | 19:00 | Getafe | 0.9 | 4–2 | 0.7 | Granada | 7,634 | Coliseum Alfonso Pérez | Isidro Díaz de Mera | Match Report | |
| 22 | Fri | 2022-01-21 | 21:00 | Espanyol | 1.4 | 1–4 | 2.4 | Betis | 17,637 | RCDE Stadium | Alberola Rojas | Match Report | |
| 22 | Sat | 2022-01-22 | 14:00 | Levante | 1.0 | 0–2 | 0.7 | Cádiz | 14,063 | Estadio Ciudad de Valencia | César Soto | Match Report | |
| 22 | Sat | 2022-01-22 | 16:15 | Villarreal | 1.9 | 3–0 | 1.2 | Mallorca | 13,207 | Estadio de la Cerámica | Miguel Ángel Ortiz Arias | Match Report | |
| 22 | Sat | 2022-01-22 | 18:30 | Sevilla | 1.1 | 2–2 | 0.7 | Celta Vigo | 30,059 | Estadio Ramón Sánchez Pizjuán | José Sánchez | Match Report | |
| 22 | Sat | 2022-01-22 | 21:00 | Atlético Madrid | 2.5 | 3–2 | 0.7 | Valencia | 44,999 | Estadio Wanda Metropolitano | Isidro Díaz de Mera | Match Report | |
| 22 | Sun | 2022-01-23 | 14:00 | Granada | 0.7 | 0–2 | 2.1 | Osasuna | 12,471 | Estadio Nuevo Los Cármenes | Santiago Jaime | Match Report | |
| 22 | Sun | 2022-01-23 | 16:15 | Real Madrid | 3.4 | 2–2 | 0.6 | Elche | 39,796 | Estadio Santiago Bernabéu | Ricardo de Burgos | Match Report | |
| 22 | Sun | 2022-01-23 | 18:30 | Real Sociedad | 0.8 | 0–0 | 0.3 | Getafe | 27,368 | Estadio Municipal de Anoeta | José Luis Munuera | Match Report | |
| 22 | Sun | 2022-01-23 | 18:30 | Rayo Vallecano | 2.0 | 0–1 | 0.4 | Athletic Club | 9,034 | Estadio del Rayo Vallecano | Adrián Cordero | Match Report | |
| 22 | Sun | 2022-01-23 | 21:00 | Alavés | 0.6 | 0–1 | 1.5 | Barcelona | 14,056 | Estadio de Mendizorroza | Jorge Figueroa | Match Report | |
| 23 | Fri | 2022-02-04 | 21:00 | Getafe | 0.8 | 3–0 | 0.5 | Levante | 8,475 | Coliseum Alfonso Pérez | Alejandro Muñíz | Match Report | |
| 23 | Sat | 2022-02-05 | 14:00 | Elche | 0.9 | 3–1 | 0.9 | Alavés | 12,923 | Estadio Manuel Martínez Valero | Mario Melero | Match Report | |
| 23 | Sat | 2022-02-05 | 16:15 | Mallorca | 2.3 | 2–1 | 0.8 | Cádiz | 12,226 | Iberostar Estadi | Carlos del Cerro | Match Report | |
| 23 | Sat | 2022-02-05 | 18:30 | Celta Vigo | 0.7 | 2–0 | 0.8 | Rayo Vallecano | 12,546 | Estadio de Balaídos | José Luis Munuera | Match Report | |
| 23 | Sat | 2022-02-05 | 21:00 | Osasuna | 0.4 | 0–0 | 1.3 | Sevilla | 17,635 | Estadio El Sadar | Valentín Pizarro | Match Report | |
| 23 | Sun | 2022-02-06 | 14:00 | Valencia | 1.1 | 0–0 | 0.4 | Real Sociedad | 31,351 | Estadio de Mestalla | José Sánchez | Match Report | |
| 23 | Sun | 2022-02-06 | 16:15 | Barcelona | 1.0 | 4–2 | 1.3 | Atlético Madrid | 74,221 | Camp Nou | Jesús Gil | Match Report | |
| 23 | Sun | 2022-02-06 | 18:30 | Betis | 0.6 | 0–2 | 0.9 | Villarreal | 44,870 | Estadio Benito Villamarín | Pablo González | Match Report | |
| 23 | Sun | 2022-02-06 | 21:00 | Real Madrid | 2.1 | 1–0 | 0.6 | Granada | 36,665 | Estadio Santiago Bernabéu | Antonio Matéu Lahoz | Match Report | |
| 23 | Mon | 2022-02-07 | 21:00 | Athletic Club | 0.8 | 2–1 | 0.6 | Espanyol | 30,753 | San Mamés | César Soto | Match Report | |
| 24 | Fri | 2022-02-11 | 21:00 | Sevilla | 0.8 | 2–0 | 0.3 | Elche | 33,411 | Estadio Ramón Sánchez Pizjuán | Miguel Ángel Ortiz Arias | Match Report | |
| 24 | Sat | 2022-02-12 | 14:00 | Cádiz | 0.7 | 0–0 | 1.0 | Celta Vigo | 15,635 | Estadio Nuevo Mirandilla | Antonio Matéu Lahoz | Match Report | |
| 24 | Sat | 2022-02-12 | 16:15 | Villarreal | 0.4 | 0–0 | 1.7 | Real Madrid | 17,894 | Estadio de la Cerámica | José Sánchez | Match Report | |
| 24 | Sat | 2022-02-12 | 18:30 | Rayo Vallecano | 0.9 | 0–3 | 1.6 | Osasuna | 8,596 | Estadio del Rayo Vallecano | Jorge Figueroa | Match Report | |
| 24 | Sat | 2022-02-12 | 21:00 | Atlético Madrid | 2.5 | 4–3 | 2.1 | Getafe | 49,375 | Estadio Wanda Metropolitano | Ricardo de Burgos | Match Report | |
| 24 | Sun | 2022-02-13 | 14:00 | Alavés | 1.8 | 2–1 | 1.2 | Valencia | 12,845 | Estadio de Mendizorroza | Adrián Cordero | Match Report | |
| 24 | Sun | 2022-02-13 | 16:15 | Levante | 1.7 | 2–4 | 2.2 | Betis | 16,103 | Estadio Ciudad de Valencia | Santiago Jaime | Match Report | |
| 24 | Sun | 2022-02-13 | 18:30 | Real Sociedad | 2.9 | 2–0 | 1.2 | Granada | 29,847 | Estadio Municipal de Anoeta | Alberola Rojas | Match Report | |
| 24 | Sun | 2022-02-13 | 21:00 | Espanyol | 1.1 | 2–2 | 1.5 | Barcelona | 25,049 | RCDE Stadium | Alejandro Hernández | Match Report | |
| 24 | Mon | 2022-02-14 | 21:00 | Mallorca | 1.9 | 3–2 | 1.6 | Athletic Club | 12,904 | Iberostar Estadi | Isidro Díaz de Mera | Match Report | |
| 21 | Wed | 2022-02-16 | 19:00 | Atlético Madrid | 1.3 | 0–1 | 0.6 | Levante | 43,456 | Estadio Wanda Metropolitano | José Luis Munuera | Match Report | |
| 25 | Fri | 2022-02-18 | 21:00 | Elche | 2.5 | 2–1 | 0.7 | Rayo Vallecano | 14,742 | Estadio Manuel Martínez Valero | Alejandro Muñíz | Match Report | |
| 25 | Sat | 2022-02-19 | 14:00 | Granada | 2.3 | 1–4 | 4.9 | Villarreal | 13,389 | Estadio Nuevo Los Cármenes | Jesús Gil | Match Report | |
| 25 | Sat | 2022-02-19 | 16:15 | Osasuna | 0.6 | 0–3 | 1.1 | Atlético Madrid | 20,040 | Estadio El Sadar | Mario Melero | Match Report | |
| 25 | Sat | 2022-02-19 | 18:30 | Cádiz | 0.5 | 1–1 | 0.9 | Getafe | 15,948 | Estadio Nuevo Mirandilla | Alberola Rojas | Match Report | |
| 25 | Sat | 2022-02-19 | 21:00 | Real Madrid | 2.9 | 3–0 | 0.6 | Alavés | 42,180 | Estadio Santiago Bernabéu | José Luis Munuera | Match Report | |
| 25 | Sun | 2022-02-20 | 14:00 | Espanyol | 1.5 | 1–1 | 0.5 | Sevilla | 24,897 | RCDE Stadium | Pablo González | Match Report | |
| 25 | Sun | 2022-02-20 | 16:15 | Valencia | 0.8 | 1–4 | 2.0 | Barcelona | 38,315 | Estadio de Mestalla | Carlos del Cerro | Match Report | |
| 25 | Sun | 2022-02-20 | 18:30 | Betis | 1.5 | 2–1 | 0.4 | Mallorca | 48,652 | Estadio Benito Villamarín | César Soto | Match Report | |
| 25 | Sun | 2022-02-20 | 21:00 | Athletic Club | 2.8 | 4–0 | 0.4 | Real Sociedad | 40,698 | San Mamés | Juan Martínez | Match Report | |
| 25 | Mon | 2022-02-21 | 21:00 | Celta Vigo | 1.2 | 1–1 | 1.7 | Levante | 9,776 | Estadio de Balaídos | Valentín Pizarro | Match Report | |
| 26 | Fri | 2022-02-25 | 21:00 | Levante | 2.1 | 3–0 | 0.6 | Elche | 14,237 | Estadio Ciudad de Valencia | Pablo González | Match Report | |
| 26 | Sat | 2022-02-26 | 14:00 | Mallorca | 1.8 | 0–1 | 0.6 | Valencia | 14,417 | Iberostar Estadi | Jorge Figueroa | Match Report | |
| 26 | Sat | 2022-02-26 | 16:15 | Getafe | 1.1 | 2–2 | 1.0 | Alavés | 7,720 | Coliseum Alfonso Pérez | Santiago Jaime | Match Report | |
| 26 | Sat | 2022-02-26 | 18:30 | Rayo Vallecano | 0.9 | 0–1 | 2.1 | Real Madrid | 9,952 | Estadio del Rayo Vallecano | Isidro Díaz de Mera | Match Report | |
| 26 | Sat | 2022-02-26 | 21:00 | Atlético Madrid | 0.6 | 2–0 | 0.8 | Celta Vigo | 48,009 | Estadio Wanda Metropolitano | Alejandro Hernández | Match Report | |
| 26 | Sun | 2022-02-27 | 14:00 | Villarreal | 4.4 | 5–1 | 1.1 | Espanyol | 15,600 | Estadio de la Cerámica | Ricardo de Burgos | Match Report | |
| 26 | Sun | 2022-02-27 | 16:15 | Sevilla | 1.4 | 2–1 | 0.7 | Betis | 37,250 | Estadio Ramón Sánchez Pizjuán | Carlos del Cerro | Match Report | |
| 26 | Sun | 2022-02-27 | 18:30 | Real Sociedad | 1.0 | 1–0 | 0.4 | Osasuna | 30,145 | Estadio Municipal de Anoeta | Antonio Matéu Lahoz | Match Report | |
| 26 | Sun | 2022-02-27 | 21:00 | Barcelona | 3.1 | 4–0 | 0.3 | Athletic Club | 69,770 | Camp Nou | Guillermo Cuadra | Match Report | |
| 26 | Mon | 2022-02-28 | 21:00 | Granada | 0.2 | 0–0 | 0.7 | Cádiz | 14,785 | Estadio Nuevo Los Cármenes | José Sánchez | Match Report | |
| 21 | Wed | 2022-03-02 | 21:00 | Mallorca | 0.5 | 0–2 | 1.6 | Real Sociedad | 11,550 | Iberostar Estadi | Mario Melero | Match Report | |
| 27 | Fri | 2022-03-04 | 21:00 | Alavés | 1.4 | 0–0 | 1.2 | Sevilla | 13,121 | Estadio de Mendizorroza | Alberola Rojas | Match Report | |
| 27 | Sat | 2022-03-05 | 14:00 | Osasuna | 0.8 | 1–0 | 0.5 | Villarreal | 16,659 | Estadio El Sadar | José Luis Munuera | Match Report | |
| 27 | Sat | 2022-03-05 | 16:15 | Espanyol | 0.1 | 2–0 | 0.4 | Getafe | 18,519 | RCDE Stadium | Adrián Cordero | Match Report | |
| 27 | Sat | 2022-03-05 | 18:30 | Valencia | 1.6 | 3–1 | 0.4 | Granada | 31,227 | Estadio de Mestalla | Valentín Pizarro | Match Report | |
| 27 | Sat | 2022-03-05 | 21:00 | Real Madrid | 2.0 | 4–1 | 0.8 | Real Sociedad | 52,410 | Estadio Santiago Bernabéu | Jesús Gil | Match Report | |
| 27 | Sun | 2022-03-06 | 14:00 | Cádiz | 1.1 | 2–0 | 1.1 | Rayo Vallecano | 15,677 | Estadio Nuevo Mirandilla | César Soto | Match Report | |
| 27 | Sun | 2022-03-06 | 16:15 | Elche | 1.1 | 1–2 | 4.1 | Barcelona | 30,146 | Estadio Manuel Martínez Valero | Alejandro Hernández | Match Report | |
| 27 | Sun | 2022-03-06 | 18:30 | Celta Vigo | 2.7 | 4–3 | 1.5 | Mallorca | 11,320 | Estadio de Balaídos | Miguel Ángel Ortiz Arias | Match Report | |
| 27 | Sun | 2022-03-06 | 21:00 | Betis | 1.0 | 1–3 | 2.8 | Atlético Madrid | 44,383 | Estadio Benito Villamarín | Guillermo Cuadra | Match Report | |
| 27 | Mon | 2022-03-07 | 21:00 | Athletic Club | 3.1 | 3–1 | 0.5 | Levante | 29,485 | San Mamés | Alejandro Muñíz | Match Report | |
| 28 | Fri | 2022-03-11 | 21:00 | Atlético Madrid | 0.3 | 2–1 | 0.8 | Cádiz | 50,573 | Estadio Wanda Metropolitano | Pablo González | Match Report | |
| 28 | Sat | 2022-03-12 | 14:00 | Levante | 1.1 | 1–1 | 0.4 | Espanyol | 13,407 | Estadio Ciudad de Valencia | Isidro Díaz de Mera | Match Report | |
| 28 | Sat | 2022-03-12 | 16:15 | Granada | 1.4 | 0–1 | 1.2 | Elche | 15,345 | Estadio Nuevo Los Cármenes | Carlos del Cerro | Match Report | |
| 28 | Sat | 2022-03-12 | 18:30 | Villarreal | 1.3 | 1–0 | 0.8 | Celta Vigo | 14,929 | Estadio de la Cerámica | Santiago Jaime | Match Report | |
| 28 | Sat | 2022-03-12 | 21:00 | Getafe | 0.9 | 0–0 | 0.2 | Valencia | 10,349 | Coliseum Alfonso Pérez | Guillermo Cuadra | Match Report | |
| 28 | Sun | 2022-03-13 | 14:00 | Rayo Vallecano | 0.4 | 1–1 | 0.3 | Sevilla | 9,073 | Estadio del Rayo Vallecano | Juan Martínez | Match Report | |
| 28 | Sun | 2022-03-13 | 16:15 | Betis | 0.7 | 1–0 | 0.5 | Athletic Club | 48,876 | Estadio Benito Villamarín | Antonio Matéu Lahoz | Match Report | |
| 28 | Sun | 2022-03-13 | 18:30 | Real Sociedad | 2.2 | 1–0 | 0.8 | Alavés | 31,573 | Estadio Municipal de Anoeta | Jorge Figueroa | Match Report | |
| 28 | Sun | 2022-03-13 | 21:00 | Barcelona | 3.6 | 4–0 | 0.2 | Osasuna | 54,507 | Camp Nou | Ricardo de Burgos | Match Report | |
| 28 | Mon | 2022-03-14 | 21:00 | Mallorca | 1.4 | 0–3 | 1.8 | Real Madrid | 17,191 | Iberostar Estadi | José Sánchez | Match Report | |
| 29 | Fri | 2022-03-18 | 21:00 | Athletic Club | 2.0 | 1–1 | 0.4 | Getafe | 37,367 | San Mamés | Jesús Gil | Match Report | |
| 29 | Sat | 2022-03-19 | 14:00 | Alavés | 1.7 | 2–3 | 2.1 | Granada | 16,209 | Estadio de Mendizorroza | Guillermo Cuadra | Match Report | |
| 29 | Sat | 2022-03-19 | 16:15 | Elche | 0.6 | 0–1 | 0.9 | Valencia | 15,780 | Estadio Manuel Martínez Valero | Miguel Ángel Ortiz Arias | Match Report | |
| 29 | Sat | 2022-03-19 | 18:30 | Osasuna | 2.3 | 3–1 | 1.0 | Levante | 19,429 | Estadio El Sadar | Alberola Rojas | Match Report | |
| 29 | Sat | 2022-03-19 | 21:00 | Rayo Vallecano | 1.4 | 0–1 | 1.4 | Atlético Madrid | 10,349 | Estadio del Rayo Vallecano | José Luis Munuera | Match Report | |
| 29 | Sun | 2022-03-20 | 14:00 | Espanyol | 1.3 | 1–0 | 0.5 | Mallorca | 17,578 | RCDE Stadium | Alejandro Muñíz | Match Report | |
| 29 | Sun | 2022-03-20 | 16:15 | Cádiz | 1.7 | 1–0 | 0.2 | Villarreal | 13,325 | Estadio Nuevo Mirandilla | Alejandro Hernández | Match Report | |
| 29 | Sun | 2022-03-20 | 16:15 | Celta Vigo | 0.9 | 0–0 | 0.5 | Betis | 13,149 | Estadio de Balaídos | Ricardo de Burgos | Match Report | |
| 29 | Sun | 2022-03-20 | 18:30 | Sevilla | 0.3 | 0–0 | 1.1 | Real Sociedad | 24,861 | Estadio Ramón Sánchez Pizjuán | César Soto | Match Report | |
| 29 | Sun | 2022-03-20 | 21:00 | Real Madrid | 0.8 | 0–4 | 3.4 | Barcelona | 60,017 | Estadio Santiago Bernabéu | Juan Martínez | Match Report | |
| 30 | Sat | 2022-04-02 | 14:00 | Getafe | 1.7 | 1–0 | 0.4 | Mallorca | 8,946 | Coliseum Alfonso Pérez | Antonio Matéu Lahoz | Match Report | |
| 30 | Sat | 2022-04-02 | 16:15 | Levante | 2.0 | 2–0 | 1.2 | Villarreal | 14,908 | Estadio Ciudad de Valencia | Adrián Cordero | Match Report | |
| 30 | Sat | 2022-04-02 | 18:30 | Celta Vigo | 1.6 | 1–2 | 2.9 | Real Madrid | 15,714 | Estadio de Balaídos | Pablo González | Match Report | |
| 30 | Sat | 2022-04-02 | 21:00 | Atlético Madrid | 3.0 | 4–1 | 0.5 | Alavés | 51,467 | Estadio Wanda Metropolitano | Mario Melero | Match Report | |
| 30 | Sun | 2022-04-03 | 14:00 | Athletic Club | 1.9 | 2–1 | 0.5 | Elche | 34,572 | San Mamés | Jorge Figueroa | Match Report | |
| 30 | Sun | 2022-04-03 | 16:15 | Betis | 4.4 | 4–1 | 0.4 | Osasuna | 49,103 | Estadio Benito Villamarín | Valentín Pizarro | Match Report | |
| 30 | Sun | 2022-04-03 | 18:30 | Granada | 2.1 | 2–2 | 0.8 | Rayo Vallecano | 15,823 | Estadio Nuevo Los Cármenes | Alejandro Hernández | Match Report | |
| 30 | Sun | 2022-04-03 | 18:30 | Valencia | 0.2 | 0–0 | 0.1 | Cádiz | 32,949 | Estadio de Mestalla | Isidro Díaz de Mera | Match Report | |
| 30 | Sun | 2022-04-03 | 21:00 | Barcelona | 1.9 | 1–0 | 0.6 | Sevilla | 76,112 | Camp Nou | José Sánchez | Match Report | |
| 30 | Mon | 2022-04-04 | 21:00 | Real Sociedad | 2.2 | 1–0 | 0.4 | Espanyol | 20,869 | Estadio Municipal de Anoeta | Santiago Jaime | Match Report | |
| 31 | Fri | 2022-04-08 | 21:00 | Sevilla | 2.9 | 4–2 | 0.9 | Granada | 33,504 | Estadio Ramón Sánchez Pizjuán | Miguel Ángel Ortiz Arias | Match Report | |
| 31 | Sat | 2022-04-09 | 14:00 | Cádiz | 1.3 | 1–2 | 1.3 | Betis | 18,063 | Estadio Nuevo Mirandilla | Jesús Gil | Match Report | |
| 31 | Sat | 2022-04-09 | 16:15 | Mallorca | 1.1 | 1–0 | 0.5 | Atlético Madrid | 15,437 | Iberostar Estadi | Juan Martínez | Match Report | |
| 31 | Sat | 2022-04-09 | 18:30 | Villarreal | 1.3 | 1–1 | 1.8 | Athletic Club | 16,603 | Estadio de la Cerámica | Carlos del Cerro | Match Report | |
| 31 | Sat | 2022-04-09 | 21:00 | Real Madrid | 1.6 | 2–0 | 0.4 | Getafe | 50,740 | Estadio Santiago Bernabéu | César Soto | Match Report | |
| 31 | Sun | 2022-04-10 | 14:00 | Osasuna | 2.1 | 1–0 | 0.5 | Alavés | 19,220 | Estadio El Sadar | Alejandro Muñíz | Match Report | |
| 31 | Sun | 2022-04-10 | 16:15 | Espanyol | 1.3 | 1–0 | 0.8 | Celta Vigo | 18,471 | RCDE Stadium | Alberola Rojas | Match Report | |
| 31 | Sun | 2022-04-10 | 18:30 | Elche | 0.6 | 1–2 | 1.7 | Real Sociedad | 17,011 | Estadio Manuel Martínez Valero | Guillermo Cuadra | Match Report | |
| 31 | Sun | 2022-04-10 | 21:00 | Levante | 3.4 | 2–3 | 1.2 | Barcelona | 20,785 | Estadio Ciudad de Valencia | José Luis Munuera | Match Report | |
| 31 | Mon | 2022-04-11 | 21:00 | Rayo Vallecano | 0.6 | 1–1 | 0.5 | Valencia | 9,302 | Estadio del Rayo Vallecano | Ricardo de Burgos | Match Report | |
| 32 | Fri | 2022-04-15 | 21:00 | Real Sociedad | 0.9 | 0–0 | 0.5 | Betis | 28,893 | Estadio Municipal de Anoeta | Isidro Díaz de Mera | Match Report | |
| 32 | Sat | 2022-04-16 | 14:00 | Elche | 1.6 | 3–0 | 1.5 | Mallorca | 20,257 | Estadio Manuel Martínez Valero | José Sánchez | Match Report | |
| 32 | Sat | 2022-04-16 | 16:15 | Alavés | 0.5 | 1–0 | 1.0 | Rayo Vallecano | 10,165 | Estadio de Mendizorroza | Juan Martínez | Match Report | |
| 32 | Sat | 2022-04-16 | 18:30 | Valencia | 1.3 | 1–2 | 1.1 | Osasuna | 30,148 | Estadio de Mestalla | Mario Melero | Match Report | |
| 32 | Sat | 2022-04-16 | 21:00 | Getafe | 0.9 | 1–2 | 2.7 | Villarreal | 9,657 | Coliseum Alfonso Pérez | Pablo González | Match Report | |
| 32 | Sun | 2022-04-17 | 14:00 | Granada | 1.0 | 1–4 | 3.9 | Levante | 15,323 | Estadio Nuevo Los Cármenes | Valentín Pizarro | Match Report | |
| 32 | Sun | 2022-04-17 | 16:15 | Atlético Madrid | 1.2 | 2–1 | 0.7 | Espanyol | 54,011 | Estadio Wanda Metropolitano | Jorge Figueroa | Match Report | |
| 32 | Sun | 2022-04-17 | 18:30 | Athletic Club | 0.5 | 0–2 | 0.4 | Celta Vigo | 35,541 | San Mamés | Alejandro Hernández | Match Report | |
| 32 | Sun | 2022-04-17 | 21:00 | Sevilla | 0.9 | 2–3 | 1.2 | Real Madrid | 40,629 | Estadio Ramón Sánchez Pizjuán | Guillermo Cuadra | Match Report | |
| 32 | Mon | 2022-04-18 | 21:00 | Barcelona | 1.2 | 0–1 | 1.7 | Cádiz | 57,495 | Camp Nou | Santiago Jaime | Match Report | |
| 33 | Tue | 2022-04-19 | 19:00 | Mallorca | 0.8 | 2–1 | 0.6 | Alavés | 15,264 | Iberostar Estadi | César Soto | Match Report | |
| 33 | Tue | 2022-04-19 | 21:00 | Betis | 1.2 | 0–1 | 0.6 | Elche | 43,257 | Estadio Benito Villamarín | Alberola Rojas | Match Report | |
| 33 | Tue | 2022-04-19 | 21:30 | Villarreal | 2.4 | 2–0 | 0.3 | Valencia | 13,570 | Estadio de la Cerámica | José Luis Munuera | Match Report | |
| 33 | Wed | 2022-04-20 | 19:00 | Atlético Madrid | 1.1 | 0–0 | 0.2 | Granada | 43,517 | Estadio Wanda Metropolitano | Jesús Gil | Match Report | |
| 33 | Wed | 2022-04-20 | 20:00 | Celta Vigo | 0.4 | 0–2 | 1.1 | Getafe | 9,934 | Estadio de Balaídos | Santiago Jaime | Match Report | |
| 33 | Wed | 2022-04-20 | 21:30 | Osasuna | 1.1 | 1–3 | 4.5 | Real Madrid | 21,360 | Estadio El Sadar | Ricardo de Burgos | Match Report | |
| 33 | Thu | 2022-04-21 | 19:00 | Levante | 2.7 | 2–3 | 1.8 | Sevilla | 18,107 | Estadio Ciudad de Valencia | Isidro Díaz de Mera | Match Report | |
| 33 | Thu | 2022-04-21 | 19:00 | Espanyol | 0.4 | 0–1 | 0.6 | Rayo Vallecano | 11,873 | RCDE Stadium | Antonio Matéu Lahoz | Match Report | |
| 33 | Thu | 2022-04-21 | 20:00 | Cádiz | 3.1 | 2–3 | 1.6 | Athletic Club | 17,360 | Estadio Nuevo Mirandilla | Valentín Pizarro | Match Report | |
| 33 | Thu | 2022-04-21 | 21:30 | Real Sociedad | 0.8 | 0–1 | 1.1 | Barcelona | 35,128 | Estadio Municipal de Anoeta | Carlos del Cerro | Match Report | |
| 21 | Sun | 2022-04-24 | 21:00 | Barcelona | 1.7 | 0–1 | 0.3 | Rayo Vallecano | 57,023 | Camp Nou | Isidro Díaz de Mera | Match Report | |
| 34 | Fri | 2022-04-29 | 21:00 | Sevilla | 0.7 | 1–1 | 0.9 | Cádiz | 37,113 | Estadio Ramón Sánchez Pizjuán | José Sánchez | Match Report | |
| 34 | Sat | 2022-04-30 | 14:00 | Alavés | 2.4 | 2–1 | 1.3 | Villarreal | 12,579 | Estadio de Mendizorroza | Miguel Ángel Ortiz Arias | Match Report | |
| 34 | Sat | 2022-04-30 | 16:15 | Real Madrid | 1.8 | 4–0 | 1.3 | Espanyol | 58,686 | Estadio Santiago Bernabéu | José Luis Munuera | Match Report | |
| 34 | Sat | 2022-04-30 | 18:30 | Valencia | 0.5 | 1–1 | 1.3 | Levante | 35,099 | Estadio de Mestalla | Jorge Figueroa | Match Report | |
| 34 | Sat | 2022-04-30 | 21:00 | Athletic Club | 1.3 | 2–0 | 0.7 | Atlético Madrid | 43,398 | San Mamés | Antonio Matéu Lahoz | Match Report | |
| 34 | Sun | 2022-05-01 | 14:00 | Elche | 0.6 | 1–1 | 1.1 | Osasuna | 16,305 | Estadio Manuel Martínez Valero | Carlos del Cerro | Match Report | |
| 34 | Sun | 2022-05-01 | 16:15 | Granada | 0.7 | 1–1 | 1.1 | Celta Vigo | 15,036 | Estadio Nuevo Los Cármenes | Juan Martínez | Match Report | |
| 34 | Sun | 2022-05-01 | 18:30 | Rayo Vallecano | 1.4 | 1–1 | 0.7 | Real Sociedad | 9,395 | Estadio del Rayo Vallecano | Alejandro Muñíz | Match Report | |
| 34 | Sun | 2022-05-01 | 21:00 | Barcelona | 1.2 | 2–1 | 1.0 | Mallorca | 62,789 | Camp Nou | Pablo González | Match Report | |
| 34 | Mon | 2022-05-02 | 21:00 | Getafe | 0.7 | 0–0 | 0.2 | Betis | 9,916 | Coliseum Alfonso Pérez | Adrián Cordero | Match Report | |
| 35 | Fri | 2022-05-06 | 21:00 | Levante | 2.1 | 2–1 | 2.1 | Real Sociedad | 17,278 | Estadio Ciudad de Valencia | Alberola Rojas | Match Report | |
| 35 | Sat | 2022-05-07 | 14:00 | Mallorca | 1.4 | 2–6 | 1.6 | Granada | 18,466 | Iberostar Estadi | Ricardo de Burgos | Match Report | |
| 35 | Sat | 2022-05-07 | 16:15 | Athletic Club | 1.3 | 0–0 | 0.1 | Valencia | 41,091 | San Mamés | Isidro Díaz de Mera | Match Report | |
| 35 | Sat | 2022-05-07 | 18:30 | Cádiz | 1.8 | 3–0 | 0.1 | Elche | 17,615 | Estadio Nuevo Mirandilla | Alejandro Hernández | Match Report | |
| 35 | Sat | 2022-05-07 | 18:30 | Celta Vigo | 1.9 | 4–0 | 0.5 | Alavés | 10,567 | Estadio de Balaídos | Guillermo Cuadra | Match Report | |
| 35 | Sat | 2022-05-07 | 21:00 | Betis | 0.7 | 1–2 | 1.2 | Barcelona | 46,132 | Estadio Benito Villamarín | Antonio Matéu Lahoz | Match Report | |
| 35 | Sun | 2022-05-08 | 14:00 | Getafe | 0.6 | 0–0 | 0.7 | Rayo Vallecano | 10,125 | Coliseum Alfonso Pérez | Mario Melero | Match Report | |
| 35 | Sun | 2022-05-08 | 16:15 | Villarreal | 2.2 | 1–1 | 0.8 | Sevilla | 17,461 | Estadio de la Cerámica | Jesús Gil | Match Report | |
| 35 | Sun | 2022-05-08 | 18:30 | Espanyol | 0.6 | 1–1 | 0.6 | Osasuna | 18,903 | RCDE Stadium | Santiago Jaime | Match Report | |
| 35 | Sun | 2022-05-08 | 21:00 | Atlético Madrid | 2.3 | 1–0 | 1.1 | Real Madrid | 63,874 | Estadio Wanda Metropolitano | César Soto | Match Report | |
| 36 | Tue | 2022-05-10 | 19:00 | Valencia | 1.2 | 0–3 | 1.6 | Betis | 28,091 | Estadio de Mestalla | Carlos del Cerro | Match Report | |
| 36 | Tue | 2022-05-10 | 20:00 | Granada | 0.9 | 1–0 | 0.3 | Athletic Club | 16,638 | Estadio Nuevo Los Cármenes | José Sánchez | Match Report | |
| 36 | Tue | 2022-05-10 | 21:30 | Barcelona | 1.1 | 3–1 | 0.7 | Celta Vigo | 55,899 | Camp Nou | Miguel Ángel Ortiz Arias | Match Report | |
| 36 | Wed | 2022-05-11 | 19:00 | Osasuna | 0.6 | 1–1 | 0.3 | Getafe | 17,850 | Estadio El Sadar | Alejandro Muñíz | Match Report | |
| 36 | Wed | 2022-05-11 | 19:00 | Alavés | 2.6 | 2–1 | 0.9 | Espanyol | 12,729 | Estadio de Mendizorroza | Valentín Pizarro | Match Report | |
| 36 | Wed | 2022-05-11 | 20:30 | Sevilla | 1.5 | 0–0 | 0.6 | Mallorca | 33,242 | Estadio Ramón Sánchez Pizjuán | Alejandro Hernández | Match Report | |
| 36 | Wed | 2022-05-11 | 21:30 | Elche | 0.2 | 0–2 | 1.9 | Atlético Madrid | 21,266 | Estadio Manuel Martínez Valero | Pablo González | Match Report | |
| 36 | Thu | 2022-05-12 | 19:00 | Real Sociedad | 3.0 | 3–0 | 0.7 | Cádiz | 29,014 | Estadio Municipal de Anoeta | Juan Martínez | Match Report | |
| 36 | Thu | 2022-05-12 | 20:00 | Rayo Vallecano | 1.8 | 1–5 | 2.4 | Villarreal | 7,945 | Estadio del Rayo Vallecano | Isidro Díaz de Mera | Match Report | |
| 36 | Thu | 2022-05-12 | 21:30 | Real Madrid | 3.5 | 6–0 | 1.0 | Levante | 38,421 | Estadio Santiago Bernabéu | Adrián Cordero | Match Report | |
| 37 | Sat | 2022-05-14 | 18:30 | Espanyol | 0.7 | 1–1 | 1.6 | Valencia | 14,990 | RCDE Stadium | Alejandro Muñíz | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Levante | 1.9 | 3–1 | 0.5 | Alavés | 12,438 | Estadio Ciudad de Valencia | Guillermo Cuadra | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Villarreal | 0.7 | 1–2 | 2.1 | Real Sociedad | 16,689 | Estadio de la Cerámica | Pablo González | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Getafe | 0.3 | 0–0 | 0.2 | Barcelona | 13,072 | Coliseum Alfonso Pérez | Jesús Gil | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Athletic Club | 1.1 | 2–0 | 0.9 | Osasuna | 37,869 | San Mamés | Jorge Figueroa | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Atlético Madrid | 1.2 | 1–1 | 0.7 | Sevilla | 58,138 | Estadio Wanda Metropolitano | José Sánchez | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Betis | 2.3 | 2–0 | 1.1 | Granada | 45,016 | Estadio Benito Villamarín | Ricardo de Burgos | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Celta Vigo | 2.1 | 1–0 | 0.5 | Elche | 10,773 | Estadio de Balaídos | Mario Melero | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Mallorca | 0.8 | 2–1 | 1.2 | Rayo Vallecano | 17,930 | Iberostar Estadi | José Luis Munuera | Match Report | |
| 37 | Sun | 2022-05-15 | 19:30 | Cádiz | 2.7 | 1–1 | 1.6 | Real Madrid | 19,643 | Estadio Nuevo Mirandilla | Antonio Matéu Lahoz | Match Report | |
| 38 | Fri | 2022-05-20 | 21:00 | Real Madrid | 1.2 | 0–0 | 0.9 | Betis | 52,232 | Estadio Santiago Bernabéu | Santiago Jaime | Match Report | |
| 38 | Fri | 2022-05-20 | 21:00 | Rayo Vallecano | 2.5 | 2–4 | 2.5 | Levante | 8,446 | Estadio del Rayo Vallecano | Mario Melero | Match Report | |
| 38 | Sat | 2022-05-21 | 17:30 | Valencia | 1.5 | 2–0 | 0.9 | Celta Vigo | 16,189 | Estadio de Mestalla | Adrián Cordero | Match Report | |
| 38 | Sun | 2022-05-22 | 17:30 | Elche | 2.7 | 3–1 | 1.3 | Getafe | 17,336 | Estadio Manuel Martínez Valero | Guillermo Cuadra | Match Report | |
| 38 | Sun | 2022-05-22 | 20:00 | Osasuna | 0.8 | 0–2 | 1.2 | Mallorca | 18,717 | Estadio El Sadar | César Soto | Match Report | |
| 38 | Sun | 2022-05-22 | 20:00 | Granada | 1.7 | 0–0 | 0.3 | Espanyol | 17,951 | Estadio Nuevo Los Cármenes | Alejandro Hernández | Match Report | |
| 38 | Sun | 2022-05-22 | 20:00 | Alavés | 0.4 | 0–1 | 1.8 | Cádiz | 11,138 | Estadio de Mendizorroza | José Sánchez | Match Report | |
| 38 | Sun | 2022-05-22 | 22:00 | Barcelona | 0.6 | 0–2 | 0.8 | Villarreal | 54,850 | Camp Nou | José Luis Munuera | Match Report | |
| 38 | Sun | 2022-05-22 | 22:00 | Sevilla | 1.2 | 1–0 | 0.7 | Athletic Club | 31,305 | Estadio Ramón Sánchez Pizjuán | Carlos del Cerro | Match Report | |
| 38 | Sun | 2022-05-22 | 22:00 | Real Sociedad | 2.5 | 1–2 | 0.7 | Atlético Madrid | 23,586 | Estadio Municipal de Anoeta | Jesús Gil | Match Report |
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